Diagnostic markers for neuropsychiatric disease

ABSTRACT

Biomarkers for the diagnosis of neuropsychiatric diseases are presented herein. In particular embodiments, biomarkers are identified that are useful for diagnosing multiple sclerosis, chronic fatigue syndrome, or Neurologic Lyme disease. Also encompassed is a method for diagnosing a patient with a neuropsychiatric disease, such as multiple sclerosis, chronic fatigue syndrome, or Neurologic Lyme disease, by analyzing biological samples isolated from the patient or the patient as a whole to assess levels of the biomarkers described herein.

FIELD OF THE INVENTION

The present invention relates to identifying biologic markers (biomarkers) that can be used for diagnosis of a neuropsychiatric disease. As described herein, neuropsychiatric disease may be used to refer to diseases having neurologic or psychiatric or combined neurologic and psychiatric features. Such neuropsychiatric diseases include, without limitation, multiple sclerosis, chronic fatigue syndrome, and Neurologic Lyme disease. In particular embodiments, the present invention relates to identifying biomarkers for diagnosis of multiple sclerosis, chronic fatigue syndrome (CFS; also referred to herein as CF), or Neurologic Lyme disease. In a more particular aspect, the invention pertains to the identification of a biomarker signature that is diagnostic for each of multiple sclerosis, chronic fatigue syndrome, Neurologic Lyme disease. Accordingly, the invention further relates to a method for diagnosing a person or other mammal with a neuropsychiatric disease, such as multiple sclerosis, or at risk of developing same. The biomarkers and diagnostic signatures described herein also identify metabolic/biochemical pathways as potential candidates for therapeutic targeting. The invention further relates to guidance pertaining to appropriate treatment of the person or mammal diagnosed with a particular neuropsychiatric disease in accordance the methods described herein. Accurate diagnosis of neuropsychiatric disease, particularly with respect to diseases that are difficult to distinguish clinically, should reduce the duration and/or severity of the disease by ensuring that the patient is treated using an appropriate therapeutic regimen.

BACKGROUND OF THE INVENTION

Knowledge of the entire protein content, the proteome, of normal human cerebrospinal fluid (CSF) would provide a critical standard to allow meaningful comparisons with and between neurologic and psychiatric disorders. CSF contains both cellular and soluble components providing insights into processes occurring in the central nervous system (CNS). As much as 30 to 40% of CSF is formed by the extracellular fluid of the brain and spinal cord. CSF contains both normal and disease specific components, and provides an accessible liquid window into the brain. In fact, recent data suggest CSF may provide more relevant evidence for initial or propagating pathology than the brain parenchyma itself in certain neuropsychiatric diseases [Ransohoff (2009) Nature 457: 155-156]. Comprehensive characterization of the normal CSF proteome, furthermore, facilitates identification of disease-specific markers [Ekegren et al. (2008) J Mass Spectrom 43: 559-571]. Knowledge of which proteins are present, absent, or of changed concentrations may lead to diagnostic, prognostic, or disease-activity biomarkers as well as provide insights into disease etiology and pathogenesis. An advantage of a full proteome analysis is the ability to identify not just one but a multitude of proteins at a single instance.

Multiple sclerosis, for example, is an excellent candidate disease for such an approach because it is often a progressive debilitating disease that is difficult to diagnose definitively, especially during the early stages of the disease. Multiple sclerosis is a common demyelinating disease of the central nervous system (CNS) that affects up to 0.1% of the Caucasian population of northern European descent. Multiple sclerosis is more common in women than men and generally begins between ages 20 and 40, but can develop at any age. Multiple sclerosis is generally viewed as an autoimmune syndrome directed against unidentified central nervous tissue antigens. The determination of susceptibility to multiple sclerosis development is complex and appears to be governed by both environmental and genetic factors. Some of the symptoms of multiple sclerosis are caused by damage to the myelin sheath, the protective covering that surrounds nerve cells. When this nerve covering is damaged, nerve impulses are slowed down or stopped. Ultimately, damage to the myelin sheath results in nerve damage. Multiple sclerosis is, moreover, commonly a progressive disease that leads to more severe neurologic dysfunction over time. Nerve damage may be caused by inflammation that occurs when the body's immune cells attack the nervous system. Repeated episodes of inflammation can occur along any area of the brain and spinal cord, which is why the disease is often referred to as one characterized by symptoms and signs over time and space.

Multiple sclerosis is difficult to diagnose because the progress, severity and specific symptoms of multiple sclerosis are quite variable and unpredictable. There are no laboratory tests, symptoms or physical findings that can singly determine if a person has multiple sclerosis. The differential diagnosis of multiple sclerosis is quite varied and includes metabolic, genetic, oncologic, immunologic, and infectious disease assessment. Other diseases that may need to be considered in the differential diagnoses, but should be considered depending on the clinical presentation, include: Acute disseminated encephalomyelitis, CNS vasculitis, Behçet disease, Sjögren syndrome, Sarcoid, neoplasms, CADASIL (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy), Migrainous ischemia, Cerebrovascular disease, Progressive multifocal leukoencephalopathy, Inherited white matter diseases, effects of radiation therapy or drugs, CNS lymphoma, Lyme disease, HTLV-1 infection, CNS lupus, Mitochondrial encephalopathies, Antiphospholipid antibody syndrome, cerebral emboli, Thrombocytopenic purpura, Progressive multifocal leukoencephalopathy, Mycoplasma encephalopathy, Vitamin B12 deficiency, Paraneoplastic syndromes, Psychiatric syndromes (Rolak L A, Fleming J O. The Neurologist 2007; 13: 57-72). Over the last twenty years, tests such as magnetic resonance imaging (MRI), examination of CSF, and evoked response testing have played an increasingly important role in the diagnostic process. In 2005, revised McDonald criteria for multiple sclerosis were published (Polman et al. Diagnostic Criteria for Multiple Sclerosis: 2005 Revisions to the “McDonald” Criteria. Ann Neurol. (2005) 58:840-846 and Polman et al. Ann Neurol (2011) 69:292-302). In addition to the traditional diagnostic tools, the revised criteria provide specific guidelines for using findings of MRI, cerebrospinal fluid analysis and visual evoked potentials to support a diagnosis of multiple sclerosis. However, even with these revised criteria, diagnosis of multiple sclerosis is still challenging and frequently takes several months or even years.

Rendering a conclusive diagnosis of multiple sclerosis on an expedited basis would be of great benefit to patients in light of the potential for recurrence of attacks and progression of the disease. Drugs for the treatment of multiple sclerosis are now available which slow or prevent progression of the disease in many patients, and an early diagnosis would, therefore, allow early intervention and could significantly improve the quality of life for many multiple sclerosis patients.

It is therefore an object of the present invention to provide an efficient diagnosis system for neuropsychiatric disease in general, a particular example of which is multiple sclerosis, so as to provide biomarkers with which a clinician can diagnose or exclude a particular disease in a patient or other mammal. The same reasoning applies to Neurologic Lyme Disease and Chronic Fatigue syndrome.

The citation of references herein shall not be construed as an admission that such is prior art to the present invention. Several publications and patent documents are referenced in this application in order to more fully describe the state of the art to which this invention pertains. The disclosure of each of these publications and documents is incorporated by reference herein.

Other features and advantages of the invention will be apparent from the detailed description, the drawings, and the claims.

SUMMARY OF THE INVENTION

The present invention is based on the discovery of biomarkers useful for diagnosing and monitoring neuropsychiatric diseases. Neuropsychiatric diseases which may be diagnosed or monitored using the biomarkers of the invention include, without limitation: multiple sclerosis (especially focused on first attack multiple sclerosis), Neurologic Lyme Disease, and Chronic Fatigue Syndrome. Biomarkers identified for such neuropsychiatric diseases are listed herein in Tables 1m, 2m, 3, 4H-m, 4H-1, 4H-c, 5c, 6c, 7L, 8L, 9, and 10. As indicated in the tables presented herein, the presence or absence of at least one biomarker in a biological sample isolated from a patient is indicative of a positive diagnosis of a neuropsychiatric disease. As indicated herein, the identification of a plurality of biomarkers correlated with a particular disease may strengthen the confidence level of the diagnostic prediction. Biomarkers identified herein have also been assessed using software programs (such as, e.g., Ingenuity Pathway Analysis) to identify metabolic pathways implicated in disease etiology, maintenance, and/or progression. Multiple hits in a particular metabolic pathway underscore the potential importance of the pathway for the disease and direct therapeutic intervention toward appropriate modulation of same.

Accordingly, the present invention is directed to a method for diagnosing a neuropsychiatric disease in a patient, wherein said method comprises isolating a biological sample from the patient and analyzing the biological sample to determine if at least one of the biomarkers indicative of the presence of the neuropsychiatric disease is identified in the biological sample, thereby diagnosing the neuropsychiatric disease in the patient. As described herein, the presence or absence of at least one biomarker in a biological sample isolated from a patient is indicative of a positive diagnosis of a neuropsychiatric disease.

In another aspect, a method for diagnosing multiple sclerosis in a patient is presented, the method comprising: a) isolating a biological sample from the patient; and b) analyzing the biological sample for expression of a panel of biomarkers, wherein the panel of biomarkers is set forth in any one of Tables 1m, 3m, 4H-m or 2m, to determine if at least one of the biomarkers listed in any one of Tables 1m, 3m, 4H-m or Table 2m is identified in the biological sample, wherein identification of at least one of the biomarkers in the biological sample indicates a positive diagnosis or is indicative of multiple sclerosis in the patient. In an embodiment thereof, the at least one biomarker identified in the biological sample is present in the biological sample and set forth in Table 1m, 3m, or 4H-m, and the presence of the at least one biomarker indicates a positive diagnosis or is indicative of multiple sclerosis. In another embodiment, the at least one biomarker identified in the biological sample is absent from the biological sample and set forth in Table 2m and the absence of the at least one biomarker indicates a positive diagnosis or is indicative of multiple sclerosis.

In yet another aspect, a method for differentially diagnosing a neuropsychiatric disease in a patient is presented, wherein the patient exhibits clinical symptoms common to both Neurologic Lyme disease and Chronic Fatigue Syndrome, the method comprising: a) isolating a biological sample from the patient; and b) analyzing the biological sample for expression of a first panel of biomarkers, wherein the first panel of biomarkers is set forth in any one of Tables 4H-1, 7L, or 8L, to determine if at least one of the biomarkers listed in any one of Tables 4H-1, 7L, or 8L is identified in the biological sample, wherein identification of at least one of the biomarkers in the biological sample indicates a positive diagnosis or is indicative of Neurologic Lyme disease. In an embodiment thereof, the at least one biomarker identified in the biological sample is present in the biological sample and set forth in Table 4H-1 or 7L and the presence of the at least one biomarker indicates a positive diagnosis or is indicative of Neurologic Lyme disease. In another embodiment, the at least one biomarker identified in the biological sample is absent from the biological sample and set forth in Table 8L and the absence of the at least one biomarker indicates a positive diagnosis or is indicative of Neurologic Lyme disease.

The method may further comprise analyzing the biological sample for expression of a second panel of biomarkers, wherein the second panel of biomarkers is set forth in any one of Tables 4H-c, 5c, or 6c, to determine if at least one of the biomarkers listed in any one of Tables 4H-c, 5c, or 6c is identified in the biological sample, wherein identification of at least one of the biomarkers in the biological sample indicates a positive diagnosis or is indicative of Chronic Fatigue Syndrome. In an embodiment thereof, the at least one biomarker identified in the biological sample is present in the biological sample and set forth in Table 4H-c or 5c and the presence of the at least one biomarker indicates a positive diagnosis or is indicative of Chronic Fatigue Syndrome. In another embodiment, the at least one biomarker identified in the biological sample is absent from the biological sample and set forth in Table 6c and the absence of the at least one biomarker indicates a positive diagnosis or is indicative of Chronic Fatigue Syndrome.

In yet another aspect, a method for diagnosing Neurologic Lyme disease in a patient is presented, the method comprising: a) isolating a biological sample from the patient; and b) analyzing the biological sample for expression of a panel of biomarkers, wherein the panel of biomarkers is set forth in any one of Tables 4H-1, 7L, or to determine if at least one of the biomarkers listed in any one of Tables 4H-1, 7L, or 8L is identified in the biological sample, wherein identification of at least one of the biomarkers in the biological sample indicates a positive diagnosis or is indicative of Neurologic Lyme disease in the patient. In an embodiment thereof, the at least one biomarker identified in the biological sample is present in the biological sample and set forth in Table 4H-1 or 7L, and the presence of the at least one biomarker indicates a positive diagnosis or is indicative of Neurologic Lyme disease. In another embodiment, the at least one biomarker identified in the biological sample is absent from the biological sample and set forth in Table 8L and the absence of the at least one biomarker indicates a positive diagnosis or is indicative of Neurologic Lyme disease.

In yet another aspect, a method for diagnosing Chronic Fatigue Syndrome in a patient is presented, the method comprising: a) isolating a biological sample from the patient; and b) analyzing the biological sample for expression of a panel of biomarkers, wherein the panel of biomarkers is set forth in any one of Tables 4H-c, 5c, or 6c, to determine if at least one of the biomarkers listed in any one of Tables 4H-c, 5c, or 6c is identified in the biological sample, wherein identification of at least one of the biomarkers in the biological sample indicates a positive diagnosis or is indicative of Chronic Fatigue Syndrome in the patient. In an embodiment thereof, the at least one biomarker identified in the biological sample is present in the biological sample and set forth in Table 4H-c or 5c, and the presence of the at least one biomarker indicates a positive diagnosis or is indicative of Chronic Fatigue Syndrome. In another embodiment, the at least one biomarker identified in the biological sample is absent from the biological sample and set forth in Table 6c and the absence of the at least one biomarker indicates a positive diagnosis or is indicative of Chronic Fatigue Syndrome.

In accordance with the methods described herein, the biological sample may be cerebrospinal fluid, blood or a component thereof (e.g., plasma, serum, cells), tissue or tissue-related fluids, urine, or saliva.

Also encompassed herein is a method for diagnosing a neuropsychiatric disease, the method comprising: a) isolating a biological sample from the patient; b) analyzing the biological sample to determine a first level of at least one of the biomarkers indicative of the presence of the neuropsychiatric disease in the biological sample; and c) comparing the first level of the at least one of the biomarkers to a second level of the at least one of the biomarkers determined for a subject, wherein the subject does not have the neuropsychiatric disease, and wherein at least a two-fold difference in the ratio of the first level to the second level indicates a positive diagnosis of the neuropsychiatric disease. In a particular embodiment, the at least two-fold difference is an increase, which is indicative of a positive diagnosis of the neuropsychiatric disease. In an alternative embodiment, the at least two-fold difference is a decrease, which is indicative of a positive diagnosis of the neuropsychiatric disease. As described herein, in certain circumstances the subject is a healthy subject. In accordance with the invention, the subject may have a second neuropsychiatric disease, wherein the second neuropsychiatric disease differs from the neuropsychiatric disease for which the instant method is diagnostic. Under such a circumstance, the two-fold difference in the ratio may be used to confer a differential diagnosis between the neuropsychiatric disease for which the instant method is diagnostic and the second neuropsychiatric disease. This is a particularly useful feature of the present method when the clinical presentation for the neuropsychiatric disease for which the instant method is diagnostic and the second neuropsychiatric disease is similar.

In a particular embodiment thereof, a method is presented for diagnosing a neuropsychiatric disease in a patient, wherein the patient exhibits clinical symptoms common to both Chronic Fatigue Syndrome and Neurologic Lyme disease, the method comprising: a) isolating a biological sample from the patient; b) analyzing the biological sample to evaluate expression levels of the biomarkers listed in Table 9 to determine a first level of at least one of the biomarkers indicative of the presence of the neuropsychiatric disease in the biological sample; and c) comparing the first level of the at least one of the biomarkers to a second level of the at least one of the biomarkers determined for a subject, wherein the subject does not have the neuropsychiatric disease, and wherein at least a two-fold difference in the ratio of the first level to the second level indicates a positive diagnosis of the neuropsychiatric disease. In an embodiment thereof, the diagnosis is directed to determining if the patient has Chronic Fatigue Syndrome or Neurologic Lyme disease. In a particular embodiment, the at least a two-fold difference is at least a two-fold increase or at least a two-fold decrease. In another particular embodiment, the subject is a healthy subject.

Also encompassed herein are kits for diagnosing neuropsychiatric diseases. In a particular aspect, a kit for diagnosing multiple sclerosis is presented, wherein the kit comprises probes (e.g., antibodies or fragments or derivatives thereof) for detecting expression of at least one biomarker listed in Table 1m, 3m, 4H-m, or Table 2m, wherein detectable expression of at least one biomarker listed in Table 1m, 3m, or 4H-m is indicative of a positive diagnosis of multiple sclerosis and wherein an absence of detectable expression of at least one biomarker listed in Table 2m is indicative of a positive diagnosis of multiple sclerosis.

In another aspect, a kit for diagnosing Chronic Fatigue Syndrome is presented, wherein the kit comprises probes (e.g., antibodies or fragments or derivatives thereof) for detecting expression of at least one biomarker listed in Table 4H-c, 5c, or Table 6c, wherein detectable expression of at least one biomarker listed in Table 4H-c or 5c is indicative of a positive diagnosis of Chronic Fatigue Syndrome and wherein an absence of detectable expression of at least one biomarker listed in Table 6c is indicative of a positive diagnosis of Chronic Fatigue Syndrome.

In yet another aspect, a kit for diagnosing Neurologic Lyme Disease is presented, wherein the kit comprises probes (e.g., antibodies or fragments or derivatives thereof) for detecting expression of at least one biomarker listed in Table 7L or Table 8L, wherein detectable expression of at least one biomarker listed in Table 7L is indicative of a positive diagnosis of Neurologic Lyme Disease and wherein an absence of detectable expression of at least one biomarker listed in Table 8L is indicative of a positive diagnosis of Neurologic Lyme Disease.

As described herein, the kits embodied herein may comprise probes for detecting expression of at least 2, 3, 4, 5, 6, 7, 8, 9, 10, 15, 20, 25, or 30 of the biomarkers listed in any one of Tables 1m, 3m, 4H-m, 2m, 4H-c, 5c, 6c, 7L or 8L, wherein the number of biomarkers listed in any one of Tables 1m, 3m, 4H-m, 2m, 4H-c, 5c, 6c, 7L or 8L establishes the upper limit of biomarkers detected by the kit. In other words, each of the Tables encompasses a maximum number of biomarkers as indicated therein and the number of biomarkers listed in the Tables may differ between each Table. In a particular embodiment, a kit may comprise probes for detecting expression of all of the biomarkers listed in any one of Tables 1m, 3m, 4H-m, 2m, 4H-c, 5c, 6c, 7L or 8L. In particular embodiments, the probes may be immobilized on a solid surface.

In another aspect, the invention is directed to a method for monitoring efficacy of a treatment for a neuropsychiatric disease in a patient, wherein said method comprises isolating a first biological sample from the patient prior to initiating the treatment and isolating a second biological sample from the patient after initiating the treatment, analyzing the biological samples to determine the level of at least one of the biomarkers indicative of the presence of the neuropsychiatric disease in the first and second biological samples, and comparing the level of the at least one of the biomarkers in the first and second biological samples, wherein a change in the level of the at least one of the biomarkers reflects the efficacy of the treatment. In one embodiment, wherein the presence of the at least one biomarker is associated with a positive diagnosis or presence of the disease, a detectable reduction in the level of the at least one biomarker following initiating the treatment indicates that the treatment is efficacious. In another embodiment, wherein the absence of the at least one biomarker is associated with a positive diagnosis or presence of the disease, a detectable increase in level in the at least one biomarker following initiating the treatment indicates that the treatment is efficacious.

In another aspect, the invention is directed to a method for monitoring disease progression of a neuropsychiatric disease in a patient, wherein said method comprises isolating a first biological sample from the patient at an initial or first temporal window and isolating a second biological sample from the patient at a later (e.g., second) temporal window, analyzing the biological samples to determine the level of at least one of the biomarkers indicative of the presence of the neuropsychiatric disease in the first and second biological samples, and comparing the level of the at least one of the biomarkers in the first and second biological samples, wherein a change in the level of the at least one of the biomarkers in the first and second biological samples reflects progression of the disease. In one embodiment, wherein the presence of the at least one biomarker is associated with a positive diagnosis or presence of the disease, a detectable increase in the level of the at least one biomarker at the later temporal time window relative to the initial temporal window indicates that the disease has progressed or worsened. In another embodiment, wherein the absence of the at least one biomarker is associated with a positive diagnosis or presence of the disease, a detectable decrease in the level of the at least one biomarker at the later temporal time window relative to the initial temporal window indicates that the disease has improved.

The present invention is, moreover, directed to a method for diagnosing a neuropsychiatric disease in a patient, wherein said method comprises visualizing or detecting at least one of the biomarkers indicative of the presence of the neuropsychiatric disease in the patient, thereby diagnosing the neuropsychiatric disease in the patient. As described herein, the presence or absence of at least one biomarker in a patient is indicative of a positive diagnosis of a neuropsychiatric disease. In accordance with such an embodiment, various detection imaging techniques may be utilized including, but not limited to, magnetic resonance imaging (MRI), positron emission tomography (PET), and CAT scans.

In one embodiment, the present invention relates to the identification and use of biomarkers in methods for diagnosing multiple sclerosis, particularly diagnosis of first attack multiple sclerosis. The invention also pertains to the use of these biomarkers in methods for assessing relapse of multiple sclerosis patients and disease progression in multiple sclerosis patients. Biomarkers identified in accordance with the invention are also useful for identifying treatments for and monitoring efficacy of treatment of patients with multiple sclerosis. As shown herein, the inventors have identified a plurality of biomarkers whose presence is indicative of multiple sclerosis; such biomarkers are listed in Tables 1m, 3m, or 4H-m. The inventors have also identified a plurality of biomarkers whose absence is indicative of multiple sclerosis; such biomarkers are listed in Table 2m.

In another embodiment, the present invention relates to the identification and use of biomarkers in methods for diagnosing chronic fatigue syndrome (CFS) in patients. Biomarkers identified in accordance with the invention are also useful for identifying treatments for and monitoring efficacy of treatment of patients with CFS. As shown herein, the inventors have identified a plurality of biomarkers whose presence is indicative of CFS; such biomarkers are listed in Table 4H-c, and 5c. The inventors have also identified a plurality of biomarkers whose absence is indicative of CFS; such biomarkers are listed in Table 6c.

In yet another embodiment, the present invention relates to the identification and use of biomarkers in methods for diagnosing Neurologic Lyme disease in patients. Biomarkers identified in accordance with the invention are also useful for identifying treatments for and monitoring efficacy of treatment of patients with Neurologic Lyme disease. As shown herein, the inventors have identified a plurality of biomarkers whose presence is indicative of Neurologic Lyme disease; such biomarkers are listed in Table 7L. The inventors have also identified a plurality of biomarkers whose absence is indicative of Neurologic Lyme disease; such biomarkers are listed in Table 8L.

Also encompassed herein are diagnostic signatures for neuropsychiatric diseases. Such diagnostic signatures comprise biomarkers for diagnosing a neuropsychiatric disease, wherein the presence or absence of at least one biomarker indicates a positive diagnosis of the neuropsychiatric disease. In particular aspects, the diagnostic signature is indicative of multiple sclerosis, Chronic Fatigue Syndrome, or Neurologic Lyme Disease. In a particular embodiment, the diagnostic signature relates to the presence of at least one biomarker listed in Table 1m, 3m, or 4H-m and is indicative of a positive diagnosis of multiple sclerosis. In another embodiment, the diagnostic signature relates to the absence of at least one biomarker listed in Table 2m and is indicative of a positive diagnosis of multiple sclerosis. In yet another embodiment, the diagnostic signature relates to the presence of at least one biomarker listed in Table 4H-c or 5c and is indicative of a positive diagnosis of Chronic Fatigue Syndrome. In a further embodiment, the diagnostic signature relates to the absence of at least one biomarker listed in Table 6c and is indicative of a positive diagnosis of Chronic Fatigue Syndrome. In another embodiment, the diagnostic signature relates to the presence of at least one biomarker listed in Table 7L and is indicative of a positive diagnosis of Neurologic Lyme Disease. In yet another embodiment, the diagnostic signature relates to the absence of at least one biomarker listed in Table 8L and is indicative of a positive diagnosis of Neurologic Lyme Disease.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows a Venn diagram revealing the amount of overlap of the present dataset with a comparable dataset of proteins detected in the CSF of “normal clinical value” or “neurologic surrogate-normal” individuals who required a lumbar puncture for clinical reasons as reported by Zougman et al. [(2008) J Proteome Res 7: 386-399]. The large circle represents the 2630 proteins observed in the present comprehensive dataset of proteins detected in the CSF of normal individuals. The small circle represents the 798 proteins identified in the analysis by Zougman et al. [(2008) J Proteome Res 7: 386-399].

DETAILED DESCRIPTION OF THE INVENTION

The present inventors had a unique opportunity to generate what may be the most comprehensive database of true normal CSF proteins to date. The inventors were able to do this because they had sufficient numbers and total volume of true normal CSF samples to employ immunoaffinity depletion, followed by extensive fractionation and high-resolution liquid chromatography (LC) separation and mass spectrometry (MS) analysis. The combination of the normal CSF samples, including a set of serial CSF samples, and advanced technology contribute to the uniqueness and value of the present study. Knowledge as to the normal CSF proteome, in turn, makes possible a meaningful comparison with disease proteomes (i.e., proteomes characteristic of a particular disease).

Until recently, technological limitations have prevented full characterization of the CSF proteome. Comprehensive analysis of CSF has been challenged by low protein levels (0.3 to 0.7 mg/ml) compared to plasma, protein concentration variability up to twelve orders of magnitude, potential masking of brain-specific proteins by highly abundant proteins [Rozek et al. (2007) J Proteome Res 6: 4189-4199], and limited access to an adequate number of appropriate biological samples. Despite some of these limitations, a number of earlier studies have provided increasing levels of characterization of the CSF proteome. For the most part, these studies have used pooled samples from patient populations with diseases or from people with normal CSF clinical laboratory values (chemistries, cell counts, and microbiology) who underwent lumbar puncture for investigation of neurological complaints. These CSF samples were used as substitutes or surrogates for true normals (healthy volunteers) possibly due to lack of availability of such normal CSF samples. Sickmann et al., [(2000) Electrophoresis 21: 2721-2728] used two-dimensional polyacrylamide gel electrophoresis (2D-PAGE) followed by mass spectrometry (MS) to identify close to 70 CSF proteins. Yuan et al., [(2005) Proteomics 5:541-550] used matrix-assisted laser desorption ionization (MALDI) MS to identify 22 proteins in desalted CSF. Wenner et al., [(2004) J Proteome Res 3: 97-103] used 2D liquid chromatography (LC) coupled to tandem mass spectrometry (2D-LC-MS/MS) to identify 249 proteins in pooled CSF. Maccarrone et al. [(2004) Electrophoresis 25: 2402-2412]; used immunodepletion techniques and shotgun LC-MS/MS, to identify more than 100 proteins in CSF from a patient with normal pressure hydrocephalus. More recently Zougman et al. [(2008) J Proteome Res 7: 386-399], using LC-MS/MS, reported 798 proteins in a pool of 6 patients with neurologic complaints that warranted a lumbar puncture, but whose subsequent clinical CSF laboratory values were reported as normal; for the purposes of this application these types of patients as referred to as neurologic surrogate-normals. A notable exception to use of surrogates was the work by Zhang et al. [(2005) Neurobiol Aging 26: 207-227], who used 2D-LC-MS/MS to identify 315 proteins in pools of CSF comparing healthy younger versus older individuals. Subsequently, with Xu et al. [(2006) Int Rev Neurobiol 73: 29-98], they analyzed CSF from the younger group with two different LC-MS/MS platforms and identified a combined total of 915 proteins. Pan et al., reported a total of 2594 CSF protein identifications from different combined (cumulative) results of several CSF studies with a focus on neurodegenerative diseases such as Alzheimer's disease [(2007) Proteomics 7: 469-473].

Towards the principal purpose of establishing a comprehensive list or proteome of normal CSF, the present inventors have prepared CSF samples from healthy normal people for analysis by using immunoaffinity depletion of abundant proteins (with masking potential) to enhance coverage and detection of low abundance proteins [Qian et al. (2009) J Proteome Res 8: 290-299]. It is noteworthy that the present inventors also analyzed the abundant sample fraction in parallel. Samples were then analyzed employing high throughput, high sensitivity, and high resolution nanocapillary liquid chromatography-mass spectrometry (LC-MS [Petyuk et al. (2007) Genome Res 17: 328-336] and LC-MS/MS [Qian et al. (2009) J Proteome Res 8: 290-299]). Pre-fractionation (immunoaffinity depletion chromatography) and ultra-high resolution nanocapillary LC separations were used to effectively reduce the sample complexity and concentration dynamic range (thereby reducing or eliminating the “masking” effect [Ramstrom et al. (2005) J Proteome Res 4: 410-416]), high efficiency ion transmission technologies (e.g., electrodynamic ion funnel [Shaffer et al. (1997) Rapid Commun Mass Spectrom 11: 1813-1817]) for highly sensitive global MS analysis, and the accurate mass and time (AMT) tag strategy [Smith et al. (2002) Proteomics 2: 513-523] for high-throughput analysis (e.g. of individual CSF samples) and accurate quantitation. The general approach for AMT tag generation and application as described herein has been successfully implemented for whole microbial [Lipton et al. (2002) Proc Natl Acad Sci USA 99: 11049-11054] and mammalian tissue [Petyuk et al. (2007) Genome Res 17: 328-336] and plasma proteomes [Qian et al. (2009) J Proteome Res 8: 290-299; Qian et al. (2005) Mol Cell Proteomics 4: 700-709], but has not been previously applied to CSF from normal subjects.

As described herein, pooled CSF isolated from 11 normal healthy volunteers (8 women and 3 men, aged 24 to 55, median=28 years) who reported their health as excellent or good and were taking no medications was examined. Standard clinical laboratory testing on their CSF was normal (none had more than 3 white blood cells/mm³ and protein levels ranged from 14 to 40 mg/dl with a median of 25 mg/dl). Also examined were pairs of individual serial CSF samples, obtained at least 4 weeks apart, from 10 additional normal healthy volunteers to assess the potential variability of particular CSF protein levels in an individual from one time point to another.

To illustrate the utility of such a normal database and how one clinical condition might be compared to another the present inventors also analyzed and compared one set of CSF samples to another set processed in the same manner to evaluate, among other issues, if there might be significant differences among different surrogate-normal groups.

In summary and as described in greater detail herein below, the present inventors applied immunoaffinity separation and high sensitivity and resolution liquid chromatography-mass spectrometry to examine CSF from healthy normal individuals. 2630 proteins in CSF from normal subjects were identified, of which 56% were CSF-specific (i.e., as determined using the techniques described herein), not found in the much larger set of 3654 proteins identified in plasma. The above-mentioned 2630 proteins identified in normal subjects were identified with high confidence, meaning that two or more peptides corresponding to a particular protein were required as confirmation that the particular protein was, indeed, present in normal CSF. The present inventors also examined CSF from groups like those of subjects previously examined by others as surrogates for normals, where neurologic symptoms warranted a lumbar puncture but where clinical laboratory were reported as normal. Statistically significant differences between their CSF proteins and those determined for non-neurological normals examined herein were noted. The inventors also examined CSF from 10 volunteer subjects who had lumbar punctures at least 4 weeks apart and found that there was little variability in CSF proteins in an individual as compared from subject to subject.

The present results represent the most comprehensive characterization of true normal CSF to date. This normal CSF proteome establishes a comparative standard and basis for investigations into a variety of diseases with neurological and psychiatric features. With this essential information, the present inventors were able to identify biomarkers diagnostic for a number of neuropsychiatric diseases. See Examples I-IV.

Accordingly, the present invention encompasses identification of biomarkers diagnostic for a number of neuropsychiatric diseases. As indicated in each of Tables 1-10, the present inventors have identified biomarkers, whose presence or absence as indicated herein is a positive indicator of the presence of a neuropsychiatric disease in a patient. Thus, the presence or absence of at least one biomarker for a neuropsychiatric disease serves as a diagnostic tool for clinicians. It is understood that a clinician will evaluate a patient as a whole based on known criteria well established in the field for diagnosis of a neuropsychiatric disease and utilize the diagnostic method of the present invention in conjunction with such known diagnostic criteria to establish a definitive diagnosis.

According to the present invention, the term “neuropsychiatric diseases” refers to, without limitation, multiple sclerosis and in particular first attack or early multiple sclerosis, Neurologic Lyme Disease, Chronic Fatigue Syndrome, and other diseases with similar features that may place them in the differential diagnosis in evaluating a patient.

According to the present invention, the term “multiple sclerosis” is used to describe the art-recognized disease characterized by inflammation, demyelination, oligodendrocyte death, membrane damage, other neurologic damage, and axonal death. Multiple sclerosis can be characterized as one of four main varieties as defined in an international survey of neurologists (Lublin and Reingold, 1996, Neurology 46(4):907-11), which are namely: Relapsing-Remitting multiple sclerosis (RRMS), Primary Progressive multiple sclerosis (PPMS), Secondary-Progressive multiple sclerosis (SPMS), Progressive-Relapsing multiple sclerosis (PRMS).

According to the present invention, the term “Neurologic Lyme Disease” is used to describe a range of neurologic or psychiatric manifestations that may be associated with Lyme disease. As referred to herein, “Neurologic Lyme Disease” encompasses the range from an acute neurologic syndrome in an acute case of active Lyme Disease and late manifestation of Lyme disease (both sometimes referred to as neuroborreliosis), to the more poorly defined post-treatment Lyme disease syndrome and “chronic Lyme Disease”

According to the present invention, the term “Chronic Fatigue Syndrome” is used to describe a constellation of symptoms including fatigue that approach those described in the 1994 proposed case definition [Fukuda et al, Annals of Internal Medicine, Vol. 121, Dec. 15, 1994, pp. 953-959] that are subject to revision. In practice it is often a clinical diagnosis of exclusion.

As used herein, the terms “patient” or “subject” are used interchangeably. Such patients may have a neuropsychiatric disease or disorder, such as multiple sclerosis, CFS, and Neurologic Lyme Disease. With respect to multiple sclerosis, for example, the terms “multiple sclerosis patient”, “a subject who has multiple sclerosis”, “a patient who has multiple sclerosis”, “a multiple sclerosis subject”, and similar phrases, are intended to refer to subjects who have been diagnosed with multiple sclerosis.

The terms “healthy subject” or “normal subject”, and similar phrases, are intended to refer to a subject who has not been diagnosed with a neuropsychiatric disease or disorder. A healthy subject has no other acute systemic disease or, at the least, has no detectable acute systemic disease. With respect to aspects of the invention directed to, for example, multiple sclerosis, the terms “healthy subject”, “non-multiple sclerosis subject”, “a subject who does not have multiple sclerosis”, “a patient who does not have multiple sclerosis”, and similar phrases, are intended to refer to a subject who has not been diagnosed with multiple sclerosis.

As used herein, the term “patient” or “subject” may refer to a mammal, including a human.

As used herein, the term “biological sample” includes a sample of any cell type or from any tissue or body fluid, body fluids including, but not limited to: cerebrospinal fluid (CSF), blood (whole blood, serum, plasma, or cellular components), saliva, urine, prostatic fluid, or fluid from any suitable tissue. In a particular embodiment, the biological sample is CSF. In another embodiment, the biological sample is blood or any component of blood (e.g., serum, plasma, cells, etc.).

The term “protein” is used herein to mean protein, polypeptide, oligopeptide or peptide. The terms “biologic marker”, “biomarker” or “disease-associated protein” are used herein to refer to proteins associated with specific diseases or conditions, including proteins from organs or tissues (“organ-specific” or “tissue-specific” proteins) affected by a disease or condition. In accordance with the present invention, the presence or absence of a biomarker is positively correlated with, indicative of, of diagnostic for the presence of a disease or condition, such as a neuropsychiatric disease, in a patient. Also in accordance with the present invention, a relative increase in levels of a particular biomarker or biomarkers as compared to a control or normal subject can also be positively correlated with, indicative of, or diagnostic for the presence of a disease or condition, such as a neuropsychiatric disease, in a patient.

The present invention, furthermore, encompasses a plurality of biomarkers or a “biomarker signature” that is positively correlated with, indicative of, or diagnostic for the presence of a disease or condition, such as a neuropsychiatric disease, in a patient. Accordingly, the presence or absence of a biomarker signature is positively correlated with, indicative of, or diagnostic for the presence of a disease or condition, such as a neuropsychiatric disease, in a patient. A biomarker signature may also encompass a plurality of biomarkers that exhibit a relative increase or decrease in levels as compared to a healthy or normal subject (e.g., a control subject) and is positively correlated with, indicative of, or diagnostic for the presence of a disease or condition, such as a neuropsychiatric disease, in a patient.

A skilled practitioner would, moreover, appreciate that the presence or absence of a particular protein in a sample may be weakly indicative of disease, but not diagnostic, if noted as a single determinant. If, however, a plurality of such single determinants are noted in a biological sample, the combined detection of several weakly indicative determinants may serve to identify a strong combinatorial diagnostic indicator of disease. Furthermore, the single protein/determinant need not even approach the threshold of weak diagnostic by itself but in combination with the detection or absence of detection of another protein or proteins may serve as a strong combinatorial diagnostic indication of a disease state. Accordingly, also encompassed herein are combinatorial diagnostic indicators that are associated with a particular disease and not observed in healthy subjects or patients with other diseases.

Accordingly, selected sets of one, two, three, and more of the biomarkers of this invention (up to the number equivalent to all of the biomarkers, including any intervening number, in whole number increments, e.g., 1, 2, 3, 4, 5, 6 . . . ) can be indicative of a positive diagnosis or used as diagnostic indicators for methods and/or kits described herein. In one embodiment, larger numbers of the biomarkers identified herein are used in methods or kits of the invention, since the accuracy of the method or kit may improve as the number of biomarkers screened increases. With respect to aspects of the invention pertaining to evaluating therapeutic efficacy, the methods and kits of the present invention include evaluating whether administration of a therapeutic composition causes a change, either a transient change or a long term change, in one or more of the biomarkers; in two or more of the biomarkers; in three or more of the biomarkers; in four or more of the biomarkers; in five or more of the biomarkers, in six or more of the biomarkers, etc.

Also envisioned are sets of at least 1%, 2%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or 100% of the biomarkers listed in any one of the tables presented herein, including Tables 1m, 2m, 3, 4H-m, 4H-1, 4H-c, 5c, 6c, 7L, 8L, and 9, wherein the envisioned sets can be indicative of a positive diagnosis or used as diagnostic indicators for methods and/or kits described herein. With respect to aspects of the invention pertaining to evaluating therapeutic efficacy, the methods and kits of the present invention include evaluating whether administration of a therapeutic composition causes a change, either a transient change or a long term change, in a percent of the biomarkers listed in any one of the Tables described herein.

Representative permutations of biomarkers and/or biomarker signatures are presented herein below for illustrative purposes. Based on the methods described herein, a biological sample isolated from a subject may be determined to exhibit any one of the following biomarker signatures, which are set forth in exemplary fashion, and are not to be viewed as limiting: a+; a−; a+, b+, c+; or a+, b−, c+; wherein “a”=specific protein “a”, “b”=specific protein “b”, “c”=specific protein “c”, etc. and “+” indicates that the protein is present or quantitatively increased relative to subjects without disease, which could be clinically normal or could have a different disease (e.g., a different disease having overlapping clinical symptoms which is, therefore difficult to distinguish) and “-” indicates that the protein is absent or quantitatively decreased relative to subjects without disease, which could be clinically normal or could have a different disease (e.g., a different disease having overlapping clinical symptoms which is, therefore difficult to distinguish).

For example, the easiest identification of a protein biomarker is the presence of a protein associated with a disease or condition and not with other conditions that might be clinically confused with the disease under consideration. Variations to this scenario include the situation wherein a biomarker is present in an increased quantity or a decreased quantity compared to other conditions or controls. Although not a protein biomarker, an example of this is the presence of glucose in the blood in high quantities in diabetics compared to normal individuals who still have glucose present but not in elevated quantities. Another variation to the first scenario is where the functional biomarker is not just one protein but two or more in combination that can be present or absent or quantitatively different, wherein the ensemble defines its biomarker potential.

In some embodiments, a biomarker of the invention is a member of a biological pathway. As used herein, the term “precursor” or “successor” refers to molecules that precede or follow the biomarker in the biological pathway. Thus, once a biomarker is identified as a member of one or more biological pathways, the present invention can include additional members of the biological pathway that come before (are upstream of or a precursor of) or follow (are downstream of) the biomarker. Such identification of biological pathways and their members is within the skill of one in the art.

Also encompassed herein is the analysis of biomarkers identified and listed in the tables presented herein to identify metabolic pathways implicated in the pathogenesis, maintenance, and/or progression of a disease. Such analyses may utilize a variety of software programs, including but not limited to the commercially available Ingenuity Pathway Analysis. Multiple hits in a particular metabolic pathway underscore the potential importance of the pathway for the disease and direct therapeutic intervention toward appropriate modulation of same. Accordingly, the present methods encompass such analyses and the identification of metabolic pathways of potential significance in a particular disease. Knowing that, for example, activation of a metabolic pathway appears to be linked or associated with a particular disease presents the opportunity to test pharmaceutical modulators of the pathway (i.e., inhibitors) to determine if such modulators could be used as therapeutics for treatment of patients with the disease.

Metabolic pathways may, for example, be associated with several disease conditions based on a quantitative assessment. Examples of pathways that may be markedly involved in one condition and not another or others may also be found. As a specific illustrative example, a comparison of Chronic Fatigue Syndrome (CFS) to Neurologic Post Treatment Lyme disease syndrome (nPTLS), when individual patient samples were analyzed, revealed that four components (CIS, C4B, C1QB, C1QC) associated with activation of the complement cascade were differentially increased in abundance consistently across the nPTLS patients compared to CFS. In another example, a comparison between CFS and nPTLS patiente, looking at the pooled results, revealed that the CDK5 signaling pathway was significantly enriched for proteins identified only in the pooled CFS proteome. This signaling pathway has been linked to Parkinson's (Smith et al. 2003. Proc. Natl. Acad. Sci. 100:13650) and Alzheimer's diseases (Lew et al. 1994. Nature 371:423). Another example is related to pathways that are involved in two conditions, that is, common to both but decreased in abundance in the two disease conditions of CFS and nPTLS, compared to normal, but at different levels. Quantitative distinguishing differences could still be found between the two conditions. A specific example relates to networks relevant to neurological function, such as axonal guidance, where the proteins in CFS were further decreased relative to nPTLS.

Also envisioned are panels of biomarkers comprising at least 1%, 2%, 5%, 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 96%, 97%, 98%, 99% or 100% of the biomarkers listed in any one of the tables presented herein, including Tables 1m, 2m, 3, 4H-m, 4H-1, 4H-c, 5c, 6c, 7L, 8L, and 9, wherein the envisioned panels can be used to assess a biological sample isolated from a patient to evaluate expression patterns of the biomarkers of the panel, which expression patterns are indicative of a positive diagnosis of a neuropsychiatric disease as described herein. Panels of biomarkers comprising at least one, two, three, and more of the biomarkers listed in any one of Tables 1m, 2m, 3, 4H-m, 4H-1, 4H-c, 5c, 6c, 7L, 8L, and 9 (up to the number equivalent to all of the biomarkers in a particular table, including any intervening number, in whole number increments, e.g., 1, 2, 3, 4, 5, 6 . . . ) are also envisioned herein. Any of the indicated panels may also be used to evaluate efficacy of a therapeutic regimen.

Polypeptide biomarkers may be isolated by any suitable method known in the art. Native polypeptide biomarkers can be purified from natural sources by standard methods known in the art such as chromatography, centrifugation, differential solubility or immunoassay. In one embodiment, polypeptide and metabolite markers may be isolated from a biological sample using standard techniques known in the art, for example, chromatographic methods or affinity purification using substrate-bound antibodies that specifically bind to the marker. As described herein, immunoaffinity depletion of abundant proteins (with masking potential) enhances coverage and detection of low abundance proteins. As indicated herein above, depletion yields separate fractions that are characterized independently.

In a positively-associated example, once a protein or peptide is identified (including one lacking name identification, such as a hypothetical protein), a less expensive platform or assay, as compared to mass spectrometry, can be devised or adapted. The ELISA assay is such an example where an antibody to the biomarker protein/peptide can be used to capture the target biomarker in the biological sample being detected. The sample may be CSF or blood, etc. Variations of this immuno-based technique may also be used such as, but not limited to, Western blots wherein a sample comprising a biomarker is transferred to a membrane and then subsequently allowed to interact with specific antibodies that are coupled to an enzyme (later to be exposed to a substrate that permits colorimetric visualization) or fluorescent material that permit visualization of one or more of the components or subcomponents (such as antigens) of the target biomarker. Alternatively, a non-coupled antibody can be used first and then a second antibody directed to this antibody, which has an enzyme or fluorescent tag attached thereto, can be used in a sandwich-like fashion. Another variation of this protein capturing technique could be multiplexing of several target biomarkers by using beads coated with multiple antibodies such as in the Luminex platform.

In another embodiment, once a disease protein/peptide biomarker is identified subsequent research may demonstrate that the body of disease subjects makes antibodies to the biomarker or biomarkers and the normal or other disease subject are negative for same. Under such circumstances, the presence of antibodies for a disease protein/peptide biomarker is indicative of disease. Experimentally, the presence of such disease specific antibodies is determined by using the disease protein/peptide biomarker as a binding target for the antibodies. This is a common indirect strategy for detection of infectious disease where the presence of an antibody indicates exposure to a foreign agent and in some cases the rise in titers (quantity of antibodies) over a short period of time indicates a very recent exposure.

As used herein, a polypeptide is referred to as “isolated” when it has been removed from its natural milieu (i.e., that has been subject to human manipulation), and can include purified polypeptides, partially purified polypeptides, synthetically produced polypeptides, and recombinantly produced polypeptides, for example. As such, “isolated” does not reflect the extent to which the polypeptide has been purified.

According to the present invention, the phrase “selectively binds to” refers to the ability of an antibody or antigen binding fragment thereof to preferentially bind to specified proteins. More specifically, the phrase “selectively binds” refers to the specific binding of one protein to another (e.g., an antibody or antigen binding fragment thereof to an antigen), wherein the level of binding, as measured by any standard assay (e.g., an immunoassay), is statistically significantly higher than the background control for the assay. For example, when performing an immunoassay, controls typically include a reaction well/tube that contain antibody or antigen binding fragment alone (i.e., in the absence of antigen), wherein an amount of reactivity (e.g., non-specific binding to the well) by the antibody or antigen binding fragment thereof in the absence of the antigen is considered to be background. Binding can be measured using a variety of methods standard in the art including enzyme immunoassays (e.g., ELISA), immunoblot assays, etc.).

As used herein, the term “specifically binding,” refers to the interaction between binding pairs such as an antibody and an antigen with an affinity constant of at most 10⁻⁶ moles/liter, at most 10⁻⁷ moles/liter, or at most 10⁻⁸ moles/liter.

The present invention includes the use of any of the biomarkers as described herein (including genes or their RNA or protein products), as targets for the development or identification of therapeutic compositions and strategies for the treatment of neuropsychiatric diseases, such as for example, multiple sclerosis and/or relapsing multiple sclerosis.

Methods to measure biomarkers of this invention, include, but are not limited to: Western blot, immunoblot, enzyme-linked immunosorbant assay (ELISA), radioimmunoassay (MA), immunoprecipitation, surface plasmon resonance, chemiluminescence, fluorescent polarization, phosphorescence, immunohistochemical analysis, liquid chromatography mass spectrometry (LC-MS), matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry, microcytometry, microarray, microscopy, fluorescence activated cell sorting (FACS), flow cytometry, laser scanning cytometry, hematology analyzer and assays based on a property of the protein including but not limited to DNA binding, ligand binding, or interaction with other protein partners. More particularly, high throughput, high sensitivity, and high resolution nanocapillary liquid chromatography-mass spectrometry (LC-MS), LC-MS/MS, pre-fractionation (immunoaffinity depletion chromatography) and ultra-high resolution nanocapillary LC separations, high efficiency ion transmission technologies (e.g., electrodynamic ion funnel), and the accurate mass and time (AMT) tag strategy for high-throughput analysis are described herein and known in the art.

As described herein, the term “probe” is used to refer to an agent that specifically binds to a biomarker listed in one of the tables presented herein. Suitable reagents for binding with a polypeptide corresponding to a biomarker of the invention include antibodies, antibody derivatives, labeled antibodies, antibody fragments; and the like. The term “probe” may also be used to refer to an agent that specifically binds to a nucleic acid sequence that encodes a biomarker listed in one of the tables presented herein. Suitable reagents for binding to a nucleic acid (e.g., a genomic DNA, an mRNA, a spliced mRNA, a cDNA, or the like) include complementary nucleic acids.

In accordance with the present disclosure, the tables present information with which an ordinarily skilled practitioner can access the amino acid sequences of the proteins identified herein as biomarkers, as well as nucleic acid sequences encoding same. A stepwise protocol for identification of the amino acid sequences listed in the tables presented herein is as follows: access one of the publicly available databases such as http://www.ebi.ac.uk/IPI/IPIhelp.html or http://www.uniprot.org/ via the Internet and enter the IPI number, or the protein name, or the Gene designation. For example, the first protein listed in Table 1m is designated “14-3-3 protein epsilon” and the corresponding Gene designation is YWHAE, and IPI designation of IPI00000816.1. Entering the IPI number, protein name, or Gene into one of the above publicly available databases will reveal the 255 amino acid sequence corresponding to “14-3-3 protein epsilon”. The above protocol is a matter of routine practice in laboratories skilled in the art and can be performed for any of the proteins listed therein. Such information may be used to design probes for detection of any of the proteins listed therein or to identify commercially available probes for detection of any of the proteins listed therein. Primers for detection nucleic acid sequences encoding any of the proteins listed in the tables presented herein are also envisioned. Such primers may be used to detect expression or lack thereof of a biomarker or biomarker signature of the invention. The design of primers for detecting expression levels of RNA (e.g., mRNA) of a biomarker or biomarkers listed herein is a matter of routine practice with the nucleic acid sequence in hand as provided by publicly available websites such as those mentioned above. Such probes and primers are useful for the kits described herein.

The present invention also includes a method to diagnose a subject as having a neuropsychiatric disease (e.g., multiple sclerosis, chronic fatigue syndrome, or Neurologic Lyme Disease, or one that conventionally may be considered among the differential diagnoses). In one embodiment, the method includes the steps of analyzing a biological sample isolated from the subject to determine if one or more of the biomarkers listed in Tables 1m, 3m, or 4H-m is present or if one or more of the biomarkers listed in Table 2m is absent, and diagnosing multiple sclerosis, wherein the presence (Tables 1m, 3m, or 4H-m) or absence (Table 2m) of one or more of these biomarkers indicates that the subject has multiple sclerosis. The present invention further encompasses circumstances wherein there is a change in the level/amount of a biomarker of the invention and such a change may also reflect the presence of multiple sclerosis or responsiveness to a therapeutic regimen.

In another embodiment, the method includes the steps of analyzing a biological sample isolated from the subject to determine if one or more of the biomarkers listed in Table 4H-c, or 5c is present or if one or more of the biomarkers listed in Table 6c is absent, and diagnosing chronic fatigue syndrome, wherein the presence (Table 4H-c or 5c) or absence (Table 6c) of one or more of these biomarkers indicates that the subject has chronic fatigue syndrome. The present invention further encompasses circumstances wherein there is a change in the level/amount of a biomarker of the invention and such a change may also reflect the presence of chronic fatigue syndrome or responsiveness to a therapeutic regimen.

In a further embodiment, the method includes the steps of analyzing a biological sample isolated from the subject to determine if one or more of the biomarkers listed in Table 7L is present or if one or more of the biomarkers listed in Table 8L is absent (within the limits of detection using methods and assays described herein), and diagnosing Neurologic Lyme Disease, wherein the presence (Table 7L) or absence (Table 8L) of one or more of these biomarkers indicates that the subject has Neurologic Lyme Disease. The present invention further encompasses circumstances wherein there is a change in the level/amount of a biomarker of the invention and such a change may also reflect the presence of Neurologic Lyme Disease or responsiveness to a therapeutic regimen.

The invention includes a kit for assessing the expression and/or expression levels of at least one of the biomarkers listed in the tables presented herein, whereby detecting the expression and/or expression levels of at least one of the biomarkers in a biological sample isolated from a patient is indicative of a positive diagnosis of the relevant disease to which the table in question pertains (e.g., MS, NLD, or CFS). The kit comprises a plurality of reagents, each of which is capable of binding specifically with a polypeptide (e.g., an antibody) or nucleic acid encoding same corresponding to a biomarker of the invention, e.g., one of the proteins listed in any one of the tables presented herein. Suitable reagents for binding with a polypeptide corresponding to a biomarker of the invention include antibodies, antibody derivatives, labeled antibodies, antibody fragments, and the like. Suitable reagents for binding to a nucleic acid (e.g., a genomic DNA, an mRNA, a spliced mRNA, a cDNA, or the like) include complementary nucleic acids. For example, the nucleic acid reagents may include oligonucleotides (labeled or non-labeled) fixed to a substrate, labeled oligonucleotides not bound with a substrate, pairs of PCR primers, molecular beacon probes, and the like.

The kit of the invention may optionally comprise additional components useful for performing the methods of the invention. By way of example, the kit may comprise fluids [e.g., phosphate buffered saline (PBS) or SSC buffer] suitable for binding an antibody to a protein for which it is immunologically specific or for annealing complementary nucleic acids, one or more sample compartments, an instructional material which describes performance of a method of the invention, a positive control or controls, such as panel of proteins corresponding one of the panels set forth in any one of the tables presented herein or a biological sample isolated from a normal subject (a subject who does not manifest clinical symptoms of disease), or a biological sample isolated from a patient known to have the disease in questions, and the like.

The following protocols are provided to facilitate the practice of the present invention.

The following examples are put forth so as to provide those of ordinary skill in the art with a complete disclosure and description of how to make and use the assay, screening, and therapeutic methods of the invention, and are not intended to limit the scope of what the inventors regard as their invention. Efforts have been made to ensure accuracy with respect to numbers used (e.g., amounts, temperature, etc.) but some experimental errors and deviations should be accounted) for. Unless indicated otherwise, parts are parts by weight, molecular weight is average molecular weight, temperature is in degrees Centigrade, and pressure is at or near atmospheric.

Example I Materials and Methods

Cerebrospinal Fluid (CSF) Specimens.

All specimens had normal clinical laboratory values with respect to microbiology, chemistry (including protein levels), and cell counts (red blood cell were 0-10/mm³ and white blood cells were 0-5/mm³). Four sets of different types of normal CSF samples were analyzed. The first set, designated as true (healthy) normals was comprised of pooled CSF from 11 healthy normal individual volunteers from the United States (8 women and 3 men; aged 24 to 55 years with a median age of 28 years) was used for the comprehensive analysis using immunoaffinity depletion and 2D-LC-MS/MS. A second set, also true normals included pairs of serial CSF aliquots taken at least 4 weeks apart from 10 healthy volunteers from the United States (age 37-44 years; 5 males and 5 females). A third set, designated as non-neurologic surrogate-normals, was a pool of 200 subjects from Sweden (all without a neurologic or psychiatric disease, most who underwent lumbar puncture for non diagnostic reasons; over 90% were undergoing spinal anesthesia in preparation for orthopedic surgery (e.g. limbs-knees and hips)). Ages ranged from 16 to 65 years with a median of 44 years; 50:50 female:male. They were used in the direct LC-MS analysis using the AMT tag approach. These samples were collected on ice and cells removed by centrifugation [Bergquist et al. (2002) Mass Spectrom Rev 21: 2-15]. A fourth set, designated as neurologic surrogate-normals consisted of a pool of CSF from 10 people from Sweden with headaches (age 18-35 years; 8 female and 2 male) who had a lumbar puncture to investigate possible CNS infection, and who had normal CSF clinical laboratory values (hence designation surrogate-normal), was collected following the same protocol as the third set and analyzed in the same fashion as the second and third sets of normal CSF. CSF from this group was also subjected to centrifugation to remove cells. CSF from this group was collected following the same protocol as the pool of the 200 non-neurological surrogate-normals. The protein concentrations were determined by Coomassie Plus protein assay (Pierce, Rockford, Ill.) using a bovine serum albumin standard.

Immunoaffinity Depletion of 14 High-Abundance CSF Proteins.

A total of 18 mL of the pooled CSF sample (from the 11 healthy volunteers) was subjected to the separations of 14 high-abundance proteins (albumin, IgG, α₁-antitrypsin, IgA, IgM, transferrin, haptoglobin, α₁-acid glycoprotein, α₂-macroglobulin, apolipoprotein A-I, apolipoprotein A-II, fibrinogen, C3 and apolipoprotein B) using a 12.7×79.0 mm Seppro® IgY14 LC10 affinity LC column (Sigma, St Louis, Mo.) on an Agilent 1100 series HPLC system (Agilent, Palo Alto, Calif.), followed the protocols described previously [Liu et al. (2006) Mol Cell Proteomics 5: 2167-2174].

Protein Digestion.

The CSF proteins were incubated in 8 M urea and 10 mM dithiothreitol at 37° C. for 60 min, followed by alkylation with 40 mM iodoacetamide in the dark for 30 min at room temperature. The samples were diluted 10-fold with 50 mM ammonium bicarbonate (pH 8) and 1 mM CaCl₂, and digested for 3 h at 37° C. using sequencing grade, modified porcine trypsin (Promega, Madison, Wis.) at a trypsin/protein ratio of 1:50. Sample cleanup was achieved using a 1-mL SPE C18 column (Supelco, Bellefonte, Pa.) as described previously [Liu et al. (2006) Mol Cell Proteomics 5: 1899-1913]. The final peptide concentration was determined by BCA assay (Pierce). All tryptic digests were snap frozen in liquid nitrogen and stored at −80° C.

Strong Cation Exchange (SCX) Fractionation.

For tryptic digests of the IgY14 bound and flow-through fractions (the first set normal CSF pool from BN), 300 μg of tryptic peptides from CSF samples were resuspended in 300 μL 10 mM ammonium formate, 25% acetonitrile and fractionated by strong cation exchange chromatography as described previously [Liu et al. (2006) Mol Cell Proteomics 5: 1899-1913]. A total of 30 fractions were collected for each sample with each fraction being lyophilized prior to reversed-phase LC-MS/MS analysis.

Reversed-Phase Capillary LC-MS/MS and LC-MS Analysis.

The SCX fractions were analyzed using a custom-built automated four-column high pressure nanocapillary LC system coupled on-line to either a linear ion trap mass spectrometer (LTQ; ThermoFisher) or a linear quadrupole ion trap-orbitrap mass spectrometer (LTQ-Orbitrap, ThermoFisher), both modified in-house with an electrodynamic ion funnel [Shaffer et al. (1997) Rapid Commun Mass Spectrom 11: 1813-1817], via an electrospray ionization interface manufactured in-house. The reversed-phase separation was performed as described previously [Liu et al. (2006) Mol Cell Proteomics 5: 1899-1913]. To analyze the SCX fractions of the IgY14 bound fraction, the LTQ mass spectrometer was operated in a data-dependent MS/MS mode (m/z 400-2000) in which a full MS scan was followed by 10 MS/MS scans. The ten most intensive precursor ions were dynamically selected in the order of highest intensity to lowest intensity and subjected to collision-induced dissociation using a normalized collision energy setting of 35% and a dynamic exclusion duration of 1 min. The heated capillary was maintained at 200° C., while the ESI voltage was kept at 2.2 kV. The SCX fractions of the IgY14 flow-through fraction, which are enriched with lower abundance proteins, were analyzed by the LTQ-Orbitrap instrument operated in a data-dependent MS/MS mode with survey full scan MS spectra (m/z 400-2000) acquired in the orbitrap with resolution of 30,000 at m/z 400 (ion accumulation target: 1,000,000), followed by MS/MS of the 10 most intense ions. In the case of label-free quantitation using the unfractionated CSF samples (the second and third set of normal CSF and the headache CSF), the LTQ-Orbitrap MS was operated in the data dependent mode with survey full scan spectra (m/z 400-2000) acquired in the orbitrap with resolution of 60,000 at m/z 400 (accumulation target: 1,000,000). The six most intense ions were sequentially isolated for fragmentation and detection in the linear ion trap.

Data Analysis.

The LTQ LC-MS/MS raw data were converted into .dta file by Extract_MSn (version 3.0) in Bioworks Cluster 3.2 (Thermo) and the SEQUEST algorithm (version 27 revision 12) was used to independently search all the MS/MS spectra against the human International Protein Index (IPI) database with a total of 69,731 total protein entries (Version 3.40, released at Feb. 7, 2008). The search parameters used were: 3-Da tolerance for precursor ion masses and 1-Da tolerance for fragment ion masses with no enzyme restraint and a maximum of 2 missed tryptic cleavages. Static carboxyamidomethylation of cysteine and dynamic oxidation of methionine were used during the database search. LTQ-Orbitrap MS/MS data were first processed by an in-house software DeconMSn [Mayampurath et al. (2008) Bioinformatics 24: 1021-1023] to accurately determine the monoisotopic mass and charge state of parent ions, followed by SEQUEST search against the IPI database in the same fashion, except that 0.1-Da tolerance for precursor ion masses and 1-Da tolerance for fragment ion masses were used. A set of criteria considering the cross correlation score (Xcorr) and delta correlation (ΔCn) values along with tryptic cleavage and charge states were developed using the decoy database approach and applied for filtering the raw data to limit false positive identifications to <1% at the peptide level [Peng et al. (2003) J Proteome Res 2: 43-50; Elias et al. (2007) Nat Methods 4: 207-214; Qian et al. (2005) J Proteome Res 4: 53-62]. For the LTQ-Orbitrap data, the distribution of mass deviation (from the theoretical masses) was first determined as having a standard deviation (a) of 2.05 part per million (ppm), and peptide identifications with mass error of greater than 3σ were filtered out. In general, slightly lower Xcorr cutoff values were used when combined with ΔCn and the mass error constraint to achieve the same level of false positive rate (<1%). For peptides identified by both LTQ-Orbitrap (IgY14 flow-through fraction) and LTQ (IgY14 bound fraction) analyses, the database matching scores are shown only for the LTQ-Orbitrap analysis, along with their mass errors.

The AMT tag strategy [Smith et al. (2002) Proteomics 2: 513-523] was used for identifying and quantifying LC-MS features measured by LTQ-Orbitrap. The filtered MS/MS peptide identifications obtained from the LTQ and LTQ-Orbitrap analyses of CSF samples were included in an AMT tag database with their theoretical mass and normalized elution time (NET; from 0 to 1) recorded. LC-MS datasets were then analyzed by in-house software VIPER [Monroe et al. (2007) Bioinformatics 23: 2021-2013] that detects features in mass-NET space and assigned them to peptides in the AMT tag database [Zimmer et al. (2006) Mass Spectrom Rev 25: 450-482]. A 11-Da shift strategy analogous to the decoy database approach used for LC-MS/MS identification of peptides was applied for estimating the false discovery rate of the AMT analysis as previously described [Petyuk et al. (2007) Genome Res 17: 328-336]. A false positive rate of <4% was estimated for each of the LC-MS data sets. The resulting lists of peptides from 2D-LC-MS/MS or direct LC-MS analysis was further analyzed by ProteinProphet software [Nesvizhskii et al. (2003) Anal Chem 75: 4646-4658] to remove redundancy in protein identification as described previously [Liu et al. (2006) Mol Cell Proteomics 5: 1899-1913].

Data normalization and quantification of the changes in protein abundance between the normal and headache CSF samples were performed and visualized using in-house software DAnTE [Polpitiya et al. (2008) Bioinformatics 24: 1556-1558]. Briefly, peptide intensities from the LC-MS analyses were log 2 transformed and normalized using a mean central tendency procedure. Peptide abundances were then “rolled up” to the protein level employing the R-rollup method (based on trends observed at peptide level) implemented in DAnTE. ANOVA and clustering analyses were also performed using DAnTE. Gene ontology annotation was performed using a software tool STRAP [Bhatia et al. (2009) Anal Chem 81: 9819-9823]. The final distribution charts were generated using Excel.

Results

A comprehensive analysis of the CSF proteome from healthy normal individuals is described herein and presents the foundation for future investigation on this biological fluid which may be highly reflective of the status of the brain and central nervous system. The results described herein make available a comprehensive coverage of CSF proteins from normal healthy individuals. From the pool of 11 CSF samples from healthy volunteers, the present inventors identified with high confidence a total of 19,051 tryptic peptides, covering 2630 non-redundant proteins, with 1506 having at least two peptide identifications. The immunoaffinity-based partitioning generated a separate bound fraction consisting of the 14 most abundant proteins and their potential associated proteins, and a flow-through fraction enriched with the less abundant proteins in CSF. Similar to plasma, the bound fraction represents approximately 95% of the total protein mass. Both fractions were subjected to 2D-LC-MS/MS analysis.

The set of 2630 CSF proteins, and a comprehensive set of 3654 proteins from our previous plasma database [Liu et al. (2006) Mol Cell Proteomics 5: 1899-1913], showed very similar distribution of gene ontology terms in biological process and molecular function, but different distributions with respect to cellular component: a total of approximately 35% of the CSF proteins are from plasma membrane, cell surface or extracellular space, while blood plasma has a total of 28% of proteins in those three categories; there are also fewer CSF proteins derived from the nucleus and cytoplasm (10% versus 15% and 11% versus 16%, respectively. Importantly, nearly 56% of the proteins are CSF-specific and are not present in our larger plasma database of 3654 proteins, also analyzed by LC-MS/MS. This is notable because the acquisition and analysis conditions likely favored the set of plasma proteins as opposed to the CSF proteins. This is because more proteins were likely available for detection in the plasma of burn patients due to severe tissue leakage, and there was the additional dimension of sample fractionation via enrichment of cysteinyl and N-linked glycopeptides. It is noteworthy that this cannot be viewed as a head-to-head comparison in light of the differences in sample type and conditions, extensiveness of fractionation and MS instrumentation.

Comparison between proteins detected in this study and those (which we have termed neurologic surrogate-normals) from the CSF study by Zougman et al., reveals a 92% overlap (see FIG. 1.

In order to assess the CSF protein variability from serial sample collections, the present inventors examined individual (non-pooled) samples from another group of 10 healthy volunteers (5 male, 5 female; age range 37-44 years old) who had two CSF samples obtained at least 4 weeks apart using the AMT tag approach. Inter-subject differences were far greater than intra-subject differences. Statistical tests of variance of differences (ANOVA) were performed for these data sets based on different factors (e.g., subject, gender, and time of sampling), followed by unsupervised hierarchical clustering analysis of the statistically significant proteins (p-value<0.01). It is clear that human heterogeneity is the major factor responsible for inter-sample differences; clustering of the “significant” proteins could not distinguish corresponding groups based on the other factors defined in the ANOVA analysis (i.e., gender and time of sampling), except for “subject” (i.e., normal volunteers).

As an example of how CSF proteomic databases may be used to better understand disease states, the present inventors compared the proteomes of two similarly processed (see Methods) pooled samples of patients using the mass spectrometry strategy [Smith et al. (2002) Proteomics 2: 513-523]. The first set, considered as neurologic surrogate-normals was a pool of 10 headache patients. CSF had been obtained to evaluate the possibility of a CNS infection or bleed but all clinical results were normal. The second set, considered as non-neurologic surrogate-normals, was a pool of 200 subjects (without a neurologic disease, who underwent lumbar puncture for non diagnostic reasons; over 90% were undergoing spinal anesthesia in preparation for orthopedic surgery (limbs-knees and hips)). Significantly distinct results were found between each group. Specifically, 191±7 and 211±8 non-redundant proteins were identified from the 3 replicates of each data set. Statistical analysis comparing these CSF data sets showed that the neurologic surrogate-normal CSF pool had distinctive quantitative differences compared to the non-neurologic surrogate normal pool (22 proteins with p-value<0.01 by ANOVA). Unsupervised hierarchical clustering of abundances of all proteins clearly separates these two groups. One interesting difference was the identification and quantification of certain hemoglobin isoforms, which were among significantly changed proteins identified by the statistical analysis, in the neurologic surrogate-normal (headache) samples. Although Zougman et al. [(2008) J Proteome Res 7: 386-399] previously identified these same proteins in a qualitative analysis of their neurologic surrogate-normal samples, the present study reveals that these isoforms were increased by about ten-fold on average. The differences found in the present study suggest that it would be attractive to extend these studies with immunoaffinity depletion applied to different defined categories of headache subjects.

Summary

The present study provides the most comprehensive CSF protein coverage and list reported to date for healthy normal individuals including serial lumbar punctures. [Schutzer et al. (2010) Establishing the Proteome of Normal Human Cerebrospinal Fluid, PLoS One 5(6): e10980]. The protein set has immediate utility for investigators interested in using CSF to study neurological or psychiatric diseases. As evidenced in Examples II-IV, it serves as a normative base to which disease states may be compared. The present study also suggests that CSF protein variability over a short time may be relatively limited in an individual and thus functionally useful.

The other major previous investigations of CSF from healthy individuals were published by Zhang et al. [(2005) Neurobiol Aging 26: 207-227] and updated by part of that group, Xu et al. [(2006) Int Rev Neurobiol 73: 29-98]. What began as detection of approximately 315 proteins was expanded to 915 using different mass spectrometry methods. Interestingly Xu et al. [(2006) Int Rev Neurobiol 73: 29-98] stated that they believed their coverage of the normal CSF was insufficient because they were unable to detect two well known CSF proteins, α-synuclein [Yuan et al. (2005) Proteomics 5: 541-550] and gelsolin [Yuan et al. (2002) Electrophoresis 23: 1185-1196]. The present methods and approach differed from these references, and included a rigorous separation of abundant from less abundant proteins to mitigate the masking effect of the most abundant proteins, as well as high-resolution LC coupled to MS/MS analysis for highly efficient peptide identification. The present inventors did identified 2630 proteins in total, including α-synuclein and gelsolin.

Due to the challenge in obtaining CSF from healthy people, most previous studies may have used CSF from “surrogate-normals,” that is CSF collected from people with neurological complaints such as headache but with normal clinical CSF laboratory values. As described herein, the present inventors compared proteomes of two different surrogate-normal groups. Significant differences were noted between the two groups. Accordingly, this study supports the potential usefulness of the “true” normal human CSF proteome data library as an invaluable tool in investigating pathophysiological abnormalities in neurological and psychiatric disorders.

Proteomic databases can be used in several ways. The present inventors' perspective with regard to using these proteomic databases for studying diseases involves a stepwise strategy. The first step is a comparison of pooled samples representative of the disease to normal subjects or a comparator disease. The second step involves the selection of specific candidate proteins. The selection of candidate proteins is not likely to be predicted in advance and may require bioinformatic strategies and knowledge related to the disease under study. A third step would involve analysis of the individual samples contributing to the pool to ascertain how many of the samples actually contained one or more of the candidate proteins. This step provides a check in the event that a single individual in the pool disproportionately contributes a protein compared to other subjects. The results would be subjected to statistical analyses in accordance with standard practice. In the case of a search for biomarker proteins, an objective is to select those that meet clinically useful criteria, such as presence, absence or relative abundance in a large percentage of disease subjects and not so in most subjects without the disease under consideration. The fourth step would involve verification of the previous results using independent individual samples with the same disease. A final validation step may involve analyzing a larger number of subjects with the disease and controls using assays targeted to the candidate proteins. In contrast to the discovery phases, it would be advantageous, if feasible, to use assay platforms already having wide clinical use. Immunobased assays such as ELISA and Western blots may serve this purpose being relatively inexpensive. Steps 3 and 4 will likely employ a type of mass spectrometry which targets selected candidate proteins, such as Multiple Reaction Monitoring (MRM) using triple quadrupole instrumentation.

The availability of the data presented here, detailing the normal human CSF proteome, should prove to be a critical base on which to compare proteins, both qualitatively and quantitatively, in studies of patients with a variety of neurological or psychiatric diseases.

Example II Multiple Sclerosis

In the experimental analysis of data on documented first attack Multiple Sclerosis subjects, long lists of proteins found in these subjects (data not shown) and small subset lists as well as a list of those proteins that appear to be absent (below the level of detection) have been found.

Specifically:

1) Table 1m shows Cerebrospinal Fluid (CSF) Proteins present only in Multiple Sclerosis patients compared to Surrogate Non-Neurologic Normals and to Surrogate Neurologic Normals

(Headaches). This is a Qualitative List of CSF Proteins Present in the Pooled First Attack Multiple Sclerosis Patients compared to the combined lists of Proteins Found in a Similarly Analyzed Group of Non-neurologic Surrogate Normal Subjects and Proteins Found in Neurologic Surrogate-Normals (Headache subjects with normal CSF clinical laboratory values).

2) Table 2m shows a Qualitative List of CSF Proteins Absent only in the Pooled First Attack Multiple Sclerosis Patients compared to the combined lists of a) Proteins Found in a similarly Analyzed Group of Non-neurologic Surrogate Normal Subjects (both groups analyzed without immunoaffinity depletion of most abundant proteins) and b) Proteins Found in an expanded list of True Normals (where immunoaffinity depletion was applied).

3) Table 3m shows a subset of CSF Proteins Present In Multiple Sclerosis not in combined lists of proteins from Normals or Headaches (immunoaffinity depletion was not applied)

4) Table 4H-m shows identified CSF proteins in first attack Multiple Sclerosis that have high potential to be candidate biomarkers because their function is not known and they remain unknown (referred to as a hypothetical or uncharacterized protein).

Example III Chronic Fatigue Syndrome

In the experimental analysis of data on Chronic Fatigue Syndrome subjects, long lists of proteins were found in these subjects and smaller subset lists as well as a list of those proteins that appear to be absent (below the level of detection). Immunoaffinity depletion of abundant proteins was applied in the analyses. In addition, semi-quantitative, or relative protein abundance comparisons were made to proteins found in a disease that has common features with Lyme disease-Chronic Fatigue Syndrome. Also found were proteins associated with this group that are considered hypothetical or uncharacterized proteins.

Specifically:

1) Table 4H-c shows the list by IPI number of those hypothetical or uncharacterized proteins that were found in Chronic Fatigue Syndrome.

2) Table 5c shows the CSF Proteins Present in Chronic Fatigue and not in Normals or Neurologic Lyme subjects. All had immunoaffinity depletion. They are listed by IPI identification numbers representing 738 CSF Proteins.

3) Table 6c shows the CSF Proteins Absent in Chronic Fatigue but Present in Neurologic Lyme or Normals.

4) Table 9 shows the Quantitative Relative Abundance of CSF Proteins in Chronic Fatigue compared to Neurologic Lyme Disease. A ratio greater than 1 indicates there is a relative quantitative difference in Chronic Fatigue compared to Neurologic Lyme disease. Ratios near 1 suggest equal relative abundances. Ratios less than 1 indicate that the protein is present in a greater relative abundance in Neurologic Lyme disease compared to Chronic Fatigue. There are 168 proteins in Chronic Fatigue that are 2 ford greater in relative abundance than those proteins Neurologic Lyme disease. There are 1081 proteins that are relatively more abundant in Neurologic Lyme disease compared to Chronic Fatigue with a ratio of 0.5 or less. Blank cell is close to 0 ratio.

Example IV Neurologic Lyme Disease

In the experimental analysis of data on documented Neurologic Lyme disease subjects, long lists of proteins were found in these subjects and smaller subset lists as well as a list of those proteins that appear to be absent (below the level of detection). Immunoaffinity depletion of abundant proteins was applied in the analyses. In addition, semi-quantitative, or relative protein abundance comparisons were made to proteins found in a disease that has common features with Lyme disease-Chronic Fatigue Syndrome. Also found were proteins associated with this group that are considered hypothetical or uncharacterized proteins.

Specifically:

1) Table 4H-L shows the list of by IPI number of those hypothetical or uncharacterized proteins that were found in Neurologic Lyme disease.

2) Table 7 L shows the Qualitative List of CSF Proteins Identified (Present) in Patients with Neurologic Lyme disease and not found in True Normals or Chronic Fatigue. All with immunoaffinity depletion. There are 692 proteins in this list.

3) Table 8 L shows the CSF Proteins Absent in Neurologic Lyme disease but Present in Normals or Chronic Fatigue subjects. There are 1597 Proteins in this list.

4) Table 9 shows the Quantitative Relative Abundance of CSF Proteins in Chronic Fatigue compared to Neurologic Lyme Disease. A ratio greater than 1 indicates there is a relative quantitative difference in Chronic Fatigue compared to Neurologic Lyme disease. Ratios near 1 suggest equal relative abundances. Ratios less than 1 indicate the protein is present in a greater relative abundance in Neurologic Lyme disease compared to Chronic Fatigue. There are 168 proteins in Chronic Fatigue that are 2 fold greater in relative abundance than those proteins Neurologic Lyme disease. There are 1081 proteins that are relatively more abundant in Neurologic Lyme disease compared to Chronic Fatigue with a ratio of 0.5 or less. Blank cell is close to 0 ratio)

While certain of the preferred embodiments of the present invention have been described and specifically exemplified above, it is not intended that the invention be limited to such embodiments. Various modifications may be made thereto without departing from the scope and spirit of the present invention, as set forth in the following claims.

TABLE 1m Cerebrospinal Fluid (CSF) Proteins present only in Multiple Sclerosis patients compared to Surrogate Non-Neurologic Normals AND Surrogate Neurologic Normals (Headaches): Qualitative List of CSF Proteins Present in the Pooled First Attack Multiple Sclerosis Patients compared to the combined lists of Proteins Found in a Similarly Analyzed Group of Non-neurologic Surrogate Normal Subjects and Proteins Found in Neurologic Surrogate-Normals (Headaches subjects with normal CSF clinical laboratory values). CSF Proteins Present In MS not MinOfORF Normals or Headaches (no IAD) Gene IPI:IPI00000816.1 14-3-3 protein epsilon YWHAE IPI:IPI00001516.1 Isoform Long of Protocadherin alpha C2 precursor PCDHAC2 IPI:IPI00001610.1 Insulin-like growth factor IA precursor IGF1 IPI:IPI00001895.1 Isoform 1 of Protocadherin-8 precursor PCDH8 IPI:IPI00006444.1 Isoform 1 of Sodium/potassium/calcium exchanger 2 precursor SLC24A2 IPI:IPI00006543.2 Complement factor H-related 5 CFHR5 IPI:IPI00007778.1 Di-N-acetylchitobiase precursor CTBS IPI:IPI00008994.2 Isoform 1 of Protein NDRG2 NDRG2 IPI:IPI00012102.1 N-acetylglucosamine-6-sulfatase precursor GNS IPI:IPI00012283.2 Isoform 1 of Semaphorin-3B precursor SEMA3B IPI:IPI00012792.1 Cadherin-5 precursor CDH5 IPI:IPI00015479.5 UPF0454 protein C12orf49 precursor C12orf49 IPI:IPI00015911.1 Dihydrolipoyl dehydrogenase, mitochondrial precursor DLD IPI:IPI00016666.1 Metallothionein-3 MT3 IPI:IPI00017569.5 Fas apoptotic inhibitory molecule 2 FAIM2 IPI:IPI00017704.3 Coactosin-like protein COTL1 IPI:IPI00021833.1 Isoform Long of Platelet-derived growth factor A chain PDGFA precursor IPI:IPI00025365.1 Isoform Long of Endothelin-3 precursor EDN3 IPI:IPI00026569.3 HLA class I histocompatibility antigen, A-1 alpha chain HLA-A precursor IPI:IPI00026946.2 Neuronal pentraxin-2 precursor NPTX2 IPI:IPI00027765.1 retbindin isoform 2 RTBDN IPI:IPI00029131.1 Neuroendocrine convertase 2 precursor PCSK2 IPI:IPI00030877.2 15 kDa selenoprotein isoform 1 precursor SEP15 IPI:IPI00060310.4 Phospholipase D4 PLD4 IPI:IPI00152540.3 Isoform 1 of CD109 antigen precursor CD109 IPI:IPI00157414.3 Ectonucleotide pyrophosphatase/phosphodiesterase family ENPP6 member 6 precursor IPI:IPI00163187.10 Fascin FSCN1 IPI:IPI00171411.4 Golgi phosphoprotein 2 GOLM1 IPI:IPI00172636.5 Isoform Delta 6 of Calcium/calmodulin-dependent protein CAMK2D kinase type II delta chain IPI:IPI00180707.8 Isoform 1 of FRAS1-related extracellular matrix protein 2 FREM2 precursor IPI:IPI00217542.4 Putative uncharacterized protein LOC130576 LOC130576 IPI:IPI00217966.7 Isoform 1 of L-lactate dehydrogenase A chain LDHA IPI:IPI00292550.2 Isoform 1 of Polypeptide N-acetylgalactosaminyltransferase 13 GALNT13 IPI:IPI00294705.1 Papilin PAPLN IPI:IPI00298547.3 Protein DJ-1 PARK7 IPI:IPI00298793.4 Beta-mannosidase precursor MANBA IPI:IPI00329688.2 Protein YIPF3 YIPF3 IPI:IPI00334666.2 Isoform 1 of Receptor-type tyrosine-protein phosphatase N2 PTPRN2 precursor IPI:IPI00337548.5 Cell growth regulator with EF hand domain protein 1 CGREF1 IPI:IPI00376394.4 Sulfhydryl oxidase 2 precursor QSOX2 IPI:IPI00382426.1 Ig lambda chain V-II region TRO IPI:IPI00382447.1 Ig lambda chain V-VI region AR IPI:IPI00382476.1 Ig heavy chain V-III region WEA IPI:IPI00382482.1 Ig heavy chain V-III region CAM IPI:IPI00382490.1 Ig heavy chain V-III region BUR IPI:IPI00384402.1 Myosin-reactive immunoglobulin kappa chain variable region (Fragment) IPI:IPI00385143.1 Microfibrillar protein 2 (Fragment) IPI:IPI00386131.1 Ig kappa chain V-III region IARC/BL41 precursor IPI:IPI00387096.1 Ig kappa chain V-I region Kue IPI:IPI00387101.1 Ig kappa chain V-I region Scw IPI:IPI00387113.1 Ig kappa chain V-III region B6 IPI:IPI00419442.3 IGLV6-57 protein IGLV6-57 IPI:IPI00455667.5 hypothetical protein LOC402665 LOC402665 IPI:IPI00465255.6 Isoform 1 of Proline-rich acidic protein 1 precursor PRAP1 IPI:IPI00748265.2 Rheumatoid factor RF-ET13 IPI:IPI00816737.1 Rheumatoid factor D5 heavy chain (Fragment) IPI:IPI00829810.1 Uncharacterized protein ENSP00000375027 IPI:IPI00854624.1 Uncharacterized protein ENSP00000375043 IPI:IPI00854745.1 Uncharacterized protein ENSP00000375019 IAD = immunoaffinity depletion

TABLE 2m Qualitative List of CSF Proteins Absent only in the Pooled First Attack Multiple Sclerosis Patients compared to the combined lists of a) Proteins Found in a similarly Analyzed Group of Non-neurologic Surrogate Normal Subjects (both groups analyzed without immunoaffinity depletion (IAD) of most abundant proteins) and b) Proteins Found in an expanded list of True Normals (where immunoaffinity depletion was applied). CSF Proteins Not Present in MS but Present in Combined MinOfORF Gene Normals and Headaches (no IAD) IPI:IPI00000024.1 PCDH1 Isoform 1 of Protocadherin-1 precursor IPI:IPI00001477.1 DDR1 Isoform 1 of Epithelial discoidin domain-containing receptor 1 precursor IPI:IPI00003176.1 HTRA1 Serine protease HTRA1 precursor IPI:IPI00003648.2 PVRL1 Isoform Delta of Poliovirus receptor-related protein 1 precursor IPI:IPI00004946.8 CXCL16 chemokine (C—X—C motif) ligand 16 IPI:IPI00010471.5 LCP1 Plastin-2 IPI:IPI00021263.3 YWHAZ 14-3-3 protein zeta/delta IPI:IPI00021856.3 APOC2 Apolipoprotein C-II precursor IPI:IPI00022333.1 BAI1 Brain-specific angiogenesis inhibitor 1 precursor IPI:IPI00024570.1 SEMA3G Semaphorin-3G precursor IPI:IPI00025155.1 FSTL3 Follistatin-related protein 3 precursor IPI:IPI00029193.1 HGFAC Hepatocyte growth factor activator precursor IPI:IPI00029343.2 CNTNAP2 Isoform 1 of Contactin-associated protein-like 2 precursor IPI:IPI00169383.3 PGK1 Phosphoglycerate kinase 1 IPI:IPI00216171.3 ENO2 Gamma-enolase IPI:IPI00218570.6 PGAM2 Phosphoglycerate mutase 2 IPI:IPI00218834.9 FCGR3A Low affinity immunoglobulin gamma Fc region receptor III- A precursor IPI:IPI00219425.3 PVR Isoform Beta of Poliovirus receptor precursor IPI:IPI00297040.2 SPINK6 Serine protease inhibitor Kazal-type 6 precursor IPI:IPI00306710.2 CHRD Isoform 1 of Chordin precursor IPI:IPI00328703.1 OAF Out at first protein homolog precursor IPI:IPI00329775.7 CPB2 Isoform 1 of Carboxypeptidase B2 precursor IPI:IPI00385980.8 ROBO2 ROBO2 isoform a IPI:IPI00387119.1 Ig kappa chain V-III region POM IPI:IPI00411680.8 PCMT1 Isoform 1 of Protein-L-isoaspartate(D-aspartate) O- methyltransferase IPI:IPI00444605.1 CDNA FLJ45296 fis, clone BRHIP3003340, moderately similar to Actin, alpha skeletal muscle 2 IPI:IPI00456736.4 RGMB Isoform 1 of RGM domain family member B precursor IPI:IPI00479116.1 CPN2 Carboxypeptidase N subunit 2 precursor IPI:IPI00554474.3 LOC284297 Hypothetical LOC284297 MinOfORF = Non redundant IPI designation

TABLE 3m A subset table of Table 1 illustrating those CSF proteins identified that have high potential as candidate biomarkers. CSF Proteins Present In Multiple Sclerosis not in combined lists of proteins from MinOfORF Normals or Headaches (no IAD) GENE IPI:IPI00001516.1 Isoform Long of Protocadherin alpha PCDHAC2 C2 precursor IPI:IPI00026569.3 HLA class I histocompatibility HLA-A antigen, A-1 alpha chain precursor IPI:IPI00382426.1 Ig lambda chain V-II region TRO IPI:IPI00382447.1 Ig lambda chain V-VI region AR IPI:IPI00382490.1 Ig heavy chain V-III region BUR IPI:IPI00829810.1 Uncharacterized protein ENSP00000375027 IPI:IPI00854624.1 Uncharacterized protein ENSP00000375043 IPI:IPI00854745.1 Uncharacterized protein ENSP00000375019 MinOfORF = Non redundant IPI designation IAD = Immunoaffinity depletion

Table 4H. This Table is divided into 3. The tables show identified CSF proteins that have high potential to be candidate biomarkers because their function is not known and they remain unknown (referred to as a hypothetical or uncharacterized protein).

Table 4H-m is a subset of Table 1 and Table 3 containing those hypothetical/uncharacterized CSF proteins identified in Multiple Sclerosis

TABLE 4H CSF Proteins Present In Multiple Sclerosis but not Normals or Headaches (no IAD) Hypothetical+++, MinOfORF where Ig removed from list Gene IPI:IPI00001516.1 Isoform Long of Protocadherin alpha PCDHAC2 C2 precursor IPI:IPI00829810.1 Uncharacterized protein ENSP00000375027 IPI:IPI00854624.1 Uncharacterized protein ENSP00000375043 IPI:IPI00854745.1 Uncharacterized protein ENSP00000375019 IAD = Immunoaffinity depletion MinOfORF = Non redundant IPI designation

TABLE 4H-l Hypothetical proteins found in neurologic Post Treatment Lyme Disease IPI IPI00166766 IPI00852979 IPI00443799 IPI00374914 IPI00554474 IPI00003269 IPI00455667 IPI00749328 IPI00414294 IPI00644752 IPI00166465 IPI00749338 IPI00328872 IPI00794307 IPI00181279 IPI00847409 IPI00644840 IPI00411480 IPI00848252 IPI00739387 IPI00847373 IPI00855747 IPI00186004 IPI00384971 IPI00395010 IPI00061520 IPI00400986 IPI00006556 IPI00795992

TABLE 4H-c Hypothetical proteins detected in Chronic fatigue IPI IPI00003269 IPI00006556 IPI00061520 IPI00166766 IPI00168255 IPI00176210 IPI00328872 IPI00374223 IPI00374914 IPI00395010 IPI00396025 IPI00398586 IPI00400986 IPI00413868 IPI00414294 IPI00418966 IPI00419675 IPI00443799 IPI00455667 IPI00550862 IPI00554474 IPI00644752 IPI00749328 IPI00789889 IPI00807406 IPI00852979

TABLE 5c CSF Proteins Present in Chronic Fatigue and not in Normals or Neurologic Lyme subjects all had immunoaffinity depletion IPI CSF Proteins 738 Gene IPI00103595 Centrosome-associated protein 350 CEP350 IPI00006173 Isoform 1 of Cholesteryl ester transfer protein precursor CETP IPI00183526 NCL protein NCL IPI00020406 Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase MGAT3 IPI00022479 guanine nucleotide exchange factor p532 HERC1 IPI00179452 Isoform 1 of Protein CBFA2T2 CBFA2T2 IPI00017480 Sonic hedgehog protein precursor SHH IPI00853133 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like DDX60L IPI00387132 CDNA FLJ32661 fis, clone TESTI1000055, weakly similar to HOMEOBOX hCG_2007354 PROTEIN SIXI IPI00878369 12 kDa protein — IPI00382492 Ig heavy chain V-III region LAY — IPI00334492 Isoform 3 of Coiled-coil domain-containing protein 144A LOC731479; CCDC144A; LOC652491; CCDC144B IPI00018880 Tumor necrosis factor receptor superfamily member 1A precursor TNFRSF1A IPI00784385 Adenylate cyclase type 1 ADCY1 IPI00465168 Isoform 1 of Serine/threonine-protein kinase TAO2 TAOK2 IPI00028213 Semaphorin-3D precursor SEMA3D IPI00296421 EH domain-binding protein 1-like protein 1 EHBP1L1 IPI00787587 similar to Temporarily Assigned Gene name family member LOC729549 IPI00028980 Uncharacterized protein KIAA0133 KIAA0133 IPI00430792 Isoform 1 of Protein ERGIC-53-like precursor LMAN1L IPI00018335 Isoform Flt1 of Vascular endothelial growth factor receptor 1 precursor FLT1 IPI00795736 Fer-1-like 4 — IPI00000656 Isoform 1 of Uncharacterized protein KIAA0892 precursor KIAA0892 IPI00169377 Isoform 1 of GAS2-like protein 2 GAS2L2 IPI00030648 Isoform 1 of Zinc finger FYVE domain-containing protein 9 ZFYVE9 IPI00419675 hypothetical protein LOC150763 LOC150763 IPI00003893 Isoform 1 of Protocadherin gamma B3 precursor PCDHGB3 IPI00410127 Transforming, acidic coiled-coil containing protein 2 TACC2 IPI00005711 Histone deacetylase 6 HDAC6 IPI00883997 Coiled-coil domain-containing protein 19 CCDC19 IPI00419180 CDNA FLJ41429 fis, clone BRHIP2005354 CC2D2B IPI00335711 Ciliary dynein heavy chain 11 DNAH11 IPI00411291 Peroxisome biogenesis factor 1 PEX1 IPI00397622 Isoform 1 of Transmembrane and immunoglobulin domain-containing protein 1 TMIGD1 precursor IPI00003564 Lymphocyte antigen 86 precursor LY86 IPI00100247 Thioredoxin domain-containing protein 13 precursor TXNDC13 IPI00059711 LRP11 protein (Fragment) LRP11 IPI00141933 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta BUB1B IPI00387098 Ig kappa chain V-I region OU — IPI00299554 Kinesin-like protein KIF14 KIF14 IPI00515034 87 kDa protein KIFAP3 IPI00044608 Isoform 1 of Protein KIAA1881 KIAA1881 IPI00444138 CDNA FLJ46074 fis, clone TESTI2001915, highly similar to Homo sapiens actin AFAP1 filament associated protein IPI00807406 hypothetical protein isoform 1 LOC285346 IPI00645729 62 kDa protein C1QTNF8 IPI00789856 tubulin tyrosine ligase-like family, member 3 TTLL3 IPI00032680 Apolipoprotein-L5 APOL5 IPI00298214 Isoform 1 of ATP-binding cassette sub-family G member 2 ABCG2 IPI00030945 Urocortin-2 precursor UCN2 IPI00333503 Uncharacterized protein ENSP00000315571 (Fragment) — IPI00005567 Isoform 3A of Voltage-dependent L-type calcium channel subunit beta-3 CACNB3 IPI00185038 Isoform 1 of Dual oxidase 1 precursor DUOX1 IPI00005537 39S ribosomal protein L12, mitochondrial precursor MRPL12 IPI00795575 39 kDa protein — IPI00221240 Isoform 2 of Leucyl-cystinyl aminopeptidase LNPEP IPI00655865 Isoform 2 of Protein diaphanous homolog 3 DIAPH3 IPI00019270 Tankyrase-2 TNKS2 IPI00302614 V-set domain containing T cell activation inhibitor 1 VTCN1 IPI00176976 Novel protein similar to mitochondrial ribosome recycling factor isoform 1 RP1-57A13.2 IPI00786931 similar to fatty acid amide hydrolase LOC729037 IPI00063878 Isoform 1 of Multidrug resistance-associated protein 9 ABCC12 IPI00029473 Protein Njmu-R1 C17orf75 IPI00884076 ENV polyprotein (coat polyprotein) family protein — IPI00449923 Isoform 1 of Retinoic acid-induced protein 1 RAI1 IPI00294187 Protein-arginine deiminase type-2 PADI2 IPI00045473 Similar to C. Elegans protein F17C8.5 LOC339123 IPI00167433 CDNA FLJ39703 fis, clone SMINT2012195 FDX1L IPI00183572 Isoform 2 of Dedicator of cytokinesis protein 7 DOCK7 IPI00001835 Zinc fmger and BTB domain-containing protein 4 ZBTB4 IPI00148768 TRIO and F-actin binding protein isoform 1 TRIOBP IPI00170548 Isoform 1 of ATPase family AAA domain-containing protein 2 ATAD2 IPI00220257 Isoform 3 of Probable tubulin polyglutamylase TTLL1 IPI00298058 Isoform 1 of Transcription elongation factor SPT5 SUPT5H IPI00102281 Retroviral-like aspartic protease 1 precursor SASP IPI00030355 Protein phosphatase 1 regulatory subunit 11 PPP1R11 IPI00217915 Isoform 1 of Transmembrane protein 136 TMEM136 IPI00220986 Isoform 3 of ADAMTS-9 precursor ADAMTS9 IPI00175169 Isoform 1 of ADP-ribosylation factor GTPase-activating protein 1 ARFGAP1 IPI00550862 hypothetical protein LOC387911 LOC387911 IPI00746459 CDNA FLJ34517 fis, clone HLUNG2006781 — IPI00444234 CDNA FLJ45743 fis, clone KIDNE2016464 FLJ45743 IPI00002534 Isoform 1 of Purine-rich element-binding protein gamma PURG IPI00556253 Isoform 1 of Coiled-coil domain-containing protein C6orf199 C6orf199 IPI00017592 Leucine zipper-EF-hand-containing transmembrane protein 1, mitochondrial LETM1 precursor IPI00016007 Myosin-Vc MYO5C IPI00744927 gastrotropin isoform 1 FABP6 IPI00024319 Forkhead box protein J1 FOXJ1 IPI00339297 Polypeptide N-acetylgalactosaminyltransferase 4 GALNT4 IPI00254408 bromodomain PHD finger transcription factor isoform 1 BPTF IPI00304324 Histone deacetylase 11 HDAC11 IPI00477693 fatty acid binding protein LOC646486 IPI00025310 Zinc finger protein 217 ZNF217 IPI00427808 Isoform 1 of Uncharacterized protein C10orf71 C10orf71 IPI00735313 similar to Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 — IPI00384013 Polypeptide N-acetylgalactosaminyltransferase-like protein 2 GALNTL2 IPI00382495 Ig heavy chain V-III region ZAP — IPI00477820 Isoform 1 of FRAS1-related extracellular matrix protein 1 precursor FREM1 IPI00024776 Calmegin precursor CLGN IPI00023110 Potassium channel subfamily K member 3 KCNK3 IPI00182833 Coiled-coil alpha-helical rod protein 1 CCHCR1 IPI00394994 Isoform 1 of Nesprin-3 C14orf49 IPI00419992 Isoform 1 of Acyl-CoA synthetase family member 4 AASDH IPI00004445 Gamma-2-syntrophin SNTG2 IPI00878015 12 kDa protein — IPI00328094 Isoform 1 of Forkhead box protein P3 FOXP3 IPI00873348 63 kDa protein A1CF IPI00640240 59 kDa protein SPTLC3 IPI00002824 Cysteine and glycine-rich protein 2 CSRP2 IPI00398272 Isoform 1 of Collagen alpha-1(XVII) chain COL17A1 IPI00061009 Isoform 1 of WD repeat-containing protein 67 WDR67 IPI00299301 Isoform 1 of Desmuslin DMN IPI00152011 PTPL1-associated RhoGAP 1 ARHGAP29 IPI00847790 Protein of unknown function DUF1725 domain containing protein — IPI00065121 Isoform 2 of Coiled-coil domain-containing protein 36 CCDC36 IPI00373867 glycolipid transfer protein domain containing 2 GLTPD2 IPI00872354 armadillo repeat containing 2 ARMC2 IPI00152975 Isoform 1 of Coiled-coil domain-containing protein 90A, mitochondrial precursor CCDC90A IPI00374804 Isoform 1 of Diacylglycerol kinase delta DGKD IPI00292894 Pre-rRNA-processing protein TSR1 homolog TSR1 IPI00028232 Putative uncharacterized protein FGF4 IPI00027269 E3 ubiquitin-protein ligase CBL CBL IPI00797567 9 kDa protein GNAI2 IPI00032958 Isoform 2 of Actin-binding protein anillin ANLN IPI00057815 intestinal facilitative glucose transporter 7 SLC2A7 IPI00014367 Isoform 1 of Non-SMC element 4 homolog A NSMCE4A IPI00884022 Similar to Immunglobulin heavy chain variable region — IPI00465319 Chondroitin sulfate synthase 2 CHPF IPI00549844 Isoform 1 of Protein FAM134B FAM134B IPI00457114 Isoform 1 of IQ motif and Sec7 domain-containing protein 1 IQSEC1 IPI00002773 Isoform 2 of Tyrosine-protein kinase JAK3 JAK3 IPI00005667 NEDD4-binding protein 1 N4BP1 IPI00300594 CDNA FLJ35435 fis, clone SMINT2002620 SPATA13 IPI00103142 NudC domain-containing protein 2 NUDCD2 IPI00290785 Isoform 1 of SET domain-containing protein 6 SETD6 IPI00297763 Retinal-specific ATP-binding cassette transporter ABCA4 IPI00000861 Isoform 1 of LIM and SH3 domain protein 1 LASP1 IPI00168255 hypothetical protein LOC400451 LOC400451 IPI00015990 Isoform 1 of Eyes absent homolog 3 EYA3 IPI00171500 Uncharacterized protein C14orf45 C14orf45 IPI00170765 Isoform 3 of Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 IPI00099977 platelet-derived growth factor C precursor PDGFC IPI00292953 Isoform 2 of Ankycorbin RAI14 IPI00159072 57 kDa protein ROD1 IPI00305692 Thioredoxin-like protein 1 TXNL1 IPI00031630 Melanocyte protein Pmel 17 precursor SILV IPI00167446 Isoform 2 of Uncharacterized protein C17orf78 C17orf78 IPI00479625 Isoform 1 of ELAV-like protein 4 ELAVL4 IPI00745395 Conserved hypothetical protein KIAA0508 IPI00043069 Ankyrin repeat domain-containing protein 30A ANKRD30A IPI00014316 Cyclin-dependent kinase 5 activator 1 precursor CDK5R1 IPI00301726 Isoform 1 of Uncharacterized protein C3orf20 C3orf20 IPI00185361 ATP-dependent RNA helicase DDX55 DDX55 IPI00293867 D-dopachrome decarboxylase DDT IPI00794779 DNA polymerase theta POLQ IPI00478354 Putative uncharacterized protein CXorf31 CXorf31 IPI00166414 Coiled-coil domain-containing protein 96 CCDC96 IPI00300053 Keratin type II cuticular Hb2 KRT82 IPI00749062 Conserved hypothetical protein — IPI00452161 Isoform 1 of Mucolipin-1 MCOLN1 IPI00384546 CDNA FLJ25883 fis, clone CBR02735 — IPI00412272 SH3 domain-binding glutamic acid-rich-like protein 2 SH3BGRL2 IPI00006298 Isoform 1 of Peptidyl-prolyl cis-trans isomerase G PPIG IPI00031497 Conserved hypothetical protein C7orf49 IPI00022061 Sodium/hydrogen exchanger 6 SLC9A6 IPI00217418 Isoform 2 of Rho GTPase-activating protein 12 ARHGAP12 IPI00743545 Conserved hypothetical protein — IPI00328156 Amine oxidase [flavin-containing] B MAOB IPI00644785 Protein PLXNB3 IPI00654693 Protein FAM44C FAM44C IPI00880011 116 kDa protein — IPI00018583 Isoform 1 of Intracellular hyaluronan-binding protein 4 HABP4 IPI00030986 Isoform Long of Kelch repeat and BTB domain-containing protein 10 KBTBD10 IPI00045503 Isoform 2 of Protein phosphatase 1 regulatory subunit 14A PPP1R14A IPI00793408 6 kDa protein ADAMTS9 IPI00024255 G patch domain and KOW motifs-containing protein GPKOW IPI00028262 67 kDa protein KIAA1754 IPI00027212 Insulin receptor-related protein precursor INSRR IPI00009724 Isoform 1 of EF-hand calcium-binding domain-containing protein 6 EFCAB6 IPI00868835 Similar to Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP C1/hnRNP — C2). Isoform 4 IPI00396658 Isoform 2 of Protein ITFG3 ITFG3 IPI00742127 Similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix-destabilizing — protein) (Single-strand RNA-binding protein) (hnRNP core protein A1). Isoform A1-A IPI00398586 hypothetical protein LOC199800 LOC199800 IPI00418164 Novel protein RP4-692D3.1; LOC731440 IPI00033019 Potassium voltage-gated channel subfamily B member 1 KCNB1 IPI00032598 Isoform 1 of ETS translocation variant 3 ETV3 IPI00217494 Isoform 1 of Protein SMG7 SMG7 IPI00000837 Metabotropic glutamate receptor 3 precursor GRM3 IPI00296535 2-hydroxyacyl-CoA lyase 1 HACL1 IPI00062882 ATP-binding domain-containing protein 3 ATPBD3 IPI00445167 CDNA FLJ44499 fis, clone UTERU3000665, highly similar to Homo sapiens SRCAP Snf2-related CBP activator protein IPI00442582 CDNA FLJ26893 fis, clone RCT00305 — IPI00011274 Isoform 1 of Heterogeneous nuclear ribonucleoprotein D-like HNRPDL IPI00002791 Isoform Wnt-16b of Protein Wnt-16 precursor WNT16 IPI00290432 Natural resistance-associated macrophage protein 1 SLC11A1 IPI00012540 Prominin-1 precursor PROM1 IPI00477396 Uncharacterized protein ZNF324B (Fragment) ZNF584; ZNF324B IPI00853149 RW1 protein TMEM131 IPI00168977 Olfactory receptor 6J1 OR6J1 IPI00165955 Isoform 1 of Mitogen-activated protein kinase 15 MAPK15 IPI00377211 Isoform 3 of Cadherin-like protein 26 precursor CDH26 IPI00736558 THAP domain containing 4 THAP4 IPI00470518 Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 IPI00005087 Tropomodulin-3 TMOD3 IPI00029227 LOC93622 protein LOC93622 IPI00218839 Cytochrome P450 1A1 CYP1A1 IPI00006356 Isoform 1 of Patatin-like phospholipase domain-containing protein 5 PNPLA5 IPI00005616 Isoform 1 of Trace amine-associated receptor 2 TAAR2 IPI00789494 8 kDa protein TUSC4 IPI00745346 Isoform 11 of Peroxisomal N(1)-acetyl-spermine/spermidine oxidase PAOX IPI00027596 Secreted frizzled-related protein 2 precursor SFRP2 IPI00008455 Isoform 2 of Myosin-VI MYO6 IPI00217850 Isoform 1 of GRAM domain-containing protein 1C GRAMD1C IPI00020771 Isoform 3 of Ensconsin MAP7 IPI00170800 Isoform 1 of Otoancorin precursor OTOA IPI00063181 CDKN2A interacting protein N-terminal like CDKN2AIPNL IPI00328225 Isoform 1 of T-box transcription factor TBX20 TBX20 IPI00166331 Ankyrin repeat domain-containing protein 35 ANKRD35 IPI00294386 Myosin-Ia MYOIA IPI00061680 SAGA-associated factor 29 homolog CCDC101 IPI00220901 TBC1D4 protein TBC1D4 IPI00059139 Vacuolar proton pump subunit E 2 ATP6V1E2 IPI00010893 Left-right determination factor 2 precursor LEFTY2 IPI00746222 ATP-binding cassette, sub-family B (MDR/TAP), member 5 ABCB5 IPI00010843 Isoform 1 of Amyloid beta A4 precursor protein-binding family B member 1 APBB1 IPI00012353 Mitochondrial 39S ribosomal protein L3 MRPL3 IPI00385065 Isoform 1 of Coiled-coil domain-containing protein 46 CCDC46 IPI00413930 Elongation of very long chain fatty acids protein 2 ELOVL2 IPI00006715 Double-strand-break repair protein rad21 homolog RAD21 IPI00787189 similar to thioredoxin domain containing 4 LOC727931 IPI00215965 Isoform A1-B of Heterogeneous nuclear ribonucleoprotein A1 HNRNPA1 IPI00030237 Isoform 1 of Uncharacterized protein C1orf49 C1orf49 IPI00088953 Phosphoinositide 3-kinase regulatory subunit 6 C17orf38 IPI00031490 Isoform 1 of Collectin-11 precursor COLEC11 IPI00430079 Isoform 2 of PHD finger protein 8 PHF8 IPI00296942 Cadherin-12 precursor CDH12 IPI00852688 Isoform 1 of Low density lipoprotein receptor-related protein 5-like protein LRP5L IPI00060440 Zinc finger protein GLI4 GLI4; ZFP41 IPI00845299 Putative uncharacterized protein LOC285733 LOC285733 IPI00003897 Isoform 1 of Protocadherin gamma B6 precursor PCDHGB6 IPI00152257 Enkurin C10orf63 IPI00043526 Uncharacterized protein C14orf44 C14orf44 IPI00013373 Orexin precursor HCRT IPI00829925 Uncharacterized protein ENSP00000365090 ELA2A IPI00009333 Transmembrane protein 9 precursor TMEM9 IPI00470917 Isoform 2 of Uncharacterized protein KIAA1529 KIAA1529 IPI00013269 Isoform 1 of Uncharacterized protein C6orf106 C6orf106 IPI00022433 Heat-shock protein beta-6 HSPB6 IPI00179694 Beta-klotho KLB IPI00027642 Isoform 1 of JmjC domain-containing histone demethylation protein 3C JMJD2C IPI00797832 Isoform 3 of Acyl-CoA dehydrogenase family member 10 ACAD10 IPI00410464 Isoform 1 of Zinc finger protein 324B ZNF324B; ZNF584 IPI00166863 Isoform 2 of Coiled-coil domain-containing protein 123, mitochondrial precursor CCDC123 IPI00008832 Growth arrest-specific protein 1 precursor GAS1 IPI00014958 Isoform 1 of Serum paraoxonase/arylesterase 2 PON2 IPI00719669 Myosin regulatory light chain MRLC2 IPI00299084 Transmembrane protein 33 TMEM33 IPI00029737 Isoform Long of Long-chain-fatty-acid--CoA ligase 4 ACSL4 IPI00005661 Isoform Gamma of Max-like protein X MLX IPI00217683 A-kinase anchor protein 12 isoform 2 AKAP12 IPI00418966 hypothetical protein LOC123688 isoform 2 LOC123688 IPI00328409 Armadillo repeat-containing protein 4 ARMC4 IPI00065457 OTTHUMP00000018353 FLJ32682 IPI00444502 CDNA FLJ45482 fis, clone BRTHA2001953 FLJ45482 IPI00001780 Ubiquitin carboxyl-terminal hydrolase 16 USP16 IPI00552840 Probable G-protein coupled receptor 112 GPR112 IPI00016373 Ras-related protein Rab-13 RAB13 IPI00552434 Myosin, heavy chain 7B, cardiac muscle, beta MYH7B IPI00876962 Isoform 2 of Inverted formin-2 INF2 IPI00026512 Isoform HERA-A of GTP-binding protein era homolog ERAL1 IPI00180375 Isoform I of Beta-arrestin-2 ARRB2 IPI00297407 Solute carrier family 45 member 4 SLC45A4 IPI00152879 Monocarboxylate transporter 10 SLC16A10 IPI00290155 66 kDa protein ZNF148 IPI00747017 Putative uncharacterized protein DKFZp686D06121 NEK1 IPI00793836 11 kDa protein ARHGDIB IPI00382422 Ig lambda chain V-I region NEWM — IPI00328842 ARHGAP4 protein ARHGAP4 IPI00008632 Isoform 1 of Putative homeodomain transcription factor 1 PHTF1 IPI00065253 Uncharacterized protein C3orf30 C3orf30 IPI00883751 RNA-directed DNA polymerase (Reverse transcriptase), related domain — containing protein IPI00216137 Synaptonemal complex protein 1 SYCP1 IPI00005621 7h3 protein (Fragment) SYDE1 IPI00001933 Coiled-coil domain-containing protein 113 CCDC113 IPI00383294 Putative uncharacterized protein pp7518 MNT IPI00016861 102 kDa protein GTF3C2 IPI00020903 Isoform 1 of AF4/FMR2 family member 2 AFF2 IPI00465247 Isoform 1 of Stimulated by retinoic acid gene 6 protein homolog STRA6 IPI00382394 Isoform 5 of Cytosolic phospholipase A2 beta PLA2G4B IPI00167913 Isoform 1 of Spermatid-associated protein SPERT IPI00874276 Putative uncharacterized protein DKFZp761N1814 EPB41L4B IPI00446767 Isoform 3 of Transducin-like enhancer protein 4 TLE4 IPI00020754 PRO1751 — IPI00300060 WD repeat-containing protein 70 WDR70 IPI00021979 Peroxisomal membrane protein 11A PEX11A IPI00031768 Hook homolog 3 HOOK3 IPI00216986 Isoform C of Complement receptor type 2 precursor CR2 IPI00470771 SAMD4B protein SAMD4B IPI00021143 Class B basic helix-loop-helix protein 2 BHLHB2 IPI00297931 Isoform 1 of AP1 subunit gamma-binding protein 1 AP1GBP1 IPI00018691 28S ribosomal protein S18a, mitochondrial precursor MRPS18A IPI00010604 Isoform 1 of 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase epsilon-1 PLCE1 IPI00022438 Isoform Long of Transcription factor Maf MAF IPI00396527 Isoform 1 of Coiled-coil domain-containing protein 128 CCDC128 IPI00291840 Isoform 1 of Zinc finger protein 90 homolog ZFP90 IPI00646410 Isoform 2 of Flavin-containing amine oxidase domain-containing protein 1 AOF1 IPI00451413 Intersectin 1 isoform 7 ITSN1 IPI00787410 similar to Polypeptide N-acetylgalactosaminyltransferase 9 GALNT9 IPI00552601 Putative uncharacterized protein DKFZp686M12165 (Fragment) — IPI00166833 LAG1 longevity assurance homolog 5 LASS5 IPI00183425 CDKN1A interacting zinc finger protein 1 CIZ1 IPI00027228 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial PET112L precursor IPI00007917 Collectin-10 precursor COLEC10 IPI00552787 similar to Matrin-3 RBM20 IPI00065484 CDNA FLJ32471 fis, clone SKNMC2000322, weakly similar to MAJOR PTRH2 CENTROMERE AUTOANTIGEN B IPI00384447 Sarcoma antigen NY-SAR-22 (Fragment) NEXN IPI00830073 Isoform 1 of RING finger protein 207 RNF207 IPI00012411 Zinc finger protein 32 ZNF32 IPI00760993 IQ motif and Sec7 domain 2 isoform 2 IQSEC2 IPI00004527 Uncharacterized protein KIAA0355 KIAA0355 IPI00018956 ALX homeobox protein 1 ALX1 IPI00154553 Centrosomal protein of 76 kDa CEP76 IPI00444208 CDNA FLJ45771 fis, clone NETRP2003103 RNF44 IPI00001641 Origin recognition complex subunit 6 ORC6L IPI00216484 Isoform 2 of LisH domain-containing protein ARMC9 ARMC9 IPI00170961 Isoform 2 of WD repeat-containing protein 16 WDR16 IPI00786880 Myosin-XVB — IPI00152722 Protein CCDC35 CCDC35 IPI00298447 Probable methyltransferase TARBP1 TARBP1 IPI00293200 OTTHUMP00000016423 PARC IPI00550272 Integrator complex subunit 10 INTS10 IPI00514197 similar to Nonhistone chromosomal protein HMG-17 LOC648822 IPI00156804 cDNA FLJ77550, highly similar to Homo sapiens zinc finger protein 665 ZNF665 (ZNF665), mRNA IPI00384140 Full-length cDNA clone CS0DA005YA22 of Neuroblastoma of Homo sapiens ESR2 (Fragment) IPI00410564 CDNA FLJ45248 fis, clone BRHIP2006819 FLJ45248 IPI00023586 Isoform 1 of Sentrin-specific protease 6 SENP6 IPI00028579 Transcription initiation factor TFIID subunit 6 TAF6 IPI00253323 Ankyrin repeat domain-containing protein 57 ANKRD57 IPI00166361 Putative uncharacterized protein FLJ33590 FLJ33590 IPI00294810 CDNA FLJ10824 fis, clone NT2RP4001086 (Fragment) FAM21A IPI00418408 Cytochrome P450 CYP2D7P1 IPI00168627 Uncharacterized protein CXorf20 CXorf20 IPI00026952 Plakophilin-3 PKP3 IPI00014852 Isoform 1 of Phosphoglucomutase-like protein 5 PGM5 IPI00332628 Otopetrin-3 OTOP3 IPI00296830 Isoform 1 of Leucine zipper protein 1 LUZP1 IPI00306127 THUMP domain-containing protein 3 THUMPD3 IPI00022881 Isoform 1 of Clathrin heavy chain 2 CLTCLI IPI00397015 A.T hook DNA-binding motif-containing protein 1 AHDC1 IPI00029184 Hyaluronan and proteoglycan link protein 2 precursor HAPLN2 IPI00795917 126 kDa protein CXorf45 IPI00815976 Transmembrane protein 120B TMEM120B IPI00382671 Isoform 6 of C-type lectin domain family 4 member M CLEC4M IPI00018303 Isoform 2 of Protocadherin-11 X-linked precursor PCDH11X IPI00176210 hypothetical protein LOC133558 FLJ40243 IPI00166153 Protein KIAA0082 KIAA0082 IPI00300621 Isoform 2B2 of Synaptojanin-2 SYNJ2 IPI00306166 germ cell associated 1 isoform 2 GSG1 IPI00401002 Zinc finger protein 740 ZNF740 IPI00607829 Isoform 1 of Ret fmger protein-like 2 RFPL2 IPI00402280 Isoform 1 of Small leucine-rich proteoglycan family member LOC150356 CHADL precursor IPI00006800 Isoform Long of Autophagy protein 5 ATG5 IPI00218559 Gamma-sarcoglycan SGCG IPI00479897 Chromosome 9 open reading frame 75 C9orf75 IPI00216003 Cullin-5 CUL5 IPI00445796 CDNA FLJ43383 fis, clone OCBBF2006058, highly similar to Homo sapiens ACAD8 acyl-Coenzyme A dehydrogenase-8 mRNA IPI00742114 similar to tripartite motif protein 11 LOC653978 IPI00023164 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4 HCN4 IPI00012480 FKSG42 RACGAP1P IPI00004538 similar to nascent polypeptide-associated complex alpha polypeptide isoform 1 NACAD IPI00297462 Uncharacterized protein C1orf65 C1orf65 IPI00793454 7 kDa protein USP19 IPI00028392 specifically androgen-regulated protein isoform 1 C1orf116 IPI00385495 Transmembrane protein 153 LMF2 IPI00017726 Isoform 1 of 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 IPI00791509 Neural precursor cell expressed, developmentally down-regulated 1 NEDD1 IPI00289931 Isoform 1 of Mucosal addressin cell adhesion molecule 1 precursor MADCAM1 IPI00442601 CDNA FLJ26817 fis, clone PRS06446 — IPI00012891 Phosphorylase b kinase gamma catalytic chain, testis/liver isoform PHKG2 IPI00021338 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate DLAT dehydrogenase complex, mitochondrial precursor IPI00455083 Uncharacterized protein ENSP00000371558 — IPI00168877 helicase (DNA) B HELB IPI00641214 177 kDa protein ADCY10 IPI00290837 Isoform 2 of F-box/WD repeat-containing protein 10 FBXW10 IPI00009213 Isoform 1 of B-cell lymphoma/leukemia 11B BCL11B IPI00003421 T-brain-1 protein TBR1 IPI00396314 Isoform 3 of CCR4-NOT transcription complex subunit 10 CNOT10 IPI00000106 Signal transducer and activator of transcription 4 STAT4 IPI00339217 Ovochymase-1 precursor OVCH1 IPI00395631 Isoform 1 of E3 ubiquitin-protein ligase TRAF7 TRAF7 IPI00455397 DMWD protein DMWD IPI00744557 kazrin isoform E RPI-21O18.1 IPI00152692 D-tyrosyl-tRNA(Tyr) deacylase 1 DTD1 IPI00397526 Isoform 1 of Myosin-10 MYH10 IPI00640654 RAP1 GTPase activating protein RAP1GAP IPI00791831 10 kDa protein ADRBK I IPI00479904 Uncharacterized protein COL27A1 COL27A1 IPI00013256 Isoform 1 of Cleavage stimulation factor 64 kDa subunit CSTF2 IPI00059279 Exocyst complex component 4 EXOC4 IPI00299402 Pyruvate carboxylase, mitochondrial precursor PC IPI00167639 Vacuolar proton pump subunit d 2 ATP6V0D2 IPI00170855 tetratricopeptide repeat domain 19 TTC19 IPI00445563 Putative uncharacterized protein MGC21675/FLJ43787 C4orf42 IPI00884334 Conserved hypothetical protein LOC729968 IPI00007910 Isoform 1 of Sodium-dependent phosphate transport protein 2B SLC34A2 IPI00083708 BAT2-iso BAT2D1 IPI00328715 Protein LYRIC MTDH IPI00290035 Isoform 1 of Protocadherin-15 precursor PCDH15 IPI00385511 Uncharacterized protein TNRC6B TNRC6B IPI00006561 Isoform 1 of Protein KIAA0317 KIAA0317 IPI00375294 Laminin subunit alpha-1 precursor LAMA1 IPI00375325 Keratin-associated protein 10-10 KRTAP10-10 IPI00640293 23 kDa protein TIMP3 IPI00235003 Tumor necrosis factor receptor superfamily, member 6 isoform 1 variant FAS (Fragment) IPI00216702 Isoform 1 of ATP-binding cassette sub-family A member 9 ABCA9 IPI00167930 ring finger protein 190 MARCH10 IPI00470657 Anti-colorectal carcinoma heavy chain — IPI00413868 hypothetical protein LOC79632 isoform 1 C6orf60 IPI00066367 Endothelial cells scavenger receptor precursor SCARF1 IPI00397740 zinc finger protein 749 ZNF749 IPI00300426 Isoform 1 of Tetratricopeptide repeat protein 29 TTC29 IPI00307259 DnaJ homolog subfamily C member 13 DNAJCI3 IPI00386113 CDNA: FLJ23412 fis, clone HEP20516 C20orf59 IPI00153060 Angiopoietin-related protein 4 precursor ANGPTL4 IPI00020354 Interleukin-13 receptor alpha-1 chain precursor IL13RAI IPI00177888 Isoform 1 of Leukocyte receptor cluster member 8 LENG8 IPI00101267 Isoform 1 of Uncharacterized protein C19orf60 C19orf60 IPI00739927 similar to vasoactive intestinal peptide receptor 2 LOC645464 IPI00782965 huntingtin interacting protein 1 HIP1 IPI00444375 Rh blood group, CcEe antigens RHCE IPI00794880 Isoform 1 of Chromodomain-helicase-DNA-binding protein 7 CHD7 IPI00419791 Isoform 1 of Arginine/serine-rich coiled-coil protein 2 RSRC2 IPI00100106 resistance to inhibitors of cholinesterase 8 homolog A RIC8A IPI00216593 Isoform NOH-1LV of NADPH oxidase homolog 1 NOX1 IPI00395667 Interferon-related IFRD2 (PC4-B) protein NAT6; IFRD2 IPI00008708 Ribosomal L1 domain-containing protein 1 RSL1D1 IPI00748649 25 kDa protein — IPI00100362 erythrocyte membrane protein band 4.1 like 4B isoform 1 EPB41L4B IPI00219898 Isoform 2 of Nephrin precursor NPHS1; PRODH2 IPI00872098 Zinc finger protein Pegasus IKZF5 IPI00043294 Isoform 1 of Uncharacterized protein C7orf26 C7orf26 IPI00152535 Chromodomain-helicase-DNA-binding protein 5 CHD5 IPI00217507 Neurofilament medium polypeptide NEFM IPI00216356 Isoform 2 of RasGAP-activating-like protein 1 RASAL1 IPI00290562 Nuclear factor interleukin-3-regulated protein NFIL3 IPI00006003 CD83 antigen precursor CD83 IPI00166528 Isoform 3 of Rapamycin-insensitive companion of mTOR RICTOR IPI00221325 E3 SUMO-protein ligase RanBP2 RANBP2 IPI00084684 similar to Zinc finger protein 469 ZNF469 IPI00643809 Protein CNTNAP3B IPI00164776 Similar to RIKEN cDNA A230078105 gene TMEM198 IPI00023410 Integrin alpha-8 precursor ITGA8 IPI00787593 similar to CG33300-PA LOC730407 IPI00180781 Isoform 1 of Mixed lineage kinase domain-like protein MLKL IPI00339309 Isoform 1 of Proto-oncogene DBL MCF2 IPI00843923 Phosphodiesterase PDE7B2 PDE7B IPI00640865 Integrin beta-like protein 1 precursor ITGBLI IPI00029144 Isoform PR130 of Serine/threonine-protein phosphatase 2A regulatory subunit B″ PPP2R3A subunit alpha IPI00175439 F-box only protein 43 FBXO43 IPI00646485 Protein EFCAB2 IPI00023105 Peptidylglycine alpha-amidating monooxygenase COOH-terminal interactor PAMCI IPI00301144 Isoform 1 of Sulfatase-modifying factor 1 precursor SUMF1 IPI00439935 UDP-glucuronosyltransferase 1-4 precursor UGT1A4; UGT1A6 IPI00001753 Myosin-4 MYH4 IPI00401829 Putative uncharacterized protein ENST00000281581 — IPI00056324 Isoform 1 of Hermansky-Pudlak syndrome 3 protein HPS3 IPI00220493 U6 snRNA-associated Sm-like protein LSm5 LSM5 IPI00386390 Olfactory receptor 6N2 OR6N2 IPI00044761 Pseudouridylate synthase 7 homolog PUS7 IPI00032342 TRIP12 protein TRIP12 IPI00307536 Isoform 1 of Testis-expressed sequence 11 protein TEX11 IPI00244812 Tetratricopeptide repeat protein 6 TTC6 IPI00030487 CDNA FLJ30993 fis, clone HLUNG1000064, weakly similar to KARYOGAMY KIAA1627 PROTEIN KAR4 IPI00787443 similar to Collagen alpha-2(XI) chain precursor LOC730037 IPI00013371 Protein sprouty homolog 3 SPRY3 IPI00414259 Isoform 2 of Pregnancy-specific beta-1-glycoprotein 4 precursor PSG4 IPI00410590 Isoform 2 of LSM14 protein homolog A LSM14A IPI00023330 Isoform 2 of LisH domain and HEAT repeat-containing protein KIAA1468 KIAA1468 IPI00645614 Isoform 2 of Cadherin-3 precursor CDH3 IPI00744574 Similar to Tropomyosin alpha-4 chain — IPI00737735 similar to cell division cycle 10 isoform 1 LOC646913 IPI00065415 Isoform 1 of Coiled-coil domain-containing protein 138 CCDC138 IPI00376206 Isoform 2 of 17-beta hydroxysteroid dehydrogenase 13 precursor HSD17B13 IPI00011589 Isoform A of Septin-4 SEPT4 IPI00032158 Isoform 2 of NMDA receptor-regulated protein 1 NARG1 IPI00013468 Mitotic checkpoint protein BUB3 BUB3 IPI00745955 EBNA1 binding protein 2 EBNA1BP2 IPI00157237 Isoform 1 of MAGUK p55 subfamily member 4 MPP4 IPI00009040 Ornithine decarboxylase antizyme 3 OAZ3 IPI00383774 Mih1/Tx protein CASP4 IPI00182774 SH3YL1 protein SH3YL1 IPI00217691 Isoform 1 of EF-hand domain-containing protein C17orf57 C17orf57 IPI00514843 KIAA0082 KIAA0082 IPI00216346 Isoform 2 of Nucleolar protein 3 NOL3 IPI00644968 Similar to Heterogeneous nuclear ribonucleoprotein A1 — IPI00414122 coiled-coil domain containing 141 CCDC141 IPI00884216 RNA-directed DNA polymerase (Reverse transcriptase), related domain — containing protein IPI00397759 similar to ribosomal protein L21 LOC388621 IPI00156871 Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 49 USP49 IPI00168692 Isoform 2 of Zinc finger protein 318 ZNF318 IPI00187082 Isoform 3 of Multiple C2 and transmembrane domain-containing protein 1 MCTP1 IPI00018805 Uncharacterized protein C14orf105 C14orf105 IPI00446685 CDNA FLJ41345 fis, clone BRAWH2002761 — IPI00470515 Isoform 1 of Uncharacterized protein C1orf173 C1orf173 IPI00001317 Rho-related BTB domain-containing protein 1 RHOBTB1 IPI00024523 Isoform A of DnaJ homolog subfamily B member 6 DNAJB6 IPI00030814 Fibroblast growth factor 22 precursor FGF22 IPI00441064 Isoform 1 of Uncharacterized protein C15orf26 C15orf26 IPI00867744 Isoform 3 of Pleckstrin homology domain-containing family H member 2 PLEKHH2 IPI00784027 Rod cGMP-specific 3′,5′-cyclic phosphodiesterase subunit beta precursor PDE6B IPI00879277 436 kDa protein TRRAP IPI00011631 Centromere/kinetochore protein zw10 homolog ZW10 IPI00014186 Isoform A of Zinc forger homeobox protein 3 ZFHX3 IPI00852699 4 kDa protein — IPI00400834 Mediator of RNA polymerase II transcription subunit 13-like MED13L IPI00018203 Isoform SRP55-2 of Splicing factor, arginine/serine-rich 6 SFRS6 IPI00335259 deleted in liver cancer 1 isoform 1 DLC1 IPI00239405 Isoform 1 of Nesprin-2 SYNE2 IPI00788010 similar to 60S ribosomal protein L21 RPL21; LOC728501 IPI00027487 Creatine kinase M-type CKM IPI00029662 Isoform 1 of Potassium voltage-gated channel subfamily H member 2 KCNH2 IPI00651669 Putative uncharacterized protein — IPI00029446 Isoform 1 of Myotubularin-related protein 5 SBF1 IPI00883929 Conserved hypothetical protein — IPI00641155 20 kDa protein HIRIP3 IPI00030307 Solute carrier family 41 member 2 SLC41A2 IPI00398162 Isoform 2 of Nebulin-related-anchoring protein NRAP IPI00158506 Isoform 3 of Zinc finger protein 688 ZNF688 IPI00003768 Isoform 1 of Pescadillo homolog 1 PES1 IPI00100910 Isoform 2 of Armadillo repeat-containing protein 5 ARMC5 IPI00445894 CDNA FLJ42978 fis, clone BRTHA2004821 — IPI00022325 Isoform 4 of Pro-neuregulin-2, membrane-bound isoform precursor NRG2 IPI00747271 zinc finger protein SBZF3 ZNF695 IPI00006178 Y6 encoding protein NPY6R IPI00796745 22 kDa protein PPP1R14D IPI00299880 Isoform 2 of Calcium-activated potassium channel subunit beta-3 KCNMB3 IPI00328885 eEF1A2 binding protein DKFZp434B1231 IPI00009305 Glucosamine-6-phosphate isomerase GNPDA1 IPI00465054 Putative uncharacterized protein DKFZp686C1054 THUMPD1 IPI00456676 Isoform 1 of F-box only protein 38 FBXO38 IPI00328089 Kappa B and V(D)J recombination signal sequences binding protein HIVEP3 IPI00002506 Dolichyl-phosphate beta-glucosyltransferase ALG5 IPI00410325 Low-density lipoprotein receptor class A domain-containing protein 3 precursor LDLRAD3 IPI00450358 Putative uncharacterized protein TOP IPI00004472 Isoform 1 of Serine/threonine-protein kinase WNK1 WNK1 IPI00428677 Putative olfactory receptor (Fragment) — IPI00788014 similar to Opioid growth factor receptor LOC729015 IPI00442208 CDNA FLJ16344 fis, clone TESTI2032643, moderately similar to ADCY4 ADENYLATE CYCLASE, TYPE IV IPI00019932 ubiquitin-conjugating enzyme E2D 2 isoform 2 UBE2D2 IPI00869224 Pseudogene candidate — IPI00000102 Progonadoliberin-1 precursor GNRH1 IPI00470896 Isoform 2 of Zinc finger FYVE domain-containing protein 26 ZFYVE26 IPI00329488 Isoform IB of Tyrosine-protein kinase ABL2 ABL2 IPI00219604 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 IPI00000030 Isoform Delta-1 of Serine/threonine-protein phosphatase 2A 56 kDa regulatory PPP2R5D subunit delta isoform IPI00017538 Isoform 2 of Separin ESPL1 IPI00787099 similar to SR protein related family member LOC728676 IPI00297235 cDNA FLJ77204 CCPG1 IPI00002405 2′-5′-oligoadenylate synthetase 3 OAS3 IPI00013205 Isoform 1 of JmjC domain-containing histone demethylation protein 3B JMJD2B IPI00218715 Isoform 2 of ADAM 33 precursor ADAM33 IPI00410666 Isoform 3 of Protein LAP4 SCRIB IPI00827815 Light chain Fab (Fragment) — IPI00013651 Isoform 3 of RNA-binding protein 33 RBM33 IPI00002344 steroid 5 alpha-reductase 3 SRD5A3 IPI00444408 CDNA FLJ45600 fis, clone BRTHA3020369 — IPI00005013 poly(rC) binding protein 4 isoform b PCBP4 IPI00294728 DmX-like protein 1 DMXL1 IPI00004288 Isoform 1 of Sialic acid-binding Ig-like lectin 7 precursor SIGLEC7 IPI00855960 Integral membrane protein GPR137C GPR137C IPI00003571 Isoform S-CaBP1 of Calcium-binding protein 1 CABP1 IPI00021751 Neurofilament heavy polypeptide NEFH IPI00174347 Inactive dual specificity phosphatase 27 DUSP27 IPI00787774 similar to collagen, type I, alpha 1 LOC730756 IPI00419903 Putative L-aspartate dehydrogenase LOC554235 IPI00165357 Isoform 1 of Metastasis-associated protein MTA3 MTA3 IPI00299406 Pituitary adenylate cyclase-activating polypeptide type I receptor precursor ADCYAP1R1 IPI00401789 Isoform 2 of Highly divergent homeobox HDX IPI00303732 Uncharacterized protein C20orf106 precursor C20orf106 IPI00016425 Isoform 2 of Synaptopodin 2-like protein SYNPO2L IPI00017640 Isoform 1 of Slit homolog 3 protein precursor SLIT3 IPI00014577 Ras-related protein Rab-18 RAB18 IPI00023856 Peregrin BRPF1 IPI00294241 Transcription factor IIIA GTF3A IPI00025717 Metaxin-2 MTX2 IPI00023095 Myeloid leukemia factor 2 MLF2 IPI00009645 Ran-binding protein 17 RANBP17 IPI00022629 Isoform 1 of Protein regulator of cytokinesis 1 PRC1 IPI00031082 Putative uncharacterized protein DKFZp761O17121 LDOC1L IPI00788120 similar to CG14182-PA LOC730094 IPI00396063 C-myc promoter-binding protein DENND4A IPI00013296 40S ribosomal protein S18 RPS18 IPI00004362 MORC family CW-type zinc finger protein 1 MORC1 IPI00787625 similar to 60S ribosomal protein L23a LOC389101 IPI00385020 Putative uncharacterized protein DKFZp686D159 (Fragment) CAPRIN2 IPI00374223 hypothetical protein LOC389119 C3orf54 IPI00039626 Isoform D of UPF0318 protein FAM120A FAM120A IPI00295253 Isoform 1 of Cell surface glycoprotein OX2 receptor precursor CD200R1 IPI00299040 Polycystin-2 PKD2 IPI00307165 Tripartite motif-containing protein 47 TRIM47 IPI00152685 Tetratricopeptide repeat protein 15 TTC15 IPI00013789 SET and MYND domain-containing protein 5 SMYD5 IPI00396025 hypothetical protein LOC254122 FLJ30934 IPI00014232 ADP-ribosylation factor-like protein 6-interacting protein 1 ARL6IP1 IPI00021715 Isoform 1 of Collagen alpha-5(IV) chain precursor COL4A5 IPI00026305 Hook homolog 1 HOOK1 IPI00184160 Isoform 2 of RING finger protein 180 RNF180 IPI00216308 Voltage-dependent anion-selective channel protein 1 VDAC1 IPI00651633 CASKIN1 protein (Fragment) CASKIN1 IPI00247063 Neprilysin MME IPI00398779 Isoform 4 of Plectin-1 PLEC1 IPI00168418 Putative uncharacterized protein C11orf64 C11orf64 IPI00167764 Transmembrane protein 102 TMEM102 IPI00171716 OTTHUMP00000028696 TTC28 IPI00394818 Isoform 1 of Ankyrin repeat domain-containing protein 47 KANK3 IPI00830137 Uncharacterized protein ENSP00000374864 — IPI00030874 Uncharacterized gastric protein YA42P (Fragment) — IPI00455675 Isoform 2 of Centrosomal protein of 192 kDa CEP192 IPI00789889 Hypothetical protein — IPI00829625 Uncharacterized protein FAM91A1 FAM91A1 IPI00000873 Valyl-tRNA synthetase VARS IPI00386185 FLJ00370 protein (Fragment) — IPI00829697 Uncharacterized protein ENSP00000375030 — IPI00000690 Isoform 1 of Apoptosis-inducing factor 1, mitochondrial precursor AIFM1 IPI00016988 WD repeat-containing protein 13 WDR13 IPI00478058 Isoform 2 of NMDA receptor-regulated 1-like protein NARG1L IPI00782960 Isoform 1 of Leucine-rich repeat and IQ domain-containing protein 3 LRRC44 IPI00103373 Cytoglobin CYGB IPI00646831 34 kDa protein — IPI00384164 Full-length cDNA clone CS0DI075YC18 of Placenta of Homo sapiens PGF (Fragment) IPI00739611 similar to golgi autoantigen, golgin subfamily a, 8A isoform 3 LOC727909 IPI00012451 Guanine nucleotide-binding protein subunit beta-4 GNB4 IPI00394960 Isoform 1 of Probable G-protein coupled receptor 133 precursor GPR133 IPI00555595 Ubiquitin carboxyl-terminal esterase L1 (Ubiquitin thiolesterase) variant — (Fragment) IPI00431697 Cancer/testis antigen 45-5 RP13-36C9.6 IPI00028066 class IV alcohol dehydrogenase 7 mu or sigma subunit ADH7 IPI00152960 RNA polymerase I-specific transcription initiation factor RRN3 RRN3 IPI00792370 6 kDa protein GNAT1 IPI00167762 Isoform 1 of Uncharacterized protein C19orf47 C19orf47 IPI00385321 Isoform 2 of Protein kinase C-binding protein 1 ZMYND8 IPI00385153 HUMEEP ATXN10 IPI00337348 Growth differentiation factor 7 GDF7 IPI00060627 Coiled-coil domain-containing protein 124 CCDC124 IPI00401190 LOC155006 protein LOC155006 IPI00025039 rRNA 2′-O-methyltransferase fibrillarin FBL IPI00479578 similar to Nonhistone chromosomal protein HMG-14 hCG_1659830 IPI00018245 Isoform 3 of DNA-directed RNA polymerase III subunit RPC5 POLR3E IPI00020565 PRO1598 — IPI00446711 CDNA FLJ41261 fis, clone BRAMY2034920 — IPI00787990 similar to ribosomal protein S14 LOC644119 IPI00218743 Isoform 2 of Bestrophin-1 BEST1 IPI00736826 similar to Temporarily Assigned Gene name family member LOC402217 IPI00412024 Zinc finger protein 485 ZNF485 IPI00297559 Isoform 1 of USH1C-binding protein 1 USHBP1 IPI00396147 Protocadherin-20 precursor PCDH20 IPI00478572 Collagen alpha-4(IV) chain precursor COL4A4 IPI00032785 Isoform II of Amyloid beta A4 precursor protein-binding family B member 3 APBB3 IPI00009982 Isoform 1 of Tudor and KH domain-containing protein TDRKH IPI00216164 Peroxisomal bifunctional enzyme EHHADH IPI00419912 YY2 transcription factor YY2 IPI00735531 proline-rich synapse-associated protein 2 isoform 4 SHANK3 IPI00005104 Inhibitor of nuclear factor kappa-B kinase subunit alpha CHUK IPI00008837 Tyrosine-protein phosphatase non-receptor type 5 PTPN5 IPI00017800 ATP-binding cassette sub-family A member 3 ABCA3 IPI00737972 Transcription factor 24 (Fragment) TCF24 IPI00374074 similar to CG40449-PA.3 LOC388795 IPI00220533 Isoform D of Transmembrane protease, serine 3 TMPRSS3 IPI00302458 Exportin-7 XPO7 IPI00646826 Putative uncharacterized protein FLJ32658 FLJ32658 IPI00016859 Isoform 1 of Transcription factor IIIB 90 kDa subunit BRF1 IPI00031386 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha isoform PIK3CA IPI00065547 OTTHUMP00000031495 RP11-93B14.6 IPI00043370 WD repeat-containing protein 52 WDR52 IPI00064767 Isoform 1 of Rho GTPase-activating protein 17 ARHGAP17 IPI00219689 Isoform Beta of Protein vav-3 VAV3 IPI00328291 Cytoskeleton-associated protein 2-like CKAP2L IPI00647897 RING finger protein 113B RNF113B IPI00024285 similar to testicular serine protease 2 LOC138652 IPI00783200 38 kDa protein RAPGEF3 IPI00014877 Isoform 2 of Glutaminyl-peptide cyclotransferase-like protein QPCTL IPI00186554 Uncharacterized protein KIAA1853 KIAA1853 IPI00418336 Isoform 2 of Integrator complex subunit 3 INTS3 IPI00872730 Macrophin 1 isoform MACF1 IPI00303207 ATP-binding cassette sub-family E member 1 ABCE1 IPI00301609 Serine/threonine-protein kinase Nek9 NEK9 IPI00744527 Conserved hypothetical protein — IPI00302351 Isoform 1 of Serine/threonine-protein kinase 33 STK33 IPI00878483 30 kDa protein — IPI00744179 Uncharacterized protein ENSP00000370856 (Fragment) — IPI00396279 Isoform 1 of CLIP-associating protein 1 CLASP1 IPI00013378 Isoform Long of DNA topoisomerase 3-alpha TOP3A IPI00429190 Ras-related protein Rab-11A RAB11A IPI00464994 Isoform 1 of tRNA modification GTPase GTPBP3, mitochondrial precursor GTPBP3 IPI00008449 Isoform 3 of Pre-mRNA 3′-end-processing factor FIP1 FIP1L1 IPI00414402 Olfactory receptor 2T27 OR2T27 IPI00168913 Isoform 2 of Limbin EVC2 IPI00009315 Golgi resident protein GCP60 ACBD3 IPI00871625 cDNA FLJ77072, highly similar to Homo sapiens prostaglandin E receptor 3 PTGER3 (subtype EP3) (PTGER3), transcript variant 9, mRNA IPI00479296 Isoform 1 of ATP-binding cassette sub-family A member 8 ABCA8 IPI00300221 Putative uncharacterized protein DKFZp43411916 ELL IPI00026036 Isoform 5 of Dipeptidyl peptidase 8 DPP8 IPI00647205 Uncharacterized protein C6orf174 precursor C6orf174 IPI00006932 Isoform 1 of Putative RNA-binding protein Luc7-like 2 LUC7L2 IPI00017819 Bile acid-CoA:amino acid N-acyltransferase BAAT IPI00145121 GPI mannosyltransferase 3 PIGB IPI00744357 Conserved hypothetical protein — IPI00410320 Sodium-dependent glucose transporter SLC5A11 IPI00065085 CDNA FLJ25371 fis, clone TST01885 FLJ25371 IPI00289914 MutS protein homolog 4 MSH4 IPI00012438 Isoform Long of 52 kDa repressor of the inhibitor of the protein kinase PRKRIR IPI00217895 rai-like protein SHC4 IPI00294618 Proline-rich protein PRCC PRCC IPI00000784 Isoform MEF2DAB of Myocyte-specific enhancer factor 2D MEF2D IPI00848180 Conserved hypothetical protein — IPI00045208 Zinc finger protein 300-B ZNF300 IPI00871452 Isoform 1 of PWWP domain-containing protein 2A PWWP2A IPI00102820 Isoform 3 of Mitochondrial tumor suppressor 1 MTUS1 IPI00215786 3′,5′-cyclic nucleotide phosphodiesterase 10A2 PDE10A IPI00845401 Isoform 6 of Neuron navigator 1 NAV1 IPI00217979 Myeloid/lymphoid or mixed-lineage leukemia 5 MLL5 IPI00440764 Isoform 1 of Gamma-glutamyltransferase 6 precursor GGT6 IPI00374068 Isoform 1 of ADAMTS-like protein 4 precursor ADAMTSL4 IPI00186439 Zinc finger protein 643 ZNF643 IPI00062467 Isoform 1 of Zinc fmger protein 274 ZNF274 IPI00000890 Isoform 1 of Growth hormone variant precursor GH2 IPI00065351 Zinc finger protein 354B ZNF354B IPI00552455 12 kDa protein INPP5A IPI00395473 Zinc finger protein 135 ZNF135 IPI00003842 Isoform 1 of Microtubule-associated protein 2 MAP2 IPI00655760 Envelope polyprotein — IPI00384767 FLJ00332 protein (Fragment) TBC1D10C IPI00028050 Selenocysteine-specific elongation factor EEFSEC IPI00152033 Isoform 1 of Transient receptor potential cation channel subfamily M member 8 TRPM8 IPI00789564 Isoform 3 of Metallophosphoesterase 1 MPPE1 IPI00011253 40S ribosomal protein S3 RPS3 IPI00454620 HERV-K_11q22.1 provirus ancestral Pol protein — IPI00337335 Isoform 1 of Myosin-14 MYH14 IPI00103426 Isoform 1 of Solute carrier family 13 member 3 SLC13A3 IPI00291839 Isoform 2 of Rap guanine nucleotide exchange factor 6 RAPGEF6

TABLE 6c CSF Proteins Absent in Chronic Fatigue but Present in Neurologic Lyme or Normals CleanIPI Protein Gene IPI00160369 PRKCA-binding protein PICK1 IPI00289862 Secernin-1 SCRN1 IPI00002478 Isoform B of Endothelin-converting enzyme 1 ECE1 IPI00027438 Flotillin-1 FLOT1 IPI00852669 Zinc finger protein 516 ZNF516 IPI00017297 Matrin-3 MATR3 IPI00642645 Methylenetetrahydrofolate reductase MTHFR IPI00470812 Putative uncharacterized protein DKFZp781E21107 LOC339977 IPI00556381 Putative uncharacterized protein (Fragment) TRIM16 IPI00004569 Isoform MZF1A of Myeloid zinc finger 1 MZF1 IPI00240059 Transmembrane and coiled-coil domains protein 3 TMCC3 IPI00022361 Band 3 anion transport protein SLC4A1 IPI00017964 Small nuclear ribonucleoprotein Sm D3 SNRPD3 IPI00478640 Isoform 1 of Transmembrane protein C17orf87 C17orf87 IPI00013290 hepatoma-derived growth factor-related protein 2 isoform 1 HDGF2 IPI00011051 T-cell leukemia homeobox protein 1 TLX1 IPI00004838 Isoform Crk-II of Proto-oncogene C-crk CRK IPI00154858 Platelet endothelial aggregation receptor 1 precursor PEAR1 IPI00748733 Similar to Slit homolog 3 protein precursor — IPI00023919 26S protease regulatory subunit 8 PSMC5 IPI00830051 Similar to Immunolgoobulin heavy chain LOC90925 IPI00007423 Isoform 1 of Acidic leucine-rich nuclear phosphoprotein 32 ANP32B family member B IPI00553215 V1-5 protein IGLV2-18 IPI00020005 Arylsulfatase E precursor ARSE IPI00550720 Isoform 1 of Uncharacterized protein C19orf57 C19orf57 IPI00103510 Relaxin receptor 2 RXFP2 IPI00373872 polycystin 1-like 2 isoform a PKD1L2 IPI00015181 Integrin alpha-9 precursor ITGA9 IPI00013945 Isoform 1 of Uromodulin precursor UMOD IPI00295172 Ninjurin-1 NINJ1 IPI00328522 KTEL motif-containing protein 1 KTELC1 IPI00000811 Proteasome subunit beta type-6 precursor PSMB6 IPI00847415 Isoform 4 of Dual specificity protein kinase CLK3 CLK3 IPI00251596 Isoform 1 of Collagen alpha-1(XXIII) chain COL23A1 IPI00550906 Cleavage stimulation factor 64 kDa subunit, tau variant CSTF2T IPI00550263 Isoform 5 of Serine/threonine-protein kinase MRCK alpha CDC42BPA IPI00045219 Sorting nexin-18 SNAG1 IPI00063245 Uncharacterized protein FUBP3 FUBP3 IPI00221235 nucleoporin 160 kDa NUP160 IPI00167560 PAP-associated domain-containing protein 4 PAPD4 IPI00005719 Isoform 1 of Ras-related protein Rab-1A RAB1A IPI00013933 Isoform DPI of Desmoplakin DSP IPI00098902 2-oxoglutarate dehydrogenase E1 component, OGDH mitochondrial precursor IPI00012079 Eukaryotic translation initiation factor 4B EIF4B IPI00005793 AP-3 complex subunit beta-2 AP3B2 IPI00289271 Liprin-alpha-2 PPFIA2 IPI00216470 Isoform 1 of Phosphatidylinositol-5-phosphate 4-kinase PIP4K2B type-2 beta IPI00410391 Isoform 1 of Major facilitator superfamily domain- MFSD2 containing protein 2 IPI00441952 Isoform 1 of Ninein NIN IPI00744825 Conserved hypothetical protein — IPI00016940 Phospholipid scramblase 2 PLSCR2 IPI00217264 Isoform 3 of MAP7 domain-containing protein 3 MAP7D3 IPI00005675 NF-kappa-B-repressing factor NKRF IPI00218628 Isoform 2 of Integrin alpha-IIb precursor ITGA2B IPI00217989 Isoform 1 of Protein-associating with the carboxyl-terminal SCYL3 domain of ezrin IPI00217405 Isoform 1 of E3 ubiquitin-protein ligase UBR1 UBR1 IPI00829915 similar to PR domain zinc finger protein 16 LOC647868 IPI00455731 Protein FAM26F FAM26F IPI00411656 Isoform 1 of Protein piccolo PCLO IPI00217258 CCDC100 protein CCDC100 IPI00604430 Isoform 2 of Receptor expression-enhancing protein 2 REEP2 IPI00456670 Isoform 13 of Peroxisomal N(1)-acetyl- PAOX spermine/spermidine oxidase IPI00414927 Transmembrane and immunoglobulin domain-containing C1orf32 protein C1orf32 IPI00871458 39 kDa protein C10orf4 IPI00101299 C1GALT1-specific chaperone 1 C1GALT1C1 IPI00186621 Orofacial clefting chromosomal breakpoint region 1 OFCC1 IPI00295098 Signal recognition particle receptor subunit beta SRPRB IPI00071824 Isoform 1 of Cytoskeleton-associated protein 2 CKAP2 IPI00747494 Glutamate receptor delta-2 subunit precursor GRID2 IPI00879409 28 kDa protein — IPI00760941 Uncharacterized protein ENSP00000371687 DKFZp434J1015 IPI00169259 Small VCP/p97-interacting protein SVIP IPI00514966 Recombining binding protein suppressor of hairless RBPJL IPI00106506 Isoform 1 of Evolutionarily conserved signaling ECSIT intermediate in Toll pathway, mitochondrial precursor IPI00006900 Something about silencing protein 10 UTP3 IPI00021772 S-adenosylmethionine synthetase isoform type-1 MAT1A IPI00472332 similar to polyhomeotic 1-like isoform 4 LOC653441 IPI00240909 similar to eukaryotic translation initiation factor 3, subunit 5 hCG_15200 IPI00004671 Golgin subfamily B member 1 GOLGB1 IPI00789245 Isoform 2 of Probable organic cation transporter protein SLC22A23 C6orf85 IPI00291922 Proteasome subunit alpha type-5 PSMA5 IPI00217899 RING finger protein 168 RNF168 IPI00242905 Uncharacterized protein ENSP00000344689 (Fragment) — IPI00152145 Protein odd-skipped-related 1 OSR1 IPI00152462 Ciliary dynein heavy chain 3 DNAH3 IPI00021770 Isoform 1 of 3-hydroxy-3-methylglutaryl-coenzyme A HMGCR reductase IPI00465045 DIP2 disco-interacting protein 2 homolog B DIP2B IPI00004509 Leukotriene N synthase LTC4S IPI00018803 homeobox D12 HOXD12 IPI00884371 Uncharacterized protein ENSP00000383215 — IPI00002881 Bcl-2-related protein A1 BCL2A1 IPI00021594 Isoform 1 of Glycosylphosphatidylinositol anchor GPAA1 attachment 1 protein IPI00010360 Isoform 1 of Collagen alpha-3(IV) chain precursor COL4A3 IPI00022890 Ig lambda chain V region 4A precursor IGLV7-43 IPI00219468 Isoform IIa of Profilin-2 PFN2 IPI00065352 Isoform 1 of Uncharacterized serine/threonine-protein FLJ25006 kinase SgK494 IPI00000388 Zinc finger protein 175 ZNF175 IPI00017163 Isoform 1 of E3 ubiquitin-protein ligase HECW2 HECW2 IPI00465044 Protein RCC2 RCC2 IPI00013847 Cytochrome b-c1 complex subunit 1, mitochondrial UQCRC1 precursor IPI00394807 Regenerating islet-derived protein 3 gamma precursor REG3G IPI00024248 Sodium/iodide cotransporter SLC5A5 IPI00022830 Isoform 2 of NSFL1 cofactor p47 NSFL1C IPI00026665 Glutaminyl-tRNA synthetase QARS IPI00180386 Isoform GN-1L of Glycogenin-1 GYG1 IPI00465345 Isoform 3 of Pre-mRNA-processing factor 40 homolog B PRPF40B IPI00065388 Isoform 1 of Coiled-coil domain-containing protein 17 CCDC17 IPI00289540 Isoform 2 of Usherin precursor USH2A IPI00748216 CDNA FLJ20187 fis, clone COLF0433 GTF3C5 IPI00167638 Isoform 1 of GTP-binding protein 10 GTPBP10 IPI00294713 Isoform 1 of Mannan-binding lectin serine protease 2 MASP2 precursor IPI00022143 Isoform 1 of Extended-synaptotagmin-1 FAM62A IPI00023663 Putative transcription factor Ovo-like 1 OVOL1 IPI00003406 Isoform 1 of Drebrin DBN1 IPI00015602 Mitochondrial precursor proteins import receptor TOMM70A IPI00072377 Isoform 1 of Protein SET SET IPI00554752 cAMP-dependent protein kinase type II-beta regulatory PRKAR2B subunit IPI00011604 Glycine cleavage system H protein, mitochondrial GCSH; LOC730107 precursor IPI00401586 Chromosome 18 open reading frame 62 C18orf62 IPI00026492 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial GCAT precursor IPI00384861 Isoform 1 of ARF GTPase-activating protein GIT1 GIT1 IPI00644529 Isoform 2 of Zinc finger protein 615 ZNF615 IPI00028880 Putative DNA polymerase POLN IPI00020008 NEDD8 precursor NEDD8 IPI00180707 Isoform 1 of FMS1-related extracellular matrix protein 2 FREM2 precursor IPI00014878 Uncharacterized protein PRKD1 PRKD1 IPI00794791 Isoform 2 of IQ domain-containing protein D IQCD IPI00009853 Vomeronasal type-1 receptor 1 VN1R1 IPI00022250 Lymphocyte antigen 96 precursor LY96 IPI00332371 Isoform 1 of 6-phosphofructokinase, liver type PFKL IPI00004337 Zinc finger and BTB domain-Containing protein 11 ZBTB11 IPI00478860 Glycoprotein endo-alpha-1,2-mannosidase MANEA IPI00005708 Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 HS3ST3B1 IPI00169430 Isoform 1 of Spermatid perinuclear RNA-binding protein STRBP IPI00007057 Rabenosyn-5 ZFYVE20 IPI00386822 Putative uncharacterized protein (Fragment) TGFBI IPI00477539 Uncharacterized protein C14orf102 C14orf102 IPI00296219 Glutaminase liver isoform, mitochondrial precursor GLS2 IPI00005564 Stanniocalcin-1 precursor STC1 IPI00376087 putative binding protein 7a5 7A5 IPI00413344 Cofilin-2 CFL2 IPI00006648 IDN4-GGTR14 protein RABGAP1L IPI00302176 Isoform 1 of H/ACA ribonucleoprotein complex subunit 1 NOLA1 IPI00014850 Astrocytic phosphoprotein PEA-15 PEA15 IPI00794679 Major histocompatibility complex, class I, B MICA; HLA-B; HLA- A; LOC730410; HLA- C; HLA-A29.1 IPI00008282 Isoform 1 of Calcium/calmodulin-dependent 3′,5′-cyclic PDE1A nucleotide phosphodiesterase 1A IPI00007277 Isoform 1 of Leucine-rich repeat flightless-interacting LRRFIP2 protein 2 IPI00294519 Isoform 1 of Telomerase protein component 1 TEP1 IPI00478586 Isoform 2 of Vacuolar protein sorting-associated protein VPS13A 13A IPI00060439 KIAA0226 protein KIAA0226 IPI00303343 Splicing factor, arginine/serine-rich 19 SCAF1 IPI00179589 Myotrophin MTPN IPI00744811 Low-density lipoprotein receptor-related protein 5 LRP5 precursor IPI00031485 Mitochondrial ribosomal protein 63 MRP63 IPI00784044 Isoform 1 of Methylcrotonoyl-CoA carboxylase beta chain, MCCC2 mitochondrial precursor IPI00869070 Ankyrin repeat containing protein — IPI00783186 Isoform 2 of Ankyrin repeat domain-containing protein 17 ANKRD17 IPI00303152 collagen, type XXII, alpha I COL22A1 IPI00429191 Eukaryotic peptide chain release factor subunit 1 ETF1 IPI00514594 Isoform 1 of Protein FAM5B precursor FAM5B IPI00853376 additional sex combs like 3 ASXL3 IPI00216914 Vitelline membrane outer layer protein 1 homolog VMO1 precursor IPI00423379 Putative uncharacterized protein DKFZp686G24192 C20orf96 IPI00025308 Homeobox protein prophet of Pit-1 PROP1 IPI00219358 Isoform 1 of Mannose-6-phosphate isomerase MPI IPI00400967 KIAA1843 protein (Fragment) KIAA1843 IPI00166010 Isoform 1 of CCR4-NOT transcription complex subunit 1 CNOT1 IPI00793576 7 kDa protein PRH2; PRB4; PRH1 IPI00307757 Isoform 1 of Membrane-associated phosphatidylinositol PITPNM3 transfer protein 3 IPI00166738 Zinc-binding alcohol dehydrogenase domain-containing ZADH2 protein 2 IPI00399252 Isoform 1 of Protein Jade-1 PHF17 IPI00412977 Prothymosin alpha — IPI00396077 Isoform 1 of E3 ubiquitin-protein ligase Topors TOPORS IPI00144243 Human immunodeficiency virus type I enhancer-binding HIVEP2 protein 2 IPI00446355 CDNA FLJ41803 fis, clone NHNPC2002749 IER5L IPI00167861 Protein SMG5 SMG5 IPI00005530 FMRFamide-related peptides precursor NPVF IPI00186004 hypothetical protein LOC57730 KIAA1641 IPI00465178 Isoform 1 of Vacuolar proton translocating ATPase 116 kDa ATP6V0A1 subunit a isoform 1 IPI00291463 Radical S-adenosyl methionine domain-containing protein 2 RSAD2 IPI00472171 RPL7 protein RPL7 IPI00187091 Isoform 2 of MAP kinase-interacting serine/threonine- MKNK1 protein kinase 1 IPI00398421 Isoform 1 of Potassium channel subfamily T member 2 KCNT2 IPI00007040 Zinc finger protein 222 ZNF222 IPI00220578 Guanine nucleotide-binding protein G GNAI3 IPI00740191 similar to Forkhead box protein L1 LOC651986 IPI00044607 Protein phosphatase inhibitor 2-like protein 1 PPP1R2P1 IPI00301923 Isoform 1 of Cell division protein kinase 9 CDK9 IPI00255145 hypothetical protein LOC342346 IPI00022228 Vigilin HDLBP IPI00010737 Thrombomodulin precursor THBD IPI00059395 Kinesin-like protein KIFC2 KIFC2 IPI00030319 Forkhead box protein F2 FOXF2 IPI00168806 Isoform 1 of Myeloid/lymphoid or mixed-lineage leukemia MLL3 protein 3 homolog IPI00018275 Prion-like protein doppel precursor PRND IPI00216704 Isoform 2 of Spectrin beta chain, erythrocyte SPTB IPI00034277 Isoform A of Probable cation-transporting ATPase 13A1 ATP13A1 IPI00015285 Ethanolamine-phosphate cytidylyltransferase PCYT2 IPI00152853 Isoform 1 of Phostensin KIAA1949 IPI00302850 Small nuclear ribonucleoprotein Sm DI SNRPDI IPI00478124 61 kDa protein UCKL1 IPI00013681 N-terminally extended type 3 canonical transient receptor TRPC3 potential channel IPI00446785 CDNA FLJ41116 fis, clone BRACE1000572 — IPI00784272 Putative uncharacterized protein — IPI00293460 ATP-binding cassette sub-family A member 1 ABCA1 IPI00019208 Similar to 60S ribosomal protein L29 — IPI00304596 Non-POU domain-containing octamer-binding protein NONO IPI00411452 Uncharacterized protein DOCK11 DOCK11 IPI00444395 CDNA FLJ45615 fis, clone BRTHA3026180 — IPI00019278 Thiamine transporter 2 SLC19A3 IPI00012895 Isoform 1 of Carbonic anhydrase 12 precursor CA12 IPI00299627 Dual oxidase 2 precursor DUOX2 IPI00216132 Isoform Alpha 1 of Ribosomal protein S6 kinase beta-1 RPS6KB1 IPI00023513 Isoform 1 of E3 ubiquitin-protein ligase CHFR CHFR IPI00063827 Isoform 1 of Abhydrolase domain-containing protein 14B ABHD14B IPI00025019 Proteasome subunit beta type-1 precursor PSMB1 IPI00328115 Isoform 3 of 5′-3′ exoribonuclease 1 XRN1 IPI00022048 Prostaglandin F2 receptor negative regulator precursor PTGFRN IPI00103055 Isoform 1 of Solute carrier family 35 member F5 SLC35F5 IPI00167194 CDNA FLJ25694 fis, clone TST04471 FLJ25694 IPI00002966 Heat shock 70 kDa protein 4 HSPA4 IPI00152536 Isoform 1 of Transmembrane channel-like protein 2 TMC2 IPI00783271 Leucine-rich PPR motif-containing protein, mitochondrial LRPPRC precursor IPI00298476 Isoform 1 of Gremlin-1 precursor GREM1 IPI00150057 Isoform 2 of SWI/SNF-related matrix-associated actin- SMARCC2 dependent regulator of chromatin subfamily C member 2 IPI00456996 Conserved hypothetical protein PVT1 IPI00232891 Isoform 3 of Fibronectin type III domain-containing protein 1 FNDC1 IPI00018402 Tubulin-specific chaperone E TBCE IPI00166817 Zinc finger protein 561 ZNF561 IPI00375174 Ankyrin repeat and sterile alpha motif domain-containing ANKS1B protein 1B IPI00030404 Transcriptional repressor NF-X1 NFX1 IPI00296866 interphotoreceptor matrix proteoglycan 2 IMPG2 IPI00219661 Isoform 1 of Myelin proteolipid protein PLPI IPI00040730 protocadherin 21 precursor PCDH21 IPI00013508 Alpha-actinin-1 ACTN1 IPI00186853 pecanex-like 2 PCNXL2 IPI00001120 CDNA F1131810 fis, clone NT2RI2009289, weakly LINGO2 similar to CARBOXYPEPTIDASE N 83 KD CHAIN IPI00395376 Isoform 1 of Semaphorin-5B SEMA5B IPI00555621 p21-activated kinase 2 variant (Fragment) — IPI00746232 coiled-coil domain containing 112 isoform 2 CCDC112 IPI00022020 Type II inositol-3,4-bisphosphate 4-phosphatase INPP4B IPI00644231 Isoform 1 of Cytoplasmic FMR1-interacting protein 1 CYFIP1 IPI00007193 Isoform 2 of Ankyrin repeat domain-containing protein 26 ANKRD26 IPI00418236 Factor in the germline alpha FIGLA IPI00328762 Isoform 1 of ATP-binding cassette sub-family A member ABCA13 13 IPI00748342 Beclin-1 BECN1 IPI00739423 similar to c11.1 CG12132-PA isoform 11 LOC377711 IPI00026970 FACT complex subunit SPT16 SUPT16H IPI00013466 Arsenical pump-driving ATPase ASNA1 IPI00016605 Uncharacterized protein C1orf123 C1orf123 IPI00872861 PTD016 protein LOC51136 IPI00010130 Glutamine synthetase GLUL IPI00166619 Isoform 2 of Putative transporter SVOPL SVOPL IPI00549384 Isoform 1 of Bromodomain-containing protein 9 BRD9 IPI00479893 Isoform 2 of Uncharacterized protein C10orf18 C10orf18 IPI00410585 Isoform 1 of Crumbs homolog 2 precursor CRB2 IPI00876910 Isoform 1 of Ankyrin repeat and SOCS box-containing ASB18 protein 18 IPI00008202 Headcase protein homolog HECA IPI00477766 Isoform 3 of Protein PTHB1 BBS9 IPI00029722 Kinesin heavy chain isoform 5A KIF5A IPI00301503 Isoform 1 of Splicing factor, arginine/serine-rich 10 SFRS10 IPI00031696 FAST kinase domain-containing protein 3 FASTKD3 IPI00425688 Isoform I of RUN and SH3 domain-containing protein 1 RUSC1 IPI00787427 ankyrin repeat domain 36 ANKRD36 IPI00796647 HIG1 domain family, member 1C HIGD1C IPI00852758 Similar to Ankyrin repeat domain-containing protein 26. ANKRD18B Isoform 2 IPI00023087 Ubiquitin-conjugating enzyme E2 T UBE2T IPI00167241 Zinc finger protein 283 ZNF283 IPI00220325 Isoform Short of Insulin receptor precursor INSR IPI00465322 Uncharacterized protein BOC BOC IPI00161119 Isoform 1 of NF-kappa-B inhibitor beta NFKBIB IPI00016577 CDNA: FLJ22814 fis, clone KAIA3004 CD22 IPI00032541 Keratin type II cuticular Hb5 KRT85 IPI00852633 16 kDa protein RABL2B IPI00163391 Isoform 1 of Putative methyltransferase METT10D METT10D IPI00299679 Isoform B of Ral guanine nucleotide dissociation stimulator RGL1 like 1 IPI00797699 20 kDa protein — IPI00384874 Isoform 1 of ATP-binding cassette sub-family A member ABCA10 10 IPI00019690 death-inducing-protein DIP IPI00794119 13 kDa protein ABCC8 IPI00027723 Elastase-2B precursor ELA2B IPI00816274 Chemokine-like factor superfamily 1 transcript variant 26 CMTM1 IPI00015737 15 kDa protein DCAKD IPI00641954 22 kDa protein TMED5 IPI00739676 Isoform 2 of Protein DDX26B DDX26B IPI00038378 Isoform 1 of Enolase-phosphatase E1 ENOPH1 IPI00171737 Isoform 2 of Leucine-rich repeat and death domain- LRDD containing protein IPI00385003 Putative transposase TIGD1 IPI00477763 Serine/threonine-protein kinase MRCK beta CDC42BPB IPI00029123 Isoform A of Endothelin B receptor precursor EDNRB IPI00158992 snRNA-activating protein complex subunit 4 SNAPC4 IPI00402006 Similar to DNA-binding protein — IPI00306576 Arylsulfatase B precursor ARSB IPI00184997 cDNA FLJ78771, highly similar to Homo sapiens discs, DLG7 large homolog 7 (Drosophila), mRNA IPI00477949 Isoform 1 of Zinc finger MYM-type protein 4 ZMYM4 IPI00001869 Pappalysin-1 precursor PAPPA IPI00027834 heterogeneous nuclear ribonucleoprotein L isoform a HNRNPL IPI00062730 Uncharacterized protein C16orf45 C16orf45 IPI00737448 similar to heat shock 70 kD protein binding protein LOC338805 IPI00298258 UNC13B protein UNC13B IPI00383261 Peroxin Pex6p PEX6 IPI00022735 Synaptotagmin-4 SYT4 IPI00003391 Teneurin-1 ODZ1 IPI00744366 Conserved hypothetical protein — IPI00000792 Quinone oxidoreductase CRYZ IPI00008905 UDP-glucuronosyltransferase 2B15 precursor UGT2B15 IPI00031411 Cadherin-related tumor suppressor homolog precursor FAT IPI00026058 Isoform 1 of Leucine zipper putative tumor suppressor 1 LZTS1 IPI00377077 Isoform 3 of Astrotactin-2 precursor ASTN2 IPI00479789 Isoform 1 of Uncharacterized protein C1orf103 C1orf103 IPI00186581 amplified in osteosarcoma isoform 2 precursor OS9 IPI00445364 CDNA FLJ44171 fis, clone THYMU2036058 — IPI00411637 Galactose-3-O-sulfotransferase 4 GAL3ST4 IPI00154834 Isoform 1 of Neighbor of punc e11 precursor NOPE IPI00216697 Isoform Er1 of Ankyrin-1 ANK1 IPI00021985 transmembrane 9 superfamily protein member 4 TM9SF4 IPI00166071 B-cell CLL/lymphoma 6 member B protein BCL6B IPI00007360 Zinc finger protein 238 ZNF238 IPI00217023 MMAA protein MMAA IPI00218130 Glycogen phosphorylase, muscle form PYGM IPI00384280 Prenylcysteine oxidase 1 precursor PCYOX1 IPI00152733 FLJ00237 protein (Fragment) OLFML2A IPI00034006 Tyrosine-protein phosphatase non-receptor type 23 PTPN23 IPI00793585 57 kDa protein OC90 IPI00419253 Isoform 1 of Nck-associated protein 5 NAP5 IPI00029133 ATP synthase subunit b, mitochondrial precursor ATP5F1 IPI00178727 Novel protein C10orf79 IPI00218271 Isoform 3 of MAGUK p55 subfamily member 2 MPP2 IPI00003949 Ubiquitin-conjugating enzyme E2 N UBE2N IPI00292393 Sodium channel protein type 4 subunit alpha SCN4A IPI00304992 Isoform 1 of Zinc finger protein 503 ZNF503 IPI00029012 Eukaryotic translation initiation factor 3 subunit A EIF3A IPI00043201 Centromere protein J CENPJ IPI00022891 ADP/ATP translocase 1 SLC25A4 IPI00006612 Isoform 1 of Clathrin coat assembly protein AP180 SNAP91 IPI00385042 Nucleolar GTP-binding protein 1 GTPBP4 IPI00642305 MCM8 protein MCM8 IPI00402144 Isoform 1 of Zinc finger protein 555 ZNF555 IPI00478986 Similar to 40S ribosomal protein S4 LOC126235 IPI00029623 Proteasome subunit alpha type-6 PSMA6 IPI00026320 E3 ubiquitin-protein ligase UBR5 UBR5 IPI00010142 Ubiquitin-conjugating enzyme E2 G2 UBE2G2 IPI00478521 Isoform 1 of UPF0475 protein RILPL1 IPI00029769 Isoform p59-HCK of Tyrosine-protein kinase HCK HCK IPI00446138 CDNA FLJ42768 fis, clone BRAWH3003522 — IPI00046057 lsoform 2 of Syntaxin-binding protein 1 STXBP1 IPI00449071 Isoform 5a of Paired box protein Pax-6 PAX6 IPI00328268 EIF4G3 protein EIF4G3 IPI00305477 Cystatin-SN precursor CST1 IPI00432893 INPP5F protein (Fragment) INPP5F IPI00220039 Isoform 1 of Transmembrane protein 16K TMEM16K IPI00021347 Ubiquitin-conjugating enzyme E2 L3 UBE2L3 IPI00025700 Isoform CD6A of T-cell differentiation antigen CD6 CD6 precursor IPI00061507 Isoform 3 of Ester hydrolase C11orf54 C11orf54 IPI00000270 Ribonuclease 7 precursor RNASE7 IPI00479430 Isoform 2 of Complement C1q tumor necrosis factor- CIQTNF9 related protein 9 precursor IPI00386754 Isoform 2 of Cysteine-rich with EGF-like domain protein 2 CRELD2 precursor IPI00016949 Isoform 4 of Electrogenic sodium bicarbonate cotransporter 1 SLC4A4 IPI00031547 Desmoglein-3 precursor DSG3 IPI00382756 Isoform 2 of Pleiotropic regulator 1 PLRG1 IPI00604599 Transmembrane emp24 domain-containing protein 3 TMED3 precursor IPI00296798 Isoform 1 of Fibrinogen C domain-containing protein 1 FIBCD1 IPI00743284 Methionine synthase MTR IPI00021363 Histone demethylase JARID1A JARID1A IPI00749440 Uncharacterized protein ENSP00000368180 — IPI00216683 M-phase inducer phosphatase 3 CDC25C IPI00737969 microtubule associated monoxygenase, calponin and LIM MICAL3 domain containing 3 IPI00015522 Growth/differentiation factor 5 precursor GDF5 IPI00877084 Isoform 1 of Coiled-coil domain-containing protein 144C CCDC144C IPI00060265 Zinc finger protein 775 ZNF775 IPI00171199 Isoform 2 of Proteasome subunit alpha type-3 PSMA3 IPI00003483 Isoform 1 of Neuralized-like protein 1 NEURL IPI00024802 TATA-binding protein-associated factor 172 BTAF1 IPI00374039 Conserved hypothetical protein C1orf189 IPI00419575 Protein of unknown function DUF410 family protein C7orf20 IPI00019090 Collagen alpha-1 COL19A1 IPI00011756 Homeobox protein Meis1 MEIS1 IPI00021834 Isoform Alpha of Tissue factor pathway inhibitor precursor TFPI IPI00167254 Isoform 4 of Inactive phospholipase D5 PLD5 IPI00442121 delta-aminolevulinic acid dehydratase isoform a ALAD IPI00013455 CLIP1 protein CLIP1 IPI00026299 Isoform Glycophorin C of Glycophorin-C GYPC IPI00012687 27 kDa protein C1orf83 IPI00845508 BAH domain and coiled-coil containing 1 BAHCC1 IPI00332106 Isoform 1 of Pre-B-cell leukemia transcription factor- PBXIP1 interacting protein 1 IPI00418426 Metal transporter CNNM4 CNNM4 IPI00002524 ATP-sensitive inward rectifier potassium channel 14 KCNJ14 IPI00745300 31 kDa protein NAT11 IPI00000110 Zinc finger protein 337 ZNF337 IPI00009148 Diphosphoinositol polyphosphate phosphohydrolase 1 NUDT3 IPI00297767 Casein kinase I isoform gamma-2 CSNK1G2 IPI00186826 Ephrin receptor EPHB4 IPI00787932 similar to zinc finger protein 10 hCG_1646157 IPI00007207 Isoform 1 of Lysosomal acid lipase/cholesteryl ester LIPA hydrolase precursor IPI00023868 Canalicular multispecific organic anion transporter 1 ABCC2 IPI00166161 Protein SIX6OS1 C14orf39 IPI00180426 Isoform 3 of G protein-coupled receptor kinase 4 GRK4 IPI00031522 Trifunctional enzyme subunit alpha, mitochondrial HADHA precursor IPI00013219 Integrin-linked protein kinase ILK IPI00070070 Novel protein FLJ32784 IPI00329142 Glutamate-rich protein 1 ERICH1 IPI00169253 Olfactory receptor OR1-45 OR5AT1 IPI00045801 Flt3-interacting zinc finger protein 1 FIZ1 IPI00017802 Isoform 1 of Methylglutaconyl-CoA hydratase, AUH mitochondrial precursor IPI00796906 8 kDa protein ABCF3 IPI00384549 TTC31 protein (Fragment) TTC31 IPI00028932 Microtubule-associated serine/threonine-protein kinase 3 MAST3 IPI00012756 Interferon-induced protein with tetratricopeptide repeats 5 IFIT5 IPI00297985 Uncharacterized protein C6orf103 C6orf103 IPI00514394 Family with sequence similarity 120A opposite strand FAM120AOS IPI00034088 Interleukin-27 beta chain precursor EBI3 IPI00305856 Homeobox protein Hox-D11 HOXD11 IPI00387159 Isoform 1 of Inhibitor of growth protein 3 ING3 IPI00737429 Teneurin-4 ODZ4 IPI00645089 Kv channel interacting protein 1 isoform 3 KCNIP1 IPI00797859 10 kDa protein LOC643711 IPI00385737 similar to Nonhistone chromosomal protein HMG-17 LOC646853 IPI00015195 Cleavage stimulation factor 77 kDa subunit CSTF3 IPI00006158 Lymphoid-restricted membrane protein LRMP IPI00008554 Angiogenin precursor ANG IPI00412216 vacuolar protein sorting 13C protein isoform 2B VPS13C IPI00028158 Neurotensin/neuromedin N precursor NTS IPI00020884 Plexin-A3 precursor PLXNA3 IPI00374862 Isoform 1 of Kelch-like protein 5 KLHL5 IPI00384393 Myosin-reactive immunoglobulin heavy chain variable — region (Fragment) IPI00009377 HSPC212 C3orf19 IPI00005969 F-actin-capping protein subunit alpha-1 CAPZA1 IPI00021129 Isoform 1 of AP-3 complex subunit beta-1 AP3B1 IPI00013871 Ribonucleoside-diphosphate reductase large subunit RRM1 IPI00020039 Cylicin-1 CYLC1 IPI00300244 zinc finger, CW type with PWWP domain 1 ZCWPW1 IPI00060308 Isoform 6 of PDZ and LIM domain protein 7 PDLIM7 IPI00333410 Isoform 1 of Ubiquitin-conjugating enzyme E2 Q1 UBE2Q1 IPI00737712 CCDC125 protein CCDC125 IPI00219036 dicer1 DICER1 IPI00168862 Conserved hypothetical protein PXT1 IPI00025647 Isoform 1 of F-box only protein 21 FBXO21 IPI00218075 Protein FAM9B FAM9B IPI00738499 Ferritin light chain FTL IPI00297212 Paladin KIAA1274 IPI00252845 SYT9 protein SYT9 IPI00477361 10 kDa protein SDHALP1 IPI00418185 Putative uncharacterized protein FLJ20097 CCDC132 IPI00423562 Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 6 USP6 IPI00397578 135 kDa protein PPFIA4 IPI00004101 Betaine--homocysteine S-methyltransferase 1 BHMT IPI00017659 Protein kinase substrate CapZIP RCSD1 IPI00025094 CDNA: FLJ22037 fis, clone HEP08868 (Fragment) MYH16 IPI00008475 Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 IPI00023315 Bone morphogenetic protein 3b precursor GDF10 IPI00412107 FLJ43980 protein FLJ43980 IPI00328793 Sterol regulatory element-binding protein 2 SREBF2 IPI00216963 Isoform 9 of CASP8 and FADD-like apoptosis regulator CFLAR precursor IPI00010895 Tubby-related protein 2 TULP2 IPI00739106 similar to ribosomal protein L5 isoform 1 LOC647436 IPI00022606 Isoform 1 of Proline-serine-threonine phosphatase- PSTPIP1 interacting protein 1 IPI00004563 Protein FAM105A FAM105A IPI00550232 cardiomyopathy associated 3 isoform 1 XIRP2 IPI00299147 Small ubiquitin-related modifier 3 precursor SUMO3 IPI00295502 Isoform 1 of Protein Wiz WIZ IPI00435925 PP14214 IGFBP3 IPI00216106 Isoform 3 of Obg-like ATPase 1 OLA1 IPI00013257 Single-stranded DNA-binding protein 4 SSBP4 IPI00002707 Isoform 1 of Spastin SPAST IPI00010118 Isoform 1 of Prostate tumor overexpressed gene 1 protein PTOV1 IPI00158804 basic, immunoglobulin-like variable motif containing BIVM IPI00166606 KIAA0913 protein (Fragment) KIAA0913 IPI00329014 Isoform 1 of Ankyrin repeat domain-containing protein 46 ANKRD46 IPI00300990 Isoform 1 of Uncharacterized protein C1orf77 C1orf77 IPI00741780 similar to CG4845-PA LOC652559 IPI00395603 Isoform 3 of Uncharacterized protein C18orf34 C18orf34 IPI00454858 similar to alpha 3 type VI collagen isoform 1 precursor LOC344875 IPI00399328 similar to jumonji domain containing 2D LOC390245 IPI00852619 Isoform A of Probable phospholipid-transporting ATPase ATP10B VB IPI00303980 Isoform 1 of Uncharacterized protein C14orf93 precursor C14orf93 IPI00433499 rhomboid, veinlet-like 6 isoform 1 RHBDF2 IPI00006196 Isoform 2 of Nuclear mitotic apparatus protein 1 NUMA1 IPI00004534 Phosphoribosylformylglycinamidine synthase PFAS IPI00010575 KIAA1466 protein KIAA1466 IPI00004446 Sushi repeat-containing protein SRPX2 precursor SRPX2 IPI00785015 Isoform 1 of Uncharacterized protein KIAA2030 FLJ25778 IPI00247295 Isoform 4 of Nesprin-1 SYNE1 IPI00187143 Isoform 2 of Ras-related protein Rab-4B RAB4B IPI00010448 Isoform 2 of Rho GTPase-activating protein 24 ARHGAP24 IPI00103630 Isoform 2 of Protein phosphatase 1E PPM1E 12 IPI00479669 Isoform 1 of Uncharacterized protein KIAA0701 UHRF1BP1L IPI00737392 similar to proline-rich protein BstNI subfamily 3 precursor LOC646352 IPI00017940 LMBR1 domain-containing protein 2 LMBRD2 IPI00219503 Isoform 1 of F-box only protein 24 FBXO24 IPI00414591 Flavoprotein oxidoreductase MICAL2 IPI00018240 Isoform 1 of Protein SDA1 homolog SDAD1 IPI00001872 Isoform 1 of Protocadherin gamma C3 precursor PCDHGC3; PCDHGA12 IPI00657892 Factor VIII F8 IPI00216508 Isoform 2 of Sorting nexin-3 SNX3 IPI00011400 T-lymphoma invasion and metastasis-inducing protein 1 TIAM1 IPI00060146 Isoform 1 of Smith-Magenis syndrome chromosome region SMCR7 candidate gene 7 protein IPI00175989 Rho family guanine-nucleotide exchange factor MCF2L2 IPI00386651 LOC404266 protein LOC404266 IPI00022989 Isoform Beta-1 of Retinoic acid receptor beta RARB IPI00166933 Uncharacterized protein C10orf12 C10orf12 IPI00005254 Isoform 1 of E3 ubiquitin-protein ligase parkin PARK2 IPI00152072 hypothetical protein LOC387758 FIBIN IPI00060546 Uncharacterized protein C10orf35 C10orf35 IPI00005563 Isoform 1 of Tubulointerstitial nephritis antigen-like TINAGL1 precursor IPI00043978 Isoform 1 of Partitioning-defective 3 homolog B PARD3B IPI00440221 Putative uncharacterized protein (Fragment) CDC2L5 IPI00011564 Syndecan-4 precursor SDC4 IPI00423683 Isoform 2 of EMI domain-containing protein 1 precursor EMID1 IPI00026612 Isoform Beta-1 of Protein phosphatase 1B PPM1B IPI00065378 Isoform 1 of DC-STAMP domain-containing protein 1 DCST1 IPI00163718 Isoform 4 of Vacuolar protein sorting-associated protein 54 VPS54 IPI00167137 Isoform 3 of SLAM family member 7 precursor SLAMF7 IPI00300623 Pro-MCH precursor PMCH IPI00155447 MMP28 protein MMP28 IPI00414819 Helicase SKI2W SKIV2L IPI00001434 Protocadherin beta 14 precursor PCDHB14 IPI00041588 Ral guanine nucleotide exchange factor RaIGPSIA RALGPSI IPI00100787 RANBP2-like and GRIP domain-containing protein 7 RGPD5; RGPD7 IPI00011865 Isoform 2 of Platelet-derived growth factor D precursor PDGFD IPI00043731 CDNA FLJ30671 fis, clone FCBBF1000687, moderately RUNDC3B similar to Mus musculus Rap2 interacting protein 8 (RPIP8) mRNA IPI00746388 Ezrin EZR IPI00873759 Uncharacterized protein ENSP00000381675 (Fragment) — IPI00012390 Homeobox protein Hox-D4 HOXD4 IPI00645814 Isoform 2 of MAP7 domain-containing protein 1 MAP7D1 IPI00027694 Isoform 3 of Homeobox protein Hox-A1 HOXA1 IPI00514551 OTTHUMP00000016936 SCML4 IPI00747264 Gamma-aminobutyric-acid receptor subunit rho-1 precursor GABRR1 IPI00003353 Neuronal protein 3.1 C5orf13 IPI00007402 Importin-7 IPO7 IPI00337544 Isoform 2 of Myomegalin PDE4DIP IPI00152470 Prokineticin receptor 1 PROKR1 IPI00294619 Protein TFG TFG IPI00020795 R33083_1 (Fragment) DPP9 IPI00010740 Isoform Long of Splicing factor, proline- and glutamine- SFPQ rich IPI00006094 Regulating synaptic membrane exocytosis protein 3 RIMS3 IPI00100154 Toll-interacting protein TOLLIP IPI00019243 Isoform Long of Matrix metalloproteinase-16 precursor MMP16 IPI00000203 Low-density lipoprotein receptor-related protein 6 LRP6 precursor IPI00749338 Hypothetical gene supported by BC063892 hCG_1651889 IPI00221009 Isoform 7 of Transcription factor 7-like 2 TCF7L2 IPI00101927 Leucine zipper putative tumor suppressor 2 LZTS2 IPI00010346 Neurolysin, mitochondrial precursor NLN IPI00398725 Isoform 1 of Zinc finger protein 644 ZNF644 IPI00745832 IQ calmodulin-binding region domain containing protein — IPI00167228 CDNA FLJ40966 fis, clone UTERU2012407 CHCHD7 IPI00216572 BarH-like homeobox 2 BARX2 IPI00007067 Golgi-associated plant pathogenesis-related protein 1 C9orf19 IPI00410616 Isoform 1 of Endonuclease VIII-like 2 NEIL2 IPI00644025 Isoform 1 of Synaptic vesicle glycoprotein 2A SV2A IPI00005978 Splicing factor, arginine/serine-rich 2 SFRS2 IPI00171647 Isoform 1 of Sialic acid-binding Ig-like lectin 8 precursor SIGLEC8 IPI00020058 Isoform I of Copper-transporting ATPase 2 ATP7B IPI00844512 RHOV protein (Fragment) RHOV IPI00026570 Cytochrome c oxidase polypeptide VIIa-liver/heart, COX7A2 mitochondrial precursor IPI00021997 Protein CREG1 precursor CREG1 IPI00879389 20 kDa protein ZMYND11 IPI00329251 Isoform 1 of Transmembrane protein 146 precursor TMEM146 IPI00027726 Isoform 1 of Krueppel-like factor 3 KLF3 IPI00064241 Isoform 1 of Zinc finger protein Eos IKZF4 IPI00295503 Isoform 2 of Probable ATP-dependent RNA helicase DDX58 DDX58 IPI00465087 Ubiquitin carboxyl-terminal hydrolase BAP1 BAP1 IPI00290292 Rhomboid 5 homolog 1 RHBDF1 IPI00251507 Isoform IB of Synapsin-1 SYN1 IPI00103812 PWWP domain-containing protein 2B PWWP2B IPI00008580 Antileukoproteinase precursor SLPI IPI00010953 CDNA FLJ11251 fis, clone PLACE1008813 EXOC6 IPI00639924 97 kDa protein LOC374920 IPI00003348 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit GNB2 beta-2 IPI00029533 Integrin beta-8 precursor ITGB8 IPI00815786 Hexokinase 1 (Fragment) HK1 IPI00292579 Stabilin-2 precursor STAB2 IPI00067920 FXYD domain-containing ion transport regulator 7 FXYD7 IPI00879162 Uncharacterized protein ENSP00000374866 — IPI00008998 Protein tyrosine phosphatase-like protein PTPLAD1 PTPLAD1 IPI00658112 32 kDa protein SPEG IPI00009804 DNA-binding protein SATB1 SATB1 IPI00479361 Isoform 1 of UDP-GlcNAc:betaGal beta-1,3-N- B3GNT4 acetylglucosaminyltransferase 4 IPI00448465 Isoform 1 of Ankyrin repeat domain-containing protein 12 ANKRD12 IPI00215925 Glycine N-methyltransferase GNMT IPI00006675 Multidrug resistance-associated protein 4 ABCC4 IPI00745122 Conserved hypothetical protein MGC33894 IPI00442551 CDNA FLJ26989 fis, clone SLV03395 ATP9B IPI00027436 Tumor necrosis factor receptor superfamily member 16 NGFR precursor IPI00005531 Isoform 1 of Probable DNA dC->dU-editing enzyme APOBEC3B APOBEC-3B IPI00023542 transmembrane emp24 protein transport domain containing 9 TMED9 IPI00783313 Glycogen phosphorylase, liver form PYGL IPI00166190 Isoform 1 of Uncharacterized protein C19orf19 C19orf19 IPI00383832 Protein kinase C-binding protein RACK8 DVL3 IPI00024976 Mitochondrial import receptor subunit TOM22 homolog TOMM22 IPI00154567 Isoform 2 of Spermatogenesis-associated protein 20 SPATA20 precursor IPI00027685 C-C chemokine receptor type 1 CCR1 IPI00009335 Brain protein 16 C8orf30A IPI00008495 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 IPI00179172 Isoform 2 of Liprin-beta-1 PPFIBP1 IPI00012315 Nucleoside diphosphate kinase 3 NME3 IPI00432755 PPRR6495 FAM124A IPI00550949 Bone morphogenetic protein 7 precursor BMP7 IPI00796777 17 kDa protein CRYAA IPI00872928 Several ankyrin repeat protein transcript variant 2 ANKRD42 (Fragment) IPI00412647 CDNA: FLJ21792 fis, clone HEP00441 THADA IPI00032929 Isoform 1 of Thrombospondin type-1 domain-containing THSD1 protein 1 precursor IPI00008894 Carboxypeptidase A4 precursor CPA4 IPI00154451 MMS19 nucleotide excision repair homolog MMS19 IPI00186145 Isoform 1 of Protein phosphatase 1L PPM1L IPI00847759 DENN domain-containing protein 4B DENND4B IPI00008315 Isoform 1 of Ephrin type-B receptor 1 precursor EPHB1 IPI00386364 Olfactory receptor 2L2 OR2L2 IPI00031005 Protein kinase-like protein SgK196 FLJ23356 IPI00787414 Uncharacterized protein ENSP00000381388 MGC34829 IPI00003527 Ezrin-radixin-moesin-binding phosphoprotein 50 SLC9A3R1 IPI00218823 Isoform 1 of WW domain-binding protein 7 MLL4 IPI00019988 N-sulphoglucosamine sulphohydrolase precursor SGSH IPI00059164 Galactose-3-O-sulfotransferase 3 GAL3ST3 IPI00873740 Uncharacterized protein ENSP00000383832 (Fragment) — IPI00060379 Integrator complex subunit 12 INTS12 IPI00032416 Isoform Long of Protein jagged-2 precursor JAG2 IPI00444706 CDNA FLJ45007 fis, clone BRAWH3012005 KALRN IPI00216710 Isoform 1 of Nuclear receptor ROR-gamma RORC IPI00335589 RNA methyltransferase-like protein 1 RNMTL1 IPI00411690 Isoform 3 of La-related protein 1 LARP1 IPI00295519 Isoform 1 of Uncharacterized protein C3orf17 C3orf17 IPI00514153 transmembrahe and tetratricopeptide repeat containing 4 TMTC4 isoform 1 IPI00398728 Isoform 1 of Retinitis pigmentosa 1-like 1 protein RP1L1 IPI00843819 Similar to Dual specificity protein kinase CLK2 — IPI00065276 Isoform 2 of Tether containing UBX domain for GLUT4 ASPSCR1 IPI00021473 59 kDa protein CBFA2T3 IPI00745775 Similar to PR domain containing 4 — IPI00016703 24-dehydrocholesterol reductase precursor DHCR24 IPI00013880 Semaphorin-5A precursor SEMA5A IPI00010157 S-adenosylmethionine synthetase isoform type-2 MAT2A IPI00794307 hypothetical protein LOC729505 IPI00015782 UPF0171 protein C16orf35 C16orf35 IPI00011652 Isoform Efs1 of Embryonal Fyn-associated substrate EFS IPI00644522 PNKP protein PNKP IPI00045511 Isoform 1 of Chloride channel CLIC-like protein 1 CLCC1 precursor IPI00028881 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex NDUFA3 subunit 3 IPI00604763 Transmembrane protein 66 precursor TMEM66 IPI00235647 similar to fibrillarin LOC345630 IPI00879950 15 kDa protein — IPI00413385 Inter-alpha-trypsin inhibitor heavy chain H5-like protein ITIH5L precursor IPI00294910 Protein PARM-1 precursor DKFZP564O0823 IPI00022334 Ornithine aminotransferase, mitochondrial precursor OAT IPI00023617 Zinc finger protein 197 ZNF197 IPI00008433 40S ribosomal protein S5 RPS5 IPI00642798 Nucleolar autoantigen No55 SC65 IPI00470805 Isoform 2 of Mediator of DNA damage checkpoint protein 1 MDC1 IPI00167089 Isoform 2 of Activated CDC42 kinase 1 TNK2 IPI00102575 ATPase family, AAA domain containing 5 ATAD5 IPI00783753 UPF0235 protein C15orf40 C15orf40 IPI00383895 CDNA FLJ40559 fis, clone THYMU2002910 PRDM11 IPI00152157 Isoform 1 of Zinc finger protein 509 ZNF509 IPI00296803 30 kDa protein TCP11L2 IPI00020501 Myosin-11 MYH11 IPI00168056 Zinc finger and BTB domain-containing protein 38 ZBTB38 IPI00030919 Mitogen-activated protein kinase kinase 1-interacting MAP2K1IP1 protein 1 IPI00827745 Isoform 1 of RNA-binding protein 24 RBM24 IPI00005776 Nucleotide-binding oligomerization domain-containing NOD1 protein 1 IPI00026105 Isoform SCPx of Non-specific lipid-transfer protein SCP2 IPI00385255 Ig lambda chain V-II region NIG-84 — IPI00328178 Isoform 3 of TOM1-like protein 2 TOM1L2 IPI00394879 Leucine-rich repeat-containing protein 9 LRRC9 IPI00401852 Conserved hypothetical protein DKFZP434L187 IPI00442865 CDNA FLJ26488 fis, clone KDN05770, highly similar to SLC12A1 Bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2 IPI00748891 hypothetical protein LOC283635 isoform 1 C14orf24 IPI00414320 Annexin A11 ANXA11 IPI00874023 Uncharacterized protein ENSP00000379699 — IPI00027144 Cytochrome b561 CYB561 IPI00827584 similar to kinesin family member 27 KIF27 IPI00217688 Uncharacterized protein C12orf60 C12orf60 IPI00020199 Alpha-2,8-sialyltransferase 8B ST8SIA2 IPI00003799 Isoform 2 of Heme-binding protein 2 HEBP2 IPI00220126 Isoform EP2B of Sperm-associated antigen 11B precursor SPAG11B IPI00007757 Isoform 1 of Zinc finger protein Helios IKZF2 IPI00791513 CDNA FLJ16614 fis, clone TESTI4013365 CTA-216E10.6 IPI00008756 Isoform 1 of Bullous pemphigoid antigen 1, isoforms DST 1/2/3/4/5/8 (Fragment) IPI00328400 Zygote arrest protein 1 ZAR1 IPI00020201 CMP-N-acetylneuraminate-poly-alpha-2,8-sialyltransferase ST8SIA4 IPI00465147 Isoform 1 of Uncharacterized protein C9orf97 C9orf97 IPI00002884 CDNA: FLJ22222 fis, clone HRC01658 FLJ22222 IPI00217465 Histone H1.2 HIST1H1C IPI00025092 Myosin-binding protein C, slow-type MYBPC1 IPI00003363 Isoform 1 of Protein phosphatase 1 regulatory subunit 1B PPP1R1B IPI00333016 Isoform 3 of DnaJ homolog subfamily C member 11 DNAJC11 IPI00005705 Isoform Gamma-1 of Serine/threonine-protein phosphatase PPP1CC PP1-gamma catalytic subunit IPI00014897 Isoform 2 of 1-phosphatidylinositol-4,5-bisphosphate PLCB4 phosphodiesterase beta-4 IPI00181279 hypothetical protein LRRC37A4; LOC728863 IPI00022078 Protein NDRG1 NDRG1 IPI00011894 MRNA clone with similarity to L-glycerol-3- — phosphate:NAD oxidoreductase and albumin gene sequences IPI00794248 47 kDa protein — IPI00002511 Cyclic AMP-dependent transcription factor ATF-6 alpha ATF6 IPI00164949 Isoform NELF-C of Negative elongation factor C/D TH1L IPI00029647 Zymogen granule membrane protein 16 precursor ZG16 IPI00414481 GTF3C1 protein GTF3C1 IPI00472754 Polycystic kidney disease 1-related protein KIAA0319L IPI00640818 Isoform 3 of Neuropathy target esterase PNPLA6 IPI00514774 Isoform 1 of PAB-dependent poly(A)-specific ribonuclease PAN3 subunit 3 IPI00307733 Isoform 1 of Histone-lysine N-methyltransferase SETD2 SETD2 IPI00154528 Isoform 1 of Structural maintenance of chromosomes SMC6 protein 6 IPI00164861 Isoform 3 of Kinesin-like protein KIF13A KIF13A IPI00218896 Alcohol dehydrogenase 1A ADH1A IPI00411674 Isoform 1 of Zinc finger protein 254 ZNF254 IPI00414973 FAST kinase domain-containing protein 5 FASTKD5 IPI00002441 Syndecan-1 precursor SDC1 IPI00413272 Isoform 3 of Mediator of RNA polymerase II transcription MED23 subunit 23 IPI00249982 Isoform 1 of Death-inducer obliterator 1 DIDO1 IPI00299853 Protocadherin beta 16 precursor PCDHB16 IPI00328270 Neuronal PAS domain-containing protein 2 NPAS2 IPI00442544 CDNA FLJ27034 fis, clone SLV07984 — IPI00175019 similar to Temporarily Assigned Gene name family LOC643677 member IPI00027898 Isoform A of Uncharacterized protein C21 orf70 C21orf70 IPI00023340 Histone acetyltransferase MYST3 MYST3 IPI00735857 similar to ATP-binding cassette sub-family D member 1 LOC651123 IPI00300052 Keratin type II cuticular Hb4 KRT84 IPI00454695 Histone H2B type 2-C HIST2H2BC IPI00647254 7 kDa protein — IPI00217467 Histone H1.4 HIST1H1E IPI00328118 Sperm-associated antigen 5 SPAG5 IPI00094740 Isoform 1 of RING finger protein 31 RNF31 IPI00019158 ADAM metallopeptidase domain 8 precursor ADAM8 IPI00383318 PRO2272 — IPI00045928 Sodium/hydrogen exchanger 7 SLC9A7 IPI00292470 dapper, antagonist of beta-catenin, homolog 2 DACT2 IPI00009532 4-aminobutyrate aminotransferase, mitochondrial precursor ABAT IPI00215884 Isoform ASF-1 of Splicing factor, arginine/serine-rich 1 SFRS1 IPI00306332 60S ribosomal protein L24 RPL24 IPI00013488 Isoform Alpha-2 of N-chimaerin CHN1 IPI00218687 Isoform 10 of Voltage-dependent T-type calcium channel CACNA1G subunit alpha-1G IPI00015047 8D6 antigen (Fragment) CD320 IPI00298994 Talin-1 TLN1 IPI00643937 Methylenetetrahydrofolate dehydrogenase (NADP+ MTHFD1L dependent) 1-like IPI00030909 BB1 family protein — IPI00552213 Isoform 6 of Disks large homolog 1 DLG1 IPI00001786 Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 36 USP36 IPI00397358 Similar to ribosomal protein S27 — IPI00745103 similar to melanoma associated antigen (mutated) 1-like 1 LOC728307 IPI00030876 diaphanous 1 isoform 2 DIAPH1 IPI00021786 RAF proto-oncogene serine/threonine-protein kinase RAF1 IPI00003438 DnaJ homolog subfamily C member 8 DNAJC8 IPI00398900 Homeobox protein HMX2 HMX2 IPI00031960 polymerase (RNA) I polypeptide A, 194 kDa POLR1A IPI00298870 Transmembrane protein 1 TMEM1 IPI00385791 Serologically defined breast cancer antigen NY-BR-87 MRPS26 (Fragment) IPI00017991 jumonji domain containing 2D JMJD2D IPI00151366 Isoform TRPM6a of Transient receptor potential cation TRPM6 channel subfamily M member 6 IPI00031627 DNA-directed RNA polymerase II subunit RPB1 POLR2A IPI00004488 Vacuolar proton pump subunit F ATP6V1F IPI00145805 Isoform 1 of TRAF2 and NCK-interacting protein kinase TNIK IPI00296374 Zinc finger protein-like 1 ZFPL1 IPI00328825 Isoform 1 of NEDD4-binding protein 2 N4BP2 IPI00184884 Non-structural maintenance of chromosomes element 1 NSMCE1 homolog IPI00011488 Isoform 1 of Serine/threonine-protein kinase 4 STK4 IPI00103874 Isoform 1 of Zinc finger FYVE domain-containing protein 1 ZFYVE1 IPI00737920 similar to dynein, axonemal, heavy polypeptide 1 DNAH3 IPI00243221 nardilysin (N-arginine dibasic convertase) isoform a NRD1 IPI00060569 Isoform 2 of Abhydrolase domain-containing protein 12 ABHD12 IPI00101405 Farnesyl diphosphate synthase FDPS IPI00015983 Sphingosine 1-phosphate receptor Edg-3 EDG3 IPI00075013 Complement C1q tumor necrosis factor-related protein 1 C1QTNF1 precursor IPI00289965 Potassium voltage-gated channel subfamily C member 3 KCNC3 IPI00786867 Dual Intracellular Von Willebrand factor domain A DIVA IPI00374129 NLR family, pyrin domain containing 3 isoform b NLRP3 IPI00006904 Cell death regulator Aven AVEN IPI00827486 Rheumatoid factor light chain variable region precursor — (Fragment) IPI00853079 Isoform 1 of Uncharacterized protein C14orf166B C14orf166B IPI00456578 LOC441054 protein LOC441054 IPI00376213 Isoform 1 of G-protein coupled receptor 120 GPR120 IPI00376587 Uncharacterized protein ENSP00000345065 LOC728780 IPI00333197 Isoform 2 of GRIP and coiled-coil domain-containing GCC2 protein 2 IPI00010420 ADP/ATP translocase 4 SLC25A31 IPI00004346 C-C chemokine receptor type 10 CCR10 IPI00297251 Isoform 2 of Probable E3 ubiquitin-protein ligase MGRN1 MGRN1 IPI00004419 Zinc finger protein 646 ZNF646 IPI00847409 hypothetical protein LOC440338 IPI00218131 Protein S100-A12 S100A12 IPI00005024 Isoform 1 of Myb-binding protein 1A MYBBP1A IPI00177890 54 kDa protein SMARCD2 IPI00438170 Isoform 1 of Sorting nexin-12 SNX12 IPI00373823 Cytochrome P450 26C1 CYP26C1 IPI00550917 Twinfilin-2 TWF2 IPI00023635 Isoform 1 of Inositol monophosphatase 2 IMPA2 IPI00014516 Isoform 1 of Caldesmon CALD1 IPI00008403 Carbohydrate sulfotransferase 7 CHST7 IPI00412298 Isoform I of Serine/threonine-protein kinase ATR ATR IPI00021951 Uncharacterized protein KIAA0247 precursor KIAA0247 IPI00815893 Isoform 1 of Chromodomain-helicase-DNA-binding CHD2 protein 2 IPI00009439 Synaptotagmin-1 SYT1 IPI00002243 Isoform 1 of Gamma-glutamyltransferase 5 precursor GGTLA1 IPI00159049 SET-binding protein SETBP1 IPI00005837 Angiopoietin-related protein 1 srecursor ANGPTL1 IPI00297277 Isoform 1 of RING finger protein 150 precursor RNF150 IPI00304885 Centromere protein C 1 CENPC1 IPI00784013 janus kinase 1 JAK1 IPI00216139 Isoform I of Septin-6 SEPT6 IPI00289954 Heparan sulfate glucosamine 3-O-sulfotransferase 6 HS3ST6 IPI00018134 Isoform 4 of Protein SOLO FLJ10357 IPI00855742 sterile alpha motif domain containing 12 isoform a SAMD12 IPI00415037 Isoform 12L of ADAM 12 precursor ADAM12 IPI00411298 Connector enhancer of kinase suppressor of ras 3 CNKSR3 IPI00016685 Enamelin precursor ENAM IPI00002191 Putative uncharacterized protein FLJ12684 — IPI00007928 Pre-mRNA-processing-splicing factor 8 PRPF8 IPI00031288 Claudin-14 CLDN14 IPI00028053 Gap junction alpha-9 protein GJA9 IPI00867582 Similar to SCAN domain-containing protein 2. Isoform 2 ZNF496 IPI00418885 Epididymal-specific lipocalin-10 precursor LCN10 IPI00166465 hypothetical protein LOC221416 C6orf223 IPI00795992 Hypothetical short protein — IPI00847373 hypothetical protein LOC54627 KIAA1383 IPI00030070 Gap junction beta-5 protein GJB5 IPI00293095 Isoform 1 of Coiled-coil domain-containing protein 83 CCDC83 IPI00418238 Isoform 1 of HIV-1 Rev-binding protein-like protein HRBL IPI00008504 Carbonic anhydrase 14 precursor CA14 IPI00293409 Zinc finger protein 81 ZNF81 IPI00003927 40 kDa peptidyl-prolyl cis-trans isomerase PPID IPI00747142 Centaurin-gamma-like family member 6 CTGLF6 IPI00024801 E3 ubiquitin-protein ligase NRDP1 RNF41 IPI00040900 Isoform 2 of Heparan sulfate 2-O-sulfotransferase 1 HS2ST1 IPI00103356 Uncharacterized protein ITGB2 ITGB2 IPI00604798 Bitter taste receptor T2R2 (Fragment) — IPI00011515 Protein kinase C and casein kinase substrate in neurons PACSIN1 protein 1 IPI00164066 Isoform 4 of Coiled-coil domain-containing protein 136 CCDC136 IPI00307702 H53_GS1 (Fragment) — IPI00013887 Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 IPI00025084 Calpain small subunit 1 CAPNS1 IPI00014899 CDNA FLJ20744 fis, clone HEP06585 BRPF3 IPI00307611 Isoform 1 of Microtubule-associated serine/threonine- MAST4 protein kinase 4 IPI00014444 Isoform 1 of Protein SERAC1 SERAC1 IPI00479217 Isoform Short of Heterogeneous nuclear ribonucleoprotein U HNRNPU IPI00384971 hypothetical protein LOC643155 DKFZP686E2158 IPI00025721 COP9 signalosome complex subunit 3 COPS3 IPI00017334 Prohibitin PHB IPI00183206 Isoform 1 of RIM-binding protein 2 RIMBP2 IPI00220070 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 PFKFB4 IPI00023322 Zinc finger protein ubi-d4 DPF2 IPI00216699 Isoform 2 of Unc-112-related protein 2 FERMT3 IPI00855747 hypothetical protein LOC57481 RP13-347D8.3 IPI00445054 CDNA FLJ44715 fis, clone BRACE3021430 FLJ44715 IPI00303318 Protein FAM49B FAM49B IPI00030360 RUN domain-containing protein 2A RUNDC2A IPI00220503 dynactin 2 DCTN2 IPI00784739 Uncharacterized protein C14orf43 C14orf43 IPI00328159 Isoform 1 of Uncharacterized protein C1orf88 C1orf88 IPI00003881 Heterogeneous nuclear ribonucleoprotein F HNRPF IPI00003990 Isoform 2 of Valacyclovir hydrolase precursor BPHL IPI00847485 Similar to PFIV protein — IPI00738920 similar to CG3104-PA, isoform A LOC642574 IPI00056314 Pre-rRNA-processing protein TSR2 homolog TSR2 IPI00007300 BTB/POZ domain-containing protein 3 BTBD3 IPI00019517 Wilms tumor 1 isoform D WT1 IPI00797694 3 kDa protein — IPI00294210 DNA-binding protein inhibitor ID-2 ID2 IPI00217490 Isoform 1 of Fibronectin type III domain-containing protein FNDC3B 3B IPI00848330 Conserved hypothetical protein LOC285144 IPI00000787 Isoform LMP2.L of Proteasome subunit beta type-9 PSMB9 precursor IPI00004379 Homeobox protein HMX1 HMX1 IPI00004373 Mannose-binding protein C precursor MBL2 IPI00787020 similar to Dynamin-1 LOC644153 IPI00375820 Interferon-induced transmembrane protein 5 IFITM5 IPI00411635 180 kDa protein — IPI00795566 6 kDa protein — IPI00217117 Isoform 1 of Glycerate kinase GLYCTK IPI00167941 Midasin MDN1 IPI00300086 Nicotinate-nucleotide pyrophosphorylase QPRT IPI00016701 P2Y purinoceptor 14 P2RY14 IPI00007010 Lysozyme-like protein 6 precursor LYZL6 IPI00235167 Profilin-3 PFN3 IPI00026126 Mammaglobin-B precursor SCGB2A1 IPI00009899 Uncharacterized protein C5orf5 C5orf5 IPI00220167 Isoform 1 of Putative methyltransferase NSUN7 NSUN7 IPI00155168 Leukocyte common antigen precursor (EC 3.1.3.48) (L- PTPRC CA) (T200) (CD45 antigen). Isoform 2 IPI00217948 FRMD4B protein FRMD4B IPI00384268 XRCC6BP1 protein XRCC6BP1 IPI00027457 C1q-related factor precursor C1QL1 IPI00002993 Transcription initiation factor TFIID subunit 9 TAF9 IPI00216348 Isoform 2C of Cytoplasmic dynein 1 intermediate chain 2 DYNC1I2 IPI00299507 Condensin complex subunit 2 NCAPH IPI00555600 Solute carrier family 26, member 1 isoform a variant IDUA (Fragment) IPI00419221 Membrane-bound O-acyltransferase domain-containing MBOAT2 protein 2 IPI00445643 CDNA FLJ43684 fis, clone TBAES2001492 — IPI00165591 Isoform 4 of Transmembrane channel-like protein 6 TMC6 IPI00010334 Isoform 3 of Inactive phospholipase C-like protein 2 PLCL2 IPI00021634 Kinesin light chain 2 KLC2 IPI00451429 NIF3L1 isoform gamma NIF3L1 IPI00375803 Isoform 1 of GON-4-like protein GON4L IPI00023184 Isoform 1 of Poly [ADP-ribose] polymerase 3 PARP3 IPI00872739 Uncharacterized protein C18orf2 C18orf2 IPI00241409 hypothetical protein LOC55747 FAM21B IPI00152149 CENP-B, N-terminal DNA-binding domain containing — protein IPI00090764 Toll-like receptor 1 precursor TLR1 IPI00024253 Isoform 1 of Fibroblast growth factor 14 FGF14 IPI00029643 Isoform 2 of Mitogen-activated protein kinase kinase ZAK kinase MLT IPI00218637 Major histocompatibility complex, class II, DQ beta 2 HLA-DQB2 IPI00000875 Elongation factor 1-gamma EEF1G IPI00215948 Isoform 1 of Catenin alpha-1 CTNNA1 IPI00022918 Isoform 2 of Protein FAM125B FAM125B IPI00787765 similar to solute carrier family 35, member F4 SLC35F4 IPI00216921 Isoform 2 of Stathmin-4 STMN4 IPI00011416 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, ECH1 mitochondrial precursor IPI00007208 Probable ATP-dependent RNA helicase DDX41 DDX41 IPI00260755 similar to Rho GTPase activating protein 18 C20orf95 IPI00337385 Isoform 1 of Pre-mRNA-processing factor 40 homolog A PRPF40A IPI00304527 Protein FAM83B FAM83B IPI00000459 Transmembrane gamma-carboxyglutamic acid protein 1 PRRG1 precursor IPI00030741 Uncharacterized protein C21orf13 LCA5L IPI00012007 Adenosylhomocysteinase AHCY IPI00855922 Isoform 4 of DENN domain-containing protein 3 DENND3 IPI00399296 hypothetical protein LOC390110 LOC390110 IPI00233358 islet cell autoantigen 1, 69 kDa-like isoform 2 ICA1L IPI00879842 6 kDa protein — IPI00328826 Uncharacterized protein CADPS2 CADPS2 IPI00021476 Eukaryotic translation initiation factor 4E-binding protein 3 EIF4EBP3 IPI00028383 Uncharacterized protein C16orf24 C16orf24 IPI00007074 Tyrosyl-tRNA synthetase, cytoplasmic YARS IPI00031056 Zinc finger MYND domain-containing protein 15 ZMYND15 IPI00641614 47 kDa protein AKAP8L IPI00002134 26S proteasome non-ATPase regulatory subunit 5 PSMD5 IPI00056040 Neuritin 1-like NRN1L IPI00012948 Proheparin-binding EGF-like growth factor precursor HBEGF IPI00856045 AHNAK nucleoprotein 2 AHNAK2 IPI00009329 Utrophin UTRN IPI00298337 cDNA FLJ77671 SLC14A1 IPI00218235 dehydrogenase/reductase member 2 isoform 2 DHRS2 IPI00297315 Alpha-2B adrenergic receptor ADRA2B IPI00219005 FK506-binding protein 4 FKBP4 IPI00044842 Isoform 2 of RAB3A-interacting protein RAB3IP IPI00107855 Hephaestin precursor HEPH IPI00217662 Uncharacterized protein C11orf35 C11orf35 IPI00386119 Isoform 5 of Splicing factor 1 SF1 IPI00025489 Serine/threonine-protein kinase MAK MAK IPI00013004 Isoform 1 of Pyridoxal kinase PDXK IPI00022055 Histone acetyltransferase PCAF PCAF IPI00328260 Protein FAN NSMAF IPI00807418 Isoform 9 of Lymphoid-specific helicase HELLS IPI00027774 THAP domain-containing protein 2 THAP2 IPI00183002 Isoform 1 of Protein phosphatase 1 regulatory subunit 12A PPPIRI2A IPI00027415 Isoform 1 of Probable ATP-dependent RNA helicase DHX36 DHX36 IPI00163601 Putative uncharacterized protein FLJ10213 FLJ10213 IPI00428741 LP2477 FLJ35348 IPI00006252 Multisynthetase complex auxiliary component p43 SCYE1 IPI00021907 Isoform 1 of Myelin basic protein MBP IPI00176125 Collagen XXIX alpha 1 COL29A1 IPI00007321 Isoform I of Acyl-protein thioesterase 1 LYPLA1 IPI00217617 palmitoylated membrane protein 7 MPP7 IPI00008303 Isoform 1 of N-acetylglucosamine-1-phosphodiester alpha- NAGPA N-acetylglucosaminidase precursor IPI00418614 67 kDa protein — IPI00016046 Protein MGR2 homolog C20orf52 IPI00024662 Chromobox protein homolog 5 CBX5 IPI00550364 Phosphoglucomutase-2 PGM2 IPI00169331 Phosphatidylcholine:ceramide cholinephosphotransferase 2 SGMS2 IPI00028450 Isoform 1 of Sodium/calcium exchanger 1 precursor SLC8A1 IPI00783464 dynein heavy chain domain 3 DNAH2 IPI00002841 Sodium/hydrogen exchanger 2 SLC9A2 IPI00472712 Coiled-coil domain containing 7 CCDC7 IPI00061355 Isoform 3 of Protein ZNF673 ZNF673 IPI00445804 Uncharacterized protein ENSP00000374264 DKFZp761B107 IPI00790813 8 kDa protein RAD51AP1 IPI00010405 Isoform Long of Tyrosine-protein kinase transmembrane ROR1 receptor ROR1 precursor IPI00061780 Isoform 1 of E3 ubiquitin-protein ligase Itchy homolog ITCH IPI00873774 Uncharacterized protein ENSP00000383488 (Fragment) — IPI00847335 FLJ45422 protein — IPI00030099 Adenylate cyclase type 9 ADCY9 IPI00217740 C20orf12 protein C20orf12 IPI00396961 Leucine-rich repeat and fibronectin type-III domain- LRFN5 containing protein 5 precursor IPI00514533 Uncharacterized protein SYCP2L SYCP2L IPI00016095 Transcription termination factor, mitochondrial precursor MTERF IPI00024689 Aquaporin-1 AQP1 IPI00877800 32 kDa protein — IPI00008497 Ornithine decarboxylase ODC1 IPI00741608 similar to eukaryotic translation initiation factor 5A EIF5AL3 IPI00010808 Interferon-gamma receptor alpha chain precursor IFNGR1 IPI00872550 Uncharacterized protein PRDM2 PRDM2 IPI00004521 Ewing's tumor-associated antigen 1 ETAA1 IPI00171525 Sentrin-specific protease 3 SENP3 IPI00514622 Ran-binding protein 6 RANBP6 IPI00373824 Testis serine protease 1 precursor TESSP1 IPI00017231 Neurensin-2 NRSN2 IPI00009203 Sorting nexin-7 SNX7 IPI00790021 Zinc finger protein 652 ZNF652 IPI00299729 Transcobalamin-1 precursor TCN1 IPI00018860 NKG2D ligand 2 precursor ULBP2 IPI00022290 Beta-defensin 1 precursor DEFB1 IPI00007444 Epiphycan precursor EPYC IPI00855918 mucin 5, subtype B, tracheobronchial MUC5B IPI00167014 EID2 protein (Fragment) EID2 IPI00180384 dynein, axonemal, heavy chain 7 DNAH7 IPI00007327 Isoform 1 of Tapasin precursor TAPBP IPI00244346 Troponin 1, cardiac muscle TNNI3 IPI00009066 similar to protein tyrosine phosphatase, receptor type, Q PTPRQ isoform 1 precursor IPI00303195 Syncoilin-1 SYNC1 IPI00008404 Isoform Long of Segment polarity protein dishevelled DVL1L1 homolog DVL-1-like IPI00658025 Putative novel transcript — IPI00022958 PRO0149 C16orf72 IPI00032313 Protein S100-A4 S100A4 IPI00024094 Rhesus blood group-associated glycoprotein RHAG IPI00027626 T-complex protein 1 subunit zeta CCT6A IPI00031812 Nuclease sensitive element-binding protein 1 YBX1 IPI00018854 Coiled-coil domain-containing protein 68 CCDC68 IPI00027009 Isoform 1 of Protein kinase C and casein kinase substrate in PACSIN2 neurons protein 2 IPI00084582 Isoform 7 of Collagen alpha-1(XIII) chain COL13A1 IPI00023162 UDP-N-acetylglucosamine 2-epimerase/N- GNE acetylmannosamine kinase IPI00216815 Isoform 2 of DNA topoisomerase 3-beta-1 TOP3B IPI00062599 71 kDa protein — IPI00789181 115 kDa protein PLCL1 IPI00060549 G-protein coupled receptor-associated sorting protein 1 GPRASP1 IPI00795943 7 kDa protein — IPI00005132 Guanine nucleotide-binding protein-like 3-like protein GNL3L IPI00642204 Thioredoxin domain-containing protein 16 precursor TXNDC16 IPI00646199 Zinc finger, MYM-type 2 ZMYM2 IPI00742725 Conserved hypothetical protein LOC388564 IPI00791447 Pseudogene candidate LOC339929 IPI00878755 43 kDa protein — IPI00152050 ataxin 2-binding protein 1 isoform 3 A2BP1 IPI00385480 Caskin-1 CASKIN1 IPI00745433 eukaryotic translation initiation factor 2C, 2 EIF2C2 IPI00465123 KIAA0415 gene product KIAA0415 IPI00398992 Isoform 1 of Chromodomain-helicase-DNA-binding CHD8 protein 8 IPI00026031 Uncharacterized protein C6orf72 precursor C6orf72 IPI00103090 Isoform 1 of RNA polymerase-associated protein LEO1 LEO1 IPI00012441 Isoform 1 of Synaptojanin-1 SYNJ1 IPI00006054 Syntaphilin SNPH IPI00215746 Fatty acid-binding protein, adipocyte FABP4 IPI00216780 Cartilage intermediate layer protein 2 precursor CILP2 IPI00101186 Isoform 1 of RRP12-like protein RRP12 IPI00013404 Mothers against decapentaplegic homolog 4 SMAD4 IPI00385918 CDNA FLJ90582 fis, clone PLACE1000442, moderately ZNF627 similar to ZINC FINGER PROTEIN ZFP-36 IPI00219067 Glutathione S-transferase Mu 2 GSTM2 IPI00008438 40S ribosomal protein S10 RPS10 IPI00152849 Isoform 1 of G2/mitotic-specific cyclin-B3 CCNB3 IPI00220038 Isoform B of Arsenite-resistance protein 2 ARS2 IPI00029556 Uncharacterized protein C1orf105 C1orf105 IPI00385683 Ig heavy chain V-III region GAR — IPI00441344 Beta-galactosidase precursor GLB1 IPI00217012 pleckstrin and Sec7 domain containing PSD IPI00006030 Dynein intermediate chain 1, axonemal DNAI1 IPI00215914 ADP-ribosylation factor 1 ARF1 IPI00024714 Isoform 1 of Regulator of G-protein signaling 12 RGS12 IPI00015980 Isoform 2 of Multiple PDZ domain protein MPDZ IPI00103853 Isoform 1 of Putative ribosome-binding factor A, C18orf22 mitochondrial precursor IPI00102678 Isoform 1 of Pecanex-like protein 1 PCNX IPI00020356 331 kDa protein MAP1A IPI00259671 Taste receptor type 2 member 44 TAS2R44 IPI00008226 73 kDa protein THSD3 IPI00551062 Isoform 1 of Protein canopy homolog 3 precursor CNPY3 IPI00219622 Proteasome subunit alpha type-2 PSMA2 IPI00010903 Dopey family member 1 DOPEY1 IPI00220741 spectrin, alpha, erythrocytic 1 SPTA1 IPI00735934 similar to capicua homolog LOC646070 IPI00335581 Isoform 1 of E3 ubiquitin-protein ligase UBR3 UBR3 IPI00031086 Insulin-like growth factor-binding protein 1 precursor IGFBP1 IPI00004416 Charged multivesicular body protein 2a CHMP2A IPI00465234 Cytokine receptor common beta chain precursor CSF2RB IPI00010303 Serpin B4 SERPINB4 IPI00028828 Isoform Beta of Zinc finger protein 202 ZNF202 IPI00514795 Isoform 1 of Tubulin--tyrosine ligase-like protein 7 TTLL7 IPI00008091 Putative DNA helicase INO80 complex homolog 1 INOC1 IPI00016112 peroxidasin homolog PXDN IPI00010193 Isoform 1 of Interferon-alpha/beta receptor beta chain IFNAR2 precursor IPI00101987 Uncharacterized protein C19orf62 C19orf62 IPI00853224 START domain containing 7 STARD7 IPI00329791 cDNA FLJ78679, highly similar to Homo sapiens DEAD DDX46 (Asp-Glu-Ala-Asp) box polypeptide 46 (DDX46), mRNA IPI00001141 Mitochondrial import inner membrane translocase subunit TIMM22 Tim22 IPI00152344 Pyridoxal phosphate phosphatase PHOSPHO2 PHOSPHO2 IPI00465363 Histone H2B type 1-A HIST1H2BA IPI00028601 Putative metallothionein C20orf127 MT1P3 IPI00514975 Chromosome 1 open reading frame 133 C1orf133 IPI00744029 Similar to Zinc finger, FYVE domain containing 21 — IPI00399320 Transmembrane protein 59 precursor TMEM59 IPI00479125 SLIT-ROBO Rho GTPase-activating protein 2 SRGAP2 IPI00455852 Isoform 1 of Rho guanine nucleotide exchange factor 15 ARHGEF15 IPI00019812 Serine/threonine-protein phosphatase 5 PPP5C IPI00550876 Protein maestro MRO IPI00217687 Isoform 1 of Coiled-coil domain-containing protein 135 CCDC135 IPI00829745 Cellular titin isoform PEVK variant 2 (Fragment) — IPI00216544 Isoform 2 of Protein hairless HR IPI00064296 PRO0633 — IPI00216651 Isoform 1 of Interleukin-28 receptor alpha chain precursor IL28RA IPI00792945 38 kDa protein CHFR IPI00646323 Isoform 1 of Uncharacterized protein C10orf76 C10orf76 IPI00149375 Isoform 2 of Uncharacterized protein C11orf56 C11orf56 IPI00386797 Isoform 1 of Folliculin-interacting protein 1 FNIP1 IPI00304589 Isoform 1 of 182 kDa tankyrase 1-binding protein TNKS1BP1 IPI00015913 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor TYRP1 IPI00002857 Isoform CSBP2 of Mitogen-activated protein kinase 14 MAPK14 IPI00399180 Serine/threonine-protein kinase SBK1 SBK1 IPI00007512 Glutathione transferase omega-2 GSTO2 IPI00016576 Isoform 1 of Grainyhead-like protein 2 homolog GRHL2 IPI00290308 Tribbles homolog 1 TRIB1 IPI00017567 Isoform Long of Endoglin precursor ENG IPI00005859 Keratin, type II cytoskeletal 75 KRT75 IPI00017630 Nuclear fragile × mental retardation-interacting protein 1 NUFIP1 IPI00019992 Myb-related protein A MYBL1 IPI00025622 AN1-type zinc finger protein 5 ZFAND5 IPI00168848 UDP-GlcNAc:betaGal beta-1,3-N- B3GNT7 acetylglucosaminyltransferase 7 IPI00019901 Isoform 1 of Alpha-adducin ADD1 IPI00006510 Tubulin beta-1 chain TUBB1 IPI00102808 Isoform 1 of Dual specificity protein phosphatase 19 DUSP19 IPI00023942 Isoform 2 of Syndecan-3 SDC3 IPI00031506 Potassium/sodium hyperpolarization-activated cyclic HCN1 nucleotide-gated channel 1 IPI00018208 Tetratricopeptide repeat protein 33 TTC33 IPI00166865 CDGSH iron sulfur domain-containing protein 2 CISD2 IPI00305833 Smu-1 suppressor of mec-8 and unc-52 protein homolog SMU1 IPI00219129 Ribosyldihydronicotinamide dehydrogenase NQO2 IPI00004533 Kinesin-like protein KIF3B KIF3B IPI00028614 erythrocyte membrane protein band 4.2 isoform 2 EPB42 IPI00216917 Isoform 1 of Uncharacterized protein C22orf9 C22orf9 IPI00043499 Probable urocanate hydratase UROC1 IPI00477468 RNA polymerase-associated protein CTR9 homolog CTR9 IPI00005668 Aldo-keto reductase family 1 member C2 AKR1C2 IPI00018098 Isoform 1 of Pre-mRNA-splicing factor 38B PRPF38B IPI00026241 Bone marrow stromal antigen 2 precursor BST2 IPI00056507 Isoform 1 of F-box/WD repeat-containing protein 5 FBXW5 IPI00017451 Splicing factor 3 subunit 1 SF3A1 IPI00243338 24 kDa protein KRT23 IPI00786937 similar to deleted in malignant brain tumors 1 isoform b LOC731940 precursor IPI00465273 UHRF1-binding protein 1 UHRF1BP1 IPI00550746 Nuclear migration protein nudC NUDC IPI00738999 similar to ubiquitin-conjugating enzyme E2 variant 1 LOC643227 IPI00218918 Annex in A1 ANXA1 IPI00031047 CDNA: FLJ23571 fis, clone LNG12303 IQCG IPI00295577 Receptor-type tyrosine-protein phosphatase beta precursor PTPRB IPI00718806 arylhydrocarbon receptor repressor AHRR; PDCD6 IPI00029372 Uncharacterized protein C4orf15 C4orf15 IPI00022256 AP-2 complex subunit mu-1 AP2M1 IPI00744226 Conserved hypothetical protein — IPI00299116 Podocalyxin-like protein 1 precursor PODXL IPI00792229 20 kDa protein TATDN1 IPI00151141 Isoform 1 of Serine/threonine-protein kinase WNK4 WNK4 IPI00220271 Alcohol dehydrogenase AKR1A1 IPI00786893 similar to LYRIC/3D3 LOC730296; LOC728998 IPI00027232 Insulin-like growth factor 1 receptor precursor IGF1R IPI00028387 Isoform 1 of Uncharacterized protein C20orf116 precursor C20orf116 IPI00015954 GTP-binding protein SAR1a SAR1A IPI00397949 G protein-coupled receptor 56 isoform b GPR56 IPI00328748 Protein ARMET precursor ARMET IPI00027547 Dermcidin precursor DCD IPI00009396 Isoform 1 of Cannabinoid receptor 1 CNR1 IPI00306853 Carbohydrate sulfotransferase 3 CHST3 IPI00418735 hypothetical protein LOC400566 LOC400566 IPI00553006 Probable prolyl-tRNA synthetase, mitochondrial precursor PARS2 IPI00102803 Ankyrin repeat domain-containing protein 22 ANKRD22 IPI00306413 Tubulin polymerization-promoting protein family member 3 TPPP3 IPI00018755 High mobility group protein 1-like 10 HMG1L10 IPI00030153 Tudor domain-containing protein 6 TDRD6 IPI00010212 U6 snRNA-specific terminal uridylyltransferase 1 TUT1 IPI00844501 MG44 protein SUV39H1 IPI00385543 Isoform 3 of UPF0469 protein KIAA0907 KIAA0907 IPI00456060 Protein — IPI00299076 Receptor-binding cancer antigen expressed on SiSo cells EBAG9 (Fragment) IPI00386393 CDNA FLJ13729 fis, clone PLACE3000121, weakly EXOC6B similar to VESICULAR TRAFFIC CONTROL PROTEIN SEC15 IPI00016480 Isoform 1 of NACHT, LRR and PYD domains-containing NLRP2 protein 2 IPI00166043 Isoform 2 of Progestin and adipoQ receptor family member 6 PAQR6 IPI00878511 45 kDa protein — IPI00411545 Isoform 3 of Thrombopoietin precursor THPO IPI00442564 CDNA FLJ26948 fis, clone RCT08241 — IPI00257508 Dihydropyrimidinase-related protein 2 DPYSL2 IPI00398918 Putative uncharacterized protein DKFZp686I21167 DKFZp686O24166 IPI00412408 Breast cancer type 2 susceptibility protein BRCA2 IPI00005614 Isoform Long of Spectrin beta chain, brain 1 SPTBN1 IPI00168239 Zinc finger protein GLIS1 GLIS1 IPI00165990 Isoform 4 of Transcription factor RFX4 RFX4 IPI00021831 cAMP-dependent protein kinase type I-alpha regulatory PRKAR1A subunit IPI00749489 fibrocystin L PKHD1L1 IPI00552578 Serum amyloid A protein precursor SAA1; SAA2 IPI00008422 Isoform 2 of SWI/SNF-related matrix-associated actin- SMARCAD1 dependent regulator of chromatin subfamily A containing DEAD/H box 1 IPI00018953 Dipeptidyl peptidase 4 DPP4 IPI00413778 Peptidyl-prolyl cis-trans isomerase FKBP1A IPI00007682 Vacuolar ATP synthase catalytic subunit A ATP6V1A IPI00024502 Ubiquilin-4 UBQLN4 IPI00059144 Protein FAM46B FAM46B IPI00550792 Isoform 1 of Bridging integrator 2 BIN2 IPI00029175 Strumpellin KIAA0196 IPI00045360 Capicua-like protein/double homeodomain 4 fusion protein CIC IPI00787697 similar to Oligophrenin 1 isoform 4 FLJ32810 IPI00749171 Conserved hypothetical protein LOC340184 IPI00033419 Protein Fem-1 homolog b FEM1B IPI00043237 CDNA FLJ32095 fis, clone OCBBF2000998 LOC730193; STX6 IPI00298738 DNA-directed RNA polymerase, mitochondrial precursor POLRMT IPI00028641 Isoform 4 of Protein phosphatase 1 regulatory subunit 12B PPP1R12B IPI00554711 Junction plakoglobin JUP IPI00879159 9 kDa protein — IPI00445278 CDNA FLJ44033 fis, clone TESTI4028062 — IPI00335541 Isoform 1 of Protein timeless homolog TIMELESS IPI00644840 Hypothetical protein LOC255783 IPI00009771 Lamin-B2 LMNB2 IPI00444842 CDNA FLJ45125 fis, clone BRAWH3036561 — IPI00007800 Angiopoietin-related protein 2 precursor ANGPTL2 IPI00181743 Isoform 1 of BAI1-associated protein 3 BAIAP3 IPI00018099 E3 ubiquitin-protein ligase FANCL FANCL IPI00455076 Double C2-like domain-containing protein alpha DOC2A IPI00023152 Isoform 1 of N-acetylated-alpha-linked acidic dipeptidase- NAALADL1 like protein IPI00296727 Kinesin-like protein KIF2B KIF2B IPI00005347 Zinc finger Ran-binding domain-containing protein 1 ZRANB1 IPI00295940 Protein unc-84 homolog B UNC84B IPI00470913 RANBP2-like and GRIP domain containing 1 RGPD1; RGPD2 IPI00444331 Isoform 4 of Histone-lysine N-methyltransferase NSD3 WHSC1L1 IPI00023407 Nck-associated protein 1-like NCKAP1L IPI00306046 Isoform 1 of EGF-like repeat and discoidin I-like domain-c

EDIL3 IPI00426727 Isoform 1 of Methyl-CpG-binding domain protein 4 MBD4 IPI00002970 Beta-sarcoglycan SGCB IPI00878142 68 kDa protein — IPI00554488 cAMP-dependent protein kinase type I-beta regulatory PRKAR1B subunit IPI00301288 polydom SVEP1 IPI00030279 Isoform 1 of Zinc finger Ran-binding domain-containing ZRANB3 protein 3 IPI00074656 Isoform 1 of Coiled-coil domain-containing protein C6orf65 C6orf65 IPI00031907 Isoform 1 of Transmembrane protein 108 precursor TMEM108 IPI00456635 Isoform 1 of Protein unc-13 homolog D UNC13D IPI00445315 Protein FAM47C FAM47C IPI00065931 Isoform 2 of A-kinase anchor protein 13 AKAP13 IPI00020230 Frizzled-9 precursor FZD9 IPI00149044 Isoform 2 of Suppressor of hairy wing homolog 4 ZNF280D IPI00014903 Isoform 1 of FGFR1 oncogene partner 2 FGFR1OP2 IPI00019502 Myosin-9 MYH9 IPI00007834 Isoform 1 of Ankyrin-2 ANK2 IPI00011961 Isoform 1 of Sialoadhesin precursor SIGLEC1 IPI00746681 Similar to Bcl-2-related ovarian killer protein — IPI00000977 Mitogen-activated protein kinase kinase kinase 11 MAP3K11 IPI00007047 Protein S100-A8 S100A8 IPI00884399 RNA-directed DNA polymerase (Reverse transcriptase), rel

— IPI00871556 107 kDa protein ZFYVE28 IPI00746666 hypothetical protein LOC728262 IPI00018879 Alpha-L-iduronidase precursor IDUA IPI00170770 Isoform 1 of PHD finger protein 3 PHF3 IPI00000057 Conserved oligomeric Golgi complex component 2 COG2 IPI00003814 Isoform 1 of Dual specificity mitogen-activated protein MAP2K6 kinase kinase 6 IPI00290854 A-kinase anchor protein 3 AKAP3 IPI00301058 Vasodilator-stimulated phosphoprotein VASP IPI00245940 immunoglobulin superfamily 5 like IGSF5 IPI00657699 Protein MUC19 IPI00435928 PP13187 RASGRF1 IPI00290094 Splicing factor, arginine/serine-rich 8 SFRS8 IPI00030706 Activator of 90 kDa heat shock protein ATPase homolog 1 AHSA1 IPI00013721 Serine/threonine-protein kinase PRP4 homolog PRPF4B IPI00853516 dynein, axonemal, heavy chain 17 DNAH17 IPI00410093 coiled-coil domain containing 69 CCDC69 IPI00748607 Conserved hypothetical protein — IPI00168404 Zinc finger and BTB domain containing 34 ZBTB34 IPI00021266 60S ribosomal protein L23a RPL23A; hCG_16001 IPI00644766 cDNA FLJ78048, highly similar to Homo sapiens torsin A i

TOR1AIP1 IPI00167154 Uncharacterized protein MAPKBP1 MAPKBP1 IPI00031228 Isoform 2 of Pleckstrin homology domain-containing PLEKHB2 family B member 2 IPI00871533 Uncharacterized protein C3orf48 (Fragment) C3orf48 IPI00007812 Vacuolar ATP synthase subunit B, brain isoform ATP6V1B2 IPI00877615 15 kDa protein — IPI00030352 Isoform 2 of Growth inhibition and differentiation-related C10orf28 protein 88 IPI00384051 Uncharacterized protein PSME2 PSME2 IPI00337415 Guanine nucleotide-binding protein G(i), alpha-1 subunit GNAI1 IPI00003377 Isoform 1 of Splicing factor, arginine/serine-rich 7 SFRS7 IPI00006146 serum amyloid A2 SAA1; SAA2 IPI00017551 Isoform 1 of Regucalcin RGN IPI00032338 kelch-like 20 KLHL20 IPI00293679 Isoform 1 of Potassium voltage-gated channel subfamily KCNQ4 KQT member 4 IPI00745396 Stromal RNA regulating factor HNRPLL IPI00604752 Isoform 3 of Sterile alpha motif domain-containing protein SAMD13 13 IPI00382534 Ig heavy chain V-II region OU — IPI00748682 Pheromone shutdown-related, TraB family protein — IPI00008444 Isoform 1 of Cytidine and dCMP deaminase domain- CDADC1 containing protein 1 IPI00792933 zinc finger protein 462 ZNF462 IPI00019888 Succinate-semialdehyde dehydrogenase, mitochondrial ALDH5A1 precursor IPI00032597 RNA-binding motif protein, X-linked 2 RBMX2 IPI00402005 Similar to DNA-binding protein ZNF528 IPI00020036 Neuronal acetylcholine receptor subunit alpha-4 precursor CHRNA4 IPI00783855 neighbor of BRCA1 gene 1 NBR1 IPI00329054 Osteopetrosis-associated transmembrane protein 1 OSTM1 precursor IPI00028864 Neurexophilin-3 precursor NXPH3 IPI00023757 Isoform 1 of X-linked retinitis pigmentosa GTPase RPGR regulator IPI00746987 Ribosomal protein S1 family protein — IPI00295469 Copine-6 CPNE6 IPI00000663 Isoform Mitochondrial of Malonyl-CoA decarboxylase, MLYCD mitochondrial precursor IPI00788258 similar to lysyl oxidase-like 1 preproprotein LOXL1 IPI00739387 hypothetical protein LOC401478 FLJ45872 IPI00456599 hypothetical protein LOC84792 MGC12966 IPI00607831 PRAME family member 3 PRAMEF3 IPI00399254 Isoform 1 of OTU domain-containing protein 4 OTUD4 IPI00164352 zinc finger protein 292 ZNF292 IPI00719505 RABL2A protein RABL2A IPI00008913 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ST6GALNAC5 IPI00020454 Deoxycytidine kinase DCK IPI00784880 Cancer/testis antigen 75 LOC440934 IPI00514028 21 kDa protein RNF207 IPI00884353 Ets-1 transcript variant ets-1 delta — IPI00852725 Isoform 7 of Prolactin receptor precursor PRLR IPI00024292 Low-density lipoprotein receptor-related protein 2 LRP2 precursor IPI00005600 Isoform 1 of Bifunctional heparan sulfate N-deacetylase/N- NDST2 sulfotransferase 2 IPI00028357 Exportin-4 XPO4 IPI00438355 Fibrillin-3 precursor FBN3 IPI00009043 Apoptotic-related protein PCAR (Fragment) — IPI00791593 8 kDa protein GLYCAM1 IPI00024346 snRNA-activating protein complex subunit 3 SNAPC3 IPI00293396 adaptor-related protein complex 1, gamma 1 subunit AP1G1 isoform a IPI00010859 cortistatin preproprotein CORT; APITD1 IPI00220412 S100 calcium binding protein A1 S100A1 IPI00018914 Tyrosine-protein phosphatase non-receptor type 14 PTPN14 IPI00027442 Alanyl-tRNA synthetase, cytoplasmic AARS IPI00553138 Vesicle-associated membrane protein 2 VAMP2 IPI00296913 ADP-sugar pyrophosphatase NUDT5 IPI00014845 Isoform 1 of Ciliary dynein heavy chain 8 DNAH8 IPI00185146 Importin-9 IPO9 IPI00385687 similar to Ubiquinol-cytochrome c reductase complex 14 kDa — protein IPI00143753 Isoform 1 of U2-associated protein SR140 SR140 IPI00219682 Erythrocyte band 7 integral membrane protein STOM IPI00377214 Isoform 2 of NLR family member X1 NLRX1 IPI00054521 Frizzled-1 precursor FZD1 IPI00217791 Coiled-coil domain-containing protein 105 CCDC105 IPI00329538 Prostasin precursor PRSS8 IPI00794829 16 kDa protein ACADS IPI00167006 Uncharacterized protein C13orf26 C13orf26 IPI00028481 Ras-related protein Rab-8A RAB8A IPI00294215 Uncharacterized protein KIAA0232 KIAA0232 IPI00027806 Cysteine-rich secretory protein LCCL domain-containing 1 CRISPLD1 precursor IPI00216423 Isoform 4 of Intersectin-2 ITSN2 IPI00303870 Seven transmembrane helix receptor — IPI00071185 Isoform SV1 of PITSLRE serine/threonine-protein kinase CDC2L1 CDC2L1 IPI00848229 EGF, latrophilin and seven transmembrane domain- ELTD1 containing protein 1 precursor IPI00166776 Protein CREG2 precursor CREG2 IPI00456969 Dynein heavy chain, cytosolic DYNC1H1 IPI00293857 Isoform 1A of Beta-arrestin-1 ARRB1 IPI00001796 Tumor necrosis factor receptor superfamily, member 18 TNFRSF18 (Fragment) IPI00549972 LIM domain-containing protein 2 LIMD2 IPI00604551 Isoform 1 of Cell division cycle-associated protein 7 CDCA7 IPI00293565 fms-related tyrosine kinase 4 isoform 1 FLT4 IPI00022471 minor histocompatibility antigen HA-1 HMHA1 IPI00029050 Isoform 1 of Glycosyltransferase-like protein LARGE1 LARGE IPI00848252 hypothetical protein LOC285501 LOC285501 IPI00288939 Isoform 3 of Coiled-coil domain-containing protein 40 CCDC40 IPI00029107 Werner syndrome ATP-dependent helicase WRN IPI00065057 Putative uncharacterized protein CXorf58 CXorf58 IPI00073769 48 kDa protein PALM2 IPI00065520 Isoform 1 of Protein phosphatase 1M PPM1M IPI00470468 Isoform 3 of Protein EFR3 homolog A EFR3A IPI00436518 Benzodiazepine receptor ligand — IPI00382515 CDNA FLJ30384 fis, clone BRACE2008114 — IPI00749514 attractin-like 1 ATRNL1 IPI00853312 Uncharacterized protein ENSP00000324580 — IPI00217871 Delta-1-pyrroline-5-carboxylate dehydrogenase, ALDH4A1 mitochondrial precursor IPI00015345 Cadherin EGF LAG seven-pass G-type receptor 3 CELSR3; SLC26A6 precursor IPI00644191 70 kDa protein ZNF90 IPI00847391 Isoform 1 of Zinc finger protein 276 ZNF276 IPI00001654 Isoform 3 of Pericentriolar material 1 protein PCM1 IPI00470490 Isoform 1 of Nuclear receptor coactivator 1 NCOA1 IPI00410488 Isoform 1 of CD276 antigen precursor CD276 IPI00001433 Protocadherin beta 15 precursor PCDHB15 IPI00220156 Isoform B of Transforming growth factor beta-2 precursor TGFB2 IPI00024818 Isoform 1 of Ubiquitin-specific peptidase-like protein 1 USPL1 IPI00335437 Ankyrin repeat and zinc finger domain-containing protein 1 ANKZF1 IPI00000076 Beta-nerve growth factor precursor NGFB IPI00100980 EH domain-containing protein 2 EHD2 IPI00215610 55 kDa erythrocyte membrane protein MPP1 IPI00015148 Ras-related protein Rap-1b precursor RAP1B IPI00028493 Isoform 1 of Tuberin TSC2 IPI00410657 Isoform 2 of mRNA cap guanine-N7 methyltransferase RNMT IPI00328361 Seryl-tRNA synthetase, mitochondrial precursor SARS2 IPI00029700 Isoform Long of Down syndrome cell adhesion molecule DSCAM precursor IPI00332583 chorionic somatomammotropin hormone 1 isoform 2 CSH1; CSH2; GH1 IPI00552591 V1-20 protein IGLV10-54 IPI00022277 Coiled-coil domain-containing protein 56 CCDC56 IPI00301844 Zinc fingers and homeoboxes protein 3 ZHX3 IPI00013788 HIV Tat-specific factor 1 HTATSF1 IPI00216288 Isoform 3 of Lethal L3MBTL IPI00025499 Isoform Tau-F of Microtubule-associated protein tau MAPT IPI00001151 Isoform 2 of Uncharacterized MFS-type transporter C20orf59 C20orf59 IPI00787083 similar to peptidylprolyl isomerase A isoform 1 LOC256374 IPI00856012 collagen type VI alpha 6 COL6A6 IPI00001712 Isoform 1 of Catenin alpha-3 CTNNA3 IPI00847237 Conserved hypothetical protein — IPI00295999 Isoform 2 of Collagen alpha-1(IX) chain precursor COL9A1 IPI00217831 Ankyrin repeat domain-containing protein 13A ANKRD13A IPI00296196 Dimethylglycine dehydrogenase, mitochondrial precursor DMGDH IPI00396145 FYVE finger-containing phosphoinositide kinase PIP5K3 IPI00478110 Probable G-protein coupled receptor 135 GPR135 IPI00335168 Isoform Non-muscle of Myosin light polypeptide 6 MYL6 IPI00030037 Agouti-signaling protein precursor ASIP IPI00013749 Protein kinase C zeta type PRKCZ IPI00002491 Isoform 9 of Sorbin and SH3 domain-containing protein 1 SORBS1 IPI00240793 Probable phospholipid-transporting ATPase IF ATP11B IPI00168995 Olfactory receptor 4D9 OR4D9 IPI00024704 Uronyl 2-sulfotransferase UST IPI00031195 Isoform 1 of Vang-like protein 1 VANGL1 IPI00059190 Isoform 1 of SLAM family member 9 precursor SLAMF9 IPI00043467 Tigger transposable element-derived protein 1 TIGD1 IPI00376237 Isoform 2 of Transcription factor LBX2 LBX2 IPI00235842 Zinc finger protein 483 ZNF483 IPI00220473 Isoform 2 of Calcium-transporting ATPase type 2C ATP2C1 member 1 IPI00169115 Olfactory receptor OR9-8 OR13C3 IPI00020966 Isoform 1 of Phosphatidylinositol N- PIGA acetylglucosaminyltransferase subunit A IPI00456827 Protein FAM22G precursor FAM22G IPI00382831 Cerebral protein-13 BAP1 IPI00477692 Uncharacterized protein ENSP00000330808 LOC131149 IPI00747657 Similar to Rod cGMP-specific 3′,5′-cyclic PDE6B phosphodiesterase subunit beta precursor IPI00301583 Isoform 1 of Zinc finger protein 691 ZNF691 IPI00790447 12 kDa protein — IPI00829904 Uncharacterized protein ENSP00000374814 — IPI00215777 Isoform B of Phosphate carrier protein, mitochondrial SLC25A3 precursor IPI00028912 zinc finger protein 161 VEZF1 IPI00387161 Ig lambda chain V-I region VOR — IPI00830107 V4-2 protein IGLV5-45 IPI00440493 ATP synthase subunit alpha, mitochondrial precursor ATP5A1 IPI00020533 Protein BEX1 BEX1 IPI00019242 Matrix metalloproteinase-15 precursor MMP15 IPI00376436 Isoform 4 of Vacuolar protein sorting-associated protein VPS13B 13B IPI00029162 Isoform 2 of Cell division cycle 2-like protein kinase 5 CDC2L5 IPI00419237 Isoform 1 of Cytosol aminopeptidase LAP3 IPI00065500 BRO1 domain-containing protein BROX C1orf58 IPI00740336 formin 1 FMN1 IPI00017203 Protein RMI1 homolog RMI1 IPI00024664 Isoform Long of Ubiquitin carboxyl-terminal hydrolase 5 USP5 IPI00786946 similar to Tektin-3 LOC642249 IPI00166257 CDNA FLJ37614 fis, clone BRCOC2011769 — IPI00012877 Isoform 1 of Interferon-alpha/beta receptor alpha chain IFNAR1 precursor IPI00021199 Stathmin-3 STMN3 IPI00293431 WUGSC:H_DJ0855D21.2 protein MGC70863 IPI00219563 Isoform A of 1-phosphatidylinositol-4,5-bisphosphate PLCB1 phosphodiesterase beta-1 IPI00442745 CDNA FLJ26780 fis, clone PRS03837 — IPI00295400 Tryptophanyl-tRNA synthetase, cytoplasmic WARS IPI00444330 CDNA FLJ45693 fis, clone FEBRA2012625 — IPI00170509 Isoform 3 of Calcium/calmodulin-dependent protein kinase CAMKK2 kinase 2 IPI00017256 Ras suppressor protein 1 RSU1 IPI00374301 hypothetical protein — IPI00023217 Isoform 1 of Ryanodine receptor 2 RYR2 IPI00017533 Cytochrome c oxidase subunit 3 MT-CO3 IPI00419922 Isoform 1 of IQ domain-containing protein E IQCE IPI00029997 6-phosphogluconolactonase PGLS IPI00024920 ATP synthase subunit delta, mitochondrial precursor ATP5D IPI00005710 Heparan sulfate glucosamine 3-O-sulfotransferase 2 HS3ST2 IPI00026262 Isoform 1 of Ras GTPase-activating protein 1 RASA1 IPI00744872 Isoform 1 of Uncharacterized protein KIAA0423 KIAA0423 IPI00787412 similar to Protein C11orf2 LOC441616 IPI00168607 tetratricopeptide repeat domain 21A isoform 1 TTC21A IPI00021091 Isoform 1 of Leucine-rich glioma-inactivated protein 1 LGI1 precursor IPI00419385 olfactory receptor, family 52, subfamily E, member 8 OR52E8 IPI00018843 Isoform 1 of D(3) dopamine receptor DRD3 IPI00477616 Protein phosphatase 2A activator, regulatory subunit 4 PPP2R4 IPI00021695 Isoform D of Plasma membrane calcium-transporting ATP2B1 ATPase 1 IPI00027782 Stromelysin-1 precursor MMP3 IPI00030009 Isoform A of Bifunctional 3′-phosphoadenosine 5′- PAPSS2 phosphosulfate synthetase 2 IPI00479722 Proteasome activator complex subunit 1 PSME1 IPI00006236 Platelet-derived growth factor receptor-like protein PDGFRL precursor IPI00177878 Isoform 3 of Transmembrane protein 16D TMEM16D IPI00291796 BTB (POZ) domain containing 12 BTBD12 IPI00104907 Isoform 1 of Uncharacterized potential DNA-binding C14orf106 protein C14orf106 IPI00400795 54 kDa protein — IPI00303622 Olfactory receptor OR9-23 OR1N2 IPI00031554 ATP-dependent RNA helicase DDX50 DDX50 IPI00005107 Niemann-Pick C1 protein precursor NPC1 IPI00023860 Nucleosome assembly protein 1-like 1 NAP1L1 IPI00028520 Isoform 1 of NADH dehydrogenase [ubiquinone] NDUFV1 flavoprotein 1, mitochondrial precursor IPI00009070 Isoform 1 of HBS1-like protein HBS1L IPI00375225 Olfactory receptor 2AE1 OR2AE1 IPI00235622 Isoform 3 of CUB domain-containing protein 1 precursor CDCP1 IPI00742031 similar to golgi autoantigen, golgin subfamily a, 8G LOC645137 IPI00480159 inositol polyphosphate-5-phosphatase F INPP5F IPI00221372 Isoform 2 of 1-acyl-sn-glycerol-3-phosphate acyltransferase AGPAT2 beta IPI00386576 Ig lambda chain V-IV region MOL — IPI00022295 Platelet factor 4 variant precursor PF4V1 IPI00747420 Melanoma-derived protein (Fragment) — IPI00432226 AVLL5809 — IPI00796972 62 kDa protein ETV5 IPI00171874 Ras guanyl-releasing protein 3 RASGRP3 IPI00010807 Frizzled-8 precursor FZD8 IPI00006746 Ermin ERMN IPI00178894 Zinc finger and BTB domain-containing protein 20 ZBTB20 IPI00878436 24 kDa protein SLC2A11 IPI00640810 6 kDa protein CTDP1 IPI00003921 Isoform 1 of Protein 4.1 EPB41 IPI00031410 FKBP12-rapamycin complex-associated protein FRAP1 IPI00019848 Isoform 1 of Host cell factor HCFC1 IPI00306549 CDNA FLJ11065 fis, clone PLACE1004868, weakly MLSTD1 similar to MALE STERILITY PROTEIN 2 IPI00306611 TRAF-interacting protein TRAIP IPI00003392 Transmembrane protein 5 TMEM5 IPI00153031 Isoform 1 of Uncharacterized protein C17orf80 C17orf80 IPI00289097 Isoform 1 of Ras-GEF domain-containing family member RASGEF1B 1B IPI00425404 Isoform 1 of Kinesin-like protein KIF21A KIF21A IPI00293361 Isoform 2 of Small G protein signaling modulator 2 SGSM2 IPI00477262 Uncharacterized protein TRIM41 (Fragment) TRIM41 IPI00021753 Kinesin-like protein KIF13B KIF13B IPI00030703 Motor neuron and pancreas homeobox protein 1 MNX1 IPI00025974 Charged multivesicular body protein 4b CHMP4B IPI00413655 ankyrin repeat domain 55 isoform 1 ANKRD55 IPI00253281 Isoform 2 of Epidermal growth factor receptor kinase EPS8L1 substrate 8-like protein 1 IPI00005607 Isoform 1 of Deleted in bladder cancer protein 1 precursor DBC1 IPI00027984 Putative uncharacterized protein DNAJC11 IPI00026497 Isoform 1 of Poly [ADP-ribose] polymerase 2 PARP2 IPI00296441 Adenosine deaminase ADA IPI00329605 DNA mismatch repair protein Msh3 MSH3 IPI00032425 Receptor activity-modifying protein 3 precursor RAMP3 IPI00061206 Polyadenylate-binding protein 5 PABPC5 IPI00289758 Calpain-2 catalytic subunit precursor CAPN2 IPI00001568 Vacuolar proton pump subunit D ATP6V1D IPI00465177 Transforming growth factor-alpha variant I TGFA IPI00020470 Isoform 1 of Glycosyltransferase 8 domain-containing GLT8D1 protein 1 IPI00718821 Isoform 1 of Uncharacterized protein C19orf55 C19orf55 IPI00018387 Furin precursor FURIN IPI00398229 similar to deubiquitinating enzyme 3 LOC392197 IPI00027248 Tumor suppressor candidate 2 TUSC2 IPI00163851 Isoform 1 of Eukaryotic translation initiation factor 2-alpha EIF2AK4 kinase 4 IPI00438286 Isoform 1 of Protein LAP2 ERBB2IP IPI00023780 Isoform 2 of DnaJ homolog subfamily C member 5 DNAJC5 IPI00018027 Isoform 1 of Angiogenic factor with G patch and FHA AGGF1 domains 1 IPI00180305 Isoform 5 of E3 ubiquitin-protein ligase UBR4 UBR4 IPI00010442 Phospholemman precursor FXYD1; FXYD7 IPI00292657 NADP-dependent leukotriene B4 12- LTB4DH hydroxydehydrogenase IPI00434711 Putative uncharacterized protein FP6679 — IPI00020329 Potassium voltage-gated channel subfamily S member 2 KCNS2 IPI00019244 Isoform 1 of RNA-binding protein Nova-1 NOVA1 IPI00009101 Isoform 2 of Helicase SRCAP SRCAP IPI00184650 Class B basic helix-loop-helix protein 4 BHLHB4 IPI00328298 Isoform 2 of Structural maintenance of chromosomes SMC4 protein 4 IPI00782992 Isoform 1 of Serine/arginine repetitive matrix protein 2 SRRM2 IPI00006663 Aldehyde dehydrogenase, mitochondrial precursor ALDH2 IPI00014340 Isoform 1 of Protein phosphatase 1 regulatory subunit 12C PPP1R12C IPI00807675 ZNF440 protein ZNF440 IPI00104050 Thyroid hormone receptor-associated protein 3 THRAP3 IPI00386284 olfactory receptor, family 2, subfamily AK, member 2 OR2AK2 IPI00411480 hypothetical protein LOC729461 IPI00018429 Paired mesoderm homeobox protein 2 PRRX2 IPI00646423 Isoform 2 of Transcription initiation factor TFIID subunit TAF4B 4B IPI00387004 PNAS-146 MCM7 IPI00446312 CDNA FLJ42271 fis, clone TKIDN2015788 — IPI00218667 Stathmin-2 STMN2 IPI00179298 482 kDa protein HUWE1 IPI00299547 Neutrophil gelatinase-associated lipocalin precursor LCN2 IPI00016006 Isoform 1 of Gephyrin GPHN IPI00395630 Putative uncharacterized protein pp6170 SCRIB IPI00009471 WD repeat-containing protein 3 WDR3 IPI00455967 Uncharacterized protein ENSP00000353619 (Fragment) — IPI00100067 Isoform 1 of Tumor necrosis factor receptor superfamily TNFRSF19 member 19 precursor IPI00299263 ADP-ribosylation factor GTPase-activating protein 3 ARFGAP3 IPI00186966 Isoform IIA of Myc box-dependent-interacting protein 1 BIN1 IPI00220308 Isoform 2 of Merlin NF2 IPI00045939 2-aminoethanethiol dioxygenase ADO IPI00789476 7 kDa protein — IPI00014537 Isoform 1 of Calumenin precursor CALU IPI00165009 Isoform 3 of MBT domain-containing protein 1 MBTD1 IPI00306749 Kanadaptin SLC4A1AP IPI00001922 Suppressor of tumorigenicity protein 14 ST14 IPI00374670 hypothetical protein isoform 2 LOC388588 IPI00005809 Serum deprivation-response protein SDPR IPI00453473 Histone H4 HIST2H4A; HIST1H4E; HIST1H4H; HIST4H4; HIST1H4C; HIST1H4A; HIST1H4B; HIST1H4J; HIST1H4F; HIST1H4K; HIST1H4L; HIST2H4B; HIST1H4I; HIST1H4D IPI00464980 Isoform 1 of Paired amphipathic helix protein Sin3b SIN3B IPI00289837 Coiled-coil domain-containing protein 85A CCDC85A IPI00878962 10 kDa protein — IPI00103891 Putative uncharacterized protein MTMR14 IPI00328709 Gremlin-2 precursor GREM2 IPI00744932 Conserved hypothetical protein ZDHHC1 IPI00398154 actin filament associated protein 1 AFAP1 IPI00291939 Structural maintenance of chromosomes protein 1A SMC1A IPI00444272 Leukemia inhibitory factor receptor precursor LIFR IPI00641181 MARCKS-related protein MARCKSL1 IPI00022799 Isoform 2 of Aquaporin-4 AQP4 IPI00445750 CDNA FLJ43142 fis, clone CTONG3007870 — IPI00006077 Protein Jade-3 PHF16 IPI00151990 Isoform 1 of Thioredoxin domain-containing protein 15 TXNDC15 precursor IPI00061148 Sodium bicarbonate cotransporter NBC4d SLC4A5 IPI00004944 Isoform 1 of Sodium-driven chloride bicarbonate SLC4A10 exchanger IPI00304587 Protein dispatched homolog 2 DISP2 IPI00219703 Parvalbumin alpha PVALB IPI00003384 Isoform 1 of Cadherin EGF LAG seven-pass G-type CELSR1 receptor 1 precursor IPI00007750 Tubulin alpha-4A chain TUBA4A IPI00015988 HLA class I histocompatibility antigen, alpha chain G HLA-G precursor IPI00001813 Isoform 1 of RING and PHD-finger domain-containing KIAA1542 protein KIAA1542 IPI00171412 Isoform 1 of Sulfatase-modifying factor 2 precursor SUMF2 IPI00005981 Transgelin-3 TAGLN3 IPI00032826 Hsc70-interacting protein ST13 IPI00025447 Elongation factor 1-alpha EEF1A1 IPI00152326 glutathione S-transferase M1 isoform 2 GSTM1 IPI00044751 Isoform 1 of M-phase phosphoprotein 1 MPHOSPH1 IPI00028193 192 kDa protein KNDC1 IPI00000775 Isoform 1 of Leucine-rich repeats and immunoglobulin-like LRIG1 IPI00329593 Isoform 2 of ADP-dependent glucokinase ADPGK IPI00296461 Isoform 1 of Sphingomyelin phosphodiesterase precursor SMPD1 IPI00656052 SPANX-C SPANXB2; SPANXB1; SPANXF1 IPI00658109 Creatine kinase, ubiquitous mitochondrial precursor CKMT1A; CKMT1B IPI00376383 Centrosomal protein 110 kDa CEP110 IPI00019904 Isoform 1 of Beta-adducin ADD2 IPI00413266 Isoform 1 of IQ and AAA domain-containing protein IQCA IPI00015973 Band 4.1-like protein 2 EPB41L2 IPI00166807 Isoform 3 of Oxidation resistance protein 1 OXR1 IPI00472374 zinc finger protein 98 ZNF98 IPI00032187 nischarin NISCH IPI00420014 Isoform 1 of U5 small nuclear ribonucleoprotein 200 kDa ASCC3L1 helicase IPI00386314 FLJ00064 protein (Fragment) CNDP2 IPI00021766 Isoform 1 of Reticulon-4 RTN4 IPI00221006 Isoform 4 of Transcription factor 7-like 2 TCF7L2

indicates data missing or illegible when filed

TABLE 7L Table 7L. Qualitative List of CSF Proteins Identified (Present) in Patients with Neurologic Lyme disease and not found in True Normals or Chronic Fatigue. All with with immunoaffinity depletion. 692 proteins in list. CleanIPI Protein Gene IPI00551062 Isoform 1 of Protein canopy homolog 3 precursor CNPY3 IPI00017551 Isoform 1 of Regucalcin RGN IPI00006663 Aldehyde dehydrogenase, mitochondrial precursor ALDH2 IPI00412977 Prothymosin alpha — IPI00384280 Prenylcysteine oxidase 1 precursor PCYOX1 IPI00247295 Isoform 4 of Nesprin-1 SYNE1 IPI00007800 Angiopoietin-related protein 2 precursor ANGPTL2 IPI00553215 V1-5 protein IGLV2-18 IPI00002707 Isoform 1 of Spastin SPAST IPI00005563 Isoform 1 of Tubulointerstitial nephritis antigen-like precursor TINAGL1 IPI00827486 Rheumatoid factor light chain variable region precursor (Fragment) — IPI00004671 Golgin subfamily B member 1 GOLGB1 IPI00465345 Isoform 3 of Pre-mRNA-processing factor 40 homolog B PRPF40B IPI00010130 Glutamine synthetase GLUL IPI00477763 Serine/threonine-protein kinase MRCK beta CDC42BPB IPI00328268 EIF4G3 protein EIF4G3 IPI00305477 Cystatin-SN precursor CST1 IPI00070070 Novel protein FLJ32784 IPI00852619 Isoform A of Probable phospholipid-transporting ATPase VB ATP10B IPI00000203 Low-density lipoprotein receptor-related protein 6 precursor LRP6 IPI00021473 59 kDa protein CBFA2T3 IPI00016703 24-dehydrocholesterol reductase precursor DHCR24 IPI00028881 NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 3 NDUFA3 IPI00152157 Isoform 1 of Zinc finger protein 509 ZNF509 IPI00328825 Isoform 1 of NEDD4-binding protein 2 N4BP2 IPI00060569 Isoform 2 of Abhydrolase domain-containing protein 12 ABHD12 IPI00412298 Isoform 1 of Serine/threonine-protein kinase ATR ATR IPI00166465 hypothetical protein LOC221416 C6orf223 IPI00019517 Wilms tumor 1 isoform D WT1 IPI00007074 Tyrosyl-tRNA synthetase, cytoplasmic YARS IPI00514533 Uncharacterized protein SYCP2L SYCP2L IPI00166043 Isoform 2 of Progestin and adipoQ receptor family member 6 PAQR6 IPI00018953 Dipeptidyl peptidase 4 DPP4 IPI00554711 Junction plakoglobin JUP IPI00020230 Frizzled-9 precursor FZD9 IPI00377214 Isoform 2 of NLR family member X1 NLRX1 IPI00054521 Frizzled-1 precursor FZD1 IPI00387161 Ig lambda chain V-I region VOR — IPI00219563 Isoform A of 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase PLCB1 beta-1 IPI00303622 Olfactory receptor OR9-23 OR1N2 IPI00220308 Isoform 2 of Merlin NF2 IPI00022799 Isoform 2 of Aquaporin-4 AQP4 IPI00001813 Isoform 1 of RING and PHD-finger domain-containing protein KIAA1542 KIAA1542 IPI00152733 FLJ00237 protein (Fragment) OLFML2A IPI00030360 RUN domain-containing protein 2A RUNDC2A IPI00010334 Isoform 3 of Inactive phospholipase C-like protein 2 PLCL2 IPI00441952 Isoform 1 of Ninein NIN IPI00021772 S-adenosylmethionine synthetase isoform type-1 MAT1A IPI00332371 Isoform 1 of 6-phosphofructokinase, liver type PFKL IPI00005530 FMRFamide-related peptides precursor NPVF IPI00784272 Putative uncharacterized protein — IPI00004101 Betaine--homocysteine S-methyltransferase 1 BHMT IPI00514551 OTTHUMP00000016936 SCML4 IPI00167228 CDNA FLJ40966 fis, clone UTERU2012407 CHCHD7 IPI00218687 Isoform 10 of Voltage-dependent T-type calcium channel subunit alpha- CACNA1G 1G IPI00853079 Isoform 1 of Uncharacterized protein C14orf166B C14orf166B IPI00008403 Carbohydrate sulfotransferase 7 CHST7 IPI00787765 similar to solute carrier family 35, member F4 SLC35F4 IPI00386119 Isoform 5 of Splicing factor 1 SF1 IPI00418614 67 kDa protein — IPI00017231 Neurensin-2 NRSN2 IPI00022290 Beta-defensin 1 precursor DEFB1 IPI00884399 RNA-directed DNA polymerase (Reverse transcriptase), related domain — containing protein — IPI00003377 Isoform 1 of Splicing factor, arginine/serine-rich 7 SFRS7 IPI00010859 cortistatin preproprotein CORT; APITD1 IPI00220412 S100 calcium binding protein A1 S100A1 IPI00031195 Isoform 1 of Vang-like protein 1 VANGL1 IPI00658109 Creatine kinase, ubiquitous mitochondrial precursor CKMT1A; CKMT1B IPI00852669 Zinc finger protein 516 ZNF516 IPI00017297 Matrin-3 MATR3 IPI00470812 Putative uncharacterized protein DKFZp781E21107 LOC339977 IPI00556381 Putative uncharacterized protein (Fragment) TRIM16 IPI00004569 Isoform MZF1A of Myeloid zinc finger 1 MZF1 IPI00240059 Transmembrane and coiled-coil domains protein 3 TMCC3 IPI00004838 Isoform Crk-II of Proto-oncogene C-crk CRK IPI00748733 Similar to Slit homolog 3 protein precursor — IPI00023919 26S protease regulatory subunit 8 PSMC5 IPI00007423 Isoform 1 of Acidic leucine-rich nuclear phosphoprotein 32 family ANP32B member B IPI00020005 Arylsulfatase E precursor ARSE IPI00015181 Integrin alpha-9 precursor ITGA9 IPI00847415 Isoform 4 of Dual specificity protein kinase CLK3 CLK3 IPI00063245 Uncharacterized protein FUBP3 FUBP3 IPI00012079 Eukaryotic translation initiation factor 4B EIF4B IPI00005793 AP-3 complex subunit beta-2 AP3B2 IPI00410391 Isoform 1 of Major facilitator superfamily domain-containing protein 2 MFSD2 IPI00016940 Phospholipid scramblase 2 PLSCR2 IPI00829915 similar to PR domain zinc finger protein 16 LOC647868 IPI00455731 Protein FAM26F FAM26F IPI00414927 Transmembrane and immunoglobulin domain-containing protein C1orf32 C1orf32 IPI00871458 39 kDa protein C10orf4 IPI00101299 C1GALT1-specific chaperone 1 CIGALT1C1 IPI00760941 Uncharacterized protein ENSP00000371687 DKFZp434J1015 IPI00514966 Recombining binding protein suppressor of hairless RBPJL IPI00240909 similar to eukaryotic translation initiation factor 3, subunit 5 epsilon, hCG_15200 47 kDa isoform 1 IPI00217899 RING finger protein 168 RNF168 IPI00152462 Ciliary dynein heavy chain 3 DNAH3 IPI00004509 Leukotriene C4 synthase LTC4S IPI00884371 Uncharacterized protein ENSP00000383215 — IPI00002881 Bcl-2-related protein A1 BCL2A1 IPI00065352 Isoform 1 of Uncharacterized serine/threonine-protein kinase SgK494 FLJ25006 IPI00000388 Zinc finger protein 175 ZNF175 IPI00394807 Regenerating islet-derived protein 3 gamma precursor REG3G IPI00022830 Isoform 2 of NSFL1 cofactor p47 NSFL1C IPI00065388 Isoform 1 of Coiled-coil domain-containing protein 17 CCDC17 IPI00289540 Isoform 2 of Usherin precursor USH2A IPI00748216 CDNA FLJ20187 fis, clone COLF0433 GTF3C5 IPI00022143 Isoform 1 of Extended-synaptotagmin-1 FAM62A IPI00023663 Putative transcription factor Ovo-like 1 OVOL1 IPI00015602 Mitochondrial precursor proteins import receptor TOMM70A IPI00072377 Isoform 1 of Protein SET SET IPI00011604 Glycine cleavage system H protein, mitochondrial precursor GCSH; LOC730107 IPI00401586 Chromosome 18 open reading frame 62 C18orf62 IPI00026492 2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial precursor GCAT IPI00644529 Isoform 2 of Zinc finger protein 615 ZNF615 IPI00028880 Putative DNA polymerase POLN IPI00014878 Uncharacterized protein PRKD1 PRKD1 IPI00794791 Isoform 2 of IQ domain-containing protein D IQCD IPI00009853 Vomeronasal type-1 receptor 1 VN1R1 IPI00022250 Lymphocyte antigen 96 precursor LY96 IPI00004337 Zinc finger and BTB domain-containing protein 11 ZBTB11 IPI00005708 Heparan sulfate glucosamine 3-O-sulfotransferase 3B1 HS3ST3B1 IPI00169430 Isoform 1 of Spermatid perinuclear RNA-binding protein STRBP IPI00007057 Rabenosyn-5 ZFYVE20 IPI00386822 Putative uncharacterized protein (Fragment) TGFBI IPI00477539 Uncharacterized protein C14orf102 C14orf102 IPI00006648 IDN4-GGTR14 protein RABGAP1L IPI00302176 Isoform 1 of H/ACA ribonucleoprotein complex subunit 1 NOLA1 IPI00478586 Isoform 2 of Vacuolar protein sorting-associated protein 13A VPS13A IPI00060439 KIAA0226 protein KIAA0226 IPI00303343 Splicing factor, arginine/serine-rich 19 SCAF1 IPI00869070 Ankyrin repeat containing protein — IPI00783186 Isoform 2 of Ankyrin repeat domain-containing protein 17 ANKRD17 IPI00303152 collagen, type XXII, alpha 1 COL22A1 IPI00423379 Putative uncharacterized protein DKFZp686G24192 C20orf96 IPI00025308 Homeobox protein prophet of Pit-1 PROP1 IPI00219358 Isoform 1 of Mannose-6-phosphate isomerase MPI IPI00307757 Isoform 1 of Membrane-associated phosphatidylinositol transfer protein 3 PITPNM3 IPI00166738 Zinc-binding alcohol dehydrogenase domain-containing protein 2 ZADH2 IPI00446355 CDNA FLJ41803 fis, clone NHNPC2002749 IER5L IPI00167861 Protein SMG5 SMG5 IPI00472171 RPL7 protein RPL7 IPI00187091 Isoform 2 of MAP kinase-interacting serine/threonine-protein kinase 1 MKNK1 IPI00398421 Isoform 1 of Potassium channel subfamily T member 2 KCNT2 IPI00022228 Vigilin HDLBP IPI00034277 Isoform A of Probable cation-transporting ATPase 13A1 ATP13A1 IPI00152853 Isoform 1 of Phostensin KIAA1949 IPI00446785 CDNA FLJ41116 fis, clone BRACE1000572 IPI00411452 Uncharacterized protein DOCK11 DOCKI1 IPI00444395 CDNA FLJ45615 fis, clone BRTHA3026180 — IPI00019278 Thiamine transporter 2 SLC19A3 IPI00216132 Isoform Alpha I of Ribosomal protein S6 kinase beta-1 RPS6KB1 IPI00328115 Isoform 3 of 5′-3′ exoribonuclease 1 XRN1 IPI00022048 Prostaglandin F2 receptor negative regulator precursor PTGFRN IPI00103055 Isoform 1 of Solute carrier family 35 member F5 SLC35F5 IPI00167194 CDNA FLJ25694 fis, clone TST04471 FLJ25694 IPI00152536 Isoform 1 of Transmembrane channel-like protein 2 TMC2 IPI00783271 Leucine-rich PPR motif-containing protein, mitochondrial precursor LRPPRC IPI00150057 Isoform 2 of SWI/SNF-related matrix-associated actin-dependent SMARCC2 regulator of chromatin subfamily C member 2 IPI00456996 Conserved hypothetical protein PVT1 IPI00232891 Isoform 3 of Fibronectin type III domain-containing protein 1 FNDC1 IPI00018402 Tubulin-specific chaperone E TBCE IPI00030404 Transcriptional repressor NF-X1 NFX1 IPI00219661 Isoform 1 of Myelin proteolipid protein PLP1 IPI00186853 pecanex-like 2 PCNXL2 IPI00395376 Isoform 1 of Semaphorin-5B SEMA5B IPI00555621 p21-activated kinase 2 variant (Fragment) — IPI00746232 coiled-coil domain containing 112 isoform 2 CCDC112 IPI00022020 Type II inositol-3,4-bisphosphate 4-phosphatase INPP4B IPI00418236 Factor in the germline alpha FIGLA IPI00328762 Isoform 1 of ATP-binding cassette sub-family A member 13 ABCA13 IPI00748342 Beclin-1 BECN1 IPI00739423 similar to c11.1 CG12132-PA isoform 11 LOC377711 IPI00026970 FACT complex subunit SPT16 SUPT16H IPI00549384 Isoform 1 of Bromodomain-containing protein 9 BRD9 IPI00479893 Isoform 2 of Uncharacterized protein C10orf18 C10orf18 IPI00876910 Isoform 1 of Ankyrin repeat and SOCS box-containing protein 18 ASB18 IPI00477766 Isoform 3 of Protein PTHB1 BBS9 IPI00301503 Isoform 1 of Splicing factor, arginine/serine-rich 10 SFRS10 IPI00425688 Isoform 1 of RUN and SH3 domain-containing protein 1 RUSC1 IPI00787427 ankyrin repeat domain 36 ANKRD36 IPI00167241 Zinc finger protein 283 ZNF283 IPI00220325 Isoform Short of Insulin receptor precursor INSR IPI00032541 Keratin type II cuticular Hb5 KRT85 IPI00384874 Isoform 1 of ATP-binding cassette sub-family A member 10 ABCA10 IPI00019690 death-inducing-protein DIP IPI00027723 Elastase-2B precursor ELA2B IPI00015737 15 kDa protein DCAKD IPI00641954 22 kDa protein TMED5 IPI00739676 Isoform 2 of Protein DDX26B DDX26B IPI00402006 Similar to DNA-binding protein — IPI00477949 Isoform 1 of Zinc finger MYM-type protein 4 ZMYM4 IPI00737448 similar to heat shock 70 kD protein binding protein LOC338805 IPI00383261 Peroxin Pex6p PEX6 IPI00022735 Synaptotagmin-4 SYT4 IPI00026058 Isoform 1 of Leucine zipper putative tumor suppressor 1 LZTS1 IPI00479789 Isoform 1 of Uncharacterized protein C1orf103 C1orf103 IPI00411637 Galactose-3-O-sulfotransferase 4 GAL3ST4 IPI00154834 Isoform 1 of Neighbor of punc e11 precursor NOPE IPI00007360 Zinc finger protein 238 ZNF238 IPI00793585 57 kDa protein OC90 IPI00029133 ATP synthase subunit b, mitochondrial precursor ATP5F1 IPI00218271 Isoform 3 of MAGUK p55 subfamily member 2 MPP2 IPI00003949 Ubiquitin-conjugating enzyme E2 N UBE2N IPI00304992 Isoform 1 of Zinc finger protein 503 ZNF503 IPI00006612 Isoform 1 of Clathrin coat assembly protein AP180 SNAP91 IPI00642305 MCM8 protein MCM8 IPI00026320 E3 ubiquitin-protein ligase UBR5 UBR5 IPI00010142 Ubiquitin-conjugating enzyme E2 G2 UBE2G2 IPI00029769 Isoform p59-HCK of Tyrosine-protein kinase HCK HCK IPI00446138 CDNA FLJ42768 fis, clone BRAWH3003522 — IPI00449071 Isoform 5a of Paired box protein Pax-6 PAX6 IPI00432893 INPP5F protein (Fragment) INPP5F IPI00220039 Isoform 1 of Transmembrane protein 16K TMEM16K IPI00000270 Ribonuclease 7 precursor RNASE7 IPI00479430 Isoform 2 of Complement C1q tumor necrosis factor-related protein 9 C1QTNF9 precursor IPI00296798 Isoform 1 of Fibrinogen C domain-containing protein 1 FIBCD1 IPI00003483 Isoform 1 of Neuralized-like protein 1 NEURL IPI00419575 Protein of unknown function DUF410 family protein C7orf20 IPI00019090 Collagen alpha-1 COL19A1 IPI00011756 Homeobox protein Meis1 MEIS1 IPI00012687 27 kDa protein C1orf83 IPI00332106 Isoform 1 of Pre-B-cell leukemia transcription factor-interacting protein 1 PBXIP1 IPI00418426 Metal transporter CNNM4 CNNM4 IPI00002524 ATP-sensitive inward rectifier potassium channel 14 KCNJ14 IPI00000110 Zinc finger protein 337 ZNF337 IPI00297767 Casein kinase I isoform gamma-2 CSNK1G2 IPI00007207 Isoform 1 of Lysosomal acid lipase/cholesteryl ester hydrolase precursor LIPA IPI00023868 Canalicular multispecific organic anion transporter 1 ABCC2 IPI00031522 Trifunctional enzyme subunit alpha, mitochondrial precursor HADHA IPI00329142 Glutamate-rich protein 1 ERICH1 IPI00169253 Olfactory receptor OR1-45 OR5AT1 IPI00045801 Flt3-interacting zinc finger protein 1 FIZ1 IPI00017802 Isoform 1 of Methylglutaconyl-CoA hydratase, mitochondrial precursor AUH IPI00384549 TTC31 protein (Fragment) TTC31 IPI00012756 Interferon-induced protein with tetratricopeptide repeats 5 IFIT5 IPI00297985 Uncharacterized protein C6orf103 C6orf103 IPI00514394 Family with sequence similarity 120A opposite strand FAM120AOS IPI00034088 Interleukin-27 beta chain precursor EBI3 IPI00305856 Homeobox protein Hox-D11 HOXD11 IPI00797859 10 kDa protein LOC643711 IPI00385737 similar to Nonhistone chromosomal protein HMG-17 LOC646853 IPI00015195 Cleavage stimulation factor 77 kDa subunit CSTF3 IPI00006158 Lymphoid-restricted membrane protein LRMP IPI00008554 Angiogenin precursor ANG IPI00028158 Neurotensin/neuromedin N precursor NTS IPI00384393 Myosin-reactive immunoglobulin heavy chain variable region — (Fragment) IPI00021129 Isoform 1 of AP-3 complex subunit beta-1 AP3B1 IPI00013871 Ribonucleoside-diphosphate reductase large subunit RRM1 IPI00020039 Cylicin-1 CYLC1 IPI00737712 CCDC125 protein CCDC125 IPI00219036 dicer1 DICER1 IPI00297212 Paladin KIAA1274 IPI00418185 Putative uncharacterized protein FLJ20097 CCDC132 IPI00423562 Isoform 1 of Ubiquitin carboxyl-terminal hydrolase 6 USP6 IPI00008475 Hydroxymethylglutaryl-CoA synthase, cytoplasmic HMGCS1 IPI00412107 FLJ43980 protein FLJ43980 IPI00328793 Sterol regulatory element-binding protein 2 SREBF2 IPI00004563 Protein FAM105A FAM105A IPI00013257 Single-stranded DNA-binding protein 4 SSBP4 IPI00158804 basic, immunoglobulin-like variable motif containing BIVM IPI00166606 KIAA0913 protein (Fragment) KIAA0913 IPI00329014 Isoform 1 of Ankyrin repeat domain-containing protein 46 ANKRD46 IPI00395603 Isoform 3 of Uncharacterized protein C18orf34 C18orf34 IPI00303980 Isoform 1 of Uncharacterized protein C14orf93 precursor C14orf93 IPI00433499 rhomboid, veinlet-like 6 isoform 1 RHBDF2 IPI00006196 Isoform 2 of Nuclear mitotic apparatus protein 1 NUMA1 IPI00004446 Sushi repeat-containing protein SRPX2 precursor SRPX2 IPI00010448 Isoform 2 of Rho GTPase-activating protein 24 ARHGAP24 IPI00737392 similar to proline-rich protein BstNI subfamily 3 precursor LOC646352 IPI00219503 Isoform 1 of F-box only protein 24 FBXO24 IPI00414591 Flavoprotein oxidoreductase MICAL2 IPI00018240 Isoform 1 of Protein SDA1 homolog SDAD1 IPI00657892 Factor VIII F8 IPI00386651 LOC404266 protein LOC404266 IPI00166933 Uncharacterized protein C10orf12 C10orf12 IPI00005254 Isoform 1 of E3 ubiquitin-protein ligase parkin PARK2 IPI00065378 Isoform 1 of DC-STAMP domain-containing protein 1 DCST1 IPI00163718 Isoform 4 of Vacuolar protein sorting-associated protein 54 VPS54 IPI00414819 Helicase SKI2W SKIV2L IPI00041588 Ral guanine nucleotide exchange factor RalGPS1A RALGPS1 IPI00100787 RANBP2-like and GRIP domain-containing protein 7 RGPD5; RGPD7 IPI00873759 Uncharacterized protein ENSP00000381675 (Fragment) — IPI00012390 Homeobox protein Hox-D4 HOXD4 IPI00027694 Isoform 3 of Homeobox protein Hox-A1 HOXA1 IPI00747264 Gamma-aminobutyric-acid receptor subunit rho-1 precursor GABRR1 IPI00337544 Isoform 2 of Myomegalin PDE4DIP IPI00020795 R33083_1 (Fragment) DPP9 IPI00010740 Isoform Long of Splicing factor, proline- and glutamine-rich SFPQ IPI00019243 Isoform Long of Matrix metalloproteinase-16 precursor MMP16 IPI00749338 Hypothetical gene supported by BC063892 hCG_1651889 IPI00221009 Isoform 7 of Transcription factor 7-like 2 TCF7L2 IPI00398725 Isoform 1 of Zinc finger protein 644 ZNF644 IPI00745832 IQ calmodulin-binding region domain containing protein — IPI00007067 Golgi-associated plant pathogenesis-related protein 1 C9orf19 IPI00410616 Isoform 1 of Endonuclease VIII-like 2 NEIL2 IPI00005978 Splicing factor, arginine/serine-rich 2 SFRS2 IPI00844512 RHOV protein (Fragment) RHOV IPI00879389 20 kDa protein ZMYND11 IPI00329251 Isoform 1 of Transmembrane protein 146 precursor TMEM146 IPI00465087 Ubiquitin carboxyl-terminal hydrolase BAP1 BAP1 IPI00103812 PWWP domain-containing protein 2B PWWP2B IPI00010953 CDNA FLJ11251 fis, clone PLACE1008813 EXOC6 IPI00639924 97 kDa protein LOC374920 IPI00292579 Stabilin-2 precursor STAB2 IPI00067920 FXYD domain-containing ion transport regulator 7 FXYD7 IPI00879162 Uncharacterized protein ENSP00000374866 — IPI00009804 DNA-binding protein SATB1 SATB1 IPI00215925 Glycine N-methyltransferase GNMT IPI00006675 Multidrug resistance-associated protein 4 ABCC4 IPI00442551 CDNA FLJ26989 fis, clone SLV03395 ATP9B IPI00027436 Tumor necrosis factor receptor superfamily member 16 precursor NGFR IPI00166190 Isoform 1 of Uncharacterized protein C19orf19 C19orf19 IPI00154567 Isoform 2 of Spermatogenesis-associated protein 20 precursor SPATA20 IPI00008495 NADH-ubiquinone oxidoreductase chain 4 MT-ND4 IPI00179172 Isoform 2 of Liprin-beta-1 PPFIBP1 IPI00872928 Several ankyrin repeat protein transcript variant 2 (Fragment) ANKRD42 IPI00412647 CDNA: FLJ21792 fis, clone HEP00441 THADA IPI00032929 Isoform 1 of Thrombospondin type-1 domain-containing protein 1 THSD1 precursor IPI00154451 MMS19 nucleotide excision repair homolog MMS19 IPI00186145 Isoform 1 of Protein phosphatase 1L PPM1L IPI00386364 Olfactory receptor 2L2 OR2L2 IPI00218823 Isoform 1 of WW domain-binding protein 7 MLL4 IPI00060379 Integrator complex subunit 12 INTS12 IPI00444706 CDNA FLJ45007 fis, clone BRAWH3012005 KALRN IPI00216710 Isoform 1 of Nuclear receptor ROR-gamma RORC IPI00411690 Isoform 3 of La-related protein 1 LARP1 IPI00295519 Isoform 1 of Uncharacterized protein C3orf17 C3orf17 IPI00514153 transmembrane and tetratricopeptide repeat containing 4 isoform 1 TMTC4 IPI00398728 Isoform 1 of Retinitis pigmentosa 1-like 1 protein RP1L1 IPI00745775 Similar to PR domain containing 4 — IPI00013880 Semaphorin-5A precursor SEMA5A IPI00010157 S-adenosylmethionine synthetase isoform type-2 MAT2A IPI00794307 hypothetical protein LOC729505 IPI00015782 UPF0171 protein C16orf35 C16orf35 IPI00011652 Isoform Efs1 of Embryonal Fyn-associated substrate EFS IPI00413385 Inter-alpha-trypsin inhibitor heavy chain H5-like protein precursor ITIH5L IPI00022334 Ornithine aminotransferase, mitochondrial precursor OAT IPI00023617 Zinc finger protein 197 ZNF197 IPI00642798 Nucleolar autoantigen No55 SC65 IPI00383895 CDNA FLJ40559 fis, clone THYMU2002910 PRDM11 IPI00296803 30 kDa protein TCP11L2 IPI00168056 Zinc finger and BTB domain-containing protein 38 ZBTB38 IPI00026105 Isoform SCPx of Non-specific lipid-transfer protein SCP2 IPI00385255 Ig lambda chain V-II region NIG-84 — IPI00328178 Isoform 3 of TOM1-like protein 2 TOM1L2 IPI00027144 Cytochrome b561 CYB561 IPI00217688 Uncharacterized protein C12orf60 C12orf60 IPI00220126 Isoform EP2B of Sperm-associated antigen 11B precursor SPAG11B IPI00007757 Isoform 1 of Zinc finger protein Helios IKZF2 IPI00328400 Zygote arrest protein 1 ZAR1 IPI00465147 Isoform 1 of Uncharacterized protein C9orf97 C9orf97 IPI00333016 Isoform 3 of DnaJ homolog subfamily C member 11 DNAJC11 IPI00014897 Isoform 2 of 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase PLCB4 beta-4 IPI00181279 hypothetical protein LRRC37A4; LOC728863 IPI00011894 MRNA clone with similarity to L-glycerol-3-phosphate:NAD — oxidoreductase and albumin gene sequences IPI00794248 47 kDa protein — IPI00514774 Isoform 1 of PAB-dependent poly(A)-specific ribonuclease subunit 3 PAN3 IPI00307733 Isoform 1 of Histone-lysine N-methyltransferase SETD2 SETD2 IPI00218896 Alcohol dehydrogenase 1A ADH1A IPI00414973 FAST kinase domain-containing protein 5 FASTKD5 IPI00002441 Syndecan-1 precursor SDC1 IPI00413272 Isoform 3 of Mediator of RNA polymerase II transcription subunit 23 MED23 IPI00299853 Protocadherin beta 16 precursor PCDHB16 IPI00735857 similar to ATP-binding cassette sub-family D member 1 LOC651123 IPI00647254 7 kDa protein — IPI00328118 Sperm-associated antigen 5 SPAG5 IPI00094740 Isoform 1 of RING finger protein 31 RNF31 IPI00383318 PRO2272 — IPI00292470 dapper, antagonist of beta-catenin, homolog 2 DACT2 IPI00215884 Isoform ASF-1 of Splicing factor, arginine/serine-rich 1 SFRS1 IPI00013488 Isoform Alpha-2 of N-chimaerin CHN1 IPI00030909 BB1 family protein — IPI00552213 Isoform 6 of Disks large homolog 1 DLG1 IPI00397358 Similar to ribosomal protein S27 — IPI00021786 RAF proto-oncogene serine/threonine-protein kinase RAF1 IPI00003438 DnaJ homolog subfamily C member 8 DNAJC8 IPI00398900 Homeobox protein HMX2 HMX2 IPI00031960 polymerase (RNA) 1 polypeptide A, 194 kDa POLR1A IPI00298870 Transmembrane protein 1 TMEM1 IPI00017991 jumonji domain containing 2D JMJD2D IPI00151366 Isoform TRPM6a of Transient receptor potential cation channel TRPM6 subfamily M member 6 IPI00011488 Isoform 1 of Serine/threonine-protein kinase 4 STK4 IPI00101405 Farnesyl diphosphate synthase FDPS IPI00786867 Dual Intracellular Von Willebrand factor domain A DIVA IPI00006904 Cell death regulator Aven AVEN IPI00376213 Isoform 1 of G-protein coupled receptor 120 GPR120 IPI00010420 ADP/ATP translocase 4 SLC25A31 IPI00004419 Zinc finger protein 646 ZNF646 IPI00847409 hypothetical protein LOC440338 IPI00005024 Isoform 1 of Myb-binding protein 1A MYBBP1A IPI00177890 54 kDa protein SMARCD2 IPI00023635 Isoform 1 of Inositol monophosphatase 2 IMPA2 IPI00304885 Centromere protein C 1 CENPC1 IPI00784013 Janus kinase 1 JAK1 IPI00216139 Isoform I of Septin-6 SEPT6 IPI00289954 Heparan sulfate glucosamine 3-O-sulfotransferase 6 HS3ST6 IPI00018134 Isoform 4 of Protein SOLO FLJ10357 IPI00855742 sterile alpha motif domain containing 12 isoform a SAMD12 IPI00415037 Isoform 12L of ADAM 12 precursor ADAM12 IPI00411298 Connector enhancer of kinase suppressor of ras 3 CNKSR3 IPI00031288 Claudin-14 CLDN14 IPI00867582 Similar to SCAN domain-containing protein 2. Isoform 2 ZNF496 IPI00418885 Epididymal-specific lipocalin-10 precursor LCN10 IPI00795992 Hypothetical short protein — IPI00847373 hypothetical protein LOC54627 KIAA1383 IPI00030070 Gap junction beta-5 protein GJB5 IPI00418238 Isoform 1 of HIV-1 Rev-binding protein-like protein HRBL IPI00293409 Zinc finger protein 81 ZNF81 IPI00003927 40 kDa peptidyl-prolyl cis-trans isomerase PPID IPI00024801 E3 ubiquitin-protein ligase NRDP1 RNF41 IPI00103356 Uncharacterized protein ITGB2 ITGB2 IPI00604798 Bitter taste receptor T2R2 (Fragment) — IPI00013887 Beta-galactoside alpha-2,6-sialyltransferase 1 ST6GAL1 IPI00384971 hypothetical protein LOC643155 DKFZP686E2158 IPI00025721 COP9 signalosome complex subunit 3 COPS3 IPI00855747 hypothetical protein LOC57481 RP13- 347D8.3 IPI00445054 CDNA FLJ44715 fis, clone BRACE3021430 FLJ44715 IPI00220503 dynactin 2 DCTN2 IPI00328159 Isoform 1 of Uncharacterized protein C1orf88 C1orf88 IPI00003881 Heterogeneous nuclear ribonucleoprotein F HNRPF IPI00003990 Isoform 2 of Valacyclovir hydrolase precursor BPHL IPI00847485 Similar to PFIV protein — IPI00007300 BTB/POZ domain-containing protein 3 BTBD3 IPI00217490 Isoform 1 of Fibronectin type III domain-containing protein 3B FNDC3B IPI00848330 Conserved hypothetical protein LOC285144 IPI00000787 Isoform LMP2.L of Proteasome subunit beta type-9 precursor PSMB9 IPI00004379 Homeobox protein HMX1 HMX1 IPI00375820 Interferon-induced transmembrane protein 5 IFITM5 IPI00411635 180 kDa protein — IPI00795566 6 kDa protein — IPI00217117 Isoform 1 of Glycerate kinase GLYCTK IPI00300086 Nicotinate-nucleotide pyrophosphorylase QPRT IPI00235167 Profilin-3 PFN3 IPI00026126 Mammaglobin-B precursor SCGB2A1 IPI00220167 Isoform 1 of Putative methyltransferase NSUN7 NSUN7 IPI00155168 Leukocyte common antigen precursor (EC 3.1.3.48) (L-CA) (T200) PTPRC (CD45 antigen). Isoform 2 IPI00384268 XRCC6BP1 protein XRCC6BP1 IPI00299507 Condensin complex subunit 2 NCAPH IPI00445643 CDNA FLJ43684 fis, clone TBAES2001492 — IPI00165591 Isoform 4 of Transmembrane channel-like protein 6 TMC6 IPI00152149 CENP-B, N-terminal DNA-binding domain containing protein — IPI00029643 Isoform 2 of Mitogen-activated srotein kinase kinase kinase MLT ZAK IPI00000875 Elongation factor 1-gamma EEF1G IPI00215948 Isoform 1 of Catenin alpha-1 CTNNA1 IPI00022918 Isoform 2 of Protein FAM125B FAM125B IPI00007208 Probable ATP-dependent RNA helicase DDX41 DDX41 IPI00855922 Isoform 4 of DENN domain-containing protein 3 DENND3 IPI00031056 Zinc finger MYND domain-containing protein 15 ZMYND15 IPI00641614 47 kDa protein AKAP8L IPI00002134 26S proteasome non-ATPase regulatory subunit 5 PSMD5 IPI00056040 Neuritin 1-like NRN1L IPI00856045 AHNAK nucleoprotein 2 AHNAK2 IPI00009329 Utrophin UTRN IPI00218235 dehydrogenase/reductase member 2 isoform 2 DHRS2 IPI00297315 Alpha-2B adrenergic receptor ADRA2B IPI00107855 Hephaestin precursor HEPH IPI00217662 Uncharacterized protein C11orf35 C11orf35 IPI00025489 Serine/threonine-protein kinase MAK MAK IPI00027774 THAP domain-containing protein 2 THAP2 IPI00027415 Isoform 1 of Probable ATP-dependent RNA helicase DHX36 DHX36 IPI00176125 Collagen XXIX alpha 1 COL29A1 IPI00016046 Protein MGR2 homolog C20orf52 IPI00002841 Sodium/hydrogen exchanger 2 SLC9A2 IPI00472712 Coiled-coil domain containing 7 CCDC7 IPI00061355 Isoform 3 of Protein ZNF673 ZNF673 IPI00445804 Uncharacterized protein ENSP00000374264 DKFZp761B107 IPI00790813 8 kDa protein RAD51AP1 IPI00061780 Isoform 1 of E3 ubiquitin-protein ligase Itchy homolog ITCH IPI00030099 Adenylate cyclase type 9 ADCY9 IPI00016095 Transcription termination factor, mitochondrial precursor MTERF IPI00004521 Ewing's tumor-associated antigen 1 ETAA1 IPI00171525 Sentrin-specific protease 3 SENP3 IPI00373824 Testis serine protease 1 precursor TESSP1 IPI00299729 Transcobalamin-1 precursor TCN1 IPI00007444 Epiphycan precursor EPYC IPI00167014 EID2 protein (Fragment) EID2 IPI00007327 Isoform 1 of Tapasin precursor TAPBP IPI00244346 Troponin I, cardiac muscle TNNI3 IPI00009066 similar to protein tyrosine phosphatase, receptor type, Q isoform 1 PTPRQ precursor IPI00303195 Syncoilin-1 SYNC1 IPI00031812 Nuclease sensitive element-binding protein 1 YBX1 IPI00018854 Coiled-coil domain-containing protein 68 CCDC68 IPI00084582 Isoform 7 of Collagen alpha-1(XIII) chain COL13A1 IPI00216815 Isoform 2 of DNA topoisomerase 3-beta-1 TOP3B IPI00062599 71 kDa protein — IPI00060549 G-protein coupled receptor-associated sorting protein 1 GPRASP1 IPI00795943 7 kDa protein — IPI00642204 Thioredoxin domain-containing protein 16 precursor TXNDC16 IPI00646199 Zinc finger, MYM-type 2 ZMYM2 IPI00791447 Pseudogene candidate LOC339929 IPI00745433 eukaryotic translation initiation factor 2C, 2 EIF2C2 IPI00103090 Isoform 1 of RNA polymerase-associated protein LEO1 LEO1 IPI00101186 Isoform 1 of RRP12-like protein RRP12 IPI00013404 Mothers against decapentaplegic homolog 4 SMAD4 IPI00220038 Isoform B of Arsenite-resistance protein 2 ARS2 IPI00385683 Ig heavy chain V-III region GAR — IPI00006030 Dynein intermediate chain 1, axonemal DNAI1 IPI00024714 Isoform 1 of Regulator of G-protein signaling 12 RGS12 IPI00259671 Taste receptor type 2 member 44 TAS2R44 IPI00335581 Isoform 1 of E3 ubiquitin-protein ligase UBR3 UBR3 IPI00004416 Charged multivesicular body protein 2a CHMP2A IPI00028828 Isoform Beta of Zinc finger protein 202 ZNF202 IPI00514795 Isoform 1 of Tubulin--tyrosine ligase-like protein 7 TTLL7 IPI00101987 Uncharacterized protein C19orf62 C19orf62 IPI00853224 START domain containing 7 STARD7 IPI00001141 Mitochondrial import inner membrane translocase subunit Tim22 TIMM22 IPI00514975 Chromosome 1 open reading frame 133 C1orf133 IPI00744029 Similar to Zinc finger, FYVE domain containing 21 — IPI00399320 Transmembrane protein 59 precursor TMEM59 IPI00217687 Isoform 1 of Coiled-coil domain-containing protein 135 CCDC135 IPI00829745 Cellular titin isoform PEVK variant 2 (Fragment) — IPI00216544 Isoform 2 of Protein hairless HR IPI00646323 Isoform 1 of Uncharacterized protein C10orf76 C10orf76 IPI00386797 Isoform 1 of Folliculin-interacting protein 1 FNIP1 IPI00304589 Isoform 1 of 182 kDa tankyrase 1-binding protein TNKS1BP1 IPI00002857 Isoform CSBP2 of Mitogen-activated protein kinase 14 MAPK14 IPI00017630 Nuclear fragile X mental retardation-interacting protein 1 NUFIP1 IPI00019992 Myb-related protein A MYBL1 IPI00168848 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 B3GNT7 IPI00216917 Isoform 1 of Uncharacterized protein C22orf9 C22orf9 IPI00043499 Probable urocanate hydratase UROC1 IPI00056507 Isoform 1 of F-box/WD repeat-containing protein 5 FBXW5 IPI00017451 Splicing factor 3 subunit 1 SF3A1 IPI00465273 UHRF1-binding protein 1 UHRF1BP1 IPI00738999 similar to ubiquitin-conjugating enzyme E2 variant 1 LOC643227 IPI00031047 CDNA: FLJ23571 fis, clone LNG12303 IQCG IPI00022256 AP-2 complex subunit mu-1 AP2M1 IPI00151141 Isoform 1 of Serine/threonine-protein kinase WNK4 WNK4 IPI00027232 Insulin-like growth factor 1 receptor precursor IGF1R IPI00328748 Protein ARMET precursor ARMET IPI00553006 Probable prolyl-tRNA synthetase, mitochondrial precursor PARS2 IPI00102803 Ankyrin repeat domain-containing protein 22 ANKRD22 IPI00030153 Tudor domain-containing protein 6 TDRD6 IPI00010212 U6 snRNA-specific terminal uridylyltransferase 1 TUT1 IPI00844501 MG44 protein SUV39H1 IPI00456060 Protein — IPI00016480 Isoform 1 of NACHT, LRR and PYD domains-containing protein 2 NLRP2 IPI00411545 Isoform 3 of Thrombopoietin precursor THPO IPI00168239 Zinc finger protein GLIS1 GLIS1 IPI00165990 Isoform 4 of Transcription factor RFX4 RFX4 IPI00749489 fibrocystin L PKHD1L1 IPI00059144 Protein FAM46B FAM46B IPI00787697 similar to Oligophrenin 1 isoform 4 FLJ32810 IPI00043237 CDNA FLJ32095 fis, clone OCBBF2000998 LOC730193; STX6 IPI00028641 Isoform 4 of Protein phosphatase 1 regulatory subunit 12B PPP1R12B IPI00879159 9 kDa protein — IPI00018099 E3 ubiquitin-protein ligase FANCL FANCL IPI00455076 Double C2-like domain-containing protein alpha DOC2A IPI00295940 Protein unc-84 homolog B UNC84B IPI00002970 Beta-sarcoglycan SGCB IPI00878142 68 kDa protein — IPI00554488 cAMP-dependent protein kinase type I-beta regulatory subunit PRKAR1B IPI00030279 Isoform 1 of Zinc finger Ran-binding domain-containing protein 3 ZRANB3 IPI00074656 Isoform 1 of Coiled-coil domain-containing protein C6orf65 C6orf65 IPI00014903 Isoform 1 of FGFR1 oncogene partner 2 FGFR1OP2 IPI00011961 Isoform 1 of Sialoadhesin precursor SIGLEC1 IPI00170770 Isoform 1 of PHD finger protein 3 PHF3 IPI00000057 Conserved oligomeric Golgi complex component 2 COG2 IPI00435928 PP13187 RASGRF1 IPI00013721 Serine/threonine-protein kinase PRP4 homolog PRPF4B IPI00748607 Conserved hypothetical protein — IPI00021266 60S ribosomal protein L23a RPL23A; hCG_16001 IPI00031228 Isoform 2 of Pleckstrin homology domain-containing family B member 2 PLEKHB2 IPI00337415 Guanine nucleotide-binding protein G(i), alpha-1 subunit GNAI1 IPI00745396 Stromal RNA regulating factor HNRPLL IPI00604752 Isoform 3 of Sterile alpha motif domain-containing protein 13 SAMD13 IPI00382534 Ig heavy chain V-II region OU — IPI00008444 Isoform 1 of Cytidine and dCMP deaminase domain-containing protein 1 CDADC1 IPI00792933 zinc finger protein 462 ZNF462 IPI00402005 Similar to DNA-binding protein ZNF528 IPI00020036 Neuronal acetylcholine receptor subunit alpha-4 precursor CHRNA4 IPI00329054 Osteopetrosis-associated transmembrane protein 1 precursor OSTM1 IPI00028864 Neurexophilin-3 precursor NXPH3 IPI00023757 Isoform 1 of X-linked retinitis pigmentosa GTPase regulator RPGR IPI00000663 Isoform Mitochondrial of Malonyl-CoA decarboxylase, mitochondrial precursor MLYCD IPI00739387 hypothetical protein LOC401478 FLJ45872 IPI00164352 zinc finger protein 292 ZNF292 IPI00008913 Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5 ST6GALNAC 5 IPI00020454 Deoxycytidine kinase DCK IPI00514028 21 kDa protein RNF207 IPI00024292 Low-density lipoprotein receptor-related protein 2 precursor LRP2 IPI00028357 Exportin-4 XPO4 IPI00438355 Fibrillin-3 precursor FBN3 IPI00009043 Apoptotic-related protein PCAR (Fragment) — IPI00027442 Alanyl-tRNA synthetase, cytoplasmic AARS IPI00014845 Isoform 1 of Ciliary dynein heavy chain 8 DNAH8 IPI00385687 similar to Ubiquinol-cytochrome c reductase complex 14 kDa protein — IPI00794829 16 kDa protein ACADS IPI00216423 Isoform 4 of Intersectin-2 ITSN2 IPI00303870 Seven transmembrane helix receptor — IPI00848229 EGF, latrophilin and seven transmembrane domain-containing protein 1 ELTD1 precursor IPI00293857 Isoform 1A of Beta-arrestin-1 ARRB1 IPI00293565 fms-related tyrosine kinase 4 isoform 1 FLT4 IPI00022471 minor histocompatibility antigen HA-1 HMHA1 IPI00848252 hypothetical protein LOC285501 LOC285501 IPI00288939 Isoform 3 of Coiled-coil domain-containing protein 40 CCDC40 IPI00065057 Putative uncharacterized protein CXorf58 CXorf58 IPI00073769 48 kDa protein PALM2 IPI00065520 Isoform 1 of Protein phosphatase 1M PPM1M IPI00436518 Benzodiazepine receptor ligand — IPI00015345 Cadherin EGF LAG seven-pass G-type receptor 3 precursor CELSR3; SLC26A6 IPI00847391 Isoform 1 of Zinc finger protein 276 ZNF276 IPI00001654 Isoform 3 of Pericentriolar material 1 protein PCM1 IPI00028493 Isoform 1 of Tuberin TSC2 IPI00332583 chorionic somatomammotropin hormone 1 isoform 2 CSH1; CSH2; GH1 IPI00301844 Zinc fingers and homeoboxes protein 3 ZHX3 IPI00013788 HIV Tat-specific factor 1 HTATSF1 IPI00001151 Isoform 2 of Uncharacterized MFS-type transporter C20orf59 C20orf59 IPI00847237 Conserved hypothetical protein — IPI00295999 Isoform 2 of Collagen alpha-1(IX) chain precursor COL9A1 IPI00296196 Dimethylglycine dehydrogenase, mitochondrial precursor DMGDH IPI00396145 FYVE finger-containing phosphoinositide kinase PIP5K3 IPI00478110 Probable G-protein coupled receptor 135 GPR135 IPI00168995 Olfactory receptor 4D9 OR4D9 IPI00059190 Isoform 1 of SLAM family member 9 precursor SLAMF9 IPI00043467 Tigger transposable element-derived protein 1 TIGD1 IPI00235842 Zinc finger protein 483 ZNF483 IPI00220473 Isoform 2 of Calcium-transporting ATPase type 2C member 1 ATP2C1 IPI00382831 Cerebral protein-13 BAP1 IPI00477692 Uncharacterized protein ENSP00000330808 LOC131149 IPI00301583 Isoform 1 of Zinc finger protein 691 ZNF691 IPI00790447 12 kDa protein — IPI00829904 Uncharacterized protein ENSP00000374814 — IPI00020533 Protein BEX1 BEX1 IPI00376436 Isoform 4 of Vacuolar protein sorting-associated protein 13B VPS13B IPI00029162 Isoform 2 of Cell division cycle 2-like protein kinase 5 CDC2L5 IPI00065500 BRO1 domain-containing protein BROX C1orf58 IPI00740336 formin 1 FMN1 IPI00017203 Protein RMI1 homolog RMI1 IPI00293431 WUGSC:H_DJ0855D21.2 protein MGC70863 IPI00295400 Tryptophanyl-tRNA synthetase, cytoplasmic WARS IPI00444330 CDNA FLJ45693 fis, clone FEBRA2012625 — IPI00170509 Isoform 3 of Calcium/calmodulin-dependent protein kinase kinase 2 CAMKK2 IPI00017533 Cytochrome c oxidase subunit 3 MT-CO3 IPI00419922 Isoform 1 of IQ domain-containing protein E IQCE IPI00005710 Heparan sulfate glucosamine 3-O-sulfotransferase 2 HS3ST2 IPI00744872 Isoform 1 of Uncharacterized protein KIAA0423 KIAA0423 IPI00787412 similar to Protein C11orf2 LOC441616 IPI00168607 tetratricopeptide repeat domain 21A isoform 1 TTC21A IPI00419385 olfactory receptor, family 52, subfamily E, member 8 OR52E8 IPI00006236 Platelet-derived growth factor receptor-like protein precursor PDGFRL IPI00291796 BTB (POZ) domain containing 12 BTBD12 IPI00400795 54 kDa protein — IPI00031554 ATP-dependent RNA helicase DDX50 DDX50 IPI00023860 Nucleosome assembly protein 1-like 1 NAP1L1 IPI00375225 Olfactory receptor 2AE1 OR2AE1 IPI00235622 Isoform 3 of CUB domain-containing protein 1 precursor CDCP1 IPI00742031 similar to golgi autoantigen, golgin subfamily a, 8G LOC645137 IPI00221372 Isoform 2 of 1-acyl-sn-glycerol-3-phosphate acyltransferase beta AGPAT2 IPI00796972 62 kDa protein ETV5 IPI00010807 Frizzled-8 precursor FZD8 IPI00031410 FKBP12-rapamycin complex-associated protein FRAP1 IPI00019848 Isoform 1 of Host cell factor HCFC1 IPI00306611 TRAF-interacting protein TRAIP IPI00153031 Isoform 1 of Uncharacterized protein C17orf80 C17orf80 IPI00289097 Isoform 1 of Ras-GEF domain-containing family member 1B RASGEF1B IPI00425404 Isoform 1 of Kinesin-like protein KIF21A KIF21A IPI00477262 Uncharacterized protein TRIM41 (Fragment) TRIM41 IPI00030703 Motor neuron and pancreas homeobox protein 1 MNX1 IPI00025974 Charged multivesicular body protein 4b CHMP4B IPI00413655 ankyrin repeat domain 55 isoform 1 ANKRD55 IPI00026497 Isoform 1 of Poly [ADP-ribose] polymerase 2 PARP2 IPI00061206 Polyadenylate-binding protein 5 PABPC5 IPI00289758 Calpain-2 catalytic subunit precursor CAPN2 IPI00465177 Transforming growth factor-alpha variant I TGFA IPI00180305 Isoform 5 of E3 ubiquitin-protein ligase UBR4 UBR4 IPI00019244 Isoform 1 of RNA-binding protein Nova-1 NOVA1 IPI00009101 Isoform 2 of Helicase SRCAP SRCAP IPI00782992 Isoform 1 of Serine/arginine repetitive matrix protein 2 SRRM2 IPI00807675 ZNF440 protein ZNF440 IPI00104050 Thyroid hormone receptor-associated protein 3 THRAP3 IPI00411480 hypothetical protein LOC729461 IPI00646423 Isoform 2 of Transcription initiation factor TFIID subunit 4B TAF4B IPI00446312 CDNA FLJ42271 fis, clone TKIDN2015788 — IPI00179298 482 kDa protein HUWE1 IPI00016006 Isoform 1 of Gephyrin GPHN IPI00395630 Putative uncharacterized protein pp6170 SCRIB IPI00100067 Isoform 1 of Tumor necrosis factor receptor superfamily member 19 TNFRSF19 precursor IPI00789476 7 kDa protein — IPI00306749 Kanadaptin SLC4A1AP IPI00001922 Suppressor of tumorigenicity protein 14 ST14 IPI00464980 Isoform 1 of Paired amphipathic helix protein Sin3b SIN3B IPI00744932 Conserved hypothetical protein ZDHHC1 IPI00445750 CDNA FLJ43142 fis, clone CTONG3007870 — IPI00006077 Protein Jade-3 PHF16 IPI00061148 Sodium bicarbonate cotransporter NBC4d SLC4A5 IPI00004944 Isoform 1 of Sodium-driven chloride bicarbonate exchanger SLC4A10 IPI00304587 Protein dispatched homolog 2 DISP2 IPI00219703 Parvalbumin alpha PVALB IPI00656052 SPANX-C SPANXB2; SPANXB1; SPANXF1 IPI00413266 Isoform 1 of IQ and AAA domain-containing protein IQCA IPI00472374 zinc finger protein 98 ZNF98

TABLE 8l Table 8l. Proteins Absent in Neurologic Lyme disease but Present in Normals or Chronic Fatigue. 1597 Proteins IPI Protein Gene IPI00216704 Isoform 2 of Spectrin beta chain, erythrocyte SPTB IPI00022361 Band 3 anion transport protein SLC4A1 IPI00003921 Isoform 1 of Protein 4.1 EPB41 IPI00014592 Chondroadherin precursor CHAD IPI00028614 erythrocyte membrane protein band 4.2 isoform 2 EPB42 IPI00246058 PDCD6IP protein PDCD6IP IPI00027462 Protein S100-A9 S100A9 IPI00019502 Myosin-9 MYH9 IPI00005981 Transgelin-3 TAGLN3 IPI00024094 Rhesus blood group-associated glycoprotein RHAG IPI00251507 Isoform IB of Synapsin-1 SYN1 IPI00218345 Isoform 2 of Tubulin alpha-3C/D chain TUBA3C; TUBA3D; LOC654264 IPI00023576 Leucine-rich repeat transmembrane neuronal protein 2 precursor LRRTM2 IPI00871227 Isoform 1 of Hemicentin-1 precursor HMCN1 IPI00005652 Isoform 1 of WSC domain-containing protein 2 WSCD2 IPI00217466 Histone H1.3 HIST1H1D IPI00031789 Isoform 1 of Interleukin-1 receptor accessory protein precursor IL1RAP IPI00007102 Uncharacterized protein C17orf25 GLOD4 IPI00257508 Dihydropyrimidinase-related protein 2 DPYSL2 IPI00168520 Isoform 2 of Matrilin-2 precursor MATN2 IPI00410585 Isoform 1 of Crumbs homolog 2 precursor CRB2 IPI00217465 Histone H1.2 HIST1H1C IPI00217467 Histone H1.4 HIST1H1E IPI00007709 Isoform 1 of ADAM 28 precursor ADAM28 IPI00219930 Cellular retinoic acid-binding protein 1 CRABP1 IPI00302944 Isoform 4 of Collagen alpha-1(XII) chain precursor COL12A1 IPI00017567 Isoform Long of Endoglin precursor ENG IPI00005809 Serum deprivation-response protein SDPR IPI00022774 Transitional endoplasmic reticulum ATPase VCP IPI00028082 Reversion-inducing cysteine-rich protein with Kazal motifs precursor RECK IPI00219910 22 kDa protein — IPI00012510 EMILIN-2 precursor EMILIN2 IPI00029928 Elastin ELN IPI00472754 Polycystic kidney disease 1-related protein KIAA0319L IPI00441344 Beta-galactosidase precursor GLB1 IPI00396378 Isoform B1 of Heterogeneous nuclear ribonucleoproteins A2/B1 HNRNPA2B1 IPI00411656 Isoform 1 of Protein piccolo PCLO IPI00021347 Ubiquitin-conjugating enzyme E2 L3 UBE2L3 IPI00007047 Protein S100-A8 S100A8 IPI00024689 Aquaporin-1 AQP1 IPI00025812 Carbonic anhydrase-related protein 11 precursor CA11 IPI00646689 Thioredoxin domain-containing protein 17 TXNDC17 IPI00220281 Guanine nucleotide-binding protein G(o) subunit alpha 1 GNAO1 IPI00024067 Isoform 1 of Clathrin heavy chain 1 CLTC IPI00217005 Ankyrin repeat domain-containing protein 18A ANKRD18A IPI00294713 Isoform 1 of Mannan-binding lectin serine protease 2 precursor MASP2 IPI00004488 Vacuolar proton pump subunit F ATP6V1F IPI00007812 Vacuolar ATP synthase subunit B, brain isoform ATP6V1B2 IPI00219806 Protein S100-A7 S100A7 IPI00011865 Isoform 2 of Platelet-derived growth factor D precursor PDGFD IPI00009439 Synaptotagmin-1 SYT1 IPI00219682 Erythrocyte band 7 integral membrane protein STOM IPI00004047 Isoform 1 of Exostosin-2 EXT2 IPI00384016 Full-length cDNA 5-PRIME end of clone CS0DJ009YL13 of T cells DLST (Jurkat cell line) of Homo sapiens (Fragment) IPI00152524 Isoform 3 of Neuropilin and tolloid-like protein 1 precursor NETO1 IPI00552943 V1-11 protein IGLV1-36 IPI00031718 Isoform 1 of Ectonucleoside triphosphate diphosphohydrolase 4 ENTPD4 IPI00300623 Pro-MCH precursor PMCH IPI00008756 Isoform 1 of Bullous pemphigoid antigen 1, isoforms 1/2/3/4/5/8 DST (Fragment) IPI00002511 Cyclic AMP-dependent transcription factor ATF-6 alpha ATF6 IPI00216699 Isoform 2 of Unc-112-related protein 2 FERMT3 IPI00023942 Isoform 2 of Syndecan-3 SDC3 IPI00009396 Isoform 1 of Cannabinoid receptor 1 CNR1 IPI00426727 Isoform 1 of Methyl-CpG-binding domain protein 4 MBD4 IPI00018879 Alpha-L-iduronidase precursor IDUA IPI00788258 similar to lysyl oxidase-like 1 preproprotein LOXL1 IPI00019904 Isoform 1 of Beta-adducin ADD2 IPI00020407 Alpha-1,6-mannosylglycoprotein 6-beta-N- MGAT5 acetylglucosaminyltransferase A IPI00295767 Noelin-2 precursor OLFM2 IPI00216694 plastin 3 PLS3 IPI00306844 Corticotropin-releasing factor-binding protein precursor CRHBP IPI00024580 Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial MCCC1 precursor IPI00023191 Target of myb1 TOM1 IPI00005690 Matrilin-3 precursor MATN3 IPI00465261 Isoform 1 of Endoplasmic reticulum aminopeptidase 2 ERAP2 IPI00026546 Platelet-activating factor acetylhydrolase IB subunit beta PAFAH1B2 IPI00061354 Isoform 2 of Bromodomain adjacent to zinc finger domain protein 2B BAZ2B IPI00297779 T-complex protein 1 subunit beta CCT2 IPI00168920 collagen, type XXIV, alpha 1 COL24A1 IPI00003441 Isoform 1 of Protein C1orf9 precursor C1orf9 IPI00020692 Isoform 1 of Sodium channel protein type 3 subunit alpha SCN3A IPI00289862 Secernin-1 SCRN1 IPI00013945 Isoform 1 of Uromodulin precursor UMOD IPI00242905 Uncharacterized protein ENSP00000344689 (Fragment) — IPI00554752 cAMP-dependent protein kinase type II-beta regulatory subunit PRKAR2B IPI00293460 ATP-binding cassette sub-family A member 1 ABCA1 IPI00002966 Heat shock 70 kDa protein 4 HSPA4 IPI00298476 Isoform 1 of Gremlin-1 precursor GREM1 IPI00008202 Headcase protein homolog HECA IPI00306576 Arylsulfatase B precursor ARSB IPI00003391 Teneurin-1 ODZ1 IPI00178727 Novel protein C10orf79 IPI00029623 Proteasome subunit alpha type-6 PSMA6 IPI00171199 Isoform 2 of Proteasome subunit alpha type-3 PSMA3 IPI00020884 Plexin-A3 precursor PLXNA3 IPI00001872 Isoform 1 of Protocadherin gamma C3 precursor PCDHGC3; PCDHGA12 IPI00175989 Rho family guanine-nucleotide exchange factor MCF2L2 IPI00294619 Protein TFG TFG IPI00100154 Toll-interacting protein TOLLIP IPI00024976 Mitochondrial import receptor subunit TOM22 homolog TOMM22 IPI00012315 Nucleoside diphosphate kinase 3 NME3 IPI00879950 15 kDa protein — IPI00454695 Histone H2B type 2-C HIST2H2BC IPI00216348 Isoform 2C of Cytoplasmic dynein 1 intermediate chain 2 DYNC1I2 IPI00328826 Uncharacterized protein CADPS2 CADPS2 IPI00396961 Leucine-rich repeat and fibronectin type-III domain-containing LRFN5 protein 5 precursor IPI00026031 Uncharacterized protein C6orf72 precursor C6orf72 IPI00305833 Smu-1 suppressor of mec-8 and unc-52 protein homolog SMU1 IPI00550746 Nuclear migration protein nudC NUDC IPI00299116 Podocalyxin-like protein 1 precursor PODXL IPI00181743 Isoform 1 of BAI1-associated protein 3 BAIAP3 IPI00031907 Isoform 1 of Transmembrane protein 108 precursor TMEM108 IPI00749514 attractin-like 1 ATRNL1 IPI00024704 Uronyl 2-sulfotransferase UST IPI00419237 Isoform 1 of Cytosol aminopeptidase LAP3 IPI00021695 Isoform D of Plasma membrane calcium-transporting ATPase 1 ATP2B1 IPI00480159 inositol polyphosphate-5-phosphatase F INPP5F IPI00019901 Isoform 1 of Alpha-adducin ADD1 IPI00017163 Isoform 1 of E3 ubiquitin-protein ligase HECW2 HECW2 IPI00027464 Calcineurin subunit B isoform 1 PPP3R1 IPI00001568 Vacuolar proton pump subunit D ATP6V1D IPI00005776 Nucleotide-binding oligomerization domain-containing protein 1 NOD1 IPI00432707 Caspase-12 CASP12 IPI00106502 Kelch-like ECH-associated protein 1 KEAP1 IPI00746177 similar to Tubulin alpha-2 chain LOC730222 IPI00013272 Isoform 1 of Golgin subfamily A member 4 GOLGA4 IPI00043201 Centromere protein J CENPJ IPI00642259 Dystonin DST IPI00879575 71 kDa protein — IPI00004315 Sialic acid-binding Ig-like lectin 9 precursor SIGLEC9 IPI00005159 Actin-related protein 2 ACTR2 IPI00001755 Glypican-6 precursor GPC6 IPI00604430 Isoform 2 of Receptor expression-enhancing protein 2 REEP2 IPI00023315 Bone morphogenetic protein 3b precursor GDF10 IPI00219622 Proteasome subunit alpha type-2 PSMA2 IPI00328361 Seryl-tRNA synthetase, mitochondrial precursor SARS2 IPI00027248 Tumor suppressor candidate 2 TUSC2 IPI00021364 Properdin precursor CFP IPI00307612 Cadherin-20 precursor CDH20 IPI00383594 melanoma ubiquitous mutated protein MUM1 IPI00013281 Fukutin-related protein FKRP IPI00013978 Speckle-type POZ protein SPOP IPI00335946 Family with sequence similarity 120B FAM120B IPI00033600 Isoform 1 of Protein phosphatase 1 regulatory subunit 7 PPP1R7 IPI00216774 Cerebellin-2 CBLN2 IPI00152769 Isoform 1 of Trpc4-associated protein TRPC4AP IPI00647217 Superkiller viralicidic activity 2-like 2 SKIV2L2 IPI00027438 Flotillin-1 FLOT1 IPI00013933 Isoform DPI of Desmoplakin DSP IPI00003406 Isoform 1 of Drebrin DBN1 IPI00744811 Low-density lipoprotein receptor-related protein 5 precursor LRP5 IPI00465178 Isoform 1 of Vacuolar proton translocating ATPase 116 kDa subunit a ATP6V0A1 isoform 1 IPI00018275 Prion-like protein doppel precursor PRND IPI00046057 Isoform 2 of Syntaxin-binding protein 1 STXBP1 IPI00008580 Antileukoproteinase precursor SLPI IPI00003348 Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2 GNB2 IPI00008998 Protein tyrosine phosphatase-like protein PTPLAD1 PTPLAD1 IPI00847759 DENN domain-containing protein 4B DENND4B IPI00294910 Protein PARM-1 precursor DKFZP564O0823 IPI00008433 40S ribosomal protein S5 RPS5 IPI00827745 Isoform 1 of RNA-binding protein 24 RBM24 IPI00009532 4-aminobutyrate aminotransferase, mitochondrial precursor ABAT IPI00030876 diaphanous 1 isoform 2 DIAPH1 IPI00145805 Isoform 1 of TRAF2 and NCK-interacting protein kinase TNIK IPI00296374 Zinc finger protein-like 1 ZFPL1 IPI00373823 Cytochrome P450 26C1 CYP26C1 IPI00815893 Isoform 1 of Chromodomain-helicase-DNA-binding protein 2 CHD2 IPI00021907 Isoform 1 of Myelin basic protein MBP IPI00027626 T-complex protein 1 subunit zeta CCT6A IPI00398992 Isoform 1 of Chromodomain-helicase-DNA-binding protein 8 CHD8 IPI00215746 Fatty acid-binding protein, adipocyte FABP4 IPI00215914 ADP-ribosylation factor 1 ARF1 IPI00399180 Serine/threonine-protein kinase SBK1 SBK1 IPI00027547 Dermcidin precursor DCD IPI00445315 Protein FAM47C FAM47C IPI00746666 hypothetical protein LOC728262 IPI00290854 A-kinase anchor protein 3 AKAP3 IPI00604551 Isoform 1 of Cell division cycle-associated protein 7 CDCA7 IPI00787083 similar to peptidylprolyl isomerase A isoform 1 LOC256374 IPI00001712 Isoform 1 of Catenin alpha-3 CTNNA3 IPI00217831 Ankyrin repeat domain-containing protein 13A ANKRD13A IPI00024920 ATP synthase subunit delta, mitochondrial precursor ATP5D IPI00028520 Isoform 1 of NADH dehydrogenase [ubiquinone] flavoprotein 1, NDUFV1 mitochondrial precursor IPI00006746 Ermin ERMN IPI00003392 Transmembrane protein 5 TMEM5 IPI00186966 Isoform IIA of Myc box-dependent-interacting protein 1 BIN1 IPI00165009 Isoform 3 of MBT domain-containing protein 1 MBTD1 IPI00641181 MARCKS-related protein MARCKSL1 IPI00018342 Adenylate kinase isoenzyme 1 AK1 IPI00394712 Granulocyte inhibitory protein — IPI00141938 H2A histone family, member V isoform 2 H2AFV IPI00028786 Isoform 3 of Polycystin-1 precursor PKD1 IPI00299778 Serum paraoxonase/lactonase 3 PON3 IPI00456683 Isoform 3 of Transcription elongation factor SPT6 SUPT6H IPI00012391 Isoform Long of Adenomatous polyposis coli protein APC IPI00185088 immunoglobulin superfamily, member 11 isoform b IGSF11 IPI00152182 Isoform 1 of Kelch domain-containing protein 4 KLHDC4 IPI00033030 Protein ADRM1 ADRM1 IPI00185661 Ubiquitin carboxyl-terminal hydrolase 32 USP32 IPI00218292 Isoform Short of Ubiquitin fusion degradation protein 1 homolog UFD1L IPI00000104 Isoform 1 of mRNA-capping enzyme RNGTT IPI00514893 Disheveled-associated activator of morphogenesis 2 DAAM2 IPI00025363 Isoform 1 of Glial fibrillary acidic protein GFAP IPI00743898 Uncharacterized protein ENSP00000357890 (Fragment) — IPI00023359 Isoform 1 of Malonyl CoA-acyl carrier protein transacylase, MCAT mitochondrial precursor IPI00021274 Ephrin type-A receptor 8 precursor EPHA8 IPI00410013 Isoform 1 of Zinc finger CCCH domain-containing protein 3 ZC3H3 IPI00454910 Serine/threonine-protein kinase MRCK gamma CDC42BPG IPI00302133 Transient receptor potential cation channel subfamily V member 5 TRPV5 IPI00010207 Ubiquitin-fold modifier 1 precursor UFM1 IPI00018708 Isoform 2 of Centrosomal protein of 63 kDa CEP63 IPI00221034 Transcription factor RelB RELB IPI00215979 Bisphosphoglycerate mutase BPGM IPI00008274 Adenylyl cyclase-associated protein 1 CAP1 IPI00479083 Isoform 2 of Erythroid differentiation-related factor 1 C10orf137 IPI00168885 Isoform 1 of Putative ATP-dependent RNA helicase DHX57 DHX57 IPI00748955 platelet glycoprotein Ib alpha polypeptide precursor GP1BA IPI00024853 Isoform 1 of Periaxin PRX IPI00307591 Zinc finger protein 609 ZNF609 IPI00375881 Polycystic kidney disease 1-like protein 3 PKD1L3 IPI00217652 Isoform 1 of Glycosyltransferase 8 domain-containing protein 3 GLT8D3 IPI00219525 6-phosphogluconate dehydrogenase, decarboxylating PGD IPI00306884 CDNA FLJ11867 fis, clone HEMBA1006976, weakly similar to ST3GAL4 H. sapiens Gal-beta(1-3/1-4)GlcNAc alpha-2.3-sialyltransferase IPI00005158 Lon protease homolog, mitochondrial precursor LONP1 IPI00013319 Isoform 2 of 43 kDa receptor-associated protein of the synapse RAPSN IPI00290857 Keratin, type II cytoskeletal 3 KRT3 IPI00216049 Isoform 1 of Heterogeneous nuclear ribonucleoprotein K HNRPK IPI00014398 Four and a half LIM domains 1 variant FHL1 IPI00001863 Wnt inhibitory factor 1 precursor WIF1 IPI00218465 Phospholipase A-2-activating protein PLAA IPI00045839 Isoform 3 of Prolyl 3-hydroxylase 1 precursor LEPRE1 IPI00218730 Rod cGMP-specific 3′,5′-cyclic phosphodiesterase subunit alpha PDE6A IPI00301465 14-3-3-associated AKT substrate HJURP IPI00011781 Ankyrin repeat-containing protein C20orf86 precursor C20orf86 IPI00002459 annexin VI isoform 2 ANXA6 IPI00025311 Isoform 1 of Breast carcinoma-amplified sequence 1 BCAS1 IPI00021048 Isoform 1 of Myoferlin FER1L3 IPI00027744 Isoform 1 of Mineralocorticoid receptor NR3C2 IPI00029591 P-selectin glycoprotein ligand 1 precursor SELPLG IPI00026230 Heterogeneous nuclear ribonucleoprotein H2 HNRPH2 IPI00009365 COX16-like protein C14orf112, mitochondrial precursor C14orf112 IPI00170766 Isoform 2 of Protein CASC5 CASC5 IPI00741005 similar to MAX-interacting protein isoform 4 MGA IPI00853400 Isoform 1 of FK506-binding protein 15 FKBP15 IPI00867509 Coronin-1C_i3 protein CORO1C IPI00290078 keratin 4 KRT4 IPI00216592 Isoform C1 of Heterogeneous nuclear ribonucleoproteins C1/C2 HNRNPC IPI00017529 Isoform 1 of Lymphocyte function-associated antigen 3 precursor CD58 IPI00011592 Cytoplasmic dynein 1 light intermediate chain 2 DYNC1LI2 IPI00006470 Neuron-specific protein family member 2 HMP19 IPI00165229 proprotein convertase subtilisin/kexin type 5 preproprotein PCSK5 IPI00845229 Isoform 2 of DEP domain-containing protein 2 DEPDC2 IPI00221255 Isoform 2 of Myosin light chain kinase, smooth muscle MYLK IPI00297550 Coagulation factor XIII A chain precursor F13A1 IPI00304789 27 kDa protein TTLL9 IPI00792759 73 kDa protein THSD4 IPI00446588 Isoform 2 of Plexin-A4 precursor PLXNA4 IPI00419836 Isoform 1 of Discoidin, CUB and LCCL domain-containing protein 2 DCBLD2 precursor IPI00160369 PRKCA-binding protein PICK1 IPI00002478 Isoform B of Endothelin-converting enzyme 1 ECE1 IPI00642645 Methylenetetrahydrofolate reductase MTHFR IPI00017964 Small nuclear ribonucleoprotein Sm D3 SNRPD3 IPI00478640 Isoform 1 of Transmembrane protein C17orf87 C17orf87 IPI00013290 hepatoma-derived growth factor-related protein 2 isoform 1 HDGF2 IPI00011051 T-cell leukemia homeobox protein 1 TLX1 IPI00830051 Similar to Immunolgoobulin heavy chain LOC90925 IPI00550720 Isoform 1 of Uncharacterized protein C19orf57 C19orf57 IPI00103510 Relaxin receptor 2 RXFP2 IPI00373872 polycystin 1-like 2 isoform a PKD1L2 IPI00328522 KTEL motif-containing protein 1 KTELC1 IPI00000811 Proteasome subunit beta type-6 precursor PSMB6 IPI00251596 Isoform 1 of Collagen alpha-1(XXIII) chain COL23A1 IPI00550906 Cleavage stimulation factor 64 kDa subunit, tau variant CSTF2T IPI00045219 Sorting nexin-18 SNAG1 IPI00221235 nucleoporin 160 kDa NUP160 IPI00167560 PAP-associated domain-containing protein 4 PAPD4 IPI00005719 Isoform 1 of Ras-related protein Rab-1A RAB1A IPI00098902 2-oxoglutarate dehydrogenase E1 component, mitochondrial precursor OGDH IPI00289271 Liprin-alpha-2 PPFIA2 IPI00216470 Isoform 1 of Phosphatidylinositol-5-phosphate 4-kinase type-2 beta PIP4K2B IPI00744825 Conserved hypothetical protein — IPI00005675 NF-kappa-B-repressing factor NKRF IPI00218628 Isoform 2 of Integrin alpha-IIb precursor ITGA2B IPI00217989 Isoform 1 of Protein-associating with the carboxyl-terminal domain of SCYL3 ezrin IPI00217405 Isoform 1 of E3 ubiquitin-protein ligase UBR1 UBR1 IPI00217258 CCDC100 protein CCDC100 IPI00456670 Isoform 13 of Peroxisomal N(1)-acetyl-spermine/spermidine oxidase PAOX IPI00186621 Orofacial clefting chromosomal breakpoint region 1 OFCC1 IPI00295098 Signal recognition particle receptor subunit beta SRPRB IPI00071824 Isoform 1 of Cytoskeleton-associated protein 2 CKAP2 IPI00747494 Glutamate receptor delta-2 subunit precursor GRID2 IPI00879409 28 kDa protein — IPI00169259 Small VCP/p97-interacting protein SVIP IPI00106506 Isoform 1 of Evolutionarily conserved signaling intermediate in Toll ECSIT pathway, mitochondrial precursor IPI00006900 Something about silencing protein 10 UTP3- IPI00472332 similar to polyhomeotic 1-like isoform 4 LOC653441 IPI00789245 Isoform 2 of Probable organic cation transporter protein C6orf85 SLC22A23 IPI00291922 Proteasome subunit alpha type-5 PSMA5 IPI00152145 Protein odd-skipped-related 1 OSR1 IPI00021770 Isoform 1 of 3-hydroxy-3-methylglutaryl-coenzyme A reductase HMGCR IPI00465045 DIP2 disco-interacting protein 2 homolog B DIP2B IPI00018803 homeobox D12 HOXD12 IPI00021594 Isoform 1 of Glycosylphosphatidylinositol anchor attachment 1 GPAA1 protein IPI00010360 Isoform 1 of Collagen alpha-3(IV) chain precursor COL4A3 IPI00465044 Protein RCC2 RCC2 IPI00013847 Cytochrome b-c1 complex subunit 1, mitochondrial precursor UQCRC1 IPI00026665 Glutaminyl-tRNA synthetase QARS IPI00180386 Isoform GN-1L of Glycogenin-1 GYG1 IPI00167638 Isoform 1 of GTP-binding protein 10 GTPBP10 IPI00384861 lsoform 1 of ARF GTPase-activating protein GIT1 GIT1 IPI00296219 Glutaminase liver isoform, mitochondrial precursor GLS2 IPI00376087 putative binding protein 7a5 7A5 IPI00794679 Major histocompatibility complex, class I, B MICA; HLA-B; HLA- A; LOC730410; HLA-C; HLA- A29.1 IPI00008282 Isoform 1 of Calcium/calmodulin-dependent 3′,5′-cyclic nucleotide PDE1A phosphodiesterase 1A IPI00007277 Isoform 1 of Leucine-rich repeat flightless-interacting protein 2 LRRFIP2 IPI00294519 Isoform 1 of Telomerase protein component 1 TEP1 IPI00179589 Myotrophin MTPN IPI00031485 Mitochondrial ribosomal protein 63 MRP63 IPI00429191 Eukaryotic peptide chain release factor subunit 1 ETF1 IPI00514594 Isoform 1 of Protein FAM5B precursor FAM5B IPI00853376 additional sex combs like 3 ASXL3 IPI00216914 Vitelline membrane outer layer protein 1 homolog precursor VMO1 IPI00166010 Isoform 1 of CCR4-NOT transcription complex subunit 1 CNOT1 IPI00399252 Isoform 1 of Protein Jade-1 PHF17 IPI00144243 Human immunodeficiency virus type I enhancer-binding protein 2 HIVEP2 IPI00291463 Radical S-adenosyl methionine domain-containing protein 2 RSAD2 IPI00007040 Zinc finger protein 222 ZNF222 IPI00220578 Guanine nucleotide-binding protein G GNAI3 IPI00740191 similar to Forkhead box protein L1 LOC651986 IPI00044607 Protein phosphatase inhibitor 2-like protein 1 PPP1R2P1 IPI00301923 Isoform 1 of Cell division protein kinase 9 CDK9 IPI00255145 hypothetical protein LOC342346 IPI00010737 Thrombomodulin precursor THBD IPI00030319 Forkhead box protein F2 FOXF2 IPI00168806 Isoform 1 of Myeloid/lymphoid or mixed-lineage leukemia protein 3 MLL3 homolog IPI00015285 Ethanolamine-phosphate cytidylyltransferase PCYT2 IPI00302850 Small nuclear ribonucleoprotein Sm D1 SNRPD1 IPI00478124 61 kDa protein UCKL1 IPI00013681 N-terminally extended type 3 canonical transient receptor potential TRPC3 channel IPI00019208 Similar to 60S ribosomal protein L29 — IPI00012895 Isoform 1 of Carbonic anhydrase 12 precursor CA12 IPI00023513 Isoform 1 of E3 ubiquitin-protein ligase CHFR CHFR IPI00025019 Proteasome subunit beta type-1 precursor PSMB1 IPI00166817 Zinc finger protein 561 ZNF561 IPI00375174 Ankyrin repeat and sterile alpha motif domain-containing protein 1B ANKS1B IPI00296866 interphotoreceptor matrix proteoglycan 2 IMPG2 IPI00040730 protocadherin 21 precursor PCDH21 IPI00013508 Alpha-actinin-1 ACTN1 IPI00644231 Isoform 1 of Cytoplasmic FMR1-interacting protein 1 CYFIPI IPI00013466 Arsenical pump-driving ATPase ASNA1 IPI00016605 Uncharacterized protein C1orf123 C1orf123 IPI00872861 PTD016 protein LOC51136 IPI00166619 Isoform 2 of Putative transporter SVOPL SVOPL IPI00796647 HIG1 domain family, member 1C HIGD1C IPI00852758 Similar to Ankyrin repeat domain-containing protein 26. Isoform 2 ANKRD18B IPI00023087 Ubiquitin-conjugating enzyme E2 T UBE2T IPI00161119 Isoform 1 of NF-kappa-B inhibitor beta NFKBIB IPI00016577 CDNA: FLJ22814 fis, clone KAIA3004 CD22 IPI00852633 16 kDa protein RABL2B IPI00163391 Isoform 1 of Putative methyltransferase METT10D METT10D IPI00299679 Isoform B of Ral guanine nucleotide dissociation stimulator-like 1 RGL1 IPI00797699 20 kDa protein — IPI00794119 13 kDa protein ABCC8 IPI00816274 Chemokine-like factor superfamily 1 transcript variant 26 CMTM1 IPI00171737 Isoform 2 of Leucine-rich repeat and death domain-containing protein LRDD IPI00385003 Putative transposase TIGD1 IPI00029123 Isoform A of Endothelin B receptor precursor EDNRB IPI00158992 snRNA-activating protein complex subunit 4 SNAPC4 IPI00184997 cDNA FLJ78771, highly similar to Homo sapiens discs, large DLG7 homolog 7 (Drosophila), mRNA IPI00001869 Pappalysin-1 precursor PAPPA IPI00027834 heterogeneous nuclear ribonucleoprotein L isoform a HNRNPL IPI00062730 Uncharacterized protein C16orf45 C16orf45 IPI00298258 UNC13B protein UNC13B IPI00744366 Conserved hypothetical protein — IPI00000792 Quinone oxidoreductase CRYZ IPI00008905 UDP-glucuronosyltransferase 2B15 precursor UGT2B15 IPI00186581 amplified in osteosarcoma isoform 2 precursor OS9 IPI00445364 CDNA FLJ44171 fis, clone THYMU2036058 — IPI00166071 B-cell CLL/lymphoma 6 member B protein BCL6B IPI00218130 Glycogen phosphorylase, muscle form PYGM IPI00034006 Tyrosine-protein phosphatase non-receptor type 23 PTPN23 IPI00419253 Isoform 1 of Nck-associated protein 5 NAP5 IPI00292393 Sodium channel protein type 4 subunit alpha SCN4A IPI00029012 Eukaryotic translation initiation factor 3 subunit A EIF3A IPI00385042 Nucleolar GTP-binding protein 1 GTPBP4 IPI00402144 Isoform 1 of Zinc finger protein 555 ZNF555 IPI00478986 Similar to 40S ribosomal protein S4 LOC126235 IPI00478521 lsoform 1 of UPF0475 protein RILPL1 IPI00025700 Isoform CD6A of T-cell differentiation antigen CD6 precursor CD6 IPI00061507 Isoform 3 of Ester hydrolase C11orf54 C11orf54 IPI00016949 Isoform 4 of Electrogenic sodium bicarbonate cotransporter 1 SLC4A4 IPI00031547 Desmoglein-3 precursor DSG3 IPI00382756 Isoform 2 of Pleiotropic regulator 1 PLRG1 IPI00743284 Methionine synthase MTR IPI00021363 Histone demethylase JARID1A JARID1A IPI00216683 M-phase inducer phosphatase 3 CDC25C IPI00737969 microtubule associated monoxygenase, calponin and LIM domain MICAL3 containing 3 IPI00015522 Growth/differentiation factor 5 precursor GDF5 IPI00877084 Isoform 1 of Coiled-coil domain-containing protein 144C CCDC144C IPI00060265 Zinc finger protein 775 ZNF775 IPI00024802 TATA-binding protein-associated factor 172 BTAF1 IPI00374039 Conserved hypothetical protein C1orf189 IPI00442121 delta-aminolevulinic acid dehydratase isoform a ALAD IPI00013455 CLIP1 protein CLIP1 IPI00026299 Isoform Glycophorin C of Glycophorin-C GYPC IPI00845508 BAH domain and coiled-coil containing 1 BAHCC1 IPI00745300 31 kDa protein NAT11 IPI00186826 Ephrin receptor EPHB4 IPI00787932 similar to zinc finger protein 10 hCG_1646157 IPI00166161 Protein SIX6OS1 C14orf39 IPI00180426 Isoform 3 of G protein-coupled receptor kinase 4 GRK4 IPI00013219 Integrin-linked protein kinase ILK IPI00796906 8 kDa protein ABCF3 IPI00028932 Microtubule-associated serine/threonine-protein kinase 3 MAST3 IPI00387159 Isoform 1 of Inhibitor of growth protein 3 ING3 IPI00645089 Kv channel interacting protein 1 isoform 3 KCNIP1 IPI00412216 vacuolar protein sorting 13C protein isoform 2B VPS13C IPI00374862 Isoform 1 of Kelch-like protein 5 KLHL5 IPI00009377 HSPC212 C3orf19 IPI00005969 F-actin-capping protein subunit alpha-1 CAPZA1 IPI00300244 zinc finger, CW type with PWWP domain 1 ZCWPW1 IPI00333410 Isoform 1 of Ubiquitin-conjugating enzyme E2 Q1 UBE2Q1 IPI00218075 Protein FAM9B FAM9B IPI00252845 SYT9 protein SYT9 IPI00477361 10 kDa protein SDHALP1 IPI00397578 135 kDa protein PPFIA4 IPI00017659 Protein kinase substrate CapZIP RCSD1 IPI00025094 CDNA: FLJ22037 fis, clone HEP08868 (Fragment) MYH16 IPI00216963 Isoform 9 of CASP8 and FADD-like apoptosis regulator precursor CFLAR IPI00010895 Tubby-related protein 2 TULP2 IPI00739106 similar to ribosomal protein L5 isoform 1 LOC647436 IPI00022606 Isoform 1 of Proline-serine-threonine phosphatase-interacting protein 1 PSTPIP1 IPI00295502 Isoform 1 of Protein Wiz WIZ IPI00435925 PP14214 IGFBP3 IPI00010118 Isoform 1 of Prostate tumor overexpressed gene 1 protein PTOV1 IPI00300990 Isoform 1 of Uncharacterized protein C1orf77 C1orf77 IPI00741780 similar to CG4845-PA LOC652559 IPI00454858 similar to alpha 3 type VI collagen isoform 1 precursor LOC344875 IPI00399328 similar to jumonji domain containing 2D LOC390245 IPI00004534 Phosphoribosylformylglycinamidine synthase PFAS IPI00010575 KIAA1466 protein KIAA1466 IPI00785015 Isoform 1 of Uncharacterized protein KIAA2030 FLJ25778 IPI00103630 Isoform 2 of Protein phosphatase 1E PPM1E IPI00479669 Isoform 1 of Uncharacterized protein KIAA0701 UHRF1BP1L IPI00017940 LMBR1 domain-containing protein 2 LMBRD2 IPI00216508 Isoform 2 of Sorting nexin-3 SNX3 IPI00060146 Isoform 1 of Smith-Magenis syndrome chromosome region candidate SMCR7 gene 7 protein IPI00022989 Isoform Beta-1 of Retinoic acid receptor beta RARB IPI00152072 hypothetical protein LOC387758 FIBIN IPI00060546 Uncharacterized protein C10orf35 C10orf35 IPI00043978 Isoform 1 of Partitioning-defective 3 homolog B PARD3B IPI00440221 Putative uncharacterized protein (Fragment) CDC2L5 IPI00011564 Syndecan-4 precursor SDC4 IPI00423683 Isoform 2 of EMI domain-containing protein 1 precursor EMID1 IPI00026612 Isoform Beta-1 of Protein phosphatase 1B PPM1B IPI00167137 Isoform 3 of SLAM family member 7 precursor SLAMF7 IPI00155447 MMP28 protein MMP28 IPI00001434 Protocadherin beta 14 precursor PCDHB14 IPI00043731 CDNA FLJ30671 fis, clone FCBBF1000687, moderately similar to RUNDC3B Mus musculus Rap2 interacting protein 8 (RPIP8) mRNA IPI00645814 Isoform 2 of MAP7 domain-containing protein 1 MAP7D1 IPI00003353 Neuronal protein 3.1 C5orf13 IPI00007402 Importin-7 IPO7 IPI00152470 Prokineticin receptor 1 PROKR1 IPI00006094 Regulating synaptic membrane exocytosis protein 3 RIMS3 IPI00101927 Leucine zipper putative tumor suppressor 2 LZTS2 IPI00010346 Neurolysin, mitochondrial precursor NLN IPI00216572 BarH-like homeobox 2 BARX2 IPI00171647 Isoform 1 of Sialic acid-binding Ig-like lectin 8 precursor SIGLEC8 IPI00020058 Isoform 1 of Copper-transporting ATPase 2 ATP7B IPI00026570 Cytochrome c oxidase polypeptide VIIa-liver/heart, mitochondrial COX7A2 precursor IPI00027726 Isoform 1 of Krueppel-like factor 3 KLF3 IPI00064241 Isoform 1 of Zinc finger protein Eos IKZF4 IPI00295503 Isoform 2 of Probable ATP-dependent RNA helicase DDX58 DDX58 IPI00290292 Rhomboid 5 homolog 1 RHBDF1 IPI00029533 Integrin beta-8 precursor ITGB8 IPI00815786 Hexokinase 1 (Fragment) HK1 IPI00658112 32 kDa protein SPEG IPI00479361 Isoform 1 of UDP-GlcNAc:betaGal beta-1,3-N- B3GNT4 acetylglucosaminyltransferase 4 IPI00448465 Isoform 1 of Ankyrin repeat domain-containing protein 12 ANKRD12 IPI00745122 Conserved hypothetical protein MGC33894 IPI00005531 Isoform 1 of Probable DNA dC->dU-editing enzyme APOBEC-3B APOBEC3B IPI00383832 Protein kinase C-binding protein RACK8 DVL3 IPI00027685 C-C chemokine receptor type 1 CCR1 IPI00009335 Brain protein 16 C8orf30A IPI00432755 PPRR6495 FAM124A IPI00796777 17 kDa protein CRYAA IPI00008894 Carboxypeptidase A4 precursor CPA4 IPI00031005 Protein kinase-like protein SgK196 FLJ23356 IPI00787414 Uncharacterized protein ENSP00000381388 MGC34829 IPI00019988 N-sulphoglucosamine sulphohydrolase precursor SGSH IPI00873740 Uncharacterized protein ENSP00000383832 (Fragment) — IPI00032416 Isoform Long of Protein jagged-2 precursor JAG2 IPI00335589 RNA methyltransferase-like protein 1 RNMTL1 IPI00843819 Similar to Dual specificity protein kinase CLK2 — IPI00065276 Isoform 2 of Tether containing UBX domain for GLUT4 ASPSCR1 IPI00644522 PNKP protein PNKP IPI00045511 Isoform 1 of Chloride channel CLIC-like protein 1 precursor CLCC1 IPI00604763 Transmembrane protein 66 precursor TMEM66 IPI00235647 similar to fibrillarin LOC345630 IPI00470805 Isoform 2 of Mediator of DNA damage checkpoint protein 1 MDC1 IPI00167089 Isoform 2 of Activated CDC42 kinase 1 TNK2 IPI00783753 UPF0235 protein C15orf40 C15orf40 IPI00030919 Mitogen-activated protein kinase kinase 1-interacting protein 1 MAP2K1IP1 IPI00394879 Leucine-rich repeat-containing protein 9 LRRC9 IPI00401852 Conserved hypothetical protein DKFZP434L187 IPI00442865 CDNA FLJ26488 fis, clone KDN05770, highly similar to Bumetanide- SLC12A1 sensitive sodium-(potassium)-chloride cotransporter 2 IPI00748891 hypothetical protein LOC283635 isoform 1 C14orf24 IPI00414320 Annexin A11 ANXA11 IPI00874023 Uncharacterized protein ENSP00000379699 — IPI00827584 similar to kinesin family member 27 KIF27 IPI00020199 Alpha-2,8-sialyltransferase 8B ST8SIA2 IPI00791513 CDNA FLJ16614 fis, clone TESTI4013365 CTA-216E10.6 IPI00002884 CDNA: FLJ22222 fis, clone HRC01658 FLJ22222 IPI00003363 Isoform 1 of Protein phosphatase 1 regulatory subunit 1B PPP1R1B IPI00005705 Isoform Gamma-1 of Serine/threonine-protein phosphatase PP1- PPP1CC gamma catalytic subunit IPI00164949 Isoform NELF-C of Negative elongation factor C/D TH1L IPI00029647 Zymogen granule membrane protein 16 precursor ZG16 IPI00414481 GTF3C1 protein GTF3C1 IPI00154528 Isoform 1 of Structural maintenance of chromosomes protein 6 SMC6 IPI00164861 Isoform 3 of Kinesin-like protein KIF13A KIF13A IPI00411674 Isoform 1 of Zinc finger protein 254 ZNF254 IPI00249982 Isoform 1 of Death-inducer obliterator 1 DIDO1 IPI00328270 Neuronal PAS domain-containing protein 2 NPAS2 IPI00442544 CDNA FLJ27034 fis, clone SLV07984 — IPI00175019 similar to Temporarily Assigned Gene name family member LOC643677 IPI00027898 Isoform A of Uncharacterized protein C21orf70 C21orf70 IPI00023340 Histone acetyltransferase MYST3 MYST3 IPI00300052 Keratin type II cuticular Hb4 KRT84 IPI00019158 ADAM metallopeptidase domain 8 precursor ADAM8 IPI00045928 Sodium/hydrogen exchanger 7 SLC9A7 IPI00306332 60S ribosomal protein L24 RPL24 IPI00023184 Isoform 1 of Poly [ADP-ribose] polymerase 3 PARP3 IPI00872739 Uncharacterized protein C18orf2 C18orf2 IPI00241409 hypothetical protein LOC55747 FAM21B IPI00090764 Toll-like receptor 1 precursor TLR1 IPI00024253 Isoform 1 of Fibroblast growth factor 14 FGF14 IPI00218637 Major histocompatibility complex, class II, DQ beta 2 HLA-DQB2 IPI00216921 Isoform 2 of Stathmin-4 STMN4 IPI00011416 Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial ECH1 precursor IPI00260755 similar to Rho GTPase activating protein 18 C20orf95 IPI00337385 Isoform 1 of Pre-mRNA-processing factor 40 homolog A PRPF40A IPI00304527 Protein FAM83B FAM83B IPI00030741 Uncharacterized protein C21orf13 LCA5L IPI00399296 hypothetical protein LOC390110 LOC390110 IPI00233358 islet cell autoantigen 1, 69 kDa-like isoform 2 ICA1L IPI00879842 6 kDa protein — IPI00021476 Eukaryotic translation initiation factor 4E-binding protein 3 EIF4EBP3 IPI00028383 Uncharacterized protein C16orf24 C16orf24 IPI00298337 cDNA FLJ77671 SLC14A1 IPI00044842 Isoform 2 of RAB3A-interacting protein RAB3IP IPI00013004 Isoform 1 of Pyridoxal kinase PDXK IPI00328260 Protein FAN NSMAF IPI00807418 Isoform 9 of Lymphoid-specific helicase HELLS IPI00183002 Isoform 1 of Protein phosphatase 1 regulatory subunit 12A PPP1R12A IPI00163601 Putative uncharacterized protein FLJ10213 FLJ10213 IPI00428741 LP2477 FLJ35348 IPI00006252 Multisynthetase complex auxiliary component p43 SCYE1 IPI00007321 Isoform 1 of Acyl-protein thioesterase 1 LYPLA1 IPI00217617 palmitoylated membrane protein 7 MPP7 IPI00024662 Chromobox protein homolog 5 CBX5 IPI00550364 Phosphoglucomutase-2 PGM2 IPI00169331 Phosphatidylcholine:ceramide cholinephosphotransferase 2 SGMS2 IPI00028450 Isoform 1 of Sodium/calcium exchanger 1 precursor SLC8A1 IPI00010405 Isoform Long of Tyrosine-protein kinase transmembrane receptor ROR1 ROR1 precursor IPI00873774 Uncharacterized protein ENSP00000383488 (Fragment) — IPI00847335 FLJ45422 protein — IPI00217740 C20orf12 protein C20orf12 IPI00008497 Ornithine decarboxylase ODC1 IPI00010808 Interferon-gamma receptor alpha chain precursor IFNGR1 IPI00872550 Uncharacterized protein PRDM2 PRDM2 IPI00514622 Ran-binding protein 6 RANBP6 IPI00009203 Sorting nexin-7 SNX7 IPI00790021 Zinc finger protein 652 ZNF652 IPI00855918 mucin 5, subtype B, tracheobronchial MUC5B IPI00008404 Isoform Long of Segment polarity protein dishevelled homolog DVL- DVL1L1 1-like IPI00658025 Putative novel transcript — IPI00022958 PRO0149 C16orf72 IPI00032313 Protein S100-A4 S100A4 IPI00027009 Isoform 1 of Protein kinase C and casein kinase substrate in neurons PACSIN2 protein 2 IPI00023162 UDP-N-acetylglucosamine 2-epimerase/N-acetylmannosamine kinase GNE IPI00789181 115 kDa protein PLCL1 IPI00005132 Guanine nucleotide-binding protein-like 3-like protein GNL3L IPI00742725 Conserved hypothetical protein LOC388564 IPI00878755 43 kDa protein — IPI00152050 ataxin 2-binding protein 1 isoform 3 A2BP1 IPI00385480 Caskin-1 CASKIN1 IPI00465123 KIAA0415 gene product KIAA0415 IPI00012441 Isoform 1 of Synaptojanin-1 SYNJ1 IPI00006054 Syntaphilin SNPH IPI00385918 CDNA FLJ90582 fis, clone PLACE1000442, moderately similar to ZNF627 ZINC FINGER PROTEIN ZFP-36 IPI00008438 40S ribosomal protein S10 RPS10 IPI00152849 Isoform 1 of G2/mitotic-specific cyclin-B3 CCNB3 IPI00029556 Uncharacterized protein C1orf105 C1orf105 IPI00217012 pleckstrin and Sec7 domain containing PSD IPI00015980 Isoform 2 of Multiple PDZ domain protein MPDZ IPI00102678 Isoform 1 of Pecanex-like protein 1 PCNX IPI00020356 331 kDa protein MAP1A IPI00008226 73 kDa protein THSD3 IPI00010903 Dopey family member 1 DOPEY1 IPI00735934 similar to capicua homolog LOC646070 IPI00465234 Cytokine receptor common beta chain precursor CSF2RB IPI00010303 Serpin B4 SERPINB4 IPI00008091 Putative DNA helicase INO80 complex homolog 1 INOC1 IPI00016112 peroxidasin homolog PXDN IPI00329791 cDNA FLJ78679, highly similar to Homo sapiens DEAD (Asp-Glu- DDX46 Ala-Asp) box polypeptide 46 (DDX46), mRNA IPI00152344 Pyridoxal phosphate phosphatase PHOSPHO2 PHOSPHO2 IPI00028601 Putative metallothionein C20orf127 MT1P3 IPI00479125 SLIT-ROBO Rho GTPase-activating protein 2 SRGAP2 IPI00455852 Isoform 1 of Rho guanine nucleotide exchange factor 15 ARHGEF15 IPI00550876 Protein maestro MRO IPI00064296 PRO0633 — IPI00216651 Isoform 1 of Interleukin-28 receptor alpha chain precursor IL28RA IPI00792945 38 kDa protein CHFR IPI00149375 Isoform 2 of Uncharacterized protein C11orf56 C11orf56 IPI00015913 5,6-dihydroxyindole-2-carboxylic acid oxidase precursor TYRP1 IPI00007512 Glutathione transferase omega-2 GSTO2 IPI00016576 Isoform 1 of Grainyhead-like protein 2 homolog GRHL2 IPI00290308 Tribbles homolog 1 TRIB1 IPI00025622 AN1-type zinc finger protein 5 ZFAND5 IPI00102808 Isoform 1 of Dual specificity protein phosphatase 19 DUSP19 IPI00018208 Tetratricopeptide repeat protein 33 TTC33 IPI00166865 CDGSH iron sulfur domain-containing protein 2 CISD2 IPI00004533 Kinesin-like protein KIF3B KIF3B IPI00477468 RNA polymerase-associated protein CTR9 homolog CTR9 IPI00005668 Aldo-keto reductase family 1 member C2 AKR1C2 IPI00018098 Isoform 1 of Pre-mRNA-splicing factor 38B PRPF38B IPI00026241 Bone marrow stromal antigen 2 precursor BST2 IPI00243338 24 kDa protein KRT23 IPI00786937 similar to deleted in malignant brain tumors 1 isoform b precursor LOC731940 IPI00218918 Annexin A1 ANXA1 IPI00295577 Receptor-type tyrosine-protein phosphatase beta precursor PTPRB IPI00029372 Uncharacterized protein C4orf15 C4orf15 IPI00744226 Conserved hypothetical protein — IPI00792229 20 kDa protein TATDN1 IPI00220271 Alcohol dehydrogenase AKR1A1 IPI00015954 GTP-binding protein SAR1a SAR1A IPI00418735 hypothetical protein LOC400566 LOC400566 IPI00306413 Tubulin polymerization-promoting protein family member 3 TPPP3 IPI00018755 High mobility group protein 1-like 10 HMG1L10 IPI00385543 Isoform 3 of UPF0469 protein KIAA0907 KIAA0907 IPI00299076 Receptor-binding cancer antigen expressed on SiSo cells (Fragment) EBAG9 IPI00386393 CDNA FLJ13729 fis, clone PLACE3000121, weakly similar to EXOC6B VESICULAR TRAFFIC CONTROL PROTEIN SEC15 IPI00878511 45 kDa protein — IPI00442564 CDNA FLJ26948 fis, clone RCT08241 — IPI00412408 Breast cancer type 2 susceptibility protein BRCA2 IPI00005614 Isoform Long of Spectrin beta chain, brain 1 SPTBN1 IPI00021831 cAMP-dependent protein kinase type I-alpha regulatory subunit PRKAR1A IPI00008422 Isoform 2 of SWI/SNF-related matrix-associated actin-dependent SMARCAD1 regulator of chromatin subfamily A containing DEAD/H box 1 IPI00007682 Vacuolar ATP synthase catalytic subunit A ATP6V1A IPI00024502 Ubiquilin-4 UBQLN4 IPI00029175 Strumpellin KIAA0196 IPI00045360 Capicua-like protein/double homeodomain 4 fusion protein CIC IPI00749171 Conserved hypothetical protein LOC340184 IPI00298738 DNA-directed RNA polymerase, mitochondrial precursor POLRMT IPI00445278 CDNA FLJ44033 fis, clone TEST14028062 — IPI00335541 Isoform 1 of Protein timeless homolog TIMELESS IPI00444842 CDNA FLJ45125 fis, clone BRAWH3036561 — IPI00023152 Isoform 1 of N-acetylated-alpha-linked acidic dipeptidase-like protein NAALADL1 IPI00296727 Kinesin-like protein KIF2B KIF2B IPI00005347 Zinc finger Ran-binding domain-containing protein 1 ZRANB1 IPI00470913 RANBP2-like and GRIP domain containing 1 RGPD1; RGPD2 IPI00444331 Isoform 4 of Histone-lysine N-methyltransferase NSD3 WHSC1L1 IPI00023407 Nck-associated protein 1-like NCKAP1L IPI00456635 Isoform 1 of Protein unc-13 homolog D UNC13D IPI00149044 Isoform 2 of Suppressor of hairy wing homolog 4 ZNF280D IPI00007834 Isoform 1 of Ankyrin-2 ANK2 IPI00746681 Similar to Bcl-2-related ovarian killer protein — IPI00000977 Mitogen-activated protein kinase kinase kinase 11 MAP3K11 IPI00871556 107 kDa protein ZFYVE28 IPI00003814 Isoform 1 of Dual specificity mitogen-activated protein kinase kinase 6 MAP2K6 IPI00301058 Vasodilator-stimulated phosphoprotein VASP IPI00245940 immunoglobulin superfamily 5 like IGSF5 IPI00657699 Protein MUC19 IPI00290094 Splicing factor, arginine/serine-rich 8 SFRS8 IPI00030706 Activator of 90 kDa heat shock protein ATPase homolog 1 AHSA1 IPI00853516 dynein, axonemal, heavy chain 17 DNAH17 IPI00410093 coiled-coil domain containing 69 CCDC69 IPI00168404 Zinc finger and BTB domain containing 34 ZBTB34 IPI00644766 cDNA FLJ78048, highly similar to Homo sapiens torsin A interacting TOR1AIP1 protein 1, mRNA IPI00167154 Uncharacterized protein MAPKBP1 MAPKBP1 IPI00871533 Uncharacterized protein C3orf48 (Fragment) C3orf48 IPI00877615 15 kDa protein — IPI00030352 Isoform 2 of Growth inhibition and differentiation-related protein 88 C10orf28 IPI00293679 Isoform 1 of Potassium voltage-gated channel subfamily KQT KCNQ4 member 4 IPI00748682 Pheromone shutdown-related, TraB family protein — IPI00019888 Succinate-semialdehyde dehydrogenase, mitochondrial precursor ALDH5A1 IPI00032597 RNA-binding motif protein, X-linked 2 RBMX2 IPI00783855 neighbor of BRCA1 gene 1 NBR1 IPI00746987 Ribosomal protein S1 family protein — IPI00295469 Copine-6 CPNE6 IPI00456599 hypothetical protein LOC84792 MGC12966 IPI00607831 PRAME family member 3 PRAMEF3 IPI00399254 Isoform 1 of OTU domain-containing protein 4 OTUD4 IPI00719505 RABL2A protein RABL2A IPI00784880 Cancer/testis antigen 75 LOC440934 IPI00884353 Ets-1 transcript variant ets-1 delta — IPI00852725 Isoform 7 of Prolactin receptor precursor PRLR IPI00005600 Isoform 1 of Bifunctional heparan sulfate N-deacetylase/N- NDST2 sulfotransferase 2 IPI00791593 8 kDa protein GLYCAM1 IPI00024346 snRNA-activating protein complex subunit 3 SNAPC3 IPI00293396 adaptor-related protein complex 1, gamma 1 subunit isoform a AP1G1 IPI00018914 Tyrosine-protein phosphatase non-receptor type 14 PTPN14 IPI00296913 ADP-sugar pyrophosphatase NUDT5 IPI00185146 Importin-9 IPO9 IPI00217791 Coiled-coil domain-containing protein 105 CCDC105 IPI00167006 Uncharacterized protein C13orf26 C13orf26 IPI00028481 Ras-related protein Rab-8A RAB8A IPI00294215 Uncharacterized protein KIAA0232 KIAA0232 IPI00071185 Isoform SV1 of PITSLRE serine/threonine-protein kinase CDC2L1 CDC2L1 IPI00166776 Protein CREG2 precursor CREG2 IPI00001796 Tumor necrosis factor receptor superfamily, member 18 (Fragment) TNFRSF18 IPI00549972 LIM domain-containing protein 2 LIMD2 IPI00029107 Werner syndrome ATP-dependent helicase WRN IPI00470468 Isoform 3 of Protein EFR3 homolog A EFR3A IPI00382515 CDNA FLJ30384 fis, clone BRACE2008114 — IPI00853312 Uncharacterized protein ENSP00000324580 — IPI00217871 Delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial ALDH4A1 precursor IPI00470490 Isoform 1 of Nuclear receptor coactivator 1 NCOA1 IPI00001433 Protocadherin beta 15 precursor PCDHB15 IPI00220156 Isoform B of Transforming growth factor beta-2 precursor TGFB2 IPI00024818 Isoform 1 of Ubiquitin-specific peptidase-like protein 1 USPL1 IPI00335437 Ankyrin repeat and zinc finger domain-containing protein 1 ANKZF1 IPI00000076 Beta-nerve growth factor precursor NGFB IPI00100980 EH domain-containing protein 2 EHD2 IPI00215610 55 kDa erythrocyte membrane protein MPP1 IPI00015148 Ras-related protein Rap-1b precursor RAP1B IPI00410657 Isoform 2 of mRNA cap guanine-N7 methyltransferase RNMT IPI00552591 V1-20 protein IGLV10-54 IPI00022277 Coiled-coil domain-containing protein 56 CCDC56 IPI00216288 Isoform 3 of Lethal L3MBTL IPI00025499 Isoform Tau-F of Microtubule-associated protein tau MAPT IPI00856012 collagen type VI alpha 6 COL6A6 IPI00335168 Isoform Non-muscle of Myosin light polypeptide 6 MYL6 IPI00030037 Agouti-signaling protein precursor ASIP IPI00013749 Protein kinase C zeta type PRKCZ IPI00002491 Isoform 9 of Sorbin and SH3 domain-containing protein 1 SORBS1 IPI00240793 Probable phospholipid-transporting ATPase IF ATP11B IPI00376237 Isoform 2 of Transcription factor LBX2 LBX2 IPI00020966 Isoform 1 of Phosphatidylinositol N-acetylglucosaminyltransferase PIGA subunit A IPI00456827 Protein FAM22G precursor FAM22G IPI00747657 Similar to Rod cGMP-specific 3′,5′-cyclic phosphodiesterase subunit PDE6B beta precursor IPI00215777 Isoform B of Phosphate carrier protein, mitochondrial precursor SLC25A3 IPI00028912 zinc finger protein 161 VEZF1 IPI00019242 Matrix metalloproteinase-15 precursor MMP15 IPI00024664 Isoform Long of Ubiquitin carboxyl-terminal hydrolase 5 USP5 IPI00786946 similar to Tektin-3 LOC642249 IPI00166257 CDNA FLJ37614 fis, clone BRCOC2011769 — IPI00442745 CDNA FLJ26780 fis, clone PRS03837 — IPI00017256 Ras suppressor protein 1 RSU1 IPI00374301 hypothetical protein — IPI00023217 Isoform 1 of Ryanodine receptor 2 RYR2 IPI00018843 Isoform 1 of D(3) dopamine receptor DRD3 IPI00027782 Stromelysin-1 precursor MMP3 IPI00030009 Isoform A of Bifunctional 3′-phosphoadenosine 5′-phosphosulfate PAPSS2 synthetase 2 IPI00479722 Proteasome activator complex subunit 1 PSME1 IPI00177878 Isoform 3 of Transmembrane protein 16D TMEM16D IPI00104907 Isoform 1 of Uncharacterized potential DNA-binding protein C14orf106 C14orf106 IPI00005107 Niemann-Pick C1 protein precursor NPC1 IPI00009070 Isoform 1 of HBS1-like protein HBS1L IPI00386576 Ig lambda chain V-IV region MOL — IPI00747420 Melanoma-derived protein (Fragment) — IPI00432226 AVLL5809 — IPI00178894 Zinc finger and BTB domain-containing protein 20 ZBTB20 IPI00878436 24 kDa protein SLC2A11 IPI00640810 6 kDa protein CTDP1 IPI00306549 CDNA FLJ11065 fis, clone PLACE1004868, weakly similar to MLSTD1 MALE STERILITY PROTEIN 2 IPI00293361 Isoform 2 of Small G protein signaling modulator 2 SGSM2 IPI00021753 Kinesin-like protein KIF13B KIF13B IPI00253281 Isoform 2 of Epidermal growth factor receptor kinase substrate 8-like EPS8L1 protein 1 IPI00005607 Isoform 1 of Deleted in bladder cancer protein 1 precursor DBC1 IPI00027984 Putative uncharacterized protein DNAJC11 IPI00032425 Receptor activity-modifying protein 3 precursor RAMP3 IPI00020470 Isoform 1 of Glycosyltransferase 8 domain-containing protein 1 GLT8D1 IPI00718821 Isoform 1 of Uncharacterized protein C19orf55 C19orf55 IPI00018387 Furin precursor FURIN IPI00398229 similar to deubiquitinating enzyme 3 LOC392197 IPI00163851 Isoform 1 of Eukaryotic translation initiation factor 2-alpha kinase 4 EIF2AK4 IPI00023780 Isoform 2 of DnaJ homolog subfamily C member 5 DNAJC5 IPI00018027 Isoform 1 of Angiogenic factor with G patch and FHA domains 1 AGGF1 IPI00010442 Phospholemman precursor FXYD1; FXYD7 IPI00434711 Putative uncharacterized protein FP6679 — IPI00184650 Class B basic helix-loop-helix protein 4 BHLHB4 IPI00328298 Isoform 2 of Structural maintenance of chromosomes protein 4 SMC4 IPI00014340 Isoform 1 of Protein phosphatase 1 regulatory subunit 12C PPP1R12C IPI00386284 olfactory receptor, family 2, subfamily AK, member 2 OR2AK2 IPI00018429 Paired mesoderm homeobox protein 2 PRRX2 IPI00387004 PNAS-146 MCM7 IPI00009471 WD repeat-containing protein 3 WDR3 IPI00299263 ADP-ribosylation factor GTPase-activating protein 3 ARFGAP3 IPI00045939 2-aminoethanethiol dioxygenase ADO IPI00014537 Isoform 1 of Calumenin precursor CALU IPI00374670 hypothetical protein isoform 2 LOC388588 IPI00289837 Coiled-coil domain-containing protein 85A CCDC85A IPI00878962 10 kDa protein — IPI00103891 Putative uncharacterized protein MTMR14 IPI00398154 actin filament associated protein 1 AFAP1 IPI00291939 Structural maintenance of chromosomes protein 1A SMC1A IPI00151990 Isoform 1 of Thioredoxin domain-containing protein 15 precursor TXNDC15 IPI00003384 Isoform 1 of Cadherin EGF LAG seven-pass G-type receptor 1 CELSR1 precursor IPI00376383 Centrosomal protein 110 kDa CEP110 IPI00015973 Band 4.1-like protein 2 EPB41L2 IPI00420014 Isoform 1 of U5 small nuclear ribonucleoprotein 200 kDa helicase ASCC3L1 IPI00386314 FLJ00064 protein (Fragment) CNDP2 IPI00021766 Isoform 1 of Reticulon-4 RTN4 IPI00103595 Centrosome-associated protein 350 CEP350 IPI00006173 Isoform 1 of Cholesteryl ester transfer protein precursor CETP IPI00183526 NCL protein NCL IPI00020406 Beta-1,4-mannosyl-glycoprotein 4-beta-N- MGAT3 acetylglucosaminyltransferase IPI00022479 guanine nucleotide exchange factor p532 HERC1 IPI00179452 Isoform 1 of Protein CBFA2T2 CBFA2T2 IPI00017480 Sonic hedgehog protein precursor SHH IPI00853133 DEAD (Asp-Glu-Ala-Asp) box polypeptide 60-like DDX60L IPI00387132 CDNA FLJ32661 fis, clone TESTI1000055, weakly similar to hCG_2007354 HOMEOBOX PROTEIN SIX1 IPI00878369 12 kDa protein — IPI00382492 Ig heavy chain V-III region LAY — IPI00334492 Isoform 3 of Coiled-coil domain-containing protein 144A LOC731479; CCDC144A; LOC652491; CCDC144B IPI00018880 Tumor necrosis factor receptor superfamily member 1A precursor TNFRSF1A IPI00784385 Adenylate cyclase type 1 ADCY1 IPI00465168 Isoform 1 of Serine/threonine-protein kinase TAO2 TAOK2 IPI00028213 Semaphorin-3D precursor SEMA3D IPI00296421 EH domain-binding protein 1-like protein 1 EHBP1L1 IPI00787587 similar to Temporarily Assigned Gene name family member LOC729549 IPI00028980 Uncharacterized protein KIAA0133 KIAA0133 IPI00430792 Isoform 1 of Protein ERGIC-53-like precursor LMAN1L IPI00018335 Isoform Flt1 of Vascular endothelial growth factor receptor 1 FLT1 precursor IPI00795736 Fer-1-like 4 — IPI00000656 Isoform 1 of Uncharacterized protein KIAA0892 precursor KIAA0892 IPI00169377 Isoform 1 of GAS2-like protein 2 GAS2L2 IPI00030648 Isoform 1 of Zinc finger FYVE domain-containing protein 9 ZFYVE9 IPI00419675 hypothetical protein LOC150763 LOC150763 IPI00003893 Isoform 1 of Protocadherin gamma B3 precursor PCDHGB3 IPI00410127 Transforming, acidic coiled-coil containing protein 2 TACC2 IPI00005711 Histone deacetylase 6 HDAC6 IPI00883997 Coiled-coil domain-containing protein 19 CCDC19 IPI00419180 CDNA FLJ41429 fis, clone BRHIP2005354 CC2D2B IPI00335711 Ciliary dynein heavy chain 11 DNAH11 IPI00411291 Peroxisome biogenesis factor 1 PEX1 IPI00397622 Isoform 1 of Transmembrane and immunoglobulin domain-containing TMIGD1 protein 1 precursor IPI00003564 Lymphocyte antigen 86 precursor LY86 IPI00100247 Thioredoxin domain-containing protein 13 precursor TXNDC13 IPI00059711 LRP11 protein (Fragment) LRP11 IPI00141933 Mitotic checkpoint serine/threonine-protein kinase BUB1 beta BUB1B IPI00387098 Ig kappa chain V-I region OU — IPI00299554 Kinesin-like protein KIF14 KIF14 IPI00515034 87 kDa protein KIFAP3 IPI00044608 Isoform 1 of Protein KIAA1881 KIAA1881 IPI00444138 CDNA FLJ46074 fis, clone TESTI2001915, highly similar to Homo AFAP1 sapiens actin filament associated protein IPI00807406 hypothetical protein isoform 1 LOC285346 IPI00645729 62 kDa protein C1QTNF8 IPI00789856 tubulin tyrosine ligase-like family, member 3 TTLL3 IPI00032680 Apolipoprotein-L5 APOL5 IPI00298214 Isoform 1 of ATP-binding cassette sub-family G member 2 ABCG2 IPI00030945 Urocortin-2 precursor UCN2 IPI00333503 Uncharacterized protein ENSP00000315571 (Fragment) — IPI00005567 Isoform 3A of Voltage-dependent L-type calcium channel subunit CACNB3 beta-3 IPI00185038 Isoform 1 of Dual oxidase 1 precursor DUOX1 IPI00005537 39S ribosomal protein L12, mitochondrial precursor MRPL12 IPI00795575 39 kDa protein — IPI00221240 Isoform 2 of Leucyl-cystinyl aminopeptidase LNPEP IPI00655865 Isoform 2 of Protein diaphanous homolog 3 DIAPH3 IPI00019270 Tankyrase-2 TNKS2 IPI00302614 V-set domain containing T cell activation inhibitor 1 VTCN1 IPI00176976 Novel protein similar to mitochondrial ribosome recycling factor RP1-57A13.2 isoform 1 IPI00786931 similar to fatty acid amide hydrolase LOC729037 IPI00063878 Isoform 1 of Multidrug resistance-associated protein 9 ABCC12 IPI00029473 Protein Njmu-R1 C17orf75 IPI00884076 ENV polyprotein (coat polyprotein) family protein — IPI00449923 Isoform 1 of Retinoic acid-induced protein 1 RAI1 IPI00294187 Protein-arginine deiminase type-2 PADI2 IPI00045473 Similar to C. Elegans protein F17C8.5 LOC339123 IPI00167433 CDNA FLJ39703 fis, clone SMINT2012195 FDX1L IPI00183572 Isoform 2 of Dedicator of cytokinesis protein 7 DOCK7 IPI00001835 Zinc finger and BTB domain-containing protein 4 ZBTB4 IPI00148768 TRIO and F-actin binding protein isoform 1 TRIOBP IPI00170548 Isoform 1 of ATPase family AAA domain-containing protein 2 ATAD2 IPI00220257 Isoform 3 of Probable tubulin polyglutamylase TTLL1 IPI00298058 Isoform 1 of Transcription elongation factor SPT5 SUPT5H IPI00102281 Retroviral-like aspartic protease 1 precursor SASP IPI00030355 Protein phosphatase 1 regulatory subunit 11 PPP1R11 IPI00217915 Isoform 1 of Transmembrane protein 136 TMEM136 IPI00220986 Isoform 3 of ADAMTS-9 precursor ADAMTS9 IPI00175169 Isoform 1 of ADP-ribosylation factor GTPase-activating protein 1 ARFGAP1 IPI00550862 hypothetical protein LOC387911 LOC387911 IPI00746459 CDNA FLJ34517 fis, clone HLUNG2006781 — IPI00444234 CDNA FLJ45743 fis, clone KIDNE2016464 FLJ45743 IPI00002534 Isoform 1 of Purine-rich element-binding protein gamma PURG IPI00556253 Isoform 1 of Coiled-coil domain-containing protein C6orf199 C6orf199 IPI00017592 Leucine zipper-EF-hand-containing transmembrane protein 1, LETM1 mitochondrial precursor IPI00016007 Myosin-Vc MYO5C IPI00744927 gastrotropin isoform 1 FABP6 IPI00024319 Forkhead box protein J1 FOXJ1 IPI00339297 Polypeptide N-acetylgalactosaminyltransferase 4 GALNT4 IPI00254408 bromodomain PHD finger transcription factor isoform 1 BPTF IPI00304324 Histone deacetylase 11 HDAC11 IPI00477693 fatty acid binding protein LOC646486 IPI00025310 Zinc finger protein 217 ZNF217 IPI00427808 Isoform 1 of Uncharacterized protein C10orf71 C10orf71 IPI00735313 similar to Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 — IPI00384013 Polypeptide N-acetylgalactosaminyltransferase-like protein 2 GALNTL2 IPI00382495 Ig heavy chain V-III region ZAP — IPI00477820 Isoform 1 of FRAS1-related extracellular matrix protein I precursor FREM1 IPI00024776 Calmegin precursor CLGN IPI00023110 Potassium channel subfamily K member 3 KCNK3 IPI00182833 Coiled-coil alpha-helical rod protein 1 CCHCR1 IPI00394994 Isoform 1 of Nesprin-3 C14orf49 IPI00419992 Isoform 1 of Acyl-CoA synthetase family member 4 AASDH IPI00004445 Gamma-2-syntrophin SNTG2 IPI00878015 12 kDa protein — IPI00328094 Isoform 1 of Forkhead box protein P3 FOXP3 IPI00873348 63 kDa protein A1CF IPI00640240 59 kDa protein SPTLC3 IPI00002824 Cysteine and glycine-rich protein 2 CSRP2 IPI00398272 Isoform 1 of Collagen alpha-1(XVII) chain COL17A1 IPI00061009 Isoform 1 of WD repeat-containing protein 67 WDR67 IPI00299301 Isoform 1 of Desmuslin DMN IPI00152011 PTPL1-associated RhoGAP 1 ARHGAP29 IPI00847790 Protein of unknown function DUF1725 domain containing protein — IPI00065121 Isoform 2 of Coiled-coil domain-containing protein 36 CCDC36 IPI00373867 glycolipid transfer protein domain containing 2 GLTPD2 IPI00872354 armadillo repeat containing 2 ARMC2 IPI00152975 Isoform 1 of Coiled-coil domain-containing protein 90A, CCDC90A mitochondrial precursor IPI00374804 Isoform 1 of Diacylglycerol kinase delta DGKD IPI00292894 Pre-rRNA-processing protein TSR1 homolog TSR1 IPI00028232 Putative uncharacterized protein FGF4 IPI00027269 E3 ubiquitin-protein ligase CBL CBL IPI00797567 9 kDa protein GNAI2 IPI00032958 Isoform 2 of Actin-binding protein anillin ANLN IPI00057815 intestinal facilitative glucose transporter 7 SLC2A7 IPI00014367 Isoform 1 of Non-SMC element 4 homolog A NSMCE4A IPI00884022 Similar to Immunglobulin heavy chain variable region — IPI00465319 Chondroitin sulfate synthase 2 CHPF IPI00549844 Isoform 1 of Protein FAM134B FAMI34B IPI00457114 Isoform 1 of IQ motif and Sec7 domain-containing protein 1 IQSEC1 IPI00002773 Isoform 2 of Tyrosine-protein kinase JAK3 JAK3 IPI00005667 NEDD4-binding protein 1 N4BP1 IPI00300594 CDNA FLJ35435 fis, clone SMINT2002620 SPATA13 IPI00103142 NudC domain-containing protein 2 NUDCD2 IPI00290785 Isoform 1 of SET domain-containing protein 6 SETD6 IPI00297763 Retinal-specific ATP-binding cassette transporter ABCA4 IPI00000861 Isoform 1 of LIM and SH3 domain protein 1 LASP1 IPI00168255 hypothetical protein LOC400451 LOC400451 IPI00015990 Isoform 1 of Eyes absent homolog 3 EYA3 IPI00171500 Uncharacterized protein C14orf45 C14orf45 IPI00170765 Isoform 3 of Alanine--glyoxylate aminotransferase 2-like 2 AGXT2L2 IPI00099977 platelet-derived growth factor C precursor PDGFC IPI00292953 Isoform 2 of Ankycorbin RAI14 IPI00159072 57 kDa protein ROD1 IPI00305692 Thioredoxin-like protein 1 TXNL1 IPI00031630 Melanocyte protein Pmel 17 precursor SILV IPI00167446 Isoform 2 of Uncharacterized protein C17orf78 C17orf78 IPI00479625 Isoform 1 of ELAV-like protein 4 ELAVL4 IPI00745395 Conserved hypothetical protein KIAA0508 IPI00043069 Ankyrin repeat domain-containing protein 30A ANKRD30A IPI00014316 Cyclin-dependent kinase 5 activator 1 precursor CDK5R1 IPI00301726 Isoform 1 of Uncharacterized protein C3orf20 C3orf20 IPI00185361 ATP-dependent RNA helicase DDX55 DDX55 IPI00293867 D-dopachrome decarboxylase DDT IPI00794779 DNA polymerase theta POLQ IPI00478354 Putative uncharacterized protein CXorf31 CXorf31 IPI00166414 Coiled-coil domain-containing protein 96 CCDC96 IPI00300053 Keratin type II cuticular Hb2 KRT82 IPI00749062 Conserved hypothetical protein — IPI00452161 Isoform 1 of Mucolipin-1 MCOLN1 IPI00384546 CDNA FLJ25883 fis, clone CBR02735 — IPI00412272 SH3 domain-binding glutamic acid-rich-like protein 2 SH3BGRL2 IPI00006298 Isoform 1 of Peptidyl-prolyl cis-trans isomerase G PPIG IPI00031497 Conserved hypothetical protein C7orf49 IPI00022061 Sodium/hydrogen exchanger 6 SLC9A6 IPI00217418 Isoform 2 of Rho GTPase-activating protein 12 ARHGAP12 IPI00743545 Conserved hypothetical protein — IPI00328156 Amine oxidase [flavin-containing] B MAOB IPI00644785 Protein PLXNB3 IPI00654693 Protein FAM44C FAM44C IPI00880011 116 kDa protein — IPI00018583 Isoform 1 of Intracellular hyaluronan-binding protein 4 HABP4 IPI00030986 Isoform Long of Kelch repeat and BTB domain-containing protein 10 KBTBD10 IPI00045503 Isoform 2 of Protein phosphatase 1 regulatory subunit 14A PPP1R14A IPI00793408 6 kDa protein ADAMTS9 IPI00024255 G patch domain and KOW motifs-containing protein GPKOW IPI00028262 67 kDa protein KIAA1754 IPI00027212 Insulin receptor-related protein precursor INSRR IPI00009724 Isoform 1 of EF-hand calcium-binding domain-containing protein 6 EFCAB6 IPI00868835 Similar to Heterogeneous nuclear ribonucleoproteins C1/C2 (hnRNP — C1/hnRNP C2). Isoform 4 IPI00396658 Isoform 2 of Protein ITFG3 ITFG3 IPI00742127 Similar to Heterogeneous nuclear ribonucleoprotein A1 (Helix- — destabilizing protein) (Single-strand RNA-binding protein) (hnRNP core protein A1). Isoform A1-A IPI00398586 hypothetical protein LOC199800 LOC199800 IPI00418164 Novel protein RP4-692D3.1; LOC731440 IPI00033019 Potassium voltage-gated channel subfamily B member 1 KCNB1 IPI00032598 Isoform 1 of ETS translocation variant 3 ETV3 IPI00217494 Isoform 1 of Protein SMG7 SMG7 IPI00000837 Metabotropic glutamate receptor 3 precursor GRM3 IPI00296535 2-hydroxyacyl-CoA lyase 1 HACL1 IPI00062882 ATP-binding domain-containing protein 3 ATPBD3 IPI00445167 CDNA FLJ44499 fis, clone UTERU3000665, highly similar to Homo SRCAP sapiens Snf2-related CBP activator protein IPI00442582 CDNA FLJ26893 fis, clone RCT00305 — IPI00011274 Isoform 1 of Heterogeneous nuclear ribonucleoprotein D-like HNRPDL IPI00002791 Isoform Wnt-16b of Protein Wnt-16 precursor WNT16 IPI00290432 Natural resistance-associated macrophage protein 1 SLC11A1 IPI00012540 Prominin-1 precursor PROM1 IPI00477396 Uncharacterized protein ZNF324B (Fragment) ZNF584; ZNF324B IPI00853149 RW1 protein TMEM131 IPI00168977 Olfactory receptor 6J1 OR6J1 IPI00165955 Isoform 1 of Mitogen-activated protein kinase 15 MAPK15 IPI00377211 Isoform 3 of Cadherin-like protein 26 precursor CDH26 IPI00736558 THAP domain containing 4 THAP4 IPI00470518 Mitotic spindle assembly checkpoint protein MAD1 MAD1L1 IPI00005087 Tropomodulin-3 TMOD3 IPI00029227 LOC93622 protein LOC93622 IPI00218839 Cytochrome P450 1A1 CYP1A1 IPI00006356 Isoform 1 of Patatin-like phospholipase domain-containing protein 5 PNPLA5 IPI00005616 Isoform 1 of Trace amine-associated receptor 2 TAAR2 IPI00789494 8 kDa protein TUSC4 IPI00745346 Isoform 11 of Peroxisomal N(1)-acetyl-spermine/spermidine oxidase PAOX IPI00027596 Secreted frizzled-related protein 2 precursor SFRP2 IPI00008455 Isoform 2 of Myosin-VI MYO6 IPI00217850 Isoform 1 of GRAM domain-containing protein 1C GRAMD1C IPI00020771 Isoform 3 of Ensconsin MAP7 IPI00170800 Isoform 1 of Otoancorin precursor OTOA IPI00063181 CDKN2A interacting protein N-terminal like CDKN2AIPNL IPI00328225 Isoform 1 of T-box transcription factor TBX20 TBX20 IPI00166331 Ankyrin repeat domain-containing protein 35 ANKRD35 IPI00294386 Myosin-Ia MYO1A IPI00061680 SAGA-associated factor 29 homolog CCDC101 IPI00220901 TBC1D4 protein TBC1D4 IPI00059139 Vacuolar proton pump subunit E 2 ATP6V1E2 IPI00010893 Left-right determination factor 2 precursor LEFTY2 IPI00746222 ATP-binding cassette, sub-family B (MDR/TAP), member 5 ABCB5 IPI00010843 Isoform 1 of Amyloid beta A4 precursor protein-binding family B APBB1 member 1 IPI00012353 Mitochondrial 39S ribosomal protein L3 MRPL3 IPI00385065 Isoform 1 of Coiled-coil domain-containing protein 46 CCDC46 IPI00413930 Elongation of very long chain fatty acids protein 2 ELOVL2 IPI00006715 Double-strand-break repair protein rad21 homolog RAD21 IPI00787189 similar to thioredoxin domain containing 4 LOC727931 IPI00215965 Isoform A1-B of Heterogeneous nuclear ribonucleoprotein A1 HNRNPA1 IPI00030237 Isoform 1 of Uncharacterized protein C1orf49 C1orf49 IPI00088953 Phosphoinositide 3-kinase regulatory subunit 6 C17orf38 IPI00031490 Isoform 1 of Collectin-11 precursor COLEC11 IPI00430079 Isoform 2 of PHD finger protein 8 PHF8 IPI00296942 Cadherin-12 precursor CDH12 IPI00852688 Isoform 1 of Low density lipoprotein receptor-related protein 5-like LRP5L protein IPI00060440 Zinc finger protein GLI4 GLI4; ZFP41 IPI00845299 Putative uncharacterized protein LOC285733 LOC285733 IPI00003897 Isoform 1 of Protocadherin gamma B6 precursor PCDHGB6 IPI00152257 Enkurin C10orf63 IPI00043526 Uncharacterized protein C14orf44 C14orf44 IPI00013373 Orexin precursor HCRT IPI00829925 Uncharacterized protein ENSP00000365090 ELA2A IPI00009333 Transmembrane protein 9 precursor TMEM9 IPI00470917 Isoform 2 of Uncharacterized protein KIAA1529 KIAA1529 IPI00013269 Isoform 1 of Uncharacterized protein C6orf106 C6orf106 IPI00022433 Heat-shock protein beta-6 HSPB6 IPI00179694 Beta-klotho KLB IPI00027642 Isoform 1 of JmjC domain-containing histone demethylation protein JMJD2C 3C IPI00797832 Isoform 3 of Acyl-CoA dehydrogenase family member 10 ACAD10 IPI00410464 Isoform 1 of Zinc finger protein 324B ZNF324B; ZNF584 IPI00166863 Isoform 2 of Coiled-coil domain-containing protein 123, CCDC123 mitochondrial precursor IPI00008832 Growth arrest-specific protein 1 precursor GAS1 IPI00014958 Isoform 1 of Serum paraoxonase/arylesterase 2 PON2 IPI00719669 Myosin regulatory light chain MRLC2 IPI00299084 Transmembrane protein 33 TMEM33 IPI00029737 Isoform Long of Long-chain-fatty-acid--CoA ligase 4 ACSL4 IPI00005661 Isoform Gamma of Max-like protein X MLX IPI00217683 A-kinase anchor protein 12 isoform 2 AKAP12 IPI00418966 hypothetical protein LOC123688 isoform 2 LOC123688 IPI00328409 Armadillo repeat-containing protein 4 ARMC4 IPI00065457 OTTHUMP00000018353 FLJ32682 IPI00444502 CDNA FLJ45482 fis, clone BRTHA2001953 FLJ45482 IPI00001780 Ubiquitin carboxyl-terminal hydrolase 16 USP16 IPI00552840 Probable G-protein coupled receptor 112 GPR112 IPI00016373 Ras-related protein Rab-13 RAB13 IPI00552434 Myosin, heavy chain 7B, cardiac muscle, beta MYH7B IPI00876962 Isoform 2 of Inverted formin-2 INF2 IPI00026512 Isoform HERA-A of GTP-binding protein era homolog ERAL1 IPI00180375 Isoform 1 of Beta-arrestin-2 ARRB2 IPI00297407 Solute carrier family 45 member 4 SLC45A4 IPI00152879 Monocarboxylate transporter 10 SLC16A10 IPI00290155 66 kDa protein ZNF148 IPI00747017 Putative uncharacterized protein DKFZp686D06121 NEK1 IPI00793836 11 kDa protein ARHGDIB IPI00382422 Ig lambda chain V-I region NEWM — IPI00328842 ARHGAP4 protein ARHGAP4 IPI00008632 Isoform 1 of Putative homeodomain transcription factor 1 PHTF1 IPI00065253 Uncharacterized protein C3orf30 C3orf30 IPI00883751 RNA-directed DNA polymerase (Reverse transcriptase), related — domain containing protein IPI00216137 Synaptonemal complex protein 1 SYCP1 IPI00005621 7h3 protein (Fragment) SYDE1 IPI00001933 Coiled-coil domain-containing protein 113 CCDC113 IPI00383294 Putative uncharacterized protein pp7518 MNT IPI00016861 102 kDa protein GTF3C2 IPI00020903 Isoform 1 of AF4/FMR2 family member 2 AFF2 IPI00465247 Isoform 1 of Stimulated by retinoic acid gene 6 protein homolog STRA6 IPI00382394 Isoform 5 of Cytosolic phospholipase A2 beta PLA2G4B IPI00167913 Isoform 1 of Spermatid-associated protein SPERT IPI00874276 Putative uncharacterized protein DKFZp761N1814 EPB41L4B IPI00446767 Isoform 3 of Transducin-like enhancer protein 4 TLE4 IPI00020754 PRO1751 — IPI00300060 WD repeat-containing protein 70 WDR70 IPI00021979 Peroxisomal membrane protein 11A PEX11A IPI00031768 Hook homolog 3 HOOK3 IPI00216986 Isoform C of Complement receptor type 2 precursor CR2 IPI00470771 SAMD4B protein SAMD4B IPI00021143 Class B basic helix-loop-helix protein 2 BHLHB2 IPI00297931 Isoform 1 of AP1 subunit gamma-binding protein 1 AP1GBP1 IPI00018691 28S ribosomal protein S18a, mitochondrial precursor MRPS18A IPI00010604 Isoform 1 of 1-phosphatidylinositol-4,5-bisphosphate PLCE1 phosphodiesterase epsilon-1 IPI00022438 Isoform Long of Transcription factor Maf MAF IPI00396527 Isoform 1 of Coiled-coil domain-containing protein 128 CCDC128 IPI00291840 Isoform 1 of Zinc finger protein 90 homolog ZFP90 IPI00646410 Isoform 2 of Flavin-containing amine oxidase domain-containing AOF1 protein 1 IPI00451413 Intersectin 1 isoform 7 ITSN1 IPI00787410 similar to Polypeptide N-acetylgalactosaminyltransferase 9 GALNT9 IPI00552601 Putative uncharacterized protein DKFZp686M12165 (Fragment) — IPI00166833 LAG1 longevity assurance homolog 5 LASS5 IPI00183425 CDKN1A interacting zinc finger protein 1 CIZ1 IPI00027228 Probable glutamyl-tRNA(Gln) amidotransferase subunit B, PET112L mitochondrial precursor IPI00007917 Collectin-10 precursor COLEC10 IPI00552787 similar to Matrin-3 RBM20 IPI00065484 CDNA FLJ32471 fis, clone SKNMC2000322, weakly similar to PTRH2 MAJOR CENTROMERE AUTOANTIGEN B IPI00384447 Sarcoma antigen NY-SAR-22 (Fragment) NEXN IPI00830073 Isoform 1 of RING finger protein 207 RNF207 IPI00012411 Zinc finger protein 32 ZNF32 IPI00760993 IQ motif and Sec7 domain 2 isoform 2 IQSEC2 IPI00004527 Uncharacterized protein KIAA0355 KIAA0355 IPI00018956 ALX homeobox protein 1 ALX1 IPI00154553 Centrosomal protein of 76 kDa CEP76 IPI00444208 CDNA FLJ45771 fis, clone NETRP2003103 RNF44 IPI00001641 Origin recognition complex subunit 6 ORC6L IPI00216484 Isoform 2 of LisH domain-containing protein ARMC9 ARMC9 IPI00170961 Isoform 2 of WD repeat-containing protein 16 WDR16 IPI00786880 Myosin-XVB — IPI00152722 Protein CCDC35 CCDC35 IPI00298447 Probable methyltransferase TARBP1 TARBP1 IPI00293200 OTTHUMP00000016423 PARC IPI00550272 Integrator complex subunit 10 INTS10 IPI00514197 similar to Nonhistone chromosomal protein HMG-17 LOC648822 IPI00156804 cDNA FLJ77550, highly similar to Homo sapiens zinc finger protein ZNF665 665 (ZNF665), mRNA IPI00384140 Full-length cDNA clone CS0DA005YA22 of Neuroblastoma of Homo ESR2 sapiens (Fragment) IPI00410564 CDNA FLJ45248 fis, clone BRHIP2006819 FLJ45248 IPI00023586 Isoform 1 of Sentrin-specific protease 6 SENP6 IPI00028579 Transcription initiation factor TFIID subunit 6 TAF6 IPI00253323 Ankyrin repeat domain-containing protein 57 ANKRD57 IPI00166361 Putative uncharacterized protein FLJ33590 FLJ33590 IPI00294810 CDNA FLJ10824 fis, clone NT2RP4001086 (Fragment) FAM21A IPI00418408 Cytochrome P450 CYP2D7P1 IPI00168627 Uncharacterized protein CXorf20 CXorf20 IPI00026952 Plakophilin-3 PKP3 IPI00014852 Isoform 1 of Phosphoglucomutase-like protein 5 PGM5 IPI00332628 Otopetrin-3 OTOP3 IPI00296830 Isoform 1 of Leucine zipper protein 1 LUZP1 IPI00306127 THUMP domain-containing protein 3 THUMPD3 IPI00022881 Isoform 1 of Clathrin heavy chain 2 CLTCL1 IPI00397015 A.T hook DNA-binding motif-containing protein 1 AHDC1 IPI00029184 Hyaluronan and proteoglycan link protein 2 precursor HAPLN2 IPI00795917 126 kDa protein CXorf45 IPI00815976 Transmembrane protein 120B TMEM120B IPI00382671 Isoform 6 of C-type lectin domain family 4 member M CLEC4M IPI00018303 Isoform 2 of Protocadherin-11 X-linked precursor PCDH11X IPI00176210 hypothetical protein LOC133558 FLJ40243 IPI00166153 Protein KIAA0082 KIAA0082 IPI00300621 Isoform 2B2 of Synaptojanin-2 SYNJ2 IPI00306166 germ cell associated 1 isoform 2 GSG1 IPI00401002 Zinc finger protein 740 ZNF740 IPI00607829 Isoform 1 of Ret finger protein-like 2 RFPL2 IPI00402280 Isoform 1 of Small leucine-rich proteoglycan family member CHADL LOC150356 precursor IPI00006800 Isoform Long of Autophagy protein 5 ATG5 IPI00218559 Gamma-sarcoglycan SGCG IPI00479897 Chromosome 9 open reading frame 75 C9orf75 IPI00216003 Cullin-5 CUL5 IPI00445796 CDNA FLJ43383 fis, clone OCBBF2006058, highly similar to Homo ACAD8 sapiens acyl-Coenzyme A dehydrogenase-8 mRNA IPI00742114 similar to tripartite motif protein 11 LOC653978 IPI00023164 Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated HCN4 channel 4 IPI00012480 FKSG42 RACGAP1P IPI00004538 similar to nascent polypeptide-associated complex alpha polypeptide NACAD isoform 1 IPI00297462 Uncharacterized protein C1orf65 C1orf65 IPI00793454 7 kDa protein USP19 IPI00028392 specifically androgen-regulated protein isoform 1 C1orf116 IPI00385495 Transmembrane protein 153 LMF2 IPI00017726 Isoform 1 of 3-hydroxyacyl-CoA dehydrogenase type-2 HSD17B10 IPI00791509 Neural precursor cell expressed, developmentally down-regulated 1 NEDD1 IPI00289931 Isoform 1 of Mucosal addressin cell adhesion molecule 1 precursor MADCAM1 IPI00442601 CDNA FLJ26817 fis, clone PRS06446 — IPI00012891 Phosphorylase b kinase gamma catalytic chain, testis/liver isoform PHKG2 IPI00021338 Dihydrolipoyllysine-residue acetyltransferase component of pyruvate DLAT dehydrogenase complex, mitochondrial precursor IPI00455083 Uncharacterized protein ENSP00000371558 — IPI00168877 helicase (DNA) B HELB IPI00641214 177 kDa protein ADCY10 IPI00290837 Isoform 2 of F-box/WD repeat-containing protein 10 FBXW10 IPI00009213 Isoform 1 of B-cell lymphoma/leukemia 11B BCL11B IPI00003421 T-brain-1 protein TBR1 IPI00396314 Isoform 3 of CCR4-NOT transcription complex subunit 10 CNOT10 IPI00000106 Signal transducer and activator of transcription 4 STAT4 IPI00339217 Ovochymase-1 precursor OVCH1 IPI00395631 Isoform 1 of E3 ubiquitin-protein ligase TRAF7 TRAF7 IPI00455397 DMWD protein DMWD IPI00744557 kazrin isoform E RP1-21O18.1 IPI00152692 D-tyrosyl-tRNA(Tyr) deacylase 1 DTD1 IPI00397526 Isoform 1 of Myosin-10 MYH10 IPI00640654 RAP1 GTPase activating protein RAP1GAP IPI00791831 10 kDa protein ADRBK1 IPI00479904 Uncharacterized protein COL27A1 COL27A1 IPI00013256 Isoform 1 of Cleavage stimulation factor 64 kDa subunit CSTF2 IPI00059279 Exocyst complex component 4 EXOC4 IPI00299402 Pyruvate carboxylase, mitochondrial precursor PC IPI00167639 Vacuolar proton pump subunit d 2 ATP6V0D2 IPI00170855 tetratricopeptide repeat domain 19 TTC19 IPI00445563 Putative uncharacterized protein MGC21675/FLJ43787 C4orf42 IPI00884334 Conserved hypothetical protein LOC729968 IPI00007910 Isoform 1 of Sodium-dependent phosphate transport protein 2B SLC34A2 IPI00083708 BAT2-iso BAT2D1 IPI00328715 Protein LYRIC MTDH IPI00290035 Isoform 1 of Protocadherin-15 precursor PCDH15 IPI00385511 Uncharacterized protein TNRC6B TNRC6B IPI00006561 Isoform 1 of Protein KIAA0317 KIAA0317 IPI00375294 Laminin subunit alpha-1 precursor LAMA1 IPI00375325 Keratin-associated protein 10-10 KRTAP10-10 IPI00640293 23 kDa protein TIMP3 IPI00235003 Tumor necrosis factor receptor superfamily, member 6 isoform 1 FAS variant (Fragment) IPI00216702 Isoform 1 of ATP-binding cassette sub-family A member 9 ABCA9 IPI00167930 ring finger protein 190 MARCH10 IPI00470657 Anti-colorectal carcinoma heavy chain — IPI00413868 hypothetical protein LOC79632 isoform 1 C6orf60 IPI00066367 Endothelial cells scavenger receptor precursor SCARF1 IPI00397740 zinc finger protein 749 ZNF749 IPI00300426 Isoform 1 of Tetratricopeptide repeat protein 29 TTC29 IPI00307259 DnaJ homolog subfamily C member 13 DNAJC13 IPI00386113 CDNA: FLJ23412 fis, clone HEP20516 C20orf59 IPI00153060 Angiopoietin-related protein 4 precursor ANGPTL4 IPI00020354 Interleukin-13 receptor alpha-1 chain precursor IL13RA1 IPI00177888 Isoform 1 of Leukocyte receptor cluster member 8 LENG8 IPI00101267 Isoform 1 of Uncharacterized protein C19orf60 C19orf60 IPI00739927 similar to vasoactive intestinal peptide receptor 2 LOC645464 IPI00782965 huntingtin interacting protein 1 HIP1 IPI00444375 Rh blood group, CcEe antigens RHCE IPI00794880 Isoform 1 of Chromodomain-helicase-DNA-binding protein 7 CHD7 IPI00419791 Isoform 1 of Arginine/serine-rich coiled-coil protein 2 RSRC2 IPI10100106 resistance to inhibitors of cholinesterase 8 homolog A RIC8A IPI00216593 Isoform NOH-1LV of NADPH oxidase homolog 1 NOX1 IPI00395667 Interferon-related IFRD2 (PC4-B) protein NAT6; IFRD2 IPI00008708 Ribosomal L1 domain-containing protein 1 RSL1D1 IPI00748649 25 kDa protein — IPI00100362 erythrocyte membrane protein band 4.1 like 4B isoform 1 EPB41L4B IPI00219898 Isoform 2 of Nephrin precursor NPHS1; PRODH2 IPI00872098 Zinc finger protein Pegasus IKZF5 IPI00043294 Isoform 1 of Uncharacterized protein C7orf26 C7orf26 IPI00152535 Chromodomain-helicase-DNA-binding protein 5 CHD5 IPI00217507 Neurofilament medium polypeptide NEFM IPI00216356 Isoform 2 of RasGAP-activating-like protein 1 RASAL1 IPI00290562 Nuclear factor interleukin-3-regulated protein NFIL3 IPI00006003 CD83 antigen precursor CD83 IPI00166528 Isoform 3 of Rapamycin-insensitive companion of mTOR RICTOR IPI00221325 E3 SUMO-protein ligase RanBP2 RANBP2 IPI00084684 similar to Zinc finger protein 469 ZNF469 IPI00643809 Protein CNTNAP3B IPI00164776 Similar to RIKEN cDNA A230078105 gene TMEM198 IPI00023410 Integrin alpha-8 precursor ITGA8 IPI00787593 similar to CG33300-PA LOC730407 IPI00180781 Isoform 1 of Mixed lineage kinase domain-like protein MLKL IPI00339309 Isoform 1 of Proto-oncogene DBL MCF2 IPI00843923 Phosphodiesterase PDE7B2 PDE7B IPI00640865 Integrin beta-like protein 1 precursor ITGBL1 IPI00029144 Isoform PR130 of Serine/threonine-protein phosphatase 2A regulatory PPP2R3A subunit B″ subunit alpha IPI00175439 F-box only protein 43 FBXO43 IPI00646485 Protein EFCAB2 IPI00023105 Peptidylglycine alpha-amidating monooxygenase COOH-terminal PAMCI interactor IPI00301144 Isoform 1 of Sulfatase-modifying factor 1 precursor SUMF1 IPI00439935 UDP-glucuronosyltransferase 1-4 precursor UGT1A4; UGT1A6 IPI00001753 Myosin-4 MYH4 IPI00401829 Putative uncharacterized protein ENST00000281581 — IPI00056324 Isoform 1 of Hermansky-Pudlak syndrome 3 protein HPS3 IPI00220493 U6 snRNA-associated Sm-like protein LSm5 LSM5 IPI00386390 Olfactory receptor 6N2 OR6N2 IPI00044761 Pseudouridylate synthase 7 homolog PUS7 IPI00032342 TRIP12 protein TRIP12 IPI00307536 Isoform 1 of Testis-expressed sequence 11 protein TEX11 IPI00244812 Tetratricopeptide repeat protein 6 TTC6 IPI00030487 CDNA FLJ30993 fis, clone HLUNG1000064, weakly similar to KIAA1627 KARYOGAMY PROTEIN KAR4 IPI00787443 similar to Collagen alpha-2(XI) chain precursor LOC730037 IPI00013371 Protein sprouty homolog 3 SPRY3 IPI00414259 Isoform 2 of Pregnancy-specific beta-1-glycoprotein 4 precursor PSG4 IPI00410590 Isoform 2 of LSM14 protein homolog A LSM14A IPI00023330 Isoform 2 of LisH domain and HEAT repeat-containing protein KIAA1468 KIAA1468 IPI00645614 Isoform 2 of Cadherin-3 precursor CDH3 IPI00744574 Similar to Tropomyosin alpha-4 chain — IPI00737735 similar to cell division cycle 10 isoform 1 LOC646913 IPI00065415 Isoform 1 of Coiled-coil domain-containing protein 138 CCDC138 IPI00376206 Isoform 2 of 17-beta hydroxysteroid dehydrogenase 13 precursor HSD17B13 IPI00011589 Isoform A of Septin-4 SEPT4 IPI00032158 Isoform 2 of NMDA receptor-regulated protein 1 NARG1 IPI00013468 Mitotic checkpoint protein BUB3 BUB3 IPI00745955 EBNA1 binding_protein 2 EBNA1BP2 IPI00157237 Isoform 1 of MAGUK p55 subfamily member 4 MPP4 IPI00009040 Ornithine decarboxylase antizyme 3 OAZ3 IPI00383774 Mih1/Tx protein CASP4 IPI00182774 SH3YL1 protein SH3YL1 IPI00217691 Isoform 1 of EF-hand domain-containing protein C17orf57 C17orf57 IPI00514843 KIAA0082 KIAA0082 IPI00216346 Isoform 2 of Nucleolar protein 3 NOL3 IPI00644968 Similar to Heterogeneous nuclear ribonucleoprotein A1 — IPI00414122 coiled-coil domain containing 141 CCDC141 IPI00884216 RNA-directed DNA polymerase (Reverse transcriptase), related — domain containing protein IPI00397759 similar to ribosomal protein L21 LOC388621 IPI00156871 Isoform 2 of Ubiquitin carboxyl-terminal hydrolase 49 USP49 IPI00168692 Isoform 2 of Zinc finger protein 318 ZNF318 IPI00187082 Isoform 3 of Multiple C2 and transmembrane domain-containing MCTP1 protein 1 IPI00018805 Uncharacterized protein C14orf105 C14orf105 IPI00446685 CDNA FLJ41345 fis, clone BRAWH2002761 — IPI00470515 Isoform 1 of Uncharacterized protein C1orf173 C1orf173 IPI00001317 Rho-related BTB domain-containing protein 1 RHOBTB1 IPI00024523 Isoform A of DnaJ homolog subfamily B member 6 DNAJB6 IPI00030814 Fibroblast growth factor 22 precursor FGF22 IPI00441064 Isoform 1 of Uncharacterized protein C15orf26 C15orf26 IPI00867744 Isoform 3 of Pleckstrin homology domain-containing family H PLEKHH2 member 2 IPI00784027 Rod cGMP-specific 3′,5′-cyclic phosphodiesterase subunit beta PDE6B precursor IPI00879277 436 kDa protein TRRAP IPI00011631 Centromere/kinetochore protein zw10 homolog ZW10 IPI00014186 Isoform A of Zinc finger homeobox protein 3 ZFHX3 IPI00852699 4 kDa protein — IPI00400834 Mediator of RNA polymerase II transcription subunit 13-like MED13L IPI00018203 Isoform SRP55-2 of Splicing factor, arginine/serine-rich 6 SFRS6 IPI00335259 deleted in liver cancer 1 isoform 1 DLC1 IPI00239405 Isoform 1 of Nesprin-2 SYNE2 IPI00788010 similar to 60S ribosomal protein L21 RPL21; LOC728501 IPI00027487 Creatine kinase M-type CKM IPI00029662 Isoform 1 of Potassium voltage-gated channel subfamily H member 2 KCNH2 IPI00651669 Putative uncharacterized protein — IPI00029446 Isoform 1 of Myotubularin-related protein 5 SBF1 IPI00883929 Conserved hypothetical protein — IPI00641155 20 kDa protein HIRIP3 IPI00030307 Solute carrier family 41 member 2 SLC41A2 IPI00398162 Isoform 2 of Nebulin-related-anchoring protein NRAP IPI00158506 Isoform 3 of Zinc finger protein 688 ZNF688 IPI00003768 Isoform 1 of Pescadillo homolog 1 PES1 IPI00100910 Isoform 2 of Armadillo repeat-containing protein 5 ARMC5 IPI00445894 CDNA FLJ42978 fis, clone BRTHA2004821 — IPI00022325 Isoform 4 of Pro-neuregulin-2, membrane-bound isoform precursor NRG2 IPI00747271 zinc finger protein SBZF3 ZNF695 IPI00006178 Y6 encoding protein NPY6R IPI00796745 22 kDa protein PPP1R14D IPI00299880 Isoform 2 of Calcium-activated potassium channel subunit beta-3 KCNMB3 IPI00328885 eEF1A2 binding protein DKFZp434B1231 IPI00009305 Glucosamine-6-phosphate isomerase GNPDA1 IPI00465054 Putative uncharacterized protein DKFZp686C1054 THUMPD1 IPI00456676 Isoform 1 of F-box only protein 38 FBXO38 IPI00328089 Kappa B and V(D)J recombination signal sequences binding protein HIVEP3 IPI00002506 Dolichyl-phosphate beta-glucosyltransferase ALG5 IPI00410325 Low-density lipoprotein receptor class A domain-containing protein 3 LDLRAD3 precursor IPI00450358 Putative uncharacterized protein TOP IPI00004472 Isoform 1 of Serine/threonine-protein kinase WNK1 WNK1 IPI00428677 Putative olfactory receptor (Fragment) — IPI00788014 similar to Opioid growth factor receptor LOC729015 IPI00442208 CDNA FLJ16344 fis, clone TEST12032643, moderately similar to ADCY4 ADENYLATE CYCLASE, TYPE IV IPI00019932 ubiquitin-conjugating enzyme E2D 2 isoform 2 UBE2D2 IPI00869224 Pseudogene candidate — IPI00000102 Progonadoliberin-1 precursor GNRH1 IPI00470896 Isoform 2 of Zinc finger FYVE domain-containing protein 26 ZFYVE26 IPI00329488 Isoform IB of Tyrosine-protein kinase ABL2 ABL2 IPI00219604 Dual specificity mitogen-activated protein kinase kinase 1 MAP2K1 IPI00000030 Isoform Delta-1 of Serine/threonine-protein phosphatase 2A 56 kDa PPP2R5D regulatory subunit delta isoform IPI00017538 Isoform 2 of Separin ESPL1 IPI00787099 similar to SR protein related family member LOC728676 IPI00297235 cDNA FLJ77204 CCPG1 IPI00002405 2′-5′-oligoadenylate synthetase 3 OAS3 IPI00013205 Isoform 1 of JmjC domain-containing histone demethylation protein JMJD2B 3B IPI00218715 Isoform 2 of ADAM 33 precursor ADAM33 IPI00410666 Isoform 3 of Protein LAP4 SCRIB IPI00827815 Light chain Fab (Fragment) — IPI00013651 Isoform 3 of RNA-binding protein 33 RBM33 IPI00002344 steroid 5 alpha-reductase 3 SRD5A3 IPI00444408 CDNA FLJ45600 fis, clone BRTHA3020369 — IPI00005013 poly(rC) binding protein 4 isoform b PCBP4 IPI00294728 DmX-like protein 1 DMXL1 IPI00004288 Isoform 1 of Sialic acid-binding Ig-like lectin 7 precursor SIGLEC7 IPI00855960 Integral membrane protein GPR137C GPR137C IPI00003571 Isoform S-CaBP1 of Calcium-binding protein 1 CABP1 IPI00021751 Neurofilament heavy polypeptide NEFH IPI00174347 Inactive dual specificity phosphatase 27 DUSP27 IPI00787774 similar to collagen, type I, alpha 1 LOC730756 IPI00419903 Putative L-aspartate dehydrogenase LOC554235 IPI00165357 Isoform 1 of Metastasis-associated protein MTA3 MTA3 IPI00299406 Pituitary adenylate cyclase-activating polypeptide type I receptor ADCYAP1R1 precursor IPI00401789 Isoform 2 of Highly divergent homeobox HDX IPI00303732 Uncharacterized protein C20orf106 precursor C20orf106 IPI00016425 Isoform 2 of Synaptopodin 2-like protein SYNPO2L IPI00017640 Isoform 1 of Slit homolog 3 protein precursor SLIT3 IPI00014577 Ras-related protein Rab-18 RAB18 IPI00023856 Peregrin BRPF1 IPI00294241 Transcription factor IIIA GTF3A IPI00025717 Metaxin-2 MTX2 IPI00023095 Myeloid leukemia factor 2 MLF2 IPI00009645 Ran-binding protein 17 RANBP17 IPI00022629 Isoform 1 of Protein regulator of cytokinesis 1 PRC1 IPI00031082 Putative uncharacterized protein DKFZp761O17121 LDOC1L IPI00788120 similar to CG14182-PA LOC730094 IPI00396063 C-myc promoter-binding protein DENND4A IPI00013296 40S ribosomal protein S18 RPS18 IPI00004362 MORC family CW-type zinc finger protein 1 MORC1 IPI00787625 similar to 60S ribosomal protein L23a LOC389101 IPI00385020 Putative uncharacterized protein DKFZp686D159 (Fragment) CAPRIN2 IPI00374223 hypothetical protein LOC389119 C3orf54 IPI00039626 Isoform D of UPF0318 protein FAM120A FAM120A IPI00295253 Isoform 1 of Cell surface glycoprotein OX2 receptor precursor CD200R1 IPI00299040 Polycystin-2 PKD2 IPI00307165 Tripartite motif-containing protein 47 TRIM47 IPI00152685 Tetratricopeptide repeat protein 15 TTC15 IPI00013789 SET and MYND domain-containing protein 5 SMYD5 IPI00396025 hypothetical protein LOC254122 FLJ30934 IPI00014232 ADP-ribosylation factor-like protein 6-interacting protein 1 ARL6IP1 IPI00021715 Isoform 1 of Collagen alpha-5(IV) chain precursor COL4A5 IPI00026305 Hook homolog 1 HOOK1 IPI00184160 Isoform 2 of RING finger protein 180 RNF180 IPI00216308 Voltage-dependent anion-selective channel protein 1 VDAC1 IPI00651633 CASKIN1 protein (Fragment) CASKIN1 IPI00247063 Neprilysin MME IPI00398779 Isoform 4 of Plectin-1 PLEC1 IPI00168418 Putative uncharacterized protein C11orf64 C11orf64 IPI00167764 Transmembrane protein 102 TMEM102 IPI00171716 OTTHUMP00000028696 TTC28 IPI00394818 Isoform 1 of Ankyrin repeat domain-containing protein 47 KANK3 IPI00830137 Uncharacterized protein ENSP00000374864 — IPI00030874 Uncharacterized gastric protein YA42P (Fragment) — IPI00455675 Isoform 2 of Centrosomal protein of 192 kDa CEP192 IPI00789889 Hypothetical protein — IPI00829625 Uncharacterized protein FAM91A1 FAM91A1 IPI00000873 Valyl-tRNA synthetase VARS IPI00386185 FLJ00370 protein (Fragment) — IPI00829697 Uncharacterized protein ENSP00000375030 — IPI00000690 Isoform 1 of Apoptosis-inducing factor 1, mitochondrial precursor AIFM1 IPI00016988 WD repeat-containing protein 13 WDR13 IPI00478058 Isoform 2 of NMDA receptor-regulated 1-like protein NARG1L IPI00782960 Isoform 1 of Leucine-rich repeat and IQ domain-containing protein 3 LRRC44 IPI00103373 Cytoglobin CYGB IPI00646831 34 kDa protein — IPI00384164 Full-length cDNA clone CS0DI075YC18 of Placenta of Homo PGF sapiens (Fragment) IPI00739611 similar to golgi autoantigen, golgin subfamily a, 8A isoform 3 LOC727909 IPI00012451 Guanine nucleotide-binding protein subunit beta-4 GNB4 IPI00394960 Isoform 1 of Probable G-protein coupled receptor 133 precursor GPR133 IPI00555595 Ubiquitin carboxyl-terminal esterase L1 (Ubiquitin thiolesterase) — variant (Fragment) IPI00431697 Cancer/testis antigen 45-5 RP13-36C9.6 IPI00028066 class IV alcohol dehydrogenase 7 mu or sigma subunit ADH7 IPI00152960 RNA polymerase 1-specific transcription initiation factor RRN3 RRN3 IPI00792370 6 kDa protein GNAT1 IPI00167762 Isoform 1 of Uncharacterized protein C19orf47 C19orf47 IPI00385321 Isoform 2 of Protein kinase C-binding protein 1 ZMYND8 IPI00385153 HUMEEP ATXN10 IPI00337348 Growth differentiation factor 7 GDF7 IPI00060627 Coiled-coil domain-containing protein 124 CCDC124 IPI00401190 LOC155006 protein LOC155006 IPI00025039 rRNA 2′-O-methyltransferase fibrillarin FBL IPI00479578 similar to Nonhistone chromosomal protein HMG-14 hCG_1659830 IPI00018245 Isoform 3 of DNA-directed RNA polymerase III subunit RPC5 POLR3E IPI00020565 PRO1598 — IPI00446711 CDNA FLJ41261 fis, clone BRAMY2034920 — IPI00787990 similar to ribosomal protein S14 LOC644119 IPI00218743 Isoform 2 of Bestrophin-1 BEST1 IPI00736826 similar to Temporarily Assigned Gene name family member LOC402217 IPI00412024 Zinc finger protein 485 ZNF485 IPI00297559 Isoform 1 of USH1C-binding protein 1 USHBP1 IPI00396147 Protocadherin-20 precursor PCDH20 IPI00478572 Collagen alpha-4(IV) chain precursor COL4A4 IPI00032785 Isoform II of Amyloid beta A4 precursor protein-binding family B APBB3 member 3 IPI00009982 Isoform 1 of Tudor and KH domain-containing protein TDRKH IPI00216164 Peroxisomal bifunctional enzyme EHHADH IPI00419912 YY2 transcription factor YY2 IPI00735531 proline-rich synapse-associated protein 2 isoform 4 SHANK3 IPI00005104 Inhibitor of nuclear factor kappa-B kinase subunit alpha CHUK IPI00008837 Tyrosine-protein phosphatase non-receptor type 5 PTPN5 IPI00017800 ATP-binding cassette sub-family A member 3 ABCA3 IPI00737972 Transcription factor 24 (Fragment) TCF24 IPI00374074 similar to CG40449-PA.3 LOC388795 IPI00220533 Isoform D of Transmembrane protease, serine 3 TMPRSS3 IPI00302458 Exportin-7 XPO7 IPI00646826 Putative uncharacterized protein FLJ32658 FLJ32658 IPI00016859 Isoform 1 of Transcription factor IIIB 90 kDa subunit BRF1 IPI00031386 Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit PIK3CA alpha isoform IPI00065547 OTTHUMP00000031495 RP11-93B14.6 IPI00043370 WD repeat-containing protein 52 WDR52 IPI00064767 Isoform 1 of Rho GTPase-activating protein 17 ARHGAP17 IPI00219689 Isoform Beta of Protein vav-3 VAV3 IPI00328291 Cytoskeleton-associated protein 2-like CKAP2L IPI00647897 RING finger protein 113B RNF113B IPI00024285 similar to testicular serine protease 2 LOC138652 IPI00783200 38 kDa protein RAPGEF3 IPI00014877 Isoform 2 of Glutaminyl-peptide cyclotransferase-like protein QPCTL IPI00186554 Uncharacterized protein KIAA1853 KIAA1853 IPI00418336 Isoform 2 of Integrator complex subunit 3 INTS3 IPI00872730 Macrophin 1 isoform MACF1 IPI00303207 ATP-binding cassette sub-family E member 1 ABCE1 IPI00301609 Serine/threonine-protein kinase Nek9 NEK9 IPI00744527 Conserved hypothetical protein — IPI00302351 Isoform 1 of Serine/threonine-protein kinase 33 STK33 IPI00878483 30 kDa protein — IPI00744179 Uncharacterized protein ENSP00000370856 (Fragment) — IPI00396279 Isoform 1 of CLIP-associating protein 1 CLASP1 IPI00013378 Isoform Long of DNA topoisomerase 3-alpha TOP3A IPI00429190 Ras-related protein Rab-11A RAB11A IPI00464994 Isoform 1 of tRNA modification GTPase GTPBP3, mitochondrial GTPBP3 precursor IPI00008449 Isoform 3 of Pre-mRNA 3′-end-processing factor FIP1 FIP1L1 IPI00414402 Olfactory receptor 2T27 OR2T27 IPI00168913 Isoform 2 of Limbin EVC2 IPI00009315 Golgi resident protein GCP60 ACBD3 IPI00871625 cDNA FLJ77072, highly similar to Homo sapiens prostaglandin E PTGER3 receptor 3 (subtype EP3) (PTGER3), transcript variant 9, mRNA IPI00479296 Isoform 1 of ATP-binding cassette sub-family A member 8 ABCA8 IPI00300221 Putative uncharacterized protein DKFZp434I1916 ELL IPI00026036 Isoform 5 of Dipeptidyl peptidase 8 DPP8 IPI00647205 Uncharacterized protein C6orf174 precursor C6orf174 IPI00006932 Isoform 1 of Putative RNA-binding protein Luc7-like 2 LUC7L2 IPI00017819 Bile acid-CoA:amino acid N-acyltransferase BAAT IPI00145121 GPI mannosyltransferase 3 PIGB IPI00744357 Conserved hypothetical protein — IPI00410320 Sodium-dependent glucose transporter SLC5A11 IPI00065085 CDNA FLJ25371 fis, clone TST01885 FLJ25371 IPI00289914 MutS protein homolog 4 MSH4 IPI00012438 Isoform Long of 52 kDa repressor of the inhibitor of the protein PRKRIR kinase IPI00217895 rai-like protein SHC4 IPI00294618 Proline-rich protein PRCC PRCC IPI00000784 Isoform MEF2DAB of Myocyte-specific enhancer factor 2D MEF2D IPI00848180 Conserved hypothetical protein — IPI00045208 Zinc finger protein 300-B ZNF300 IPI00871452 Isoform 1 of PWWP domain-containing protein 2A PWWP2A IPI00102820 Isoform 3 of Mitochondrial tumor suppressor 1 MTUS1 IPI00215786 3′,5′-cyclic nucleotide phosphodiesterase 10A2 PDE10A IPI00845401 Isoform 6 of Neuron navigator 1 NAV1 IPI00217979 Myeloid/lymphoid or mixed-lineage leukemia 5 MLL5 IPI00440764 Isoform 1 of Gamma-glutamyltransferase 6 precursor GGT6 IPI00374068 Isoform 1 of ADAMTS-like protein 4 precursor ADAMTSL4 IPI00186439 Zinc finger protein 643 ZNF643 IPI00062467 Isoform 1 of Zinc finger protein 274 ZNF274 IPI00000890 Isoform 1 of Growth hormone variant precursor GH2 IPI00065351 Zinc finger protein 354B ZNF354B IPI00552455 12 kDa protein INPP5A IPI00395473 Zinc finger protein 135 ZNF135 IPI00003842 Isoform 1 of Microtubule-associated protein 2 MAP2 IPI00655760 Envelope polyprotein — IPI00384767 FLJ00332 protein (Fragment) TBC1D10C IPI00028050 Selenocysteine-specific elongation factor EEFSEC IPI00152033 Isoform 1 of Transient receptor potential cation channel subfamily M TRPM8 member 8 IPI00789564 Isoform 3 of Metallophosphoesterase 1 MPPE1 IPI00011253 40S ribosomal protein S3 RPS3 IPI00454620 HERV-K_11q22.1 provirus ancestral Pol protein — IPI00337335 Isoform 1 of Myosin-14 MYH14 IPI00103426 Isoform 1 of Solute carrier family 13 member 3 SLC13A3 IPI00291839 Isoform 2 of Rap guanine nucleotide exchange factor 6 RAPGEF6

TABLE 9 Relative Abundance of CSF Proteins Chronic Fatigue compared to Neurologic Lyme Table 9. Quantitative Relative Abundance of CSF Proteins in Chronic Fatigue (CF) compared to Neurologic Lyme Disease. A ratio greater than 1 indicates there is a relative quantitative difference in Chronic Fatigue compared to Neurologic Lyme disease (LD). Ratios near 1 suggest equal relative abundances. Ratios less than 1 indicate the proteins is present in a greater relative abundance in Neurologic Lyme disease compared to Chronic Fatigue. There are 168 proteins in Chronic Fatigue that are 2 fold greater in relative abundance than those proteins Neurologic Lyme disease. There are 1081 proteins that are relatively more abundant in Neurologic Lyme disease compared to Chronic Fatigue with a ratio of 0.5 or less. Blank cell is close to 0 ratio. Clean IPI CF to LD Ratio IPI00217493 18.00 IPI00783656 6.67 IPI00465436 6.50 IPI00161055 6.50 IPI00445716 5.00 IPI00384395 5.00 IPI00020747 5.00 IPI00291807 5.00 IPI00827978 4.00 IPI00827485 4.00 IPI00024887 4.00 IPI00419442 4.00 IPI00008107 4.00 IPI00022445 4.00 IPI00002307 4.00 IPI00465070 4.00 IPI00023604 4.00 IPI00395769 4.00 IPI00220706 3.60 IPI00382682 3.50 IPI00830035 3.33 IPI00465315 3.22 IPI00384407 3.00 IPI00296259 3.00 IPI00400986 3.00 IPI00010863 3.00 IPI00005153 3.00 IPI00020131 3.06 IPI00176920 3.00 IPI00176104 3.00 IPI00019600 3.00 IPI00299435 3.00 IPI00008207 3.00 IPI00830057 3.00 IPI00028931 3.00 IPI00006556 3.00 IPI00022674 3.00 IPI00043810 3.00 IPI00166892 3.00 IPI00398007 3.00 IPI00016604 3.00 IPI00003469 3.00 IPI00827643 3.00 IPI00741524 3.00 IPI00179415 3.00 IPI00442002 3.00 IPI00387099 3.00 IPI00021828 3.00 IPI00410714 2.91 IPI00383808 2.75 IPI00182138 2.67 IPI00473011 2.67 IPI00442909 2.67 IPI00023019 2.55 IPI00021833 2.50 IPI00883772 2.50 IPI00293088 2.50 IPI00216983 2.50 IPI00410079 2.50 IPI00215983 2.45 IPI00220301 2.40 IPI00024621 2.40 IPI00029275 2.40 IPI00008556 2.33 IPI00009477 2.29 IPI00023505 2.25 IPI00654755 2.15 IPI00418960 2.14 IPI00010381 2.11 IPI00003907 2.09 IPI00002818 2.00 IPI00002535 2.00 IPI00030757 2.00 IPI00217781 2.00 IPI00382478 2.00 IPI00018352 2.00 IPI00470766 2.00 IPI00007617 2.00 IPI00301098 2.00 IPI00000070 2.00 IPI00827788 2.00 IPI00003807 2.00 IPI00010133 2.00 IPI00099650 2.00 IPI00166553 2.00 IPI00221080 2.00 IPI00099838 2.00 IPI00744706 2.00 IPI00291987 2.00 IPI00031019 2.00 IPI00387101 2.00 IPI00004480 2.00 IPI00021812 2.00 IPI00008085 2.00 IPI00027972 2.00 IPI00455739 2.00 IPI00883879 2.00 IPI00297208 2.00 IPI00151036 2.00 IPI00218914 2.00 IPI00328587 2.00 IPI00005517 2.00 IPI00029605 2.00 IPI00009881 2.00 IPI00030431 2.00 IPI00384400 2.00 IPI00008997 2.00 IPI00019755 2.00 IPI00383951 2.00 IPI00000160 2.00 IPI00012048 2.00 IPI00010810 2.00 IPI00020431 2.00 IPI00297288 2.00 IPI00218474 2.00 IPI00719621 2.00 IPI00387110 2.00 IPI00329352 2.00 IPI00399089 2.00 IPI00027239 2.00 IPI00783604 2.00 IPI00008726 2.00 IPI00299399 2.00 IPI00168921 2.00 IPI00383603 2.00 IPI00179851 2.00 IPI00219684 2.00 IPI00644472 2.00 IPI00220362 2.00 IPI00006130 2.00 IPI00550363 2.00 IPI00420071 2.00 IPI00103871 2.00 IPI00218539 2.00 IPI00018941 2.00 IPI00432766 2.00 IPI00746600 2.00 IPI00419815 2.00 IPI00376197 2.00 IPI00293613 2.00 IPI00796518 2.00 IPI00007648 2.00 IPI00409659 2.00 IPI00220113 2.00 IPI00015135 2.00 IPI00306929 2.00 IPI00011092 2.00 IPI00293616 2.00 IPI00643747 2.00 IPI00465173 2.00 IPI00011832 2.00 IPI00185892 2.00 IPI00152189 2.00 IPI00176778 2.00 IPI00829979 2.00 IPI00004970 2.00 IPI00003084 2.00 IPI00025155 2.00 IPI00401776 2.00 IPI00009504 2.00 IPI00015473 2.00 IPI00304533 2.00 IPI00031101 2.00 IPI00402291 2.00 IPI00385799 2.00 IPI00829803 2.00 IPI00033541 2.00 IPI00027220 2.00 IPI00014048 2.00 IPI00329775 1.97 IPI00022284 1.90 IPI00165975 1.88 IPI00745313 1.86 IPI00016679 1.86 IPI00016666 1.83 IPI00307592 1.83 IPI00006803 1.83 IPI00382420 1.83 IPI00001895 1.83 IPI00012887 1.80 IPI00397645 1.80 IPI00873544 1.80 IPI00479116 1.78 IPI00829841 1.78 IPI00010402 1.78 IPI00025426 1.77 IPI00025318 1.75 IPI00019530 1.75 IPI00020906 1.75 IPI00375364 1.75 IPI00418471 1.75 IPI00013438 1.75 IPI00443799 1.73 IPI00219131 1.71 IPI00059366 1.69 IPI00003111 1.67 IPI00465377 1.67 IPI00419565 1.67 IPI00025473 1.67 IPI00001610 1.67 IPI00007240 1.67 IPI00009054 1.67 IPI00465255 1.67 IPI00010896 1.67 IPI00099670 1.67 IPI00419966 1.67 IPI00031708 1.67 IPI00419720 1.67 IPI00382486 1.67 IPI00337351 1.67 IPI00008752 1.67 IPI00027765 1.67 IPI00854589 1.67 IPI00294193 1.65 IPI00218192 1.65 IPI00784154 1.62 IPI00844156 1.61 IPI00743963 1.60 IPI00018311 1.60 IPI00152850 1.60 IPI00816775 1.60 IPI00440932 1.60 IPI00470607 1.60 IPI00428511 1.60 IPI00743194 1.58 IPI00743766 1.58 IPI00029131 1.57 IPI00382481 1.57 IPI00829701 1.57 IPI00292732 1.57 IPI00827522 1.57 IPI00012075 1.57 IPI00298547 1.56 IPI00001506 1.55 IPI00027350 1.53 IPI00169383 1.53 IPI00008944 1.51 IPI00854745 1.50 IPI00024035 1.50 IPI00394820 1.50 IPI00301294 1.50 IPI00014964 1.50 IPI00412541 1.50 IPI00064652 1.50 IPI00883765 1.50 IPI00002412 1.50 IPI00552852 1.50 IPI00736885 1.50 IPI00789234 1.50 IPI00165972 1.50 IPI00297180 1.50 IPI00008533 1.50 IPI00302962 1.50 IPI00045536 1.50 IPI00005222 1.50 IPI00215980 1.50 IPI00641251 1.50 IPI00015911 1.50 IPI00306322 1.50 IPI00301180 1.50 IPI00217963 1.50 IPI00293530 1.50 IPI00018246 1.50 IPI00184094 1.50 IPI00165044 1.50 IPI00030882 1.50 IPI00008223 1.50 IPI00169285 1.50 IPI00291006 1.50 IPI00021304 1.50 IPI00167215 1.50 IPI00295601 1.50 IPI00306343 1.50 IPI00387025 1.50 IPI00064429 1.50 IPI00001674 1.50 IPI00217975 1.50 IPI00291878 1.50 IPI00012544 1.50 IPI00064606 1.50 IPI00001328 1.50 IPI00000436 1.50 IPI00009375 1.50 IPI00015049 1.48 IPI00296058 1.47 IPI00001593 1.47 IPI00015479 1.45 IPI00783024 1.45 IPI00301961 1.45 IPI00829947 1.45 IPI00024601 1.45 IPI00455667 1.45 IPI00009901 1.44 IPI00299150 1.44 IPI00024307 1.44 IPI00297284 1.44 IPI00022333 1.44 IPI00293836 1.44 IPI00032179 1.44 IPI00006154 1.44 IPI00787853 1.43 IPI00550991 1.43 IPI00026991 1.43 IPI00442911 1.42 IPI00289058 1.42 IPI00029863 1.42 IPI00867665 1.42 IPI00018274 1.42 IPI00854709 1.41 IPI00743302 1.41 IPI00003590 1.40 IPI00020019 1.40 IPI00011578 1.40 IPI00829590 1.40 IPI00299083 1.40 IPI00002334 1.40 IPI00884389 1.40 IPI00003919 1.40 IPI00026285 1.40 IPI00783399 1.40 IPI00031534 1.40 IPI00019449 1.40 IPI00005516 1.40 IPI00747758 1.40 IPI00291136 1.39 IPI00019581 1.38 IPI00166039 1.38 IPI00001592 1.38 IPI00025809 1.38 IPI00010796 1.38 IPI00183321 1.38 IPI00218046 1.38 IPI00032328 1.37 IPI00465016 1.37 IPI00334667 1.37 IPI00026050 1.36 IPI00477992 1.36 IPI00032220 1.36 IPI00217345 1.36 IPI00472249 1.36 IPI00297646 1.35 IPI00328746 1.35 IPI00794450 1.35 IPI00026154 1.35 IPI00514285 1.35 IPI00646281 1.34 IPI00019176 1.33 IPI00387113 1.33 IPI00011643 1.33 IPI00005129 1.33 IPI00657936 1.33 IPI00387024 1.33 IPI00298650 1.33 IPI00884080 1.33 IPI00418125 1.33 IPI00789477 1.33 IPI00021856 1.33 IPI00789259 1.33 IPI00741710 1.33 IPI00000144 1.33 IPI00219425 1.33 IPI00783471 1.33 IPI00171196 1.33 IPI00160552 1.33 IPI00883855 1.33 IPI00006713 1.33 IPI00011518 1.33 IPI00293303 1.33 IPI00031549 1.33 IPI00296197 1.33 IPI00554786 1.33 IPI00000824 1.33 IPI00018396 1.33 IPI00165125 1.33 IPI00787265 1.33 IPI00299024 1.33 IPI00299299 1.33 IPI00009111 1.33 IPI00300838 1.33 IPI00027497 1.33 IPI00006543 1.33 IPI00142538 1.33 IPI00015614 1.33 IPI00786926 1.33 IPI00009851 1.33 IPI00013895 1.33 IPI00019943 1.33 IPI00220292 1.33 IPI00027087 1.33 IPI00654888 1.32 IPI00023807 1.32 IPI00783287 1.32 IPI00018219 1.31 IPI00007778 1.31 IPI00022431 1.31 IPI00013682 1.30 IPI00456736 1.30 IPI00103175 1.30 IPI00025461 1.30 IPI00169276 1.30 IPI00394992 1.30 IPI00163207 1.30 IPI00152847 1.29 IPI00005142 1.29 IPI00299758 1.29 IPI00022608 1.29 IPI00294615 1.29 IPI00827829 1.29 IPI00854841 1.29 IPI00008780 1.29 IPI00006657 1.29 IPI00003865 1.29 IPI00027174 1.29 IPI00003176 1.29 IPI00220739 1.29 IPI00217966 1.29 IPI00879915 1.29 IPI00328550 1.28 IPI00383732 1.28 IPI00292150 1.28 IPI00289204 1.28 IPI00162547 1.28 IPI00062037 1.27 IPI00012283 1.27 IPI00382500 1.27 IPI00514676 1.27 IPI00220342 1.27 IPI00029235 1.27 IPI00477597 1.27 IPI00029699 1.27 IPI00301255 1.27 IPI00432592 1.27 IPI00218733 1.27 IPI00795013 1.26 IPI00395488 1.26 IPI00783492 1.25 IPI00015315 1.25 IPI00016150 1.25 IPI00816155 1.25 IPI00884004 1.25 IPI00552939 1.25 IPI00783156 1.25 IPI00021817 1.25 IPI00017557 1.25 IPI00000265 1.25 IPI00002925 1.25 IPI00382493 1.25 IPI00033560 1.25 IPI00414896 1.25 IPI00028714 1.25 IPI00477714 1.25 IPI00401283 1.25 IPI00030847 1.25 IPI00006524 1.25 IPI00168479 1.25 IPI00293757 1.25 IPI00024273 1.25 IPI00646304 1.25 IPI00015964 1.25 IPI00001734 1.25 IPI00430291 1.25 IPI00382426 1.25 IPI00328840 1.25 IPI00009997 1.25 IPI00009030 1.24 IPI00032293 1.24 IPI00556287 1.24 IPI00854743 1.24 IPI00022895 1.24 IPI00019580 1.24 IPI00299738 1.23 IPI00220562 1.23 IPI00166048 1.23 IPI00000044 1.23 IPI00787050 1.23 IPI00002211 1.23 IPI00292946 1.23 IPI00215894 1.23 IPI00007853 1.22 IPI00376689 1.22 IPI00220334 1.22 IPI00739827 1.22 IPI00744835 1.22 IPI00465248 1.22 IPI00829877 1.22 IPI00011252 1.21 IPI00028413 1.21 IPI00298828 1.21 IPI00004413 1.21 IPI00795055 1.21 IPI00012503 1.21 IPI00027482 1.20 IPI00029819 1.20 IPI00387095 1.20 IPI00013701 1.20 IPI00029817 1.20 IPI00827940 1.20 IPI00219465 1.20 IPI00749328 1.20 IPI00215997 1.20 IPI00013096 1.20 IPI00478809 1.20 IPI00028015 1.20 IPI00290856 1.20 IPI00218414 1.20 IPI00410487 1.20 IPI00029273 1.20 IPI00386418 1.20 IPI00303963 1.20 IPI00022488 1.20 IPI00291866 1.20 IPI00552905 1.20 IPI00009920 1.19 IPI00171473 1.19 IPI00022937 1.19 IPI00292304 1.19 IPI00852979 1.19 IPI00465325 1.19 IPI00830047 1.19 IPI00827906 1.19 IPI00386630 1.19 IPI00294705 1.19 IPI00376394 1.19 IPI00183445 1.18 IPI00031030 1.18 IPI00301364 1.18 IPI00167710 1.18 IPI00292950 1.18 IPI00413959 1.18 IPI00456623 1.18 IPI00010949 1.18 IPI00007257 1.18 IPI00295832 1.17 IPI00292530 1.17 IPI00297124 1.17 IPI00022420 1.17 IPI00064935 1.17 IPI00023824 1.17 IPI00167093 1.17 IPI00004946 1.17 IPI00063048 1.17 IPI00022367 1.17 IPI00414717 1.17 IPI00328391 1.17 IPI00218493 1.17 IPI00329688 1.17 IPI00013569 1.17 IPI00032311 1.17 IPI00009865 1.17 IPI00002406 1.17 IPI00827650 1.17 IPI00032291 1.17 IPI00816555 1.17 IPI00027827 1.16 IPI00000130 1.16 IPI00816741 1.16 IPI00303161 1.16 IPI00745363 1.16 IPI00022337 1.16 IPI00012058 1.16 IPI00027507 1.15 IPI00385253 1.15 IPI00217146 1.15 IPI00385985 1.15 IPI00216691 1.15 IPI00296537 1.15 IPI00017696 1.15 IPI00305461 1.15 IPI00879309 1.15 IPI00853369 1.15 IPI00843910 1.15 IPI00798430 1.15 IPI00555812 1.15 IPI00791343 1.15 IPI00301143 1.15 IPI00016915 1.15 IPI00013179 1.15 IPI00642632 1.14 IPI00001793 1.14 IPI00291395 1.14 IPI00219301 1.14 IPI00021033 1.14 IPI00023845 1.14 IPI00418163 1.14 IPI00021854 1.14 IPI00742696 1.14 IPI00019568 1.14 IPI00032258 1.14 IPI00247243 1.14 IPI00328609 1.14 IPI00004440 1.14 IPI00419722 1.13 IPI00176424 1.13 IPI00022392 1.13 IPI00879665 1.13 IPI00296777 1.13 IPI00022463 1.13 IPI00296992 1.13 IPI00020996 1.13 IPI00816626 1.13 IPI00005908 1.13 IPI00032292 1.13 IPI00032405 1.13 IPI00152418 1.13 IPI00021447 1.13 IPI00182944 1.13 IPI00816799 1.13 IPI00025840 1.13 IPI00007199 1.13 IPI00019954 1.13 IPI00219526 1.13 IPI00026216 1.13 IPI00021885 1.12 IPI00064607 1.12 IPI00000828 1.12 IPI00784119 1.12 IPI00289083 1.12 IPI00176221 1.12 IPI00029260 1.12 IPI00296534 1.12 IPI00298793 1.12 IPI00299059 1.12 IPI00783390 1.12 IPI00607600 1.11 IPI00299724 1.11 IPI00011662 1.11 IPI00289831 1.11 IPI00032288 1.11 IPI00299503 1.11 IPI00001399 1.11 IPI00376427 1.11 IPI00298237 1.11 IPI00477804 1.11 IPI00020012 1.10 IPI00442297 1.10 IPI00607580 1.10 IPI00442294 1.10 IPI00218732 1.10 IPI00553177 1.10 IPI00218834 1.10 IPI00020987 1.10 IPI00060310 1.10 IPI00168626 1.10 IPI00297263 1.10 IPI00219029 1.10 IPI00003802 1.10 IPI00006166 1.10 IPI00022395 1.10 IPI00017601 1.09 IPI00019591 1.09 IPI00024966 1.09 IPI00552267 1.09 IPI00639937 1.09 IPI00011264 1.09 IPI00020986 1.09 IPI00291262 1.09 IPI00478003 1.09 IPI00451625 1.09 IPI00006608 1.09 IPI00785200 1.08 IPI00012303 1.08 IPI00010295 1.08 IPI00295414 1.08 IPI00289501 1.08 IPI00069058 1.08 IPI00828205 1.08 IPI00027851 1.08 IPI00005292 1.08 IPI00003366 1.08 IPI00854644 1.08 IPI00550162 1.08 IPI00794184 1.08 IPI00845354 1.07 IPI00241562 1.07 IPI00003351 1.07 IPI00102543 1.07 IPI00171411 1.07 IPI00219798 1.07 IPI00298388 1.07 IPI00299699 1.07 IPI00854806 1.07 IPI00829626 1.07 IPI00001611 1.07 IPI00301812 1.07 IPI00026944 1.07 IPI00384542 1.07 IPI00375205 1.07 IPI00015346 1.07 IPI00382938 1.07 IPI00104074 1.07 IPI00027310 1.07 IPI00016334 1.07 IPI00785196 1.07 IPI00827892 1.07 IPI00410210 1.07 IPI00026104 1.07 IPI00293748 1.07 IPI00784773 1.06 IPI00154742 1.06 IPI00328113 1.06 IPI00877029 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IPI00333140 1.02 IPI00022426 1.02 IPI00303210 1.02 IPI00385264 1.02 IPI00218875 1.02 IPI00218413 1.02 IPI00166729 1.01 IPI00022434 1.01 IPI00007921 1.01 IPI00647027 1.01 IPI00878517 1.01 IPI00298971 1.01 IPI00296165 1.01 IPI00021841 1.00 IPI00000027 1.00 IPI00830122 1.00 IPI00383032 1.00 IPI00297040 1.00 IPI00031008 1.00 IPI00218398 1.00 IPI00073763 1.00 IPI00167619 1.00 IPI00004798 1.00 IPI00305380 1.00 IPI00827846 1.00 IPI00025365 1.00 IPI00455521 1.00 IPI00307729 1.00 IPI00644346 1.00 IPI00829980 1.00 IPI00219219 1.00 IPI00748265 1.00 IPI00418169 1.00 IPI00171611 1.00 IPI00827839 1.00 IPI00030634 1.00 IPI00017841 1.00 IPI00011140 1.00 IPI00290744 1.00 IPI00028381 1.00 IPI00748890 1.00 IPI00816737 1.00 IPI00440153 1.00 IPI00298285 1.00 IPI00030877 1.00 IPI00024032 1.00 IPI00028600 1.00 IPI00024107 1.00 IPI00026125 1.00 IPI00029061 1.00 IPI00006128 1.00 IPI00216461 1.00 IPI00827929 1.00 IPI00830018 1.00 IPI00550533 1.00 IPI00022389 1.00 IPI00382488 1.00 IPI00854624 1.00 IPI00477868 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IPI00163724 1.00 IPI00828083 1.00 IPI00016645 1.00 IPI00645206 1.00 IPI00103471 1.00 IPI00009793 1.00 IPI00014223 1.00 IPI00019209 1.00 IPI00289924 1.00 IPI00883711 1.00 IPI00004669 1.00 IPI00019038 1.00 IPI00023014 1.00 IPI00181174 1.00 IPI00012585 1.00 IPI00025204 1.00 IPI00013162 1.00 IPI00026103 1.00 IPI00011094 1.00 IPI00000871 1.00 IPI00004494 1.00 IPI00182194 1.00 IPI00304577 1.00 IPI00030111 1.00 IPI00029046 1.00 IPI00027078 1.00 IPI00418531 1.00 IPI00296558 1.00 IPI00304962 1.00 IPI00061448 1.00 IPI00025110 1.00 IPI00021485 1.00 IPI00304925 1.00 IPI00297188 1.00 IPI00217759 1.00 IPI00880120 1.00 IPI00171410 1.00 IPI00005794 1.00 IPI00007702 1.00 IPI00024046 1.00 IPI00293276 1.00 IPI00297181 1.00 IPI00006987 1.00 IPI00873344 1.00 IPI00027264 1.00 IPI00027847 1.00 IPI00032227 1.00 IPI00012269 1.00 IPI00004409 1.00 IPI00221117 1.00 IPI00554521 1.00 IPI00218487 1.00 IPI00795481 1.00 IPI00807609 1.00 IPI00065312 1.00 IPI00259102 1.00 IPI00289746 1.00 IPI00002283 1.00 IPI00005605 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IPI00556391 1.00 IPI00290826 1.00 IPI00012989 1.00 IPI00478892 1.00 IPI00171438 1.00 IPI00431738 1.00 IPI00019862 1.00 IPI00643115 1.00 IPI00479997 1.00 IPI00002899 1.00 IPI00426267 1.00 IPI00306851 1.00 IPI00374293 1.00 IPI00060423 1.00 IPI00005806 1.00 IPI00008816 1.00 IPI00334845 1.00 IPI00240345 1.00 IPI00447328 1.00 IPI00456604 1.00 IPI00220736 1.00 IPI00410631 1.00 IPI00007127 1.00 IPI00719690 1.00 IPI00554701 1.00 IPI00008868 1.00 IPI00024134 1.00 IPI00387100 1.00 IPI00012622 1.00 IPI00032358 1.00 IPI00442474 1.00 IPI00005465 1.00 IPI00830059 1.00 IPI00217051 1.00 IPI00414784 1.00 IPI00847644 1.00 IPI00412982 1.00 IPI00782966 1.00 IPI00216969 1.00 IPI60451450 1.00 IPI00788118 1.00 IPI00250716 1.00 IPI00296563 1.00 IPI00020729 1.00 IPI00816409 1.00 IPI00376317 1.00 IPI00382439 1.00 IPI00152432 1.00 IPI00022820 1.00 IPI00744816 1.00 IPI00647124 1.00 IPI00010085 1.00 IPI00604549 1.00 IPI00012869 1.00 IPI00028122 1.00 IPI00001528 1.00 IPI00829845 1.00 IPI00290903 1.00 IPI00385578 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IPI00470596 1.00 IPI00005171 1.00 IPI00054042 1.00 IPI00025862 1.00 IPI00100867 1.00 IPI00219953 1.00 IPI00217442 1.00 IPI00873139 1.00 IPI00288940 1.00 IPI00024915 1.00 IPI00166044 1.00 IPI00470606 1.00 IPI00007836 1.00 IPI00106491 1.00 IPI00021131 1.00 IPI00010676 1.00 IPI00743360 1.00 IPI00737363 1.00 IPI00300046 1.00 IPI00000621 1.00 IPI00017603 1.00 IPI00410214 1.00 IPI00103604 1.00 IPI00153053 1.00 IPI00296434 1.00 IPI00411979 1.00 IPI00186114 1.00 IPI00216236 1.00 IPI00816289 1.00 IPI00060866 1.00 IPI00013743 1.00 IPI00829750 1.00 IPI00472782 1.00 IPI00022621 1.00 IPI00012759 1.00 IPI00166323 1.00 IPI00742682 1.00 IPI00175193 1.00 IPI00002689 1.00 IPI00103146 1.00 IPI00011951 1.00 IPI00292086 1.00 IPI00413293 1.00 IPI00382539 1.00 IPI00024975 1.00 IPI00027356 1.00 IPI00472426 1.00 IPI00792626 1.00 IPI00789954 1.00 IPI00011229 0.99 IPI00748312 0.99 IPI00021000 0.99 IPI00296608 0.99 IPI00384697 0.99 IPI00159927 0.98 IPI00027703 0.98 IPI00290315 0.98 IPI00018236 0.98 IPI00294004 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IPI00215767 0.93 IPI00220361 0.93 IPI00029193 0.93 IPI00023648 0.93 IPI00334282 0.93 IPI00414984 0.93 IPI00020557 0.92 IPI00024272 0.92 IPI00387118 0.92 IPI00328520 0.92 IPI00107731 0.92 IPI00384404 0.92 IPI00827581 0.92 IPI00056478 0.92 IPI00025846 0.92 IPI00017569 0.92 IPI00157414 0.92 IPI00827510 0.92 IPI00784950 0.92 IPI00166622 0.92 IPI00003470 0.92 IPI00300241 0.92 IPI00015260 0.92 IPI00217882 0.92 IPI00002816 0.92 IPI00024587 0.92 IPI00008290 0.91 IPI00784807 0.91 IPI00872555 0.91 IPI00292071 0.91 IPI00006114 0.91 IPI00004656 0.91 IPI00216882 0.91 IPI00257882 0.91 IPI00550558 0.91 IPI00788786 0.91 IPI00028448 0.91 IPI00829640 0.91 IPI00026199 0.91 IPI00015102 0.91 IPI00032532 0.91 IPI00784156 0.91 IPI00386879 0.91 IPI00176427 0.91 IPI00643034 0.91 IPI00827560 0.90 IPI00025818 0.90 IPI00292550 0.90 IPI00784942 0.90 IPI00387115 0.90 IPI00784830 0.90 IPI00216138 0.90 IPI00747849 0.90 IPI00000138 0.90 IPI00301459 0.90 IPI00016422 0.90 IPI00785067 0.90 IPI00162735 0.90 IPI00019399 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IPI00787625 IPI00374223 IPI00023586 IPI00028579 IPI00385020 IPI00253323 IPI00170961 IPI00166361 IPI00787587 IPI00294810 IPI00418408 IPI00004362 IPI00168627 IPI00026952 IPI00302351 IPI00299554 IPI00307165 IPI00152722 IPI00298447 IPI00396025 IPI00293200 IPI00013789 IPI00550272 IPI00410564 IPI00152685 IPI00384140 IPI00514197 IPI00299040 IPI00295253 IPI00039626 IPI00156804 IPI00396527 IPI00183526 IPI00782960 IPI00012451 IPI00739611 IPI00384164 IPI00065253 IPI00646831 IPI00383294 IPI00103373 IPI00008632 IPI00216137 IPI00005621 IPI00478058 IPI00001933 IPI00411291 IPI00387098 IPI00883751 IPI00884216 IPI00026512 IPI00180375 IPI00152960 IPI00028066 IPI00179452 IPI00297407 IPI00296421 IPI00290155 IPI00394960 IPI00747017 IPI00793836 IPI00382422 IPI00328842 IPI00555595 IPI00016861 IPI00431697 IPI00470771 IPI00830137 IPI00031768 IPI00883997 IPI00394818 IPI00171716 IPI00016988 IPI00216986 IPI00030874 IPI00168418 IPI00021143 IPI00297931 IPI00018691 IPI00010604 IPI00022438 IPI00167764 IPI00874276 IPI00000690 IPI00829697 IPI00020903 IPI00386185 IPI00465247 IPI00382394 IPI00021979 IPI00167913 IPI00300060 IPI00829625 IPI00446767 IPI00020754 IPI00789889 IPI00455675 IPI00014852 IPI00000873

TABLE 10 CSF Proteins in True Normals by IPI IPI00022434 IPI00007257 IPI00853525 IPI00816741 IPI00009920 IPI00784950 IPI00783987 IPI00032291 IPI00218874 IPI00296534 IPI00300241 IPI00550731 IPI00418163 IPI00156171 IPI00215894 IPI00218725 IPI00386879 IPI00472249 IPI00032258 IPI00414249 IPI00031030 IPI00027703 IPI00382606 IPI00654888 IPI00878517 IPI00878576 IPI00025276 IPI00423463 IPI00788835 IPI00792626 IPI00006601 IPI00413959 IPI00032328 IPI00784842 IPI00015102 IPI00171411 IPI00384697 IPI00021842 IPI00376427 IPI00219029 IPI00013976 IPI00020996 IPI00022463 IPI00064667 IPI00456623 IPI00295542 IPI00216171 IPI00783399 IPI00069058 IPI00303210 IPI00019943 IPI00744835 IPI00439446 IPI00160552 IPI00798430 IPI00006608 IPI00748312 IPI00012503 IPI00027780 IPI00294004 IPI00478003 IPI00216728 IPI00291866 IPI00418262 IPI00162735 IPI00301865 IPI00017601 IPI00007921 IPI00021885 IPI00159927 IPI00002147 IPI00216697 IPI00292071 IPI00550991 IPI00022395 IPI00784810 IPI00294395 IPI00440577 IPI00026314 IPI00009362 IPI00289831 IPI00785084 IPI00008318 IPI00061977 IPI00029751 IPI00655702 IPI00027310 IPI00011229 IPI00853454 IPI00855725 IPI00289501 IPI00795918 IPI00815926 IPI00465439 IPI00027087 IPI00020986 IPI00013179 IPI00019591 IPI00302641 IPI00016334 IPI00029863 IPI00297646 IPI00514285 IPI00290315 IPI00017696 IPI00003362 IPI00029343 IPI00845354 IPI00296777 IPI00470535 IPI00375547 IPI00853369 IPI00430842 IPI00169383 IPI00022229 IPI00291136 IPI00015260 IPI00872363 IPI00744561 IPI00004669 IPI00006114 IPI00021841 IPI00607580 IPI00423466 IPI00784998 IPI00022426 IPI00783390 IPI00177543 IPI00784828 IPI00790899 IPI00166048 IPI00022284 IPI00029739 IPI00394655 IPI00784807 IPI00334282 IPI00442294 IPI00328609 IPI00242956 IPI00479514 IPI00002714 IPI00019568 IPI00296922 IPI00219365 IPI00299059 IPI00639937 IPI00219798 IPI00296165 IPI00016915 IPI00006662 IPI00291262 IPI00021000 IPI00426051 IPI00829767 IPI00844156 IPI00004656 IPI00794184 IPI00478809 IPI00296537 IPI00292950 IPI00003351 IPI00021891 IPI00788189 IPI00022937 IPI00384542 IPI00292530 IPI00646281 IPI00018136 IPI00553177 IPI00032179 IPI00025465 IPI00023673 IPI00023845 IPI00001662 IPI00304273 IPI00023814 IPI00796279 IPI00303963 IPI00374563 IPI00477747 IPI00024284 IPI00220741 IPI00107831 IPI00000828 IPI00002280 IPI00183445 IPI00883753 IPI00019580 IPI00761159 IPI00828205 IPI00298971 IPI00784985 IPI00847179 IPI00294193 IPI00026944 IPI00451625 IPI00029260 IPI00334667 IPI00555812 IPI00024966 IPI00472345 IPI00029658 IPI00442297 IPI00784969 IPI00333776 IPI00218192 IPI00791343 IPI00016150 IPI00830132 IPI00785067 IPI00742696 IPI00218875 IPI00784894 IPI00004433 IPI00872555 IPI00430808 IPI00415032 IPI00219042 IPI00018219 IPI00012545 IPI00218733 IPI00477597 IPI00072917 IPI00306339 IPI00298497 IPI00025252 IPI00515041 IPI00301579 IPI00022488 IPI00296608 IPI00003802 IPI00220117 IPI00019157 IPI00290085 IPI00647027 IPI00739237 IPI00025257 IPI00784942 IPI00465028 IPI00022371 IPI00020557 IPI00009997 IPI00448925 IPI00022895 IPI00220562 IPI00176221 IPI00241562 IPI00305461 IPI00328829 IPI00394992 IPI00166622 IPI00480183 IPI00607600 IPI00032293 IPI00031121 IPI00550558 IPI00787050 IPI00855824 IPI00020012 IPI00220644 IPI00022432 IPI00298828 IPI00216704 IPI00289083 IPI00032220 IPI00334238 IPI00641737 IPI00163207 IPI00647704 IPI00016422 IPI00000779 IPI00022420 IPI00794070 IPI00015881 IPI00646304 IPI00292550 IPI00784830 IPI00298793 IPI00009802 IPI00787781 IPI00029693 IPI00027497 IPI00784758 IPI00001952 IPI00465184 IPI00026104 IPI00877169 IPI00815938 IPI00021854 IPI00152540 IPI00795013 IPI00000816 IPI00010949 IPI00816555 IPI00298281 IPI00027848 IPI00385980 IPI00793166 IPI00220342 IPI00015964 IPI00008787 IPI00643034 IPI00218046 IPI00299738 IPI00718977 IPI00299299 IPI00028911 IPI00026946 IPI00022337 IPI00022822 IPI00302181 IPI00301459 IPI00166729 IPI00166766 IPI00103175 IPI00218413 IPI00465325 IPI00290856 IPI00022417 IPI00154734 IPI00009865 IPI00019581 IPI00337548 IPI00029723 IPI00022431 IPI00410210 IPI00552905 IPI00006967 IPI00032532 IPI00297487 IPI00010154 IPI00008944 IPI00787853 IPI00019576 IPI00643920 IPI00027482 IPI00009028 IPI00384952 IPI00000130 IPI00028413 IPI00743766 IPI00215983 IPI00746963 IPI00180240 IPI00829877 IPI00167093 IPI00000877 IPI00790473 IPI00003590 IPI00176458 IPI00013698 IPI00018236 IPI00423461 IPI00000137 IPI00027827 IPI00011218 IPI00011264 IPI00877029 IPI00219526 IPI00477992 IPI00219217 IPI00292946 IPI00163563 IPI00027166 IPI00783665 IPI00015756 IPI00465248 IPI00329775 IPI00328391 IPI00411680 IPI00012102 IPI00002816 IPI00792115 IPI00024046 IPI00026216 IPI00852979 IPI00003921 IPI00023014 IPI00410600 IPI00221224 IPI00783492 IPI00414984 IPI00011261 IPI00021485 IPI00298237 IPI00297124 IPI00816626 IPI00791228 IPI00879084 IPI00293088 IPI00419722 IPI00297284 IPI00027230 IPI00162547 IPI00029235 IPI00020990 IPI00879665 IPI00102543 IPI00290283 IPI00022608 IPI00395488 IPI00745660 IPI00028908 IPI00550162 IPI00376689 IPI00024570 IPI00298994 IPI00414896 IPI00252731 IPI00165949 IPI00419724 IPI00008994 IPI00010471 IPI00023019 IPI00012585 IPI00056478 IPI00218732 IPI00157414 IPI00298547 IPI00002732 IPI00021304 IPI00385264 IPI00021263 IPI00443799 IPI00220642 IPI00007221 IPI00299024 IPI00418471 IPI00031461 IPI00746623 IPI00843910 IPI00018769 IPI00784773 IPI00178302 IPI00293836 IPI00829711 IPI00002211 IPI00788786 IPI00784865 IPI00465016 IPI00220334 IPI00785196 IPI00418531 IPI00064607 IPI00008603 IPI00104074 IPI00176427 IPI00743302 IPI00025426 IPI00216691 IPI00020599 IPI00012887 IPI00410714 IPI00032063 IPI00022331 IPI00005142 IPI00472961 IPI00219446 IPI00220327 IPI00301395 IPI00010796 IPI00001611 IPI00011651 IPI00154742 IPI00022361 IPI00328746 IPI00009793 IPI00000874 IPI00027851 IPI00009950 IPI00012989 IPI00298388 IPI00297263 IPI00163446 IPI00396423 IPI00012303 IPI00152418 IPI00026154 IPI00871139 IPI00027038 IPI00295741 IPI00829626 IPI00001593 IPI00217966 IPI00784156 IPI00013682 IPI00853045 IPI00005794 IPI00166392 IPI00014048 IPI00103597 IPI00745363 IPI00289819 IPI00295832 IPI00304925 IPI00023728 IPI00176193 IPI00106646 IPI00011252 IPI00004440 IPI00784519 IPI00015315 IPI00456736 IPI00005292 IPI00015688 IPI00030255 IPI00382938 IPI00247243 IPI00010381 IPI00292150 IPI00020091 IPI00027350 IPI00785200 IPI00216318 IPI00003919 IPI00514676 IPI00854806 IPI00291005 IPI00012440 IPI00293748 IPI00007236 IPI00376394 IPI00022429 IPI00292791 IPI00289204 IPI00829640 IPI00296176 IPI00008087 IPI00014572 IPI00027192 IPI00418446 IPI00027493 IPI00163187 IPI00014592 IPI00013303 IPI00296141 IPI00654755 IPI00026199 IPI00304962 IPI00183487 IPI00024621 IPI00152847 IPI00000138 IPI00012283 IPI00306322 IPI00021856 IPI00015902 IPI00003269 IPI00004946 IPI00301961 IPI00030887 IPI00056357 IPI00303071 IPI00009904 IPI00171473 IPI00025846 IPI00719621 IPI00329801 IPI00470607 IPI00007752 IPI00216882 IPI00011732 IPI00387168 IPI00020987 IPI00011454 IPI00477804 IPI00019399 IPI00329482 IPI00004413 IPI00018274 IPI00025110 IPI00328488 IPI00304865 IPI00015049 IPI00027078 IPI00294615 IPI00291175 IPI00022810 IPI00005908 IPI00004503 IPI00006971 IPI00029236 IPI00220292 IPI00019906 IPI00024825 IPI00018206 IPI00328257 IPI00003176 IPI00009123 IPI00013475 IPI00168479 IPI00015911 IPI00019502 IPI00295386 IPI00299571 IPI00007702 IPI00398715 IPI00011140 IPI00025204 IPI00219131 IPI00002406 IPI00329352 IPI00028448 IPI00789954 IPI00027462 IPI00291006 IPI00785079 IPI00023598 IPI00002236 IPI00011605 IPI00477611 IPI00289058 IPI00852577 IPI00292304 IPI00014964 IPI00028553 IPI00216319 IPI00032311 IPI00871326 IPI00016870 IPI00103471 IPI00029061 IPI00013897 IPI00023824 IPI00001477 IPI00854743 IPI00029046 IPI00301143 IPI00304840 IPI00007797 IPI00795055 IPI00220739 IPI00791134 IPI00060310 IPI00007750 IPI00375364 IPI00011654 IPI00043756 IPI00428511 IPI00295414 IPI00018534 IPI00289870 IPI00005707 IPI00293303 IPI00412988 IPI00006154 IPI00016645 IPI00005126 IPI00883772 IPI00292732 IPI00168884 IPI00168866 IPI00102435 IPI00031564 IPI00302592 IPI00827650 IPI00465436 IPI00017704 IPI00182438 IPI00034319 IPI00003865 IPI00021552 IPI00246058 IPI00739827 IPI00791479 IPI00021857 IPI00003366 IPI00028614 IPI00026270 IPI00301255 IPI00299652 IPI00003102 IPI00021033 IPI00004962 IPI00290328 IPI00002525 IPI00854709 IPI00550363 IPI00010295 IPI00440580 IPI00030075 IPI00382500 IPI00165975 IPI00259102 IPI00165438 IPI00375205 IPI00296099 IPI00479116 IPI00789847 IPI00017257 IPI00219465 IPI00432592 IPI00003648 IPI00009030 IPI00642861 IPI00019533 IPI00002745 IPI00031769 IPI00029605 IPI00022892 IPI00155729 IPI00879309 IPI00044369 IPI00045841 IPI00216983 IPI00216602 IPI00409640 IPI00419595 IPI00007778 IPI00025864 IPI00025818 IPI00784258 IPI00291807 IPI00216138 IPI00022296 IPI00006644 IPI00178767 IPI00386630 IPI00829590 IPI00024048 IPI00473011 IPI00218493 IPI00029273 IPI00745251 IPI00295399 IPI00642632 IPI00297224 IPI00022391 IPI00026103 IPI00008207 IPI00453473 IPI00289924 IPI00645206 IPI00333140 IPI00016679 IPI00024601 IPI00303894 IPI00328243 IPI00219757 IPI00027466 IPI00168626 IPI00024034 IPI00555693 IPI00031821 IPI00294705 IPI00019038 IPI00746388 IPI00011994 IPI00006166 IPI00023751 IPI00032292 IPI00216298 IPI00830047 IPI00002925 IPI00220827 IPI00043215 IPI00217493 IPI00029193 IPI00478483 IPI00176424 IPI00012075 IPI00412987 IPI00015346 IPI00165972 IPI00171410 IPI00337351 IPI00292300 IPI00302840 IPI00455667 IPI00745313 IPI00013569 IPI00003907 IPI00419966 IPI00022333 IPI00001895 IPI00001734 IPI00166892 IPI00060715 IPI00186903 IPI00385007 IPI00419585 IPI00023648 IPI00021903 IPI00402157 IPI00430291 IPI00023807 IPI00007798 IPI00006128 IPI00017569 IPI00002142 IPI00019954 IPI00008215 IPI00217146 IPI00299503 IPI00167215 IPI00299086 IPI00328113 IPI00007240 IPI00784119 IPI00022792 IPI00789234 IPI00029275 IPI00015351 IPI00292218 IPI00008290 IPI00328550 IPI00183321 IPI00374065 IPI00032288 IPI00007199 IPI00019190 IPI00787265 IPI00007102 IPI00218474 IPI00021833 IPI00018396 IPI00018305 IPI00020906 IPI00643348 IPI00101608 IPI00218539 IPI00465315 IPI00029606 IPI00740545 IPI00741710 IPI00216457 IPI00300838 IPI00026259 IPI00384391 IPI00010348 IPI00168520 IPI00747849 IPI00006657 IPI00022394 IPI00026050 IPI00294834 IPI00153049 IPI00549330 IPI00033560 IPI00024035 IPI00031510 IPI00829947 IPI00432525 IPI00007425 IPI00025809 IPI00022392 IPI00016862 IPI00165044 IPI00152850 IPI00020984 IPI00026197 IPI00299150 IPI00021794 IPI00021275 IPI00217882 IPI00554786 IPI00023576 IPI00004114 IPI00021447 IPI00478892 IPI00297188 IPI00019359 IPI00215767 IPI00010896 IPI00008780 IPI00556287 IPI00099670 IPI00384404 IPI00024094 IPI00024273 IPI00296197 IPI00854841 IPI00219930 IPI00218834 IPI00827510 IPI00020977 IPI00009276 IPI00736885 IPI00387115 IPI00017841 IPI00829663 IPI00012011 IPI00009145 IPI00016467 IPI00024129 IPI00784154 IPI00883855 IPI00028931 IPI00005474 IPI00827892 IPI00299699 IPI00006451 IPI00456589 IPI00328703 IPI00030205 IPI00479997 IPI00166339 IPI00025476 IPI00024036 IPI00030739 IPI00027377 IPI00790775 IPI00000824 IPI00827940 IPI00419720 IPI00031549 IPI00029997 IPI00736860 IPI00075248 IPI00829752 IPI00387118 IPI00293849 IPI00329685 IPI00017968 IPI00880120 IPI00749328 IPI00291395 IPI00385252 IPI00218570 IPI00867665 IPI00442911 IPI00871227 IPI00022367 IPI00789477 IPI00306710 IPI00181174 IPI00008494 IPI00180707 IPI00002307 IPI00219575 IPI00431738 IPI00414467 IPI00023858 IPI00005652 IPI00001399 IPI00387120 IPI00307592 IPI00010790 IPI00027223 IPI00009111 IPI00006713 IPI00011662 IPI00410122 IPI00021983 IPI00410585 IPI00219301 IPI00827482 IPI00026991 IPI00550115 IPI00044743 IPI00299724 IPI00007709 IPI00008107 IPI00030111 IPI00020672 IPI00005981 IPI00167710 IPI00019209 IPI00783024 IPI00013162 IPI00027174 IPI00006482 IPI00218414 IPI00001506 IPI00162329 IPI00017745 IPI00829701 IPI00026174 IPI00465255 IPI00854667 IPI00217345 IPI00220361 IPI00006803 IPI00744692 IPI00182944 IPI00827560 IPI00023643 IPI00374914 IPI00107886 IPI00794450 IPI00103871 IPI00007249 IPI00470484 IPI00024105 IPI00171928 IPI00401283 IPI00293128 IPI00031534 IPI00428967 IPI00470625 IPI00304331 IPI00014439 IPI00217236 IPI00217466 IPI00455739 IPI00307276 IPI00607655 IPI00025840 IPI00383732 IPI00643115 IPI00171412 IPI00383032 IPI00816799 IPI00296058 IPI00414717 IPI00217759 IPI00182138 IPI00219425 IPI00328745 IPI00011302 IPI00219684 IPI00218345 IPI00016666 IPI00012269 IPI00011730 IPI00021855 IPI00027341 IPI00478890 IPI00029131 IPI00788824 IPI00783689 IPI00178926 IPI00008223 IPI00011518 IPI00293723 IPI00022959 IPI00026237 IPI00015525 IPI00414909 IPI00783184 IPI00002334 IPI00477714 IPI00386133 IPI00296992 IPI00021817 IPI00251507 IPI00478414 IPI00019449 IPI00296558 IPI00302944 IPI00437751 IPI00019501 IPI00019176 IPI00010182 IPI00413912 IPI00784430 IPI00017567 IPI00432723 IPI00382481 IPI00292496 IPI00063048 IPI00305380 IPI00219025 IPI00644472 IPI00022977 IPI00297655 IPI00003021 IPI00029699 IPI00010706 IPI00217465 IPI00643667 IPI00028015 IPI00027721 IPI00001893 IPI00257508 IPI00012058 IPI00219219 IPI00385253 IPI00783287 IPI00012386 IPI00293925 IPI00217467 IPI00293757 IPI00179851 IPI00013096 IPI00413451 IPI00031789 IPI00847670 IPI00011094 IPI00021347 IPI00029928 IPI00008556 IPI00013701 IPI00165125 IPI00289862 IPI00099650 IPI00401264 IPI00027463 IPI00784368 IPI00012048 IPI00013945 IPI00008756 IPI00015842 IPI00297252 IPI00884389 IPI00418960 IPI00465261 IPI00008164 IPI00005222 IPI00303476 IPI00854644 IPI00168847 IPI00215997 IPI00002511 IPI00440932 IPI00410487 IPI00016621 IPI00168921 IPI00382476 IPI00009901 IPI00184019 IPI00025447 IPI00387116 IPI00184851 IPI00024307 IPI00009477 IPI00414676 IPI00029168 IPI00384392 IPI00027507 IPI00294713 IPI00012792 IPI00030871 IPI00299145 IPI00827876 IPI00081836 IPI00554752 IPI00412492 IPI00022674 IPI00005123 IPI00018941 IPI00397645 IPI00306844 IPI00178352 IPI00000044 IPI00297181 IPI00883765 IPI00220748 IPI00384016 IPI00413587 IPI00003799 IPI00387119 IPI00748265 IPI00019771 IPI00477868 IPI00017334 IPI00374732 IPI00030882 IPI00006556 IPI00016014 IPI00022640 IPI00044600 IPI00289876 IPI00884080 IPI00374590 IPI00301180 IPI00644346 IPI00012007 IPI00300725 IPI00411656 IPI00018860 IPI00005038 IPI00027847 IPI00441498 IPI00018381 IPI00375879 IPI00556391 IPI00010402 IPI00009867 IPI00004457 IPI00028082 IPI00032050 IPI00883711 IPI00303161 IPI00002966 IPI00382493 IPI00009826 IPI00026285 IPI00441344 IPI00022389 IPI00029756 IPI00337612 IPI00220301 IPI00402293 IPI00019862 IPI00419442 IPI00007853 IPI00024466 IPI00006130 IPI00384402 IPI00019600 IPI00004573 IPI00465322 IPI00012009 IPI00157454 IPI00829740 IPI00827829 IPI00257882 IPI00103755 IPI00217963 IPI00062037 IPI00006444 IPI00829841 IPI00293276 IPI00550533 IPI00382488 IPI00019755 IPI00024929 IPI00031506 IPI00025812 IPI00002283 IPI00022445 IPI00220362 IPI00020747 IPI00293539 IPI00291488 IPI00419565 IPI00006510 IPI00739099 IPI00829812 IPI00010470 IPI00382478 IPI00029623 IPI00000914 IPI00220766 IPI00293971 IPI00011899 IPI00007047 IPI00171199 IPI00299116 IPI00552852 IPI00884092 IPI00024587 IPI00413641 IPI00149097 IPI00400935 IPI00107731 IPI00022891 IPI00005516 IPI00027444 IPI00021834 IPI00783156 IPI00293464 IPI00783393 IPI00012510 IPI00299083 IPI00001610 IPI00176581 IPI00018146 IPI00176398 IPI00217376 IPI00299547 IPI00001592 IPI00023191 IPI00029817 IPI00017562 IPI00553138 IPI00170814 IPI00382682 IPI00217005 IPI00219129 IPI00010148 IPI00020396 IPI00009890 IPI00061354 IPI00219682 IPI00184094 IPI00883879 IPI00000832 IPI00219468 IPI00009054 IPI00029700 IPI00219910 IPI00299399 IPI00760721 IPI00413344 IPI00297779 IPI00024919 IPI00398918 IPI00022649 IPI00465377 IPI00008586 IPI00168920 IPI00022039 IPI00552267 IPI00001633 IPI00828105 IPI00006524 IPI00215980 IPI00004047 IPI00031708 IPI00171438 IPI00743194 IPI00026800 IPI00100154 IPI00387106 IPI00022774 IPI00376131 IPI00387024 IPI00216461 IPI00021997 IPI00305975 IPI00026240 IPI00005517 IPI00444605 IPI00735451 IPI00418169 IPI00440493 IPI00005722 IPI00827581 IPI00304577 IPI00075013 IPI00012315 IPI00419237 IPI00169285 IPI00827637 IPI00301364 IPI00006009 IPI00552943 IPI00024067 IPI00396378 IPI00298650 IPI00030847 IPI00329332 IPI00008726 IPI00218795 IPI00299758 IPI00873863 IPI00008533 IPI00384400 IPI00021727 IPI00382482 IPI00007960 IPI00000760 IPI00657742 IPI00033466 IPI00411706 IPI00292657 IPI00387117 IPI00102575 IPI00218667 IPI00289926 IPI00027972 IPI00216694 IPI00005809 IPI00472754 IPI00008997 IPI00016371 IPI00383951 IPI00384395 IPI00023754 IPI00432766 IPI00219067 IPI00021091 IPI00013933 IPI00216914 IPI00019904 IPI00300623 IPI00410079 IPI00021695 IPI00024248 IPI00399252 IPI00829827 IPI00011865 IPI00827929 IPI00413781 IPI00028714 IPI00144243 IPI00219806 IPI00015479 IPI00019812 IPI00480159 IPI00063827 IPI00186004 IPI00873344 IPI00294619 IPI00010343 IPI00005690 IPI00215899 IPI00000070 IPI00552939 IPI00003441 IPI00023942 IPI00289746 IPI00412264 IPI00255145 IPI00827939 IPI00043810 IPI00305833 IPI00295767 IPI00024887 IPI00552874 IPI00065312 IPI00024976 IPI00550746 IPI00296441 IPI00005837 IPI00010737 IPI00152524 IPI00550949 IPI00003470 IPI00827906 IPI00024138 IPI00168806 IPI00182194 IPI00006034 IPI00028387 IPI00383887 IPI00335946 IPI00302850 IPI00165936 IPI00297180 IPI00009396 IPI00385985 IPI00807609 IPI00013681 IPI00783818 IPI00003527 IPI00828156 IPI00064652 IPI00021900 IPI00019208 IPI00242905 IPI00061520 IPI00181743 IPI00024572 IPI00026358 IPI00025019 IPI00022890 IPI00219420 IPI00426727 IPI00384407 IPI00030877 IPI00013508 IPI00026546 IPI00005774 IPI00552937 IPI00030431 IPI00000265 IPI00470766 IPI00293460 IPI00879950 IPI00787936 IPI00220706 IPI00386575 IPI00023359 IPI00032227 IPI00004494 IPI00031907 IPI00028193 IPI00000190 IPI00031696 IPI00064377 IPI00396383 IPI00018879 IPI00000775 IPI00790122 IPI00038378 IPI00816775 IPI00454695 IPI00399089 IPI00221117 IPI00026125 IPI00029819 IPI00298476 IPI00031718 IPI00387097 IPI00646689 IPI00002818 IPI00003933 IPI00830035 IPI00021119 IPI00007812 IPI00218319 IPI00296259 IPI00184997 IPI00002320 IPI00004488 IPI00170692 IPI00004367 IPI00642645 IPI00004409 IPI00166613 IPI00514517 IPI00854707 IPI00029591 IPI00386131 IPI00556643 IPI00001120 IPI00009439 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IPI00171611 IPI00854745 IPI00175654 IPI00465178 IPI00299679 IPI00031547 IPI00477361 IPI00043731 IPI00873740 IPI00291463 IPI00797699 IPI00384722 IPI00397578 IPI00645814 IPI00032416 IPI00007040 IPI00333126 IPI00382756 IPI00031019 IPI00003353 IPI00335589 IPI00220578 IPI00794119 IPI00604599 IPI00017659 IPI00007402 IPI00843819 IPI00740191 IPI00816274 IPI00743284 IPI00744706 IPI00152470 IPI00065276 IPI00044607 IPI00032830 IPI00021363 IPI00025094 IPI00006094 IPI00644522 IPI00301923 IPI00171737 IPI00749440 IPI00830057 IPI00169426 IPI00045511 IPI00059395 IPI00385003 IPI00216683 IPI00023315 IPI00816794 IPI00604763 IPI00030319 IPI00029123 IPI00015522 IPI00010895 IPI00010346 IPI00829759 IPI00018275 IPI00218487 IPI00877084 IPI00739106 IPI00013216 IPI00235647 IPI00025363 IPI00158992 IPI00060265 IPI00022606 IPI00216572 IPI00294910 IPI00015285 IPI00394712 IPI00024802 IPI00550232 IPI00644025 IPI00217652 IPI00554799 IPI00001869 IPI00374039 IPI00295502 IPI00171647 IPI00470805 IPI00478124 IPI00027834 IPI00302133 IPI00216106 IPI00020058 IPI00167089 IPI00304596 IPI00062730 IPI00028786 IPI00010118 IPI00026570 IPI00385143 IPI00012895 IPI00298258 IPI00167254 IPI00300990 IPI00027726 IPI00783753 IPI00299627 IPI00018352 IPI00013455 IPI00741780 IPI00064241 IPI00445716 IPI00023513 IPI00744366 IPI00026299 IPI00454858 IPI00295503 IPI00030919 IPI00394870 IPI00008905 IPI00845508 IPI00399328 IPI00307591 IPI00827745 IPI00166817 IPI00377077 IPI00745300 IPI00479083 IPI00290292 IPI00005776 IPI00375174 IPI00009294 IPI00009148 IPI00168885 IPI00003348 IPI00394879 IPI00296866 IPI00186581 IPI00787932 IPI00010575 IPI00299435 IPI00401852 IPI00040730 IPI00445364 IPI00166161 IPI00785015 IPI00029533 IPI00306884 IPI00829980 IPI00021985 IPI00180426 IPI00106502 IPI00815786 IPI00748891 IPI00028561 IPI00166071 IPI00382420 IPI00830025 IPI00375881 IPI00874023 IPI00743898 IPI00217023 IPI00166553 IPI00187143 IPI00008998 IPI00020199 IPI00644231 IPI00455521 IPI00004315 IPI00103630 IPI00658112 IPI00297714 IPI00007193 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IPI00640818 IPI00021951 IPI00241409 IPI00790021 IPI00329791 IPI00418735 IPI00164861 IPI00815893 IPI00090764 IPI00000027 IPI00152344 IPI00306413 IPI00411674 IPI00002243 IPI00141938 IPI00033600 IPI00465363 IPI00018755 IPI00025365 IPI00159049 IPI00024253 IPI00375746 IPI00028601 IPI00385543 IPI00020131 IPI00297277 IPI00387096 IPI00180384 IPI00011781 IPI00299076 IPI00828191 IPI00031765 IPI00218637 IPI00176920 IPI00419908 IPI00386393 IPI00249982 IPI00016685 IPI00216921 IPI00045839 IPI00479125 IPI00878511 IPI00025473 IPI00002191 IPI00011416 IPI00008404 IPI00455852 IPI00816155 IPI00328270 IPI00007928 IPI00260755 IPI00658025 IPI00174976 IPI00442564 IPI00432707 IPI00022542 IPI00337385 IPI00022958 IPI00550876 IPI00412408 IPI00442544 IPI00028053 IPI00304527 IPI00006987 IPI00795481 IPI00008422 IPI00175019 IPI00005732 IPI00000459 IPI00023162 IPI00064296 IPI00746177 IPI00027898 IPI00293095 IPI00030741 IPI00019146 IPI00002459 IPI00550792 IPI00019485 IPI00747142 IPI00399296 IPI00789181 IPI00025311 IPI00029175 IPI00023340 IPI00040900 IPI00233358 IPI00742725 IPI00216651 IPI00045360 IPI00300052 IPI00011515 IPI00879842 IPI00878755 IPI00216774 IPI00001755 IPI00383594 IPI00164066 IPI00021476 IPI00152050 IPI00792945 IPI00749171 IPI00019158 IPI00307702 IPI00028383 IPI00385480 IPI00027464 IPI00033419 IPI00005605 IPI00307611 IPI00001863 IPI00465123 IPI00293530 IPI00170635 IPI00045928 IPI00014444 IPI00298337 IPI00013495 IPI00399180 IPI00830018 IPI00306332 IPI00479217 IPI00044842 IPI00398992 IPI00007512 IPI00026230 IPI00015047 IPI00183206 IPI00022055 IPI00827724 IPI00016576 IPI00009365 IPI00001786 IPI00220070 IPI00328260 IPI00012441 IPI00290308 IPI00445278 IPI00745103 IPI00023322 IPI00807418 IPI00006054 IPI00005859 IPI00644840 IPI00827846 IPI00784739 IPI00183002 IPI00008438 IPI00025622 IPI00301098 IPI00385791 IPI00738920 IPI00163601 IPI00152849 IPI00019901 IPI00009771 IPI00145805 IPI00056314 IPI00428741 IPI00029556 IPI00102808 IPI00444842 IPI00296374 IPI00797694 IPI00006252 IPI00217012 IPI00073763 IPI00023152 IPI00021733 IPI00294210 IPI00007321 IPI00218730 IPI00018208 IPI00296727 IPI00184884 IPI00787020 IPI00217617 IPI00215914 IPI00166865 IPI00005347 IPI00103874 IPI00167941 IPI00306850 IPI00290826 IPI00477468 IPI00470913 IPI00243221 IPI00016701 IPI00024662 IPI00553092 IPI00005668 IPI00023407 IPI00306046 IPI00884353 IPI00217831 IPI00657936 IPI00434711 IPI00445315 IPI00852725 IPI00030037 IPI00329593 IPI00009881 IPI00065931 IPI00005600 IPI00013749 IPI00296461 IPI00020329 IPI00149044 IPI00791593 IPI00645078 IPI00376383 IPI00243451 IPI00007834 IPI00293396 IPI00395866 IPI00015973 IPI00184650 IPI00003971 IPI00018914 IPI00240793 IPI00304789 IPI00328298 IPI00746681 IPI00185146 IPI00376237 IPI00792759 IPI00386284 IPI00383808 IPI00143753 IPI00847723 IPI00446588 IPI00289329 IPI00871556 IPI00217791 IPI00169115 IPI00419836 IPI00018429 IPI00746666 IPI00167006 IPI00020966 IPI00217435 IPI00032904 IPI00003814 IPI00028481 IPI00456827 IPI00021766 IPI00424119 IPI00245940 IPI00294215 IPI00747657 IPI00221006 IPI00387004 IPI00657699 IPI00027806 IPI00215777 IPI00290358 IPI00218946 IPI00290094 IPI00071185 IPI00028912 IPI00013272 IPI00024766 IPI00413826 IPI00166776 IPI00003807 IPI00009070 IPI00009471 IPI00030706 IPI00853400 IPI00830107 IPI00386576 IPI00455967 IPI00410093 IPI00473033 IPI00019242 IPI00022295 IPI00186966 IPI00168404 IPI00749245 IPI00786946 IPI00747420 IPI00045939 IPI00644766 IPI00152182 IPI00166257 IPI00432226 IPI00165009 IPI00167154 IPI00783604 IPI00011592 IPI00171874 IPI00374670 IPI00871533 IPI00456969 IPI00442745 IPI00165229 IPI00289837 IPI00877615 IPI00001796 IPI00374301 IPI00006746 IPI00030352 IPI00549972 IPI00024920 IPI00178894 IPI00221080 IPI00604551 IPI00026262 IPI00878436 IPI00032338 IPI00470468 IPI00018843 IPI00640810 IPI00293679 IPI00382515 IPI00027782 IPI00845229 IPI00152769 IPI00853312 IPI00030009 IPI00306549 IPI00748682 IPI00644191 IPI00177878 IPI00003392 IPI00019888 IPI00470490 IPI00104907 IPI00293361 IPI00291987 IPI00001433 IPI00827978 IPI00827788 IPI00170766 IPI00220156 IPI00005107 IPI00253281 IPI00032597 IPI00024818 IPI00152216 IPI00005607 IPI00783855 IPI00335437 IPI00028520 IPI00014371 IPI00746987 IPI00000076 IPI00027264 IPI00329605 IPI00295469 IPI00290078 IPI00878962 IPI00032425 IPI00044326 IPI00100980 IPI00103891 IPI00300020 IPI00884004 IPI00328361 IPI00328709 IPI00001568 IPI00478997 IPI00022277 IPI00398154 IPI00020470 IPI00456599 IPI00216288 IPI00291939 IPI00718821 IPI00607831 IPI00025499 IPI00444272 IPI00018387 IPI00399254 IPI00030757 IPI00641181 IPI00398229 IPI00171230 IPI00787083 IPI00418125 IPI00027248 IPI00719505 IPI00856012 IPI00151990 IPI00438286 IPI00784880 IPI00001712 IPI00024272 IPI00023780 IPI00741005 IPI00216592 IPI00003384 IPI00018027 

1. A method for diagnosing multiple sclerosis in a patient, the method comprising: a) isolating a biological sample from the patient; and b) analyzing the biological sample for expression of a panel of biomarkers, wherein the panel of biomarkers is set forth in any one of Tables 1m, 3m, 4H-m or 2m, to determine if at least two of the biomarkers listed in any one of Tables 1m, 3m, 4H-m or Table 2m are in the biological sample, wherein identification of at least two of the biomarkers in the biological sample indicates a positive diagnosis of multiple sclerosis in the patient.
 2. The method of claim 1, wherein the at least two biomarkers identified in the biological sample are present in the biological sample and set forth in Table 1m, 3m, or 4H-m, and the presence of the at least two biomarkers indicates a positive diagnosis of multiple sclerosis.
 3. The method of claim 1, wherein the at least two biomarkers identified in the biological sample are absent from the biological sample and set forth in Table 2m and the absence of the at least two biomarkers indicates a positive diagnosis of multiple sclerosis.
 4. A method for differentially diagnosing a neuropsychiatric disease in a patient, wherein the patient exhibits clinical symptoms common to both Neurologic Lyme disease and Chronic Fatigue Syndrome, the method comprising: a) isolating a biological sample from the patient; and b) analyzing the biological sample for expression of a first panel of biomarkers, wherein the first panel of biomarkers is set forth in any one of Tables 4H-1, 7L, or 8L, to determine if at least two of the biomarkers listed in any one of Tables 4H-1, 7L, or 8L are identified in the biological sample, wherein identification of at least two of the biomarkers in the biological sample indicates a positive diagnosis of Neurologic Lyme disease.
 5. The method of claim 4, wherein the at least two biomarkers identified in the biological sample are present in the biological sample and set forth in Table 4H-1 or 7L and the presence of the at least two biomarkers indicates a positive diagnosis of Neurologic Lyme disease.
 6. The method of claim 4, wherein the at least two biomarkers identified in the biological sample are absent from the biological sample and set forth in Table 8L and the absence of the at least two biomarkers indicates a positive diagnosis of Neurologic Lyme disease.
 7. The method of claim 4, further comprising analyzing the biological sample for expression of a second panel of biomarkers, wherein the second panel of biomarkers is set forth in any one of Tables 4H-c, 5c, or 6c, to determine if at least two of the biomarkers listed in any one of Tables 4H-c, 5c, or 6c are identified in the biological sample, wherein identification of at least two of the biomarkers in the biological sample indicates a positive diagnosis of Chronic Fatigue Syndrome.
 8. The method of claim 7, wherein the at least two biomarkers identified in the biological sample are present in the biological sample and set forth in Table 4H-c or 5c and the presence of the at least two biomarkers indicates a positive diagnosis of Chronic Fatigue Syndrome.
 9. The method of claim 7, wherein the at least two biomarkers identified in the biological sample are absent from the biological sample and set forth in Table 6c and the absence of the at least two biomarkers indicates a positive diagnosis of Chronic Fatigue Syndrome.
 10. The method of claim 1, wherein the biological sample is cerebrospinal fluid, blood or a component thereof, tissue or tissue-related fluids, urine, or saliva.
 11. A method for diagnosing a neuropsychiatric disease in a patient, wherein the patient exhibits clinical symptoms common to both Chronic Fatigue Syndrome and Neurologic Lyme disease, the method comprising: a) isolating a biological sample from the patient; b) analyzing the biological sample to evaluate expression levels of the biomarkers listed in Table 9 to determine a first level of at least two of the biomarkers indicative of the presence of the neuropsychiatric disease in the biological sample; and c) comparing the first level of the at least two of the biomarkers to a second level of the at least two of the biomarkers determined for a subject, wherein the subject does not have the neuropsychiatric disease, and wherein at least a two-fold difference in the ratio of the first level to the second level indicates a positive diagnosis of the neuropsychiatric disease.
 12. The method of claim 11, wherein the neuropsychiatric disease is Chronic Fatigue Syndrome or Neurologic Lyme disease.
 13. The method of claim 11, wherein the at least a two-fold difference is at least a two-fold increase or at least a two-fold decrease.
 14. The method of claim 11, wherein the subject is a healthy subject. 15-28. (canceled)
 29. The method of claim 4, wherein the biological sample is cerebrospinal fluid, blood or a component thereof, tissue or tissue-related fluids, urine, or saliva.
 30. The method of claim 11, wherein the biological sample is cerebrospinal fluid, blood or a component thereof, tissue or tissue-related fluids, urine, or saliva. 